Mark, D. F., Kelley, S. P., Lee, M. R., Parnell, J., Sherlock, S. C., Brown, D. J.
We have analysed two distinct generations of authigenic K-feldspar in Fucoid Bed sandstones from An-t-Sron and Skiag Bridge, NW Highlands, Scotland, which have experienced post-growth heating to...
Peering into the eyes of trilobites using EBSD (2008)
Torney, C., Lee, M.R., Owen, A.W.
The compound eyes of trilobites, an extinct group of marine arthropods, contain many sub-millimeter sized calcium carbonate lenses whose microstructures are the key to understanding how this ancient...
An electron backscatter diffraction study of geesops: a broader view of trilobite vision? (2008)
Torney, C., Lee, M.R., Owen, A.W.
The calcite eyes of trilobites have been studied for over 100 years using methods including light microscopy (e.g. Clarke 1889; Campbell 1975; Towe 1973; Clarkson 1979 and Bruton and Haas 2003) and...
New Solution Method of Time-dependent Schrödinger Equation Using Improved Boundary Conditions (2001)
C. P. Song, M. R. Lee, K. F. Yarn
Numerical solution of the time-dependent Schrödinger equation for open system structures has been impeded by the difficulty in handing open-system boundary conditions. This paper presents a new...
Bland, P.A., Lee, M.R., Sexton, A.S., Franchi, I.A., Fallick, A.E.T., Miller, M.F., ...
Primitive meteorites exhibit certain features that are consistent with aqueous and thermal alteration on asteroids, but O-isotopic analyses show only a modest heavy-isotope shift, interpreted as...
Eadington, D. W., Swainson, C. P., Frier, B. M., Johnston, N., Samson, R. R., Lee, M. R.
To examine the interaction between angiotensin II (ANGII) and dopamine in type I diabetes mellitus, urinary dopamine excretion was examined during ANGII infusion in 15 diabetic patients and 10...
Jeffrey, R. F., MacDonald, T. M., Freestone, S., Lee, M.R
To assess a possible role for endogenous renal dopamine in sodium excretion, the dopa decarboxylase inhibitor carbidopa was given during intravenous salt loading. In addition, the effect of lithium...
WATT, S. J., TOOKE, J. E., PERKINS, C. M., LEE, M. R.
We report our experience in the management of idiopathic orthostatic hypotension using the prostaglandin synthetase inhibitor, flurbiprofen. In five subjects with proven autonomic faihire the effect...
Hypertension and Hyperkalaemia Responding to Bendrofluazide (1979)
LEE, M. R., BALL, S. G., THOMAS, T. H., MORGAN, D. B.
A 33-year-old man is described with hyperkalaemia, hypertension and acidosis. The blood pressure was 160 to 200 mmHg systolic and 90 to 110 mmHg diastolic and the plasma potassium was between 6·0...
Sodium Losing Renal Disease: Two Cases and a Review of the Literature (1978)
MORGAN, D. B., BALL, S. R., THOMAS, T. H., LEE, M. R.
Two patients with sodium-losing renal disease were studied in detail. Both presented with shock and hypotension which was attributed at first to other causes, as was the recurrent hyponatraemia in...
The sensitivity of high order inductorless filters /--by M.R. Lee. (1972)
British Library microfilm no. : D3628/73.
Radioactivity of Sm153 and Eu155 (1954)
The radiations from Sm153 and Eu155 have been studied by means of a 180-degree, magnetic-focusing, variable-field beta-ray spectrometer-spectrograph using enriched materials. In the disintegration of...
Application of the Polaroid-Land Process to Radiographic Inspection of Wheat (1953)
Milner, Max, Katz, Robert, Lee, M. R., Pyle, W. B.
At a time when the technique of X-ray inspection of grains for internal insect infestation, announced almost two years ago, appears to have gained considerable currency in industries handling and...
Internal Fissuring of Wheat due to Weathering (1952)
Milner, Max, Shellenberger, J. A., Lee, M. R., Katz, Robert
Radiographic technique developed at this Station for the determination of internal or hidden insect infestation in stored grain has proved to be useful for the detection of other physical anomalies...
Bland, P.A., Lee, M.R., Sexton, A.S., Franchi, I.A., Fallick, A.E.T., Miller, M.F., ...
Primitive meteorites exhibit certain features that are consistent with aqueous and thermal alteration on asteroids, but O-isotopic analyses show only a modest heavy-isotope shift, interpreted as...
Albert, V R, Lee, M R, Bolden, A H, Wurzburger, R J, Aguanno, A
Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons....
Effect of anaerobic digestion on oocysts of the protozoan Eimeria tenella.
The effect of anaerobic digestion of poultry waste on oocysts of the protozoan Eimeria tenella, a common enteric pathogen that causes coccidiosis in poultry, was investigated in this study....
Evaluation of the rapid hippurate hydrolysis test with enterococcal group D streptococci.
The rapid hippurate hydrolysis test was evaluated with the conventional test, using 17 group A streptococci, 9 non-enterococcal group D streptococci, 108 enterococcal group D streptococci, and 2...
We have cloned the cDNA of rat hsc70 (clathrin-uncoating ATPase) into a T7 expression system and have expressed this enzyme in Escherichia coli. The recombinant clathrin-uncoating ATPase is in the...
A rapid simple method for the assay of renin in rabbit plasma
Ryan, J. W., McKenzie, J. K., Lee, M. R.
1. EDTA (10mm), 2,3-dimercaptopropan-1-ol (10mm) and chlorhexidine gluconate (0·005%, w/v) cause complete inactivation of plasma enzymes that degrade angiotensin I, but have no effect on the...
The preparation of rabbit renin-substrate for the assay of minute amounts of renin
1. By DEAE-cellulose chromatography and treatment with Cd2+ a partially purified renin-substrate has been prepared from rabbit serum. 2. It has the following properties: (a) Angiotensinase activity...
Does sodium restriction lower blood pressure?
Lee, M R, Critchley, J A, Jeffrey, R F, Freestone, S, MacDonald, T M
Failure of renal dopamine response to salt loading in chronic renal disease.
Casson, I F, Lee, M R, Brownjohn, A M, Parsons, F M, Davison, A M, Will, E J, ...
Eight patients with chronic glomerulonephritis and five age-matched normal volunteers were given additional sodium chloride by mouth under conditions of metabolic balance. Whereas in the normal...
Evidence for a hypothalamic disturbance in cyclical oedema.
Young, J B, Brownjohn, A M, Chapman, C, Lee, M R
Fourteen women with cyclical oedema and six healthy female controls were investigated by use of a test in which thyrotrophin releasing hormone and luteinising hormone releasing hormone were given....
Albert, V R, Lee, M R, Bolden, A H, Wurzburger, R J, Aguanno, A
Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons....
Effect of anaerobic digestion on oocysts of the protozoan Eimeria tenella.
The effect of anaerobic digestion of poultry waste on oocysts of the protozoan Eimeria tenella, a common enteric pathogen that causes coccidiosis in poultry, was investigated in this study....
Evaluation of the rapid hippurate hydrolysis test with enterococcal group D streptococci.
The rapid hippurate hydrolysis test was evaluated with the conventional test, using 17 group A streptococci, 9 non-enterococcal group D streptococci, 108 enterococcal group D streptococci, and 2...
We have cloned the cDNA of rat hsc70 (clathrin-uncoating ATPase) into a T7 expression system and have expressed this enzyme in Escherichia coli. The recombinant clathrin-uncoating ATPase is in the...
A rapid simple method for the assay of renin in rabbit plasma
Ryan, J. W., McKenzie, J. K., Lee, M. R.
1. EDTA (10mm), 2,3-dimercaptopropan-1-ol (10mm) and chlorhexidine gluconate (0·005%, w/v) cause complete inactivation of plasma enzymes that degrade angiotensin I, but have no effect on the...
The preparation of rabbit renin-substrate for the assay of minute amounts of renin
1. By DEAE-cellulose chromatography and treatment with Cd2+ a partially purified renin-substrate has been prepared from rabbit serum. 2. It has the following properties: (a) Angiotensinase activity...
Does sodium restriction lower blood pressure?
Lee, M R, Critchley, J A, Jeffrey, R F, Freestone, S, MacDonald, T M
Failure of renal dopamine response to salt loading in chronic renal disease.
Casson, I F, Lee, M R, Brownjohn, A M, Parsons, F M, Davison, A M, Will, E J, ...
Eight patients with chronic glomerulonephritis and five age-matched normal volunteers were given additional sodium chloride by mouth under conditions of metabolic balance. Whereas in the normal...
Evidence for a hypothalamic disturbance in cyclical oedema.
Young, J B, Brownjohn, A M, Chapman, C, Lee, M R
Fourteen women with cyclical oedema and six healthy female controls were investigated by use of a test in which thyrotrophin releasing hormone and luteinising hormone releasing hormone were given....
A biochemical comparison of alclofenac and D-penicillamine in rheumatoid arthritis.
Bird, H A, Dixon, J S, Pickup, M E, Lee, M R, Wright, V
In view of the claim that alclofenac has a specific antirheumatoid action a detailed biochemical study has been made over a 6-month period of 2 groups of patients with rheumatoid arthritis receiving...
Dixon, J S, Pickup, M E, Lowe, J R, Hallett, C, Lee, M R, Wright, V
A long-term study is being undertaken to classify drugs used as specific agents in the treatment of rheumatoid arthritis in terms of their effects on biochemical and clinical characteristics of the...
Dixon, J S, Pickup, M E, Bird, H A, Lee, M R, Wright, V, Downie, W W
Biochemical and clinical changes have been monitored in 30 patients with rheumatoid arthritis treated with either hydroxychloroquine or sodium aurothiomalate over a period of 6 months. Acute-phase...
Bland, P.A., Lee, M.R., Sexton, A.S., Franchi, I.A., Fallick, A.E.T., Miller, M.F., ...
Primitive meteorites exhibit certain features that are consistent with aqueous and thermal alteration on asteroids, but O-isotopic analyses show only a modest heavy-isotope shift, interpreted as...
Review Body's Report: Hospital Medical Staff
Bradshaw, R. B., Carr, C. J., Carrie, L. E. S., Cope, V., Cuddigan, B. J., Delahunty, J. E., ...
A comparison of the effects of two putative 5-hydroxytryptamine renal prodrugs in normal man.
Li Kam Wa, T C, Freestone, S, Samson, R R, Johnston, N R, Lee, M R
1. The effects of 1 h intravenous infusions of equimolar amounts of two putative 5-hydroxytryptamine (5-HT) renal prodrugs, 5-hydroxy-L-tryptophan (5-HTP, 10 micrograms kg-1 min-1) and...
Li Kam Wa, T C, Freestone, S, Samson, R R, Johnston, N R, Lee, M R
1. The effects of inhibition of peripheral aromatic L-amino acid decarboxylase during infusion of the relatively renally selective 5-hydroxytryptamine (5-HT) prodrug,...
Wa, T C, Burns, N J, Williams, B C, Freestone, S, Lee, M R
Six healthy male subjects received equimolar amounts of two 5-hydroxytryptamine (5-HT) precursors, 5-hydroxy-L-tryptophan (5-HTP) and gamma-L-glutamyl-5-hydroxy-L-tryptophan (glu-5-HTP), on two...
Jeffrey, R F, Capewell, S, Brown, J, Collier, A, Hajducka, C, Lee, M R
Eighteen patients with non-insulin dependent diabetes mellitus and hypertension were treated during two 4 week periods with the calcium antagonist felodipine or placebo in a double-blind, randomised,...
Boateng, Y A, Barber, H E, MacDonald, T M, Petrie, J C, Lee, M R
1. The pharmacokinetics of gludopa in healthy volunteers were studied at two doses, 250 micrograms kg-1 and 100 micrograms kg-1, after rapid intravenous bolus injection. 2. Gludopa had a clearance of...
The renal effects of atrial natriuretic peptide in man are not attenuated by (+)-sulpiride.
Freestone, S, MacDonald, T M, Jeffrey, R F, Brown, J, Lee, M R
1. Human alpha atrial natriuretic peptide (ANP) was infused intravenously for 1 h in eight healthy salt-replete men on two occasions, with and without pretreatment with (+)-sulpiride. 2. ANP...
The renal and haemodynamic effects of a 10 h infusion of glutamyl-L-dopa in normal man.
MacDonald, T M, Jeffrey, R F, Lee, M R
1. gamma-L-glutamyl-L-dopa (gludopa) and placebo were given by intravenous infusion to 12 healthy salt replete men for 10 h in a single-blind randomised fashion. 2. Gludopa caused a cumulative...
The effect of lithium on the renal response to the dopamine prodrug gludopa in normal man.
Jeffrey, R F, Macdonald, T M, Brown, J, Rae, P W, Lee, M R
1. The effect of oral lithium on the renal response to gamma-L-glutamyl-L-dopa (gludopa, 25 micrograms kg-1 min-1) was investigated in seven normal males. 2. Gludopa at this dose produced an 800-fold...
Jeffrey, R F, MacDonald, T M, Marwick, K, Lee, M R
1. The renal response to gamma-L-glutamyl-L-dopa (gludopa, 25 micrograms kg-1 min-1) was investigated in seven normal male volunteers. The effects of oral carbidopa (100 mg) and indomethacin (100 mg)...
(+)-sulpiride antagonises the renal effects of gamma-L-glutamyl-L-dopa in man.
MacDonald, T M, Jeffrey, R F, Freestone, S, Lee, M R
1. gamma-L-glutamyl-L-dopa (gludopa) was given by intravenous infusion to six healthy salt-replete men on two occasions, with and without pretreatment with (+)-sulpiride. 2. Gludopa increased sodium...
Studies with fenoldopam, a dopamine receptor DA1 agonist, in essential hypertension.
Harvey, J N, Worth, D P, Brown, J, Lee, M R
A series of studies were undertaken to assess the effect of oral fenoldopam, a specific DA1 dopamine receptor agonist on blood pressure and renal function in patients with mild essential...
Worth, D P, Harvey, J N, Brown, J, Worral, A, Lee, M R
The dopamine pro-drug gamma-L-glutamyl-L-dopa (gludopa) was administered intravenously to six normal subjects at a dose of 12.5 micrograms min-1 kg-1, either with or without the dopamine antagonist...
1 Carbidopa, a known inhibitor of the peripheral conversion of dopa to dopamine, was given to six normal volunteers to examine the effect of interference with dopamine synthesis on urinary sodium...
Lack of effect of ibopamine, a dopamine pro-drug, on renal function in normal subjects.
Harvey, J N, Worth, D P, Brown, J, Lee, M R
The effects of two single oral doses of ibopamine (150 and 600 mg) on heart rate, blood pressure, urine flow, sodium, potassium and creatinine excretion were studied in normal volunteers. No...
Harvey, J N, Worth, D P, Brown, J, Lee, M R
The effect of a single oral dose of 100 mg of fenoldopam on renal function and blood pressure was investigated in seven healthy male subjects in a double-blind placebo controlled study. Mean...
Boateng, Y. A., Barber, H. E., MacDonald, T. M., Petrie, J. C., Lee, M. R., Whiting, P. H.
1. The pharmacokinetics of gamma-glutamyl-L-dopa (gludopa) and its metabolite, L-dopa, have been studied in normal rats at three dose levels of gludopa: 2 mg kg-1, 5 mg kg-1 and 7.5 mg kg-1. The...
LI KAM WA, T. C., FREESTONE, S., SAMSON, R. R., JOHNSON, N. R., LEE, M. R.
1This randomized, placebo-controlled, cross-over study compared the relative effectiveness of γ-l-glutamyl-5-hydroxy-l-tryptophan (glu-5-HTP) and γ-l-glutamyl-l-tryptophan (glu-TRP) in terms of...
Effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine in normal man
LI KAM WA, T. C., FREESTONE, S., McCRINDLE, J. L., SAMSON, R. R., JOHNSTON, N. R., LEE, M. R.
The effects of frusemide on the urinary excretion of dopamine and 5hydroxytryptamine (5-HT) were investigated in eight healthy male subjects in a randomized, placebo-controlled, cross-over study....
Li, L, Eto, M, Lee, M R, Morita, F, Yazawa, M, Kitazawa, T
CPI-17 has recently been identified as a novel protein in vascular smooth muscle. In vitro, its phosphorylation and thiophosphorylation by protein kinase C (PKC) specifically inhibits the type 1...
Atrial natriuretic peptide levels in the sleep apnoea/hypopnoea syndrome.
Mackay, T W, Fitzpatrick, M F, Freestone, S, Lee, M R, Douglas, N J
BACKGROUND--Patients with the sleep apnoea/hypopnoea syndrome have increased salt and water excretion at night which has been reported to be associated with an increase in plasma levels of atrial...
Treatment of Bartter's syndrome in early childhood with prostaglandin synthetase inhibitors.
Littlewood, J M, Lee, M R, Meadow, S R
The diagnosis of Bartter's syndrome was made in a 9-month-old boy investigated for poor weight and height gain. Initial treatment with oral potassium supplements and later spironolactone had little...
Recurrence of asthma following removal of a noradrenaline-secreting phaeochromocytoma.
Harvey, J. N., Dean, H. G., Lee, M. R.
A patient with asthma and a phaeochromocytoma is described. At about the time she was first noted to be hypertensive her asthma resolved spontaneously but bronchospasm returned with some severity...
Two cases of the nephrotic syndrome with a reversible coagulation defect.
Baker, M. R., Davies, J. A., Tate, G. M., Lee, M. R.
Two cases of the nephrotic syndrome with an apparently identical defect of blood coagulation, discovered during preparation for renal biopsy are described. Plasma from both patients showed...