Smyth, M.S., Symonds, A., Brazinova, S., Martin, J.H.
Many viruses have been investigated for their oncolytic properties and potential use as therapeutic agents for cancer treatment. Most of these replication-competent viruses are human pathogens. We...
Picornavirus uncoating. (2002)
Recently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of...
Phosphonate inhibitors of protein-tyrosine and serine/threonine phosphatases.
Kole, H K, Smyth, M S, Russ, P L, Burke, T R
In all, 15 aryl-containing phosphonates have been synthesized and tested for their effect on protein-tyrosine phosphatase (PTPase) activity. Two compounds, (naphth-2-yl) difluoromethylphosphonic acid...
x Ray crystallography is currently the most favoured technique for structure determination of proteins and biological macromolecules. Increasingly, those interested in all branches of the biological...
Recently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of...
Phosphonate inhibitors of protein-tyrosine and serine/threonine phosphatases.
Kole, H K, Smyth, M S, Russ, P L, Burke, T R
In all, 15 aryl-containing phosphonates have been synthesized and tested for their effect on protein-tyrosine phosphatase (PTPase) activity. Two compounds, (naphth-2-yl) difluoromethylphosphonic acid...
x Ray crystallography is currently the most favoured technique for structure determination of proteins and biological macromolecules. Increasingly, those interested in all branches of the biological...
Recently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of...
Temperature-sensitive suppressor mutations of the Escherichia coli DNA gyrase B protein.
Blance, S. J., Williams, N. L., Preston, Z. A., Bishara, J., Smyth, M. S., Maxwell, A.
Escherichia coli strain LE316 contains a mutation in gyrB that results in the substitution of Val164 to Gly and confers both chlorobiocin resistance and temperature sensitivity. Selection for...