Rudwaleit, M, Landewe, Rene, Listing, J, Brandt, J, Braun, J, ...
Objective: Non-radiographic axial spondyloarthritis (SpA) is characterised by a lack of definitive radiographic sacroiliitis and is considered an early stage of ankylosing spondylitis. The objective...
Rudwaleit, M, Landewe, R, Listing, J, Akkoc, N, Brandt, J, ...
Objective: To validate and refine two sets of candidate criteria for the classification/diagnosis of axial spondyloarthritis (SpA). Methods: All assessment of SpondyloArthritis international Society...
Sieper, J, Landewe, R, Brandt, J, Burgos-Vagas, R, Collantes-Estevez, E, ...
Objective: Inflammatory back pain (IBP) is an important clinical symptom in patients with axial spondyloarthritis (SpA), and relevant for classification and diagnosis. In the present report, a new...
Baraliakos, X., Listing, J., Brandt, J., Haibel, H., Rudwaleit, M., Sieper, J., ...
Objectives. Anti-tumour necrosis factor therapy with infliximab has been shown to improve signs and symptoms of patients with active ankylosing spondylitis (AS). The objective of this article was to...
Ankylosing spondylitis and bowel disease (2006)
Between 5 and 10% of cases of ankylosing spondylitis (AS) are associated with inflammatory bowel disease (IBD), either Crohn's disease or ulcerative colitis. A much larger percentage of AS patients...
PHAM, T, LANDEWE, R, DOUGADOS, M, SIEPER, J, BRAUN, J, ...
Pham, T., Landewe, R., Dougados, M., Sieper, J., Braun, J., ...
Objectives: To determine the type and proportion of patients with ankylosing spondylitis who rheumatologists consider to be candidates for treatment with tumour necrosis factor (TNF)-blocking agents,...
Baraliakos, X, Listing, J, Brandt, J, Rudwaleit, M, Sieper, J, Braun, J
No abstract available.
Baraliakos, X, Listing, J, Rudwaleit, M, Brandt, J, Sieper, J, Braun, J
No abstract available.
Häupl, T, Grützkau, A, Grün, J, Krenn, V, Rudwaleit, M, Stuhlmüller, B, ...
No abstract available.
Parameters contributing to inflammatory back pain (IBP) according to experts (2005)
RUDWALEIT, M, LANDEWE, R, BRANDT, J, BURGOS-VARGAS, R, COLLANTES-ESTEVEZ, E, DIJKMANS, B, ...
Brandt, J., Listing, J., Haibel, H., Sörensen, H., Schwebig, A., Rudwaleit, M., ...
Objectives. Treatment of ankylosing spondylitis (AS) with the tumour necrosis factor α (TNF-α) receptor fusion protein etanercept has shown efficacy in patients with active disease in randomized...
Sieper, J., Baraliakos, X., Listing, J., Brandt, J., Haibel, H., Rudwaleit, M., ...
Objectives. Patients with ankylosing spondylitis (AS) benefit from anti-TNF therapy both on a clinical basis and as depicted by magnetic resonance imaging (MRI). It is not known whether spinal...
Sieper, J., Baraliakos, X., Listing, J., Brandt, J., Haibel, H., Rudwaleit, M., ...
Objectives. Patients with ankylosing spondylitis (AS) benefit from anti-TNF therapy both on a clinical basis and as depicted by magnetic resonance imaging (MRI). It is not known whether spinal...
Monocyte-specific gene signatures in rheumatoid arthritis (2004)
Grützkau, A, Grün, J, Rudwaleit, M, Goldschmidt, L, Burmester, G-R, Radbruch, A, ...
No abstract available.
Häupl, T, Grützkau, A, Grün, J, Baumgrass, R, Janitz, M, Stuhlmüller, B, ...
No abstract available.
ISSAS: International Start TNF-blocker Study in Ankylosing Spondylitis (2004)
Pham, T, Landewe, R, Dougados, M, Burgos-Vargas, R, Collantes-Estevez, E, Edmonds, J, ...
Brandt, J., Listing, J., Haibel, H., Sörensen, H., Schwebig, A., Rudwaleit, M., ...
Objective. Treatment of ankylosing spondylitis (AS) with the tumour necrosis factor α (TNF-α) receptor fusion protein etanercept has shown efficacy in patients with active disease in randomized...
Brandt, J., Listing, J., Haibel, H., Sörensen, H., Schwebig, A., Rudwaleit, M., ...
Objective. Treatment of ankylosing spondylitis (AS) with the tumour necrosis factor α (TNF-α) receptor fusion protein etanercept has shown efficacy in patients with active disease in randomized...
Zou, J., Zhang, Y., Thiel, A., Rudwaleit, M., Radbruch, A., ...
Objectives. Based on their HLA association, both ankylosing spondylitis (AS) and rheumatoid arthritis (RA) seem to be T-cell-driven diseases in which the autoantigens remain to be defined. One...
Treatment of active ankylosing spondylitis with pamidronate (2003)
Haibel, H., Brandt, J., Rudwaleit, M., Soerensen, H., Sieper, J., Braun, J.
Zou, J., Zhang, Y., Thiel, A., Rudwaleit, M., Radbruch, A., ...
Objectives. Based on their HLA association, both ankylosing spondylitis (AS) and rheumatoid arthritis (RA) seem to be T-cell-driven diseases in which the autoantigens remain to be defined. One...
Sieper, J, Rudwaleit, M, Braun, J, VAN DER HEIJDE, Desiree
Free Univ Berlin, Klinikum Benjamin Franklin, D-12200 Berlin, Germany. German Rheumatol Res Ctr, Berlin, Germany. Univ Hosp Maastricht, Maastricht, Netherlands. Limburgs Univ Ctr, Diepenbeek,...
Sieper, J, Rudwaleit, M, Braun, J, VAN DER HEIJDE, Desiree
Free Univ Berlin, Klinikum Benjamin Franklin, D-12200 Berlin, Germany. German Rheumatol Res Ctr, Berlin, Germany. Univ Hosp Maastricht, Maastricht, Netherlands. Limburgs Univ Ctr, Diepenbeek,...
Brandt, J., Bollow, M., Häberle, J., Rudwaleit, M., Eggens, U., Distler, A., ...
Objective. Clinical and magnetic resonance imaging (MRI) data of 170 consecutive patients with inflammatory back pain (IBP) and/or oligoarthritis of the lower limbs were evaluated in a retrospective...
Brown, MA, Rudwaleit, M, Pile, KD, Kennedy, LG, Shatford, J, Amos, CI, ...
HLA class II antigens associated with systemic lupus erythematosus in black South Africans.
Rudwaleit, M, Tikly, M, Gibson, K, Pile, K, Wordsworth, P
OBJECTIVE--To assess the associations of HLA class II antigens with systemic lupus erythematosus (SLE) in black South Africans. METHODS--HLA-DRB1 genotype frequencies assigned by polymerase chain...
Rudwaleit, M., Yin, Z., Siegert, S., Grolms, M., Radbruch, A., Braun, J., ...
OBJECTIVE—This study was performed to assess whether there is any change in the T cell cytokine pattern in early rheumatoid arthritis (RA) patients treated with methotrexate (MTX) and whether the...
Rudwaleit, M, Siegert, S, Yin, Z, Eick, J, Thiel, A, Radbruch, A, ...
OBJECTIVE—To test the hypothesis that ankylosing spondylitis (AS) is a T helper cell type 2 polarised disease by quantifying the T cell cytokines interferon γ (IFNγ), interleukin 4 (IL4),...
Low incidence of reactive arthritis in children following a salmonella outbreak
Rudwaleit, M, Richter, S, Braun, J, Sieper, J
OBJECTIVES—To assess the incidence of reactive arthritis (ReA) in an outbreak of salmonella infection in a large cohort of children in Germany. METHODS—A few days after the salmonella outbreak...
Atopic disorders in ankylosing spondylitis and rheumatoid arthritis
Rudwaleit, M, Andermann, B, Alten, R, Sorensen, H, Listing, J, Zink, A, ...
Background: The prevalence of atopic disorders in ankylosing spondylitis (AS) is unknown. AS and rheumatoid arthritis (RA) exhibit divergent T helper (Th) cell cytokine patterns.
Zou, J, Rudwaleit, M, Brandt, J, Thiel, A, Braun, J, Sieper, J
Objective: To assess the change in the cytokine secreting ability of CD4+ and CD8+ T cells and macrophages during etanercept treatment.
Braun, J., Xiang, J., Brandt, J., Maetzel, H., Haibel, H., Wu, P., ...
Ankylosing spondylitis: an overview
Sieper, J, Braun, J, Rudwaleit, M, Boonen, A, Zink, A
Ankylosing spondylitis (AS) is a complex, potentially debilitating disease that is insidious in onset, progressing to radiological sacroiliitis over several years. Patients with symptomatic AS lose...
How to diagnose axial spondyloarthritis early
Rudwaleit, M, Khan, M, Braun, J, Sieper, J
Background: Chronic low back pain (LBP), the leading symptom of ankylosing spondylitis (AS) and undifferentiated axial spondyloarthritis (SpA), precedes the development of radiographic sacroiliitis,...
Rudwaleit, M, Listing, J, Brandt, J, Braun, J, Sieper, J
Background: TNFα blockers have been shown to be highly efficacious in patients with active ankylosing spondylitis (AS).
Braun, J, Baraliakos, X, Golder, W, Hermann, K, Listing, J, Brandt, J, ...
Objectives: To compare conventional radiography and magnetic resonance imaging (MRI) for detection of chronic changes in the spine of patients with ankylosing spondylitis (AS).
Brandt, J, Listing, J, Sieper, J, Rudwaleit, M, Braun, J
Objective: To develop and compare candidate improvement criteria for anti-TNFα treatment in ankylosing spondylitis with optimal discriminating capacity between treatment and placebo.
Listing, J, Brandt, J, Rudwaleit, M, Zink, A, Sieper, J, Braun, J
Methods: The data of a 2 year open extension study of a 12 week, double blind, randomised, placebo controlled trial, in which all patients with AS were treated with 5 mg/kg infliximab, were used to...
Six months open label trial of leflunomide in active ankylosing spondylitis
Haibel, H, Rudwaleit, M, Braun, J, Sieper, J
Patients and methods: Twenty patients with AS fulfilling the 1984 modified New York criteria with a Bath AS Disease Activity Index (BASDAI) >3 were given leflunomide for 6 months. Clinical outcome...
Open label trial of anakinra in active ankylosing spondylitis over 24 weeks
Haibel, H, Rudwaleit, M, Listing, J, Sieper, J
Methods: Anakinra (100 mg) was given subcutaneously daily over 24 weeks to 20 NSAID refractory patients with ankylosing spondylitis. Thirteen completed the study. Clinical outcome assessments...
Baraliakos, X, Landewe, R, Hermann, K, Listing, J, Golder, W, Brandt, J, ...
Background: Magnetic resonance imaging (MRI) is increasingly used to detect inflammation in the spine of patients with ankylosing spondylitis (AS).
Analysis of the CD8+ T cell response to the G1 domain of aggrecan in ankylosing spondylitis
Zou, J, Appel, H, Rudwaleit, M, Thiel, A, Sieper, J
Background: CD4+ T cell responses to the G1 domain of aggrecan in patients with ankylosing spondylitis (AS) were recently reported. Whether such an immune response can be seen in the CD8+...
Baraliakos, X, Hermann, K, Landewe, R, Listing, J, Golder, W, Brandt, J, ...
Objectives: To compare the performance of two different MRI sequences—T1 weighted, fat saturated, spin echo after application of contrast medium, and short τ inversion recovery (STIR)...
Rudwaleit, M, Baraliakos, X, Listing, J, Brandt, J, Sieper, J, Braun, J
Objective: To assess the changes in inflammatory lesions of the spine and the sacroiliac (SI) joints as detected by magnetic resonance imaging (MRI) in patients with ankylosing spondylitis (AS) and...
Baraliakos, X, Listing, J, Rudwaleit, M, Brandt, J, Sieper, J, Braun, J
Background: Anti-tumour necrosis factor (TNF) treatment is clinically efficacious in patients with active ankylosing spondylitis (AS) and leads to improvement of spinal inflammation, as assessed by...
How early should ankylosing spondylitis be treated with tumour necrosis factor blockers?
Recognition and treatment of ankylosing spondylitis (AS) in the early stages of the disease has yet to be established. This paper considers the evidence available and the questions that need to be...
Rudwaleit, M, Rødevand, E, Holck, P, Vanhoof, J, Kron, M, Kary, S, ...