M. Simon

Publication List Details

Period

1897 - 2009

Number

392

Co-Authors

The PAMELA Space Experiment (2009)

Mocchiutti, E., Adriani, O., Barbarino, G. C., Bazilevskaya, G. A., Bellotti, R., Boezio, M., ...

The 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The apparatus comprises a time-of-flight...

Figure 1 Individual IbCos (2009)

N. Bongers, U. Hacker, K. Henn, A. Richert, M. Simon, K. Sobotta, ...

The COSY control system architecture is organieed strongly hierarchically with distributed intelligence and extensive use of standards. At the top level of computer control hardware work stations...

(1993). (2009)

M. Livingstone, P. Sziber, W. Quinn, P. Drain, E. Folkers, W. Quinn, ...

11. Complementary DNAs encoding the short forms of G � s WT and G � s * (9) were subcloned into pUAST (7) and used to transform flies [A. Spradling, in Drosophila: A Practical Approach, D....

From Captivity to the Wild and Back: An Attempt to Release Keiko the Killer Whale (2009)

Simon, M., Hanson, M. B., Murrey, L., Tougaard, J., Ugarte, F.

A number of cetaceans have been released into the wild, with research or the improved welfare of the individuals in question as the main goal. In a few cases, releases have been monitored with...

Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility (2009)

Incerti, S., Seznec, H., Simon, M., Barberet, Ph., Habchi, C., Moretto, Ph.

Microbeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the delivered dose. This paper describes...

Changing attitudes to cardiopulmonary resuscitation in older people: a 15-year follow-up study (2009)

Cotter, P. E., Simon, M., Quinn, C., O’Keeffe, S. T.

Background: while it is well established that individual patient preferences regarding cardiopulmonary resuscitation (CPR) may change with time, the stability of population preferences, especially...

Reliability characterization and process optimization of Ni-based microinsert interconnections for flip chip die on wafer attachment (2009)

Boutry, H., Brun, J., Nowodzinski, A., Sillon, N., Depoutot, F., Dubois-Bonvalot, B., ...

In many complex systems under development, the cost of integration and the compromises in performance that can result from the integration process can become prohibitive. Therefore, the establishment...

Standard free thickness determination of thin TEM samples via backscatter electron image correlation (2009)

Salzer, R., Graff, A., Simon, M., Altmann, F.

Due to the ongoing progress in nanotechnology, high resolution TEM investigations become more and more important in structural and chemical material analyses. For such investigations the thickness of...

A Millimeter-wave Interferometric Study of Dust and CO Disks Around Late Spectral Type Stars in Taurus-Auriga (2009)

Schaefer, G. H., Dutrey, Anne, Guilloteau, S., Simon, M., White, R. J.

We present a new millimeter survey of 23 pre-main-sequence stars in the Taurus-Auriga star-forming region. The main goal of the project was to identify circumstellar disks around stars of late...

A Millimeter-wave Interferometric Study of Dust and CO Disks Around Late Spectral Type Stars in Taurus-Auriga (2009)

Schaefer, G. H., Dutrey, Anne, Guilloteau, S., Simon, M., White, R. J.

We present a new millimeter survey of 23 pre-main-sequence stars in the Taurus-Auriga star-forming region. The main goal of the project was to identify circumstellar disks around stars of late...

X-ray optics fabricated by X-ray lithography. (eingeladen) (2009)

Mohr, J., Boerner, M., Nazmov, V., Reznikova, E., Simon, M., Umbach, M.

8th Internat.Workshop on High-Aspect-Ratio Micro-Structure Technology (HARMST 2009), Saskatoon, CDN, June 25-28, 2009

Standard free thickness determination of thin TEM samples via backscatter electron image correlation (2009)

Salzer, R., Graff, A., Simon, M., Altmann, F.

Due to the ongoing progress in nanotechnology, high resolution TEM investigations become more and more important in structural and chemical material analyses. For such investigations the thickness of...

Rolled refractive X-ray prism lenses. (2009)

Simon, M., Reznikova, E., Nazmov, V., Grund, T., Last, A.

20th Internat.Congress on X-Ray Optics and Microanalysis (ICXOM 2009), Karlsruhe, September 14-18, 2009

Twins Among the Low Mass Spectroscopic Binaries (2008)

Simon, M., Obbie, R. C.

We report an analysis of twins of spectral types F or later in the 9th Catalog of Spectroscopic Binaries (SB9). Twins, the components of binaries with mass ratio within 2% of 1.0, are found among the...

A new measurement of the antiproton-to-proton flux ratio up to 100 GeV in the cosmic radiation (2008)

Adriani, O., Barbarino, G. C., Bazilevskaya, G. A., Bellotti, R., Boezio, M., Bogomolov, E. A., ...

A new measurement of the cosmic ray antiproton-to-proton flux ratio between 1 and 100 GeV is presented. The results were obtained with the PAMELA experiment, which was launched into low-earth orbit...

Observation of an anomalous positron abundance in the cosmic radiation (2008)

Adriani, O., Barbarino, G. C., Bazilevskaya, G. A., Bellotti, R., Boezio, M., Bogomolov, E. A., ...

Positrons are known to be produced in interactions between cosmic-ray nuclei and interstellar matter ("secondary production"). Positrons may, however, also be created by dark matter particle...

First Results from the PAMELA Space Mission (2008)

Boezio, M., Bonvicini, V., Jerse, G., Mocchiutti, E., Vacchi, A., Zampa, G., ...

On the 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The apparatus comprises a time-of-flight...

The Highly Eccentric Pre-Main Sequence Spectroscopic Binary RX J0529.3+1210 (2008)

Mace, G. N., Prato, L., Wasserman, L. H., Schaefer, G. H., Franz, O. G., Simon, M.

The young system RX J0529.3+1210 was initially identified as a single-lined spectroscopic binary. Using high-resolution infrared spectra, acquired with NIRSPEC on Keck II, we measured radial...

The Detection of Low Mass Companions in Hyades Cluster Spectroscopic Binary Stars (2008)

Bender, C. F., Simon, M.

We have observed a large sample of spectroscopic binary stars in the Hyades Cluster, using high resolution infrared spectroscopy to detect low mass companions. We combine our double-lined infrared...

Preliminary Orbit of the Young Binary Haro 1-14c (2008)

Schaefer, G. H., Simon, M., Prato, L., Barman, T.

Using the Keck Interferometer, we spatially resolved the orbit of the pre-main sequence binary, Haro 1-14c, for the first time. We present these interferometric observations along with additional...

UNE PREMIERE VAGUE IDEE DE LA SCENE VISUELLE. Rôle de l'asynchronie dans le traitement rapide de l'information visuelle. Par (2008)

Une Premiere, Vague De, Rufin Vanrullen, M. Michel, Imbert Président, ...

1. Anatomie du système visuel_____________________________________________________ _ 3 1.1 Architecture hiérarchique _____________________________________________________ _ 3 1.2 Différentes...

Reducing of ion beam induced surface damaging using »low voltage« (2008)

Salzer, R., Simon, M., Graff, A., Altmann, F., Pastewka, L., Moseler, M.

It is of high interest to understand the FIB process in order to predict the amorphisation behaviour, sputter coefficients and their dependency on the crystallographic structure of different...

Resonant double Auger decay in carbon K-shell excitation of CO (2008)

Journel, L., Guillemin, R., Haouas, A. A., Lablanquie, P., Penent, F., Palaudoux, J., ...

We have studied double Auger decay after C 1s -> 2π* photoexcitation in gas phase carbon monoxide. Two distinct processes, namely direct double Auger decay and cascade double Auger decay, are...

X-ray prism lenses with large apertures. (2008)

Simon, M., Reznikova, E., Nazmov, V., Last, A., Jark, W.

SPIE Optics and Photonics 2008, San Diego, Calif., August 10-14, 2008

European programme towards the 1MeV ITER NB injector. (2008)

Masiello, A., Agarici, G., Bonicelli, T., Simon, M., Antoni, V., De Esch, H., ...

25th Symp.on Fusion Technology (SOFT 2008), Rostock, September 15-19, 2008

Testing of X-ray prism lenses with large apertures. (2008)

Simon, M., Reznikova, E., Nazmov, V., Last, A.

SPIE Europe Conf.'Optical Systems Design', Glasgow, GB, September 2-5, 2008

Launch of the Space experiment PAMELA (2007)

Casolino, M., Picozza, P., Altamura, F., Basili, A., De Simone, N., Di Felice, V., ...

PAMELA is a satellite borne experiment designed to study with great accuracy cosmic rays of galactic, solar, and trapped nature in a wide energy range protons: 80 MeV-700 GeV, electrons 50 MeV-400...

SU-8 als Material für die Fertigung hochpräziser LIGA-Röntgenlinsen. (2007)

Last, A., Reznikova, E., Nazmov, V., Simon, M.

Technologien und Werkstoffe in der Mikro- und Nanosystemtechnik : GMM-Workshop, Karlsruhe, 7.-8.Mai 2007

Measurement of side walls of high aspect ratio microstructures. (2007)

Simon, M., Reznikova, E., Nazmov, V., Last, A.

7th Internat.Workshop on High-Aspect-Ratio Micro-Structure Technology (HARMST 2007), Besancon, F, June 7-9, 2007

Refraktive Röntgenlinsen. (2007)

Last, A., Nazmov, V., Reznikova, E., Simon, M., Umbach, M., Saile, V.

Fachtagung Prozessnahe Röntgenanalytik (PRORA 2007), Berlin, 15.-16.November 2007

Dynamical Mass Estimates for Incomplete Orbits: Young Multiple Stars in Taurus and Ophiuchus (2006)

Schaefer, G. H., Simon, M., Beck, T. L., Nelan, E., Prato, L.

We present recent measurements of the orbital motion in the binaries, DF Tau and ZZ Tau, and in the triples, Elias 12, T Tau, and V853 Oph. We observed these systems with the Fine Guidance Sensors on...

PAMELA - A Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (2006)

Picozza, P., Galper, A. M., Castellini, G., Adriani, O., Altamura, F., Ambriola, M., ...

The PAMELA experiment is a satellite-borne apparatus designed to study charged particles in the cosmic radiation with a particular focus on antiparticles. PAMELA is mounted on the Resurs DK1...

The GL 569 Multiple System (2006)

Simon, M., Bender, C., Prato, L.

We report the results of high spectral and angular resolution infrared observations of the multiple system GL 569 A and B that were intended to measure the dynamical masses of the brown dwarf binary...

Ecotoxic effect of photocatalytic active nanoparticles (TiO2) on algae and daphnids (2006)

Hund-Rinke, K., Simon, M.

Background, Aim and Scope: Due to their large potential for manifold applications, the use of nanoparticles is of increasing importance. As large amounts of nanoparticles may reach the environment...

A novel method for unambiguous ion identification in mixed ion beams extracted from an EBIT (2006)

Meissl, W., Simon, M., Tawara, H., Ullrich, J., Winter, H., ...

A novel technique to identify small fluxes of mixed highly charged ion beams extracted from an Electron Beam Ion Trap (EBIT) is presented and practically demonstrated. The method exploits projectile...

TEM-Präparation mittels "low-voltage-FIB" (2006)

Altmann, F., Graff, A., Simon, M., Hoffmeister, H., Gnauck, P.

The most common method used for target preparation of electron-transparent cross-sections in the field of semiconductor technology is the preparation by focused Gal ion beams (FIB). As shown in the...

Service zweiter Klasse? Strategien zur Sicherung des globalen Servicegeschäfts (2006)

Schmitt, R., Simon, M., Hatfield, S., Klenter, G.

Die deutsche Maschinenbaubranche lebt vom Export. Die Verfügbarkeit von attraktiven und global verfügbaren Serviceleistungen gewinnt als Differenzierungsmerkmal zunehmend im internationalen...

Mikrogreifer (2006)

Große, C., Altmann, F., Simon, M., Hoffmeister, H., Riemer, D.

DE 102006023768 A1 UPAB: 20080111 NOVELTY - The method involves providing an even substrate surface, and applying a sacrificial layer on the substrate surface, where a material layer (3) is applied...

The loopy UV line profiles of RU Lupi: accretion, outflows, and fluorescence (2005)

Herczeg, G. J., Walter, F. M., Linsky, J. L., Gahm, G. F., Ardila, D. R., Brown, A., ...

We present far-ultraviolet spectra of the classical T Tauri star RU Lupi covering the 912-1710 A spectral range, as observed by the HST/STIS and FUSE satellites. We use these spectra, which are rich...

Constitutive activation of the Wnt/β-catenin signalling pathway in acute myeloid leukaemia (2005)

Simon, M., Grandage, V.L., Linch, D.C., Khwaja, A.

The β-catenin protein is at the core of the canonical Wnt signalling pathway. Wnt stimulation leads to β-catenin accumulation, nuclear translocation and interaction with T-cell factor/lymphoid...

Production of macroaggregates from dissolved exopolymeric substances (EPS) of bacterial and diatom origin (2005)

Bhaskar, P.V., Grossart, H.P., Bhosle, N.B., Simon, M.

Exopolymeric substance (EPS) isolated from a pure culture of the marine bacterium Marinobacter sp. and the marine diatom Skeletonema costatum (axenic) were partially purified, chemically...

Terrestrial ecotoxicity of eight chemicals in a systematic approach (2005)

Hund-Rinke, K., Simon, M.

Background and Objective. Terrestrial ecotoxicity data are required for many research purposes. The data are derived either from the literature or elaborated by own investigations. As the terrestrial...

Experiences with novel approaches in earthworm testing alternatives (2005)

Hund-Rinke, K., Lindemann, M., Simon, M.

Goal, Scope and Background: The earthworm avoidance test is a sensitive screening test. Currently, two test designs, a two-chamber system and a six-chamber system, are under standardization. In the...

Systematic analysis of gene expression in human brains before and after death (2005)

Franz, H., Ullmann, C., Becker, A., Ryan, M., Bahn, S., Arendt, T., ...

BACKGROUND: Numerous studies have employed microarray techniques to study changes in gene expression in connection with human disease, aging and evolution. The vast majority of human samples...

Stand composition affects soil quality in oak stands on reclaimed and natural sites (2005)

Mohr, D., Simon, M., Topp, W.

In many afforested reclamation sites as well as in commercial forests naturally settled shrubs or trees ("non-target species"; NTS) are cut down to improve the growth of the target trees (TT). In...

Improved CDMA Performance Using Parallel Interference Cancellation (2004)

Divsalar, D., Simon, M.

This paper considers a general parallel interference cancellation scheme that significantly reduces the degradation effect of user interference but with a lesser implementation complexity than the...

The Design of an Optimum System for Monitoring the Operational Status of a Spacecraft (2004)

Simon, M., Vilnrotter, V., Mileant, A., Hinedi, S.

The design of a spacecraft monitoring system based on a Neyman-Pearson Detection Criterion is discussed. Each noncatastrophic state of the spacecraft is indicated by the transmission of a specific...

Iterative Information-Reduced Carrier Synchronization Using Decision Feedback for Low SNR Applications (2004)

Simon, M., Vilnrotter, V.

Traditional methods for carrier synchronization of digital signals are obtained from approximations made to a closed loop structure motivated by the maximum a posteriori (MAP) estimation of carrier...

Acquisition Performance Comparison of the Generalized Maxium A Posteriori Symbol Synchronizer Versus the Data-Transition Tracking Loop (2004)

Lam, L., Yan, T. Y., Simon, M., Martin, W.

A generalized maxium a posteriori (MAP), symbol synchronizer for arbitrary nonoverlapping pulse shape and data-transition density is derived, and a simplified realization is presented.

Flexible All-Digital Receiver for Bandwidth Efficient Modulations (2004)

Srinivasan, M., Gray, A., Simon, M., Yan, T-Y.

An all-digital high data rate parallel receiver architecture developed jointly by Goddard Space Flight Center and the Jet Propulsion Laboratory is presented.

Enhanced performance of FQPSK-B receiver based on trellis-coded Viterbi demodulation (2004)

Lee, D., Simon, M., Yan, T. Y.

A simplified Viterbi receiver with a reduced trellis and significanly less complexity is introduced with only a slight BER degradation compared to the full Viterbi receiver.

Multiple bit differential detection of offset QPSK (2004)

Simon, M.

Analogous to multiple symbol differential detection of quadrature phase-shift-keying, a multiple bit differential detection scheme is described for offset QPSK that also exhibits continuous...

Multiple bit differential detection of offset quadrature phase-shift-keying (2004)

Simon, M.

Analogous to multiple symbol differential detectionof quadrature phase-shift-keying (QPSK), a multiple bit differential detection scheme is described for offset QPSK that also exhibits continuous...

An Upper Bound on the Flux Ratio of rho CrB's Companion at 1.6um (2004)

Bender, C., Simon, M., Prato, L., Mazeh, T., Zucker, S.

We use high resolution infrared spectroscopy to investigate the 2001 report by Gatewood and colleagues that rho CrB's candidate extrasolar planet companion is really a low-mass star with mass...

The Double-Lined Spectroscopic Binary Haro 1-14c (2004)

Simon, M., Prato, L.

We report detection of the low-mass secondary in the spectroscopic binary Haro 1-14c in the Ophiuchus star forming region. The secondary/primary mass ratio is $0.310\pm 0.014$. With an estimated...

A High Spatial Resolution Infrared View of the T Tauri Multiple System (2004)

Beck, Tracy L., Schaefer, G. H., Simon, M., Prato, L., Stoesz, J. A., Howell, R. R.

We present the results of our monitoring study of the IR photometric and spectroscopic variability of the T Tau multiple system. We also present data on the apparent position of T Tau S with respect...

Global Wildland Fire Emission Model (GWEM): Evaluating the use of global area burnt satellite data (2004)

Hoelzemann,Judith J., Schultz,Martin G., Brasseur,Guy P., Granier,Claire, Simon,M.

The new Global Wildland Fire Emission Model (GWEM) has been developed on the basis of data from the European Space Agency's monthly Global Burnt Scar satellite product (GLOBSCAR) and results from the...

A full belly and colostrum: two major determinants of filial love (2004)

Val-Laillet, D., Simon, M., Nowak, R.

The establishment of filial bonding in sheep relies on the success of the first suckling bouts. Previous work has shown that colostrum ingestion facilitates the development of a preference for the...

Effects of tetracycline on the soil microflora: Function, diversity, resistance (2004)

Hund-Rinke, K., Simon, M., Lukow, T.

Background. Tetracycline is a widely used antibiotic in animal production. Significant amounts of the substance reach the soil via feces, urine and manure application. As tetracycline is a persistent...

Global Wildland Fire Emission Model (GWEM): Evaluating the use of global area burnt satellite data (2004)

Hoelzemann, Judith J., Schultz, Martin G., Brasseur, Guy P., Granier, Claire, Simon, M.

The new Global Wildland Fire Emission Model (GWEM) has been developed on the basis of data from the European Space Agency's monthly Global Burnt Scar satellite product (GLOBSCAR) and results from the...

Netze knüpfen. Netzwerkfähige Gestaltung von QM-Systemen (2004)

Pfeifer, T., Rübartsch, M., Simon, M.

Immer wieder zeigen gescheiterte Industrieprojekte, dass die Beherrschung komplexer Entwicklungen nicht selbstverständlich ist. Budgets werden überschritten, Zeitpläne und Lieferfristen nicht...

The Mass Ratio Distribution in Main-Sequence Spectroscopic Binaries Measured by IR Spectroscopy (2003)

Mazeh, T., Simon, M., Prato, L., Markus, B., Zucker, S.

We report infrared spectroscopic observations of a large, well-defined sample of main-sequence, single-lined spectroscopic binaries in order to detect the secondaries and derive the mass ratio...

Dynamical Masses of Young Stars in Multiple Systems (2003)

Schaefer, G. H., Simon, M., Nelan, E., Holfeltz, S. T.

We present recent measurements of the orbital motion in the young binaries DF Tau and ZZ Tau, and the hierarchical triple Elias 12, that were obtained with the Fine Guidance Sensors on the HST and at...

Development and validation of a method to determine threshold values for effects of genetically modified plants on the habitat function of soils: Poster at the 13th SETAC Europe Annual Meeting, Hamburg, 27.4.-1.5.2003 (2003)

Simon, M., Lukow, T., Hund-Rinke, K.

The safe cultivation of genetically modified plants (GMP) requires a comprehensive investigation of possible harmful soil changes - especially with respect to the natural habitat function of soils...

Reduction of performance time for microbial respiration in the context of on-site analysis: SETAC German Language Branch. Poster zur 8. Tagung "New Blood in Ecotoxicology", Heidelberg, 21-23. September 2003 (2003)

Simon, M., Hund-Rinke, K.

The microbial respiration activity in soil can be used as an indicator for the presence of toxic substances and easily degradable carbon sources. If standardized methods are applied, the preparation...

Microbial respiration activity within the scope of on-site analysis: Poster at the 13th SETAC Europe Annual Meeting, Hamburg, 27.4.-1.5.2003 (2003)

Simon, M., Hund-Rinke, K.

The microbial respiration activity in soil can be used as an indicator for the presence of toxic substances and easily degradable carbon sources. If standardized methods are applied, the preparation...

Terrestrial ecotoxicity - Can aquatic ecotoxicity data give a clue?: Poster at the 13th SETAC Europe Annual Meeting, Hamburg, 27.4.-1.5.2003 (2003)

Hund-Rinke, K., Simon, M., Herrchen, M., Nagel, R.

At present, the amount and quality of existing ecotoxicity data is much more comprehensive for the aquatic than for the terrestrial compartment. This is a result of the historical development in...

Development and validation of a method to determine threshold values for effects of genetically modified plants on the habitat function of soils: Poster at the 13th SETAC Europe Annual Meeting, Hamburg, 27.4.-1.5.2003 (2003)

Simon, M., Lukow, T., Hund-Rinke, K.

The safe cultivation of genetically modified plants (GMP) requires a comprehensive investigation of possible harmful soil changes - especially with respect to the natural habitat function of soils...

Reduction of performance time for microbial respiration in the context of on-site analysis: SETAC German Language Branch. Poster zur 8. Tagung "New Blood in Ecotoxicology", Heidelberg, 21-23. September 2003 (2003)

Simon, M., Hund-Rinke, K.

The microbial respiration activity in soil can be used as an indicator for the presence of toxic substances and easily degradable carbon sources. If standardized methods are applied, the preparation...

Microbial respiration activity within the scope of on-site analysis: Poster at the 13th SETAC Europe Annual Meeting, Hamburg, 27.4.-1.5.2003 (2003)

Simon, M., Hund-Rinke, K.

The microbial respiration activity in soil can be used as an indicator for the presence of toxic substances and easily degradable carbon sources. If standardized methods are applied, the preparation...

Terrestrial ecotoxicity - Can aquatic ecotoxicity data give a clue?: Poster at the 13th SETAC Europe Annual Meeting, Hamburg, 27.4.-1.5.2003 (2003)

Hund-Rinke, K., Simon, M., Herrchen, M., Nagel, R.

At present, the amount and quality of existing ecotoxicity data is much more comprehensive for the aquatic than for the terrestrial compartment. This is a result of the historical development in...

Quality Services in e-Commerce - QM-Methoden als IuK-unterstützte Beratungsdienstleistung (2003)

Großmann, A., Pfeifer, T., Simon, M.

Großunternehmen bedienen sich heutzutage bereits vieler erprobter Methoden des Qualitätsmanagements (FMEA, SPC, TRIZ etc.). In KmU existiert demgegenüber noch ein großer Bedarf, diese Methoden...

Quality Services digital - Möglichkeiten des Einsatzes von IuK-Technologie in der QM-Beratung (2003)

Pfeifer, T., Simon, M.

Großunternehmen bedienen sich heutzutage bereits vieler erprobter Methoden des Qualitätsmanagements (FMEA, SPC, TRIZ etc.). In KmU existiert demgegenüber noch ein großer Bedarf, diese Methoden...

Mouse Phenotype Ontology Development and Application (2003)

Green Gkoutos Mallon, G. V. Gkoutos, A. M. Mallon, S. Greenaway, A. Blake, ...

Introduction With the completion of the mouse genome sequence in sight, emphasis is shifting to characterisation of gene function in this organism, which is the major experimental model for human...

The Cosmic-Ray Proton and Helium Spectra measured with the CAPRICE98 balloon experiment (2002)

Boezio, M., Bonvicini, V., Schiavon, P., Vacchi, A., Zampa, N., Bergstroem, D., ...

A new measurement of the primary cosmic-ray proton and helium fluxes from 3 to 350 GeV was carried out by the balloon-borne CAPRICE experiment in 1998. This experimental setup combines different...

Astrophysics of Young Star Binaries (2002)

Prato, L., Greene, T. P., Simon, M.

This paper describes our study of the astrophysics of individual components in close pre-main-sequence binaries. We observed both stars in 17 systems, located in 4 nearby star forming regions, using...

Component Masses of the Young Spectroscopic Binary UZ Tau E (2002)

Prato, L., Simon, M., Mazeh, T., Zucker, S., McLean, I. S.

We report estimates of the masses of the component stars in the pre-main-sequence spectroscopic binary UZ Tau E. These results come from the combination of our measurements of the mass ratio,...

Near Infrared Adaptive Optics Imaging of the Embedded Cluster NGC 2024 (2002)

Beck, T. L., Simon, M., Close, L. M.

We present the results of a high resolution near infrared adaptive optics survey of the young obscured star forming region NGC 2024. Out of the total 73 stars detected in the adaptive optics survey...

The Smallest Mass Ratio Young Star Spectroscopic Binaries (2002)

Prato, L., Simon, M., Mazeh, T., McLean, I. S., Norman, D., Zucker, S.

Using high resolution near-infrared spectroscopy with the Keck telescope, we have detected the radial velocity signatures of the cool secondary components in four optically identified...

Lagerung von Umweltproben für biologische Fragestellungen im Rahmen der Umweltprobenbank: Poster zu den Jahrestagungen GDCh-Fachgruppe Umweltchemie und Ökotoxikologie. SETAC-GLB, Braunschweig 2002 (2002)

Simon, M., Hund-Rinke, K., Schlüter, C.

In der Umweltprobenbank des Bundes werden bisher Bodenproben mit dem Ziel gelagert, Informationen über die langfristige Entwicklung von organischen und anorganischen Schadstoffbelastungen zu...

Comparison of soil and sediment ecotoxicity data and test methods: Poster at the 12th SETAC Europe Meeting, Vienna, May 2002 (2002)

Gildemeister, T., Fiedler, S., Metag, N., Werner, E., Hund-Rinke, K., Herrchen, M., ...

The quality, validity, representiveness and size of data collections of existing ecotoxicity data for chemicals varies to a high extend between the environmental compartments water, sediment and...

Lagerung von Umweltproben für biologische Fragestellungen im Rahmen der Umweltprobenbank: Poster zu den Jahrestagungen GDCh-Fachgruppe Umweltchemie und Ökotoxikologie. SETAC-GLB, Braunschweig 2002 (2002)

Simon, M., Hund-Rinke, K., Schlüter, C.

In der Umweltprobenbank des Bundes werden bisher Bodenproben mit dem Ziel gelagert, Informationen über die langfristige Entwicklung von organischen und anorganischen Schadstoffbelastungen zu...

Comparison of soil and sediment ecotoxicity data and test methods: Poster at the 12th SETAC Europe Meeting, Vienna, May 2002 (2002)

Gildemeister, T., Fiedler, S., Metag, N., Werner, E., Hund-Rinke, K., Herrchen, M., ...

The quality, validity, representiveness and size of data collections of existing ecotoxicity data for chemicals varies to a high extend between the environmental compartments water, sediment and...

Adsorption in noninterconnected pores open at one or at both ends: A reconsideration of the origin of the hysteresis phenomenon (2002)

Coasne, B., Grosman, Annie, Ortega, Camille, Simon, M.

We report on an experimental study of adsorption isotherm of nitrogen onto porous silicon with noninterconnected pores open at one or at both ends in order to check for the first time the old (1938)...

Adsorption in noninterconnected pores open at one or at both ends: A reconsideration of the origin of the hysteresis phenomenon (2002)

Coasne, B., Grosman, Annie, Ortega, Camille, Simon, M.

We report on an experimental study of adsorption isotherm of nitrogen onto porous silicon with noninterconnected pores open at one or at both ends in order to check for the first time the old (1938)...

Adsorption in non interconnected pores open at one or at both ends: A reconsideration of the origin of the hysteresis phenomenon (2001)

Coasne, B., Grosman, A., Ortega, C., Simon, M.

We report on an experimental study of adsorption isotherme of nitrogen onto porous silicon with non interconnected pores open at one or at both ends in order to check for the first time the old...

IR Detection of Low-Mass Secondaries in Spectroscopic Binaries (2001)

Mazeh, T., Prato, L., Simon, M., Goldberg, E., Norman, D., Zucker, S.

This paper outlines an infrared spectroscopic technique to measure the radial velocities of faint secondaries in known single-lined binaries. The paper presents our H-band observations with the...

A Dynamical Mass Constraint for Pre-Main-Sequence Evolutionary Tracks: The Binary NTT 045251+3016 (2001)

Steffen, A. T., Mathieu, R. D., Lattanzi, M. G., Latham, D. W., Mazeh, T., Prato, L., ...

We present an astrometric/spectroscopic orbital solution for the pre-main-sequence binary NTT 045251+3016. Our measurements for the primary and secondary masses are 1.45 +/- 0.19 M_sun and 0.81 +/-...

The Variability of T Tau, RY Tau and RW Aur from 1899 to 1952 (2001)

Beck, Tracy L., Simon, M.

We present the historical light curve of T Tau derived from photographic plates in the Harvard College Observatory archives. We find that the optical light of T Tau varied by 2-3 (or more) magnitudes...

The near-infrared and ice-band variability of Haro 6-10 (2001)

Leinert, Ch., Beck, T. L., Ligori, S., Simon, M., Woitas, J., Howell, R. R.

We have monitored the angularly resolved near infrared and 3.1 micron ice-band flux of the components of the young binary Haro 6-10 on 23 occasions during the years 1988 to 2000. Our observations...

Evidence for Extinction and Accretion Variability in T Tau S (2001)

Beck, Tracy, Prato, L., Simon, M.

We present angularly resolved spectra of T Tau North and South in the 3 micron water ice feature and K-band. Most of the water ice absorption lies along the line of sight toward T Tau South,...

Veränderung der Bodeneigenschaften beim Abbau der Streuschicht durch Bodenorganismen (2001)

Simon, M., Topp, W.

Detritivore zeigen geringe (I. scandinavius, Diplopoda) bzw. ausgeprägte (L.rubellus, Lumbricidae) Nahrungspräferenz. Streuabnahme und der Gehalt an extrahierbaren Nährstoffen im Bodensubstrat...

Influence of a new reclamation technique on soil properties. Investigations in the lignite open-cast mine district of the Rhineland: Field studies and laboratory investigations in microcosms (2001)

Simon, M.

The succession of two- to thirteen-year-old oak stands (Quercus robur) was investigated in an afforested reclaimed area in the Rhineland. Variables were the surface pattern (crests, troughs),...

Soil fauna of a reclaimed lignite open-cast mine of the Rhineland: Improvement of soil quality by surface pattern (2001)

Topp, W., Simon, M., Kautz, G., Dworschak, U., Nicolini, F., Prückner, S.

Reclaimed lignite open-cast mine areas in the Rhineland are covered by a mixture of loess and sand deposits containing organic material that originates from the upper quartary soil which has been...

Overview of JET results in support of the ITER physics basis (2001)

Adams, J. M., Ageladarakis, P., Alper, B., Altmann, H., Arshad, S., Bainbridge, N., ...

The JET experimental campaign has focused on studies in support of the ITER physics basis. An overview of the results obtained is given for the reference ELMy H mode and advanced scenarios, which in...

Dynamical Masses of T Tauri Stars and Calibration of PMS Evolution (2000)

Simon, M., Dutrey, A., Guilloteau, S.

We have used the high sensitivity and resolution of the IRAM interferometer to produce sub-arcsecond 12CO 2-1 images of 9 protoplanetary disks surrounding T Tauri stars in the Taurus-Auriga cloud (7...

Sensorsystem und Herstellungsverfahren sowie Selbsttestverfahren (1999)

Rothley, M., Zabler, E., Jaehne, R., Schieferdecker, J., Simon, M., Storck, K.

NOVELTY - The sensor system includes a substrate (15), on which several sensor elements (10) are mounted. The sensor elements each produce electrical signals based on the thermal radiation they...

Quantitative systolic and diastolic transmyocardial velocity gradients assessed by M-mode colour Doppler tissue imaging as reliable indicators of regional left ventricular function after acute myocardial infarction (1999)

Garot, J., Derumeaux, G.A., Monin, J.L., Duval-Moulin, A.M., Simon, M., Pascal, D., ...

Aims The aim of this study was to determine whether myocardial velocity gradients assessed by M-mode colour Doppler tissue imaging could be of clinical relevance and represent reliable indicators of...

Feasibility of tandem autologous stem-cell transplantation (ASCT) in induction failure or very unfavorable (UF) relapse from Hodgkin's disease (HD) (1999)

Brice, P., Divine, M., Simon, D., Coiffier, B., Leblond, V., Simon, M., ...

Background: Despite high-dose therapy and ASCT some patients with aggressive HD fail to achieve long-term survival. Patients and methods: Forty-three patients with induction failure (n = 19)...

Hochauflösende 3D-Röntgentomographie zur Analyse von Blasenströmungen. (1999)

Simon, M., Cherdron, W., Cacuci, D.G.

GVC-Fachausschußsitzung 'Mehrphasenströmungen', Bad Kissingen, 1.-3.März 1999

3D-Tomograph macht das Unsichtbare sichtbar. (1999)

Simon, M.

Industrieanzeiger, (1999) Nr.19, S.50-51

Anwendung von Röntgen-Computertomographie bei Zweiphasenströmungen. (1999)

Simon, M., Cherdron, W., Cacuci, D.G.

Jahrestagung der VDI-Gesellschaft Verfahrenstechnik und Chemieingenieurwesen, Leipzig, 29.September - 1.Oktober 1999

Messungen der Eigenschaften von kontinuierlicher und disperser Phase in Luft-Wasser-Blasenströmungen. (1999)

Sengpiel, W., Samstag, M., Heinzel, V., Simon, M.

3.Workshop Meßtechnik für stationäre und transiente Mehrphasenströmungen, Forschungszentrum Rossendorf, Dresden, 14.Oktober 1999

Effiziente Kopplung fossil befeuerter Kraftwerke mit solarthermischen Anlagen. (1999)

Simon, M., Schmid, S., Heinzel, V.

Fachtagung der VDI-Gesellschaft Energietechnik 'Entwicklungslinien in der Energie- und Kraftwerkstechnik', Essen, 22.-23.September 1999

THE VAPOR PRESSURE OF TETRAFLUOROMETHANE FROM 86-146K. (1998)

Simon,M., Knobler,C. M., Duncan,A. G.

The vapor pressure of CF, has been measured from 86-146K. The equation log p(torr) = 8.5019 - 769.89/T represents the data for the solid. Above the triple point, 89.55K, the vapor pressure is...

Radio Observations of the Distribution of Chromospheric Brightness Temperature, (1998)

Shimabukuro,F. I., Simon,M., Buhl,D., Cogdell,J. R., Zapata,C.

Radio observations of the solar eclipse of 7 March 1970 were made at several observatories in a cooperative effort, covering a wavelength range of 2.1 mm to 2 cm. An analysis of the radio...

On the effect of inclination on flow patterns in non-adiabetic steam/water two-phase flow. (1998)

Simon, M.

ICMF '98 : Proc.of the 3rd Internat.Conf.on Multiphase Flow, Lyon, F, June 8-12, 1998

Experimental investigation of air/water bubbly flow in vertical gaps. (1998)

Cherdron, W., Grötzbach, G., Samstag, M., Sengpiel, W., Simon, M., Tiseanu, I.

ICMF '98 : Proc.of the 3rd Internat.Conf.on Multiphase Flow, Lyon, F, June 8-12, 1998

Linear thermopile sensor array for contactless temperature measurement (1997)

Simon, M., Schieferdecker, J., Gottfried-Gottfried, R., Müller, M., Jähne, R.

Thermopile single element IR-sensors are commonly used as radiation sensors. For some applications like detection of position, size and direction of movement however, the measurement of a single spot...

Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. (1997)

Nielsen, P J, Lorenz, B, Müller, A M, Wenger, R H, Brombacher, F, Simon, M, ...

The heat stable antigen (HSA, or murine CD24) is a glycosyl phosphatidylinositol-linked surface glycoprotein expressed on immature cells of most, if not all, major hematopoietic lineages, as well as...

Fluid oscillations in flat plate boiling water collectors. (1997)

Heinzel, V., Holzinger, J., Simon, M.

Solar World Congress : Selected Proc.of ISES 1995, Harare, Zimbabwe, September 11-15, 1995 Part III

Measurement of 0.25-3.2 GeV antiprotons in the cosmic radiation (1996)

Mitchell, J. W., Barbier, L. M., Christian, E. R., Krizmanic, J. F., Krombel, K., Ormes, J. F., ...

The balloon-borne Isotope Matter-Antimatter Experiment (IMAX) was flown from Lynn Lake, Manitoba, Canada on 16–17 July 1992. Using velocity and magnetic rigidity to determine mass, we have directly...

Characterization of a porin from the outer membrane of vibrio anguillarum (1996)

Simon, M., Mathes, A., Blanch, A., Engelhardt, H.

The outer membranes of the 10 serovars of Vibrio anguillarum showed a common major protein with a size of around 40 kDa. Antibodies against the major outer membrane protein (MOMP) of V. anguillarum...

Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin (1996)

Ruhrberg, C., Hajibagheri, M.A., Simon, M., Dooley, T.P., Watt, F.M.

The cornified envelope is a layer of transglutaminase cross-linked protein that is deposited under the plasma membrane of keratinocytes in the outermost layers of the epidermis. We present the...

Simulation model of a parabolic trough collector. (1995)

Heinzel, V., Kungl, H., Simon, M.

ISES Solar World Congress, Harare, Zimbabwe, September 11-15, 1995

Purification and Thermal Stability of Intact Bacillus subtilis Flagella (1971)

Dimmitt, K., Simon, M.

Flagella were prepared and purified in a relatively intact form from bacterial lysates. Immunochemical tests showed that over 95% of the protein in the final preparation consisted of flagellar...

Synthesis of Bacterial Flagella: Chromosomal Synchrony and Flagella Synthesis (1969)

Van Alstyne, D., Grant, G. F., Simon, M.

Synchronous cultures of Bacillus subtilis 168 M were obtained from light-density spores germinated at 46 C and grown at 37 C. This procedure synchronizes both cell division and chromosome...

Instabilite en milieu alcalin des oligodesoxy-nucleotides radio-induits (1969)

Simon, M.

International Journal of Radiation Biology, 16 (1969) S. 167-82

La glose de l'épître aux Romains de Gilbert de la Porrée / (1956)

Simon, M.

Thesis (doctoral)--Université catholique de Louvain, 1956.

A Letter. (1897)

Simon, M.

Title from caption.

A polypeptide bound by the chaperonin groEL is localized within a central cavity.

Braig, K, Simon, M, Furuya, F, Hainfeld, J F, Horwich, A L

Chaperonins are oligomeric protein complexes that play an essential role in the cell, mediating ATP-dependent polypeptide chain folding in a variety of cellular compartments. They appear to bind...

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

Bowtell, D, Fu, P, Simon, M, Senior, P

Several findings suggest that signals from tyrosine kinases are transduced, at least in part, through ras proteins. These findings include (i) blockage of the transforming activity of constitutively...

Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector.

Shizuya, H, Birren, B, Kim, U J, Mancino, V, Slepak, T, Tachiiri, Y, ...

A bacterial cloning system for mapping and analysis of complex genomes has been developed. The BAC system (for bacterial artificial chromosome) is based on Escherichia coli and its single-copy...

Supercoiled DNA wraps around the bacteriophage phi 29 head-tail connector.

Turnquist, S, Simon, M, Egelman, E, Anderson, D

Supercoiled pBR322 DNA wraps around the outside of the isolated Bacillus subtilis bacteriophage phi 29 head-tail connector, the crux of the DNA packaging machine of the viral precursor capsid or...

Essential Bacillus subtilis genes

Kobayashi, K., Ehrlich, S. D., Albertini, A., Amati, G., Andersen, K. K., Arnaud, M., ...

To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, we carried out a systematic inactivation of Bacillus subtilis genes. Among ≈4,100 genes of the...

Identification in situ and dynamics of bacteria on limnetic organic aggregates (lake snow).

Weiss, P, Schweitzer, B, Amann, R, Simon, M

Microbial assemblages on large organic aggregates (lake snow) of Lake Constance, Germany, were analyzed with rRNA-directed fluorescent oligonucleotide probes specific for the domain Bacteria and the...

Early cytokine and chemokine gene expression in lymph nodes of macaques infected with simian immunodeficiency virus is predictive of disease outcome and vaccine efficacy.

Zou, W, Lackner, A A, Simon, M, Durand-Gasselin, I, Galanaud, P, Desrosiers, R C, ...

Competitive PCR was used to evaluate the expression of cytokine, granzyme B, and chemokine genes in lymph nodes of macaques recently infected with the simian immunodeficiency virus (SIV) pathogenic...

Chemotactic control of the two flagellar systems of Vibrio parahaemolyticus.

Sar, N, McCarter, L, Simon, M, Silverman, M

Vibrio parahaemolyticus synthesizes two distinct flagellar organelles, the polar flagellum (Fla), which propels the bacterium in a liquid environment (swimming), and the lateral flagella (Laf), which...

Regulation of lateral flagella gene transcription in Vibrio parahaemolyticus.

Belas, R, Simon, M, Silverman, M

Two distinctly different organelles of locomotion are produced by Vibrio parahaemolyticus. The polar flagellum is responsible for motility in a liquid environment (swimming), and the lateral flagella...

Transposon mutagenesis of marine Vibrio spp.

Belas, R, Mileham, A, Simon, M, Silverman, M

Coliphage P1 was used to transduce derivatives of transposons Tn5 and mini-Mu into marine Vibrio spp. Transposon Tn5 encoding tetracycline resistance (Tn5-132) was used to isolate mutants of Vibrio...

Homology between the invertible deoxyribonucleic acid sequence that controls flagellar-phase variation in Salmonella sp. and deoxyribonucleic acid sequences in other organisms.

Szekely, E, Simon, M

The invertible deoxyribonucleic acid (DNA) segment cloned from Salmonella sp. was radioactively labeled and used as a probe to search for homologous sequences by Southern hybridization. Only one copy...

Direct homocysteine biosynthesis from O-succinylhomoserine in Escherichia coli: an alternate pathway that bypasses cystathionine.

Simon, M, Hong, J S

Mutations were found which enable Escherichia coli K-12 to form homocysteine in the absence of cystathionase. The formation of homocysteine in the mutant strains required cystathionine...

DNA sequence adjacent to flagellar genes and evolution of flagellar-phase variation.

Szekely, E, Simon, M

A variety of factors, including phase variation, are involved in the regulation of flagellin gene expression in Salmonella sp. Flagellar-phase variation refers to the alternate expression of two...

Flagellar-phase variation: isolation of the rh1 gene.

Silverman, M, Zieg, J, Simon, M

In Salmonella, expression of flagellar antigen alternates between two serotypes (phases) encoded by two genes, H1 and H2. The mechanism which controls the alternative expression of the H1 and H2...

Identification of the structural gene for the hook subunit protein of Escherichia coli flagella.

Komeda, Y, Silverman, M, Simon, M

Previous studies showed that the structural gene for the flagellar hook subunit protein (molecular weight 42,000) was one of a group of flagellar genes located on the Escherichia coli genome near...

Genes for the hook-basal body proteins of the flagellar apparatus in Escherichia coli.

Komeda, Y, Silverman, M, Matsumura, P, Simon, M

Of the more than 30 genes required for flagellar function, 6 are located between pyrC and ptsG on the Escherichia coli genetic man. This cluster of genes is called flagellar region I. Four-point...

Biotechnology awareness study, Part 2: Meeting the information needs of biotechnologists.

Cunningham, D, Grefsheim, S, Simon, M, Lansing, P S

The second part of the biotechnology awareness study focused on health sciences libraries and how well they are meeting the needs of biotechnologists working in the study's nine medical centers. A...

Characterization of lambda Escherichia coli hybrids carrying chemotaxis genes.

Silverman, M, Matsumura, P, Hilmen, M, Simon, M

Molecular cloning techniques were used to construct hybrid Escherichia coli lambda phage and isolate Col E1 factors that carried the cheB region of the E. coli genome. The products of these genes...

Identification of polypeptides necessary for chemotaxis in Escherichia coli.

Silverman, M, Simon, M

Molecular cloning techniques were used to construct Escherichia coli-lambda hybrids that contained many of the genes necessary for flagellar rotation and chemotaxis. The properties of specific...

Genetic analysis of Escherichia coli K-12 region I flagellar mutants.

Komeda, Y, Silverman, M, Simon, M

Flagellar mutants in Escherichia coli region I were obtained by selection for resistance to the flagellotropic phage chi. F' elements carrying this region of the E. coli genome were then constructed....

Synthesis of mot and che gene products of Escherichia coli programmed by hybrid ColE1 plasmids in minicells.

Matsumura, P, Silverman, M, Simon, M

Hybrid Escherichia coli ColE1 plasmids carrying the genes for motility (mot) and chemotaxis (che) were transferred to a minicell-producing strain. The mot and che genes on the hybrid plasmid directed...

Specific uptake rates of amino acids by attached and free-living bacteria in a mesotrophic lake.

Simon, M

Seasonal and spatial patterns of specific uptake rates of amino acids by bacteria in Lake Constance were studied. The total bacterial population was divided into small (0.2- to 1.0-micron) and large...

Purification and Thermal Stability of Intact Bacillus subtilis Flagella

Dimmitt, K., Simon, M.

Flagella were prepared and purified in a relatively intact form from bacterial lysates. Immunochemical tests showed that over 95% of the protein in the final preparation consisted of flagellar...

Genetic Analysis of Flagellar Mutants in Escherichia coli

Silverman, M., Simon, M.

Flagellar mutants in Escherichia coli were obtained by selection for resistance to the flagellotropic phage χ. F elements covering various regions of the E. coli genome were then constructed, and,...

Synthesis of Bacterial Flagella I. Requirement for Protein and Ribonucleic Acid Synthesis During Flagellar Regeneration in Bacillus subtilis

Dimmitt, K., Bradford, S., Simon, M.

A relatively simple immunochemical procedure for estimating flagellar protein was developed. This procedure involved measuring the binding of purified, radioactively labeled, antiflagellar antibodies...

The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis.

Simon, M, Girbal, E, Sebbag, M, Gomès-Daudrix, V, Vincent, C, Salama, G, ...

In rheumatoid arthritis (RA), the high diagnostic value of serum antibodies to the stratum corneum of rat esophagus epithelium has been widely reported. These so-called "antikeratin antibodies,"...

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

Schauer, E, Trautinger, F, Köck, A, Schwarz, A, Bhardwaj, R, Simon, M, ...

Proopiomelanocortin (POMC), the precursor for melanotropic, corticotropic, and opioid peptides such as alpha-melanocyte-stimulating hormone (alpha MSH), ACTH, and other related peptides, was...

The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies.

Sebbag, M, Simon, M, Vincent, C, Masson-Bessière, C, Girbal, E, Durieux, J J, ...

The so-called antikeratin antibodies (AKA) and the antiperinuclear factor (APF) are the most specific serological markers of RA. Using indirect immunofluorescence, AKA label the stratum corneum of...

Construction of a yeast strain devoid of mitochondrial introns and its use to screen nuclear genes involved in mitochondrial splicing.

Séraphin, B, Boulet, A, Simon, M, Faye, G

We have constructed a respiring yeast strain devoid of mitochondrial introns to screen nuclear pet- mutants for those that play a direct role in mitochondrial intron excision. Intron-less...

Synthesis of Bacterial Flagella: Chromosomal Synchrony and Flagella Synthesis

Van Alstyne, D., Grant, G. F., Simon, M.

Synchronous cultures of Bacillus subtilis 168 M were obtained from light-density spores germinated at 46 C and grown at 37 C. This procedure synchronizes both cell division and chromosome...

A mitochondrial reading frame which may code for a maturase-like protein in Saccharomyces cerevisiae.

Séraphin, B, Simon, M, Faye, G

In S. cerevisiae, the large oxi3/oli2 mitochondrial transcript contains the products of the oxi3, aap1 and oli2 genes and an unassigned reading frame, RF3. In the work presented here, we have...

Steps in processing of the mitochondrial cytochrome oxidase subunit I pre-mRNA affected by a nuclear mutation in yeast.

Simon, M, Faye, G

In Saccharomyces cerevisiae, the mitochondrial gene encoding the subunit I of cytochrome c oxidase (oxi-3 gene) is interrupted by intervening sequences. In this report, a nuclear mutation [referred...

Analysis of the nucleotide sequence of an invertible controlling element.

Zieg, J, Simon, M

The nucleotide sequence of the inversion region responsible for flagellar phase variation in Salmonella was determined. The inversion region is 995 base pairs (bp) in length and is bounded by a 14-bp...

The Saccharomyces cerevisiae ADR1 gene is a positive regulator of transcription of genes encoding peroxisomal proteins.

Simon, M, Adam, G, Rapatz, W, Spevak, W, Ruis, H

Expression of the CTA1 gene of Saccharomyces cerevisiae, encoding catalase A, the peroxisomal catalase of this yeast, is sensitive to glucose repression. A DNA fragment cloned as a multicopy plasmid...

Phase variation in Salmonella: genetic analysis of a recombinational switch.

Silverman, M, Zieg, J, Hilmen, M, Simon, M

The alternative expression of Salmonella genes H1 and H2, which specify different flagellar antigens, results in the oscillation of phenotype known as phase variation. This alternation is controlled...

Analysis of mutations in the transmembrane region of the aspartate chemoreceptor in Escherichia coli.

Oosawa, K, Simon, M

Site-specific mutagenesis was used to replace an alanine with a lysine residue and to create a deletion of seven amino acids into the first transmembrane region (TMI region) of the aspartate...

Assignment of the human and mouse prion protein genes to homologous chromosomes.

Sparkes, R S, Simon, M, Cohn, V H, Fournier, R E, Lem, J, Klisak, I, ...

Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious...

Association of mitochondria with microtubules in cultured cells.

Heggeness, M H, Simon, M, Singer, S J

By indirect immunofluorescence techniques, microtubules and mitochondria were localized in normal rat kidney cells, human WI38 fibroblasts, mouse peritoneal macrophages, and a putative smooth muscle...

Legumin Synthesis in Developing Cotyledons of Vicia faba L. 1

Millerd, Adele, Simon, M., Stern, H.

The synthesis of legumin in developing cotyledons of Vicia faba L. has been examined as a potential system for approaching the problem of differential gene expression. The pattern of legumin...

Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III.

Boulet, A, Simon, M, Faye, G, Bauer, G A, Burgers, P M

Saccharomyces cerevisiae cdc2 mutants arrest in the S-phase of the cell cycle when grown at the non-permissive temperature, implicating this gene product as essential for DNA synthesis. The CDC2 gene...

Antigenic Nature of Bacterial Flagellar Hook Structures

Dimmitt, K., Simon, M.

The bacterial flagellar hook is antigenically distinct from the remainder of the flagellum. This conclusion is based on electron microscopic observation of intact flagella coated with antisera...

The identification of the mot gene product with Escherichia coli-lambda hybrids.

Silverman, M, Matsumura, P, Simon, M

Molecular cloning techniques were used to construct lambda-E. coli hybrid bacteriophage carrying genes involved in bacterial flagellar motility (mot) and chemotaxis (cheA). A series of hybrid...

The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.

Simon, M, Giot, L, Faye, G

In Saccharomyces cerevisiae, DNA polymerase delta (POLIII), the product of the CDC2 (POL3) gene, possesses, in its N-terminal half, the well conserved 3-domain 3' to 5' exonuclease site. Strains...

MSS18, a yeast nuclear gene involved in the splicing of intron aI5 beta of the mitochondrial cox1 transcript.

Séraphin, B, Simon, M, Faye, G

We have isolated and characterized a nuclear gene, MSS18, which is implicated in the splicing of intron aI5 beta of the mitochondrial cox1 transcript (subunit 1 of the cytochrome c oxidase). Northern...

Enterotoxin B: Serological Assay in Cultures by Passive Hemagglutination

Johnson, H. M., Hall, H. E., Simon, M.

Bis-diazotized benzidine hemagglutination with Formalinized sheep erythrocytes was adapted to the rapid and specific detection of enterotoxin B in staphylococcal culture fluids. There was complete...

Characterization of the prosome from Drosophila and its similarity to the cytoplasmic structures formed by the low molecular weight heat-shock proteins.

Arrigo, A P, Darlix, J L, Khandjian, E W, Simon, M, Spahr, P F

We have identified and characterized a ribonucleoprotein structure from the cytoplasm of Drosophila melanogaster tissue culture cells which is equivalent to the prosome, a recently described...

Radiation Sterilization of Bacon for Military Feeding

Anellis, A., Grecz, N., Huber, D. A., Berkowitz, D., Schneider, M. D., Simon, M.

Sliced, cured bacon, packed in cans and seeded with 6 × 105 spores per can of Clostridium botulinum strains 33A or 41B, or with 3 × 106 spores per can of strains 36A, 12885A, 9B, or 53B, was...

KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28.

Simon, M, Seraphin, B, Faye, G

We have isolated, in yeast, a nuclear gene named KIN28 which presents significant sequence homology with the cell-division-cycle CDC28 gene, with members of the protein-tyrosine kinase family (src,...

Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis.

Simon, M, Haftek, M, Sebbag, M, Montézin, M, Girbal-Neuhauser, E, Schmitt, D, ...

Cornified cell envelope (CE) is generated during the late stages of epidermal differentiation and is made up of proteins covalently linked together by transglutaminases. To determine whether...

Significance of Bacteriophages for Controlling Bacterioplankton Growth in a Mesotrophic Lake

Hennes, K. P., Simon, M.

Bacterium-specific viruses have attracted much interest in aquatic microbial ecology because they have been shown to be about 10 times more abundant than planktonic bacteria. So far most of the...

Involvement of the Yeast DNA Polymerase δ in DNA Repair in Vivo

Giot, L., Chanet, R., Simon, M., Facca, C., Faye, G.

The POL3 encoded catalytic subunit of DNA polymerase δ possesses a highly conserved C-terminal cysteine-rich domain in Saccharomyces cerevisiae. Mutations in some of its cysteine codons display a...

Absence of a single repeat from the coding region of the human involucrin gene leading to RFLP.

Simon, M, Phillips, M, Green, H, Stroh, H, Glatt, K, Burns, G, ...

The human involucrin gene has been mapped to the region q21-q22 of chromosome 1. Three of six Utah families examined were polymorphic for a PstI fragment of the involucrin gene. In one individual,...

A study of 609 HLA haplotypes marking for the hemochromatosis gene: (1) mapping of the gene near the HLA-A locus and characters required to define a heterozygous population and (2) hypothesis concerning the underlying cause of hemochromatosis-HLA association.

Simon, M, Le Mignon, L, Fauchet, R, Yaouanq, J, David, V, Edan, G, ...

We compared 609 haplotypes carrying the idiopathic hemochromatosis allele with 475 control haplotypes. Four haplotypes were more frequent in hemochromatosis: A3, B7 (actually A3, CW., B7, Bfs, DR2);...

Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information.

Lalouel, J M, Le Mignon, L, Simon, M, Fauchet, R, Bourel, M, Rao, D C, ...

An ongoing family study of idiopathic hemochromatosis in Brittany, France, allowed us to investigate the segregation of this trait and its linkage and association to the HLA-A locus in 147 pedigrees,...

A polypeptide bound by the chaperonin groEL is localized within a central cavity.

Braig, K, Simon, M, Furuya, F, Hainfeld, J F, Horwich, A L

Chaperonins are oligomeric protein complexes that play an essential role in the cell, mediating ATP-dependent polypeptide chain folding in a variety of cellular compartments. They appear to bind...

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

Bowtell, D, Fu, P, Simon, M, Senior, P

Several findings suggest that signals from tyrosine kinases are transduced, at least in part, through ras proteins. These findings include (i) blockage of the transforming activity of constitutively...

Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector.

Shizuya, H, Birren, B, Kim, U J, Mancino, V, Slepak, T, Tachiiri, Y, ...

A bacterial cloning system for mapping and analysis of complex genomes has been developed. The BAC system (for bacterial artificial chromosome) is based on Escherichia coli and its single-copy...

Supercoiled DNA wraps around the bacteriophage phi 29 head-tail connector.

Turnquist, S, Simon, M, Egelman, E, Anderson, D

Supercoiled pBR322 DNA wraps around the outside of the isolated Bacillus subtilis bacteriophage phi 29 head-tail connector, the crux of the DNA packaging machine of the viral precursor capsid or...

Essential Bacillus subtilis genes

Kobayashi, K., Ehrlich, S. D., Albertini, A., Amati, G., Andersen, K. K., Arnaud, M., ...

To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, we carried out a systematic inactivation of Bacillus subtilis genes. Among ≈4,100 genes of the...

Identification in situ and dynamics of bacteria on limnetic organic aggregates (lake snow).

Weiss, P, Schweitzer, B, Amann, R, Simon, M

Microbial assemblages on large organic aggregates (lake snow) of Lake Constance, Germany, were analyzed with rRNA-directed fluorescent oligonucleotide probes specific for the domain Bacteria and the...

Early cytokine and chemokine gene expression in lymph nodes of macaques infected with simian immunodeficiency virus is predictive of disease outcome and vaccine efficacy.

Zou, W, Lackner, A A, Simon, M, Durand-Gasselin, I, Galanaud, P, Desrosiers, R C, ...

Competitive PCR was used to evaluate the expression of cytokine, granzyme B, and chemokine genes in lymph nodes of macaques recently infected with the simian immunodeficiency virus (SIV) pathogenic...

Chemotactic control of the two flagellar systems of Vibrio parahaemolyticus.

Sar, N, McCarter, L, Simon, M, Silverman, M

Vibrio parahaemolyticus synthesizes two distinct flagellar organelles, the polar flagellum (Fla), which propels the bacterium in a liquid environment (swimming), and the lateral flagella (Laf), which...

Regulation of lateral flagella gene transcription in Vibrio parahaemolyticus.

Belas, R, Simon, M, Silverman, M

Two distinctly different organelles of locomotion are produced by Vibrio parahaemolyticus. The polar flagellum is responsible for motility in a liquid environment (swimming), and the lateral flagella...

Transposon mutagenesis of marine Vibrio spp.

Belas, R, Mileham, A, Simon, M, Silverman, M

Coliphage P1 was used to transduce derivatives of transposons Tn5 and mini-Mu into marine Vibrio spp. Transposon Tn5 encoding tetracycline resistance (Tn5-132) was used to isolate mutants of Vibrio...

Homology between the invertible deoxyribonucleic acid sequence that controls flagellar-phase variation in Salmonella sp. and deoxyribonucleic acid sequences in other organisms.

Szekely, E, Simon, M

The invertible deoxyribonucleic acid (DNA) segment cloned from Salmonella sp. was radioactively labeled and used as a probe to search for homologous sequences by Southern hybridization. Only one copy...

Direct homocysteine biosynthesis from O-succinylhomoserine in Escherichia coli: an alternate pathway that bypasses cystathionine.

Simon, M, Hong, J S

Mutations were found which enable Escherichia coli K-12 to form homocysteine in the absence of cystathionase. The formation of homocysteine in the mutant strains required cystathionine...

DNA sequence adjacent to flagellar genes and evolution of flagellar-phase variation.

Szekely, E, Simon, M

A variety of factors, including phase variation, are involved in the regulation of flagellin gene expression in Salmonella sp. Flagellar-phase variation refers to the alternate expression of two...

Flagellar-phase variation: isolation of the rh1 gene.

Silverman, M, Zieg, J, Simon, M

In Salmonella, expression of flagellar antigen alternates between two serotypes (phases) encoded by two genes, H1 and H2. The mechanism which controls the alternative expression of the H1 and H2...

Identification of the structural gene for the hook subunit protein of Escherichia coli flagella.

Komeda, Y, Silverman, M, Simon, M

Previous studies showed that the structural gene for the flagellar hook subunit protein (molecular weight 42,000) was one of a group of flagellar genes located on the Escherichia coli genome near...

Genes for the hook-basal body proteins of the flagellar apparatus in Escherichia coli.

Komeda, Y, Silverman, M, Matsumura, P, Simon, M

Of the more than 30 genes required for flagellar function, 6 are located between pyrC and ptsG on the Escherichia coli genetic man. This cluster of genes is called flagellar region I. Four-point...

Biotechnology awareness study, Part 2: Meeting the information needs of biotechnologists.

Cunningham, D, Grefsheim, S, Simon, M, Lansing, P S

The second part of the biotechnology awareness study focused on health sciences libraries and how well they are meeting the needs of biotechnologists working in the study's nine medical centers. A...

Characterization of lambda Escherichia coli hybrids carrying chemotaxis genes.

Silverman, M, Matsumura, P, Hilmen, M, Simon, M

Molecular cloning techniques were used to construct hybrid Escherichia coli lambda phage and isolate Col E1 factors that carried the cheB region of the E. coli genome. The products of these genes...

Identification of polypeptides necessary for chemotaxis in Escherichia coli.

Silverman, M, Simon, M

Molecular cloning techniques were used to construct Escherichia coli-lambda hybrids that contained many of the genes necessary for flagellar rotation and chemotaxis. The properties of specific...

Genetic analysis of Escherichia coli K-12 region I flagellar mutants.

Komeda, Y, Silverman, M, Simon, M

Flagellar mutants in Escherichia coli region I were obtained by selection for resistance to the flagellotropic phage chi. F' elements carrying this region of the E. coli genome were then constructed....

Synthesis of mot and che gene products of Escherichia coli programmed by hybrid ColE1 plasmids in minicells.

Matsumura, P, Silverman, M, Simon, M

Hybrid Escherichia coli ColE1 plasmids carrying the genes for motility (mot) and chemotaxis (che) were transferred to a minicell-producing strain. The mot and che genes on the hybrid plasmid directed...

Specific uptake rates of amino acids by attached and free-living bacteria in a mesotrophic lake.

Simon, M

Seasonal and spatial patterns of specific uptake rates of amino acids by bacteria in Lake Constance were studied. The total bacterial population was divided into small (0.2- to 1.0-micron) and large...

Purification and Thermal Stability of Intact Bacillus subtilis Flagella

Dimmitt, K., Simon, M.

Flagella were prepared and purified in a relatively intact form from bacterial lysates. Immunochemical tests showed that over 95% of the protein in the final preparation consisted of flagellar...

Genetic Analysis of Flagellar Mutants in Escherichia coli

Silverman, M., Simon, M.

Flagellar mutants in Escherichia coli were obtained by selection for resistance to the flagellotropic phage χ. F elements covering various regions of the E. coli genome were then constructed, and,...

Synthesis of Bacterial Flagella I. Requirement for Protein and Ribonucleic Acid Synthesis During Flagellar Regeneration in Bacillus subtilis

Dimmitt, K., Bradford, S., Simon, M.

A relatively simple immunochemical procedure for estimating flagellar protein was developed. This procedure involved measuring the binding of purified, radioactively labeled, antiflagellar antibodies...

The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis.

Simon, M, Girbal, E, Sebbag, M, Gomès-Daudrix, V, Vincent, C, Salama, G, ...

In rheumatoid arthritis (RA), the high diagnostic value of serum antibodies to the stratum corneum of rat esophagus epithelium has been widely reported. These so-called "antikeratin antibodies,"...

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

Schauer, E, Trautinger, F, Köck, A, Schwarz, A, Bhardwaj, R, Simon, M, ...

Proopiomelanocortin (POMC), the precursor for melanotropic, corticotropic, and opioid peptides such as alpha-melanocyte-stimulating hormone (alpha MSH), ACTH, and other related peptides, was...

The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies.

Sebbag, M, Simon, M, Vincent, C, Masson-Bessière, C, Girbal, E, Durieux, J J, ...

The so-called antikeratin antibodies (AKA) and the antiperinuclear factor (APF) are the most specific serological markers of RA. Using indirect immunofluorescence, AKA label the stratum corneum of...

Construction of a yeast strain devoid of mitochondrial introns and its use to screen nuclear genes involved in mitochondrial splicing.

Séraphin, B, Boulet, A, Simon, M, Faye, G

We have constructed a respiring yeast strain devoid of mitochondrial introns to screen nuclear pet- mutants for those that play a direct role in mitochondrial intron excision. Intron-less...

Synthesis of Bacterial Flagella: Chromosomal Synchrony and Flagella Synthesis

Van Alstyne, D., Grant, G. F., Simon, M.

Synchronous cultures of Bacillus subtilis 168 M were obtained from light-density spores germinated at 46 C and grown at 37 C. This procedure synchronizes both cell division and chromosome...

A mitochondrial reading frame which may code for a maturase-like protein in Saccharomyces cerevisiae.

Séraphin, B, Simon, M, Faye, G

In S. cerevisiae, the large oxi3/oli2 mitochondrial transcript contains the products of the oxi3, aap1 and oli2 genes and an unassigned reading frame, RF3. In the work presented here, we have...

Steps in processing of the mitochondrial cytochrome oxidase subunit I pre-mRNA affected by a nuclear mutation in yeast.

Simon, M, Faye, G

In Saccharomyces cerevisiae, the mitochondrial gene encoding the subunit I of cytochrome c oxidase (oxi-3 gene) is interrupted by intervening sequences. In this report, a nuclear mutation [referred...

Analysis of the nucleotide sequence of an invertible controlling element.

Zieg, J, Simon, M

The nucleotide sequence of the inversion region responsible for flagellar phase variation in Salmonella was determined. The inversion region is 995 base pairs (bp) in length and is bounded by a 14-bp...

The Saccharomyces cerevisiae ADR1 gene is a positive regulator of transcription of genes encoding peroxisomal proteins.

Simon, M, Adam, G, Rapatz, W, Spevak, W, Ruis, H

Expression of the CTA1 gene of Saccharomyces cerevisiae, encoding catalase A, the peroxisomal catalase of this yeast, is sensitive to glucose repression. A DNA fragment cloned as a multicopy plasmid...

Phase variation in Salmonella: genetic analysis of a recombinational switch.

Silverman, M, Zieg, J, Hilmen, M, Simon, M

The alternative expression of Salmonella genes H1 and H2, which specify different flagellar antigens, results in the oscillation of phenotype known as phase variation. This alternation is controlled...

Analysis of mutations in the transmembrane region of the aspartate chemoreceptor in Escherichia coli.

Oosawa, K, Simon, M

Site-specific mutagenesis was used to replace an alanine with a lysine residue and to create a deletion of seven amino acids into the first transmembrane region (TMI region) of the aspartate...

Assignment of the human and mouse prion protein genes to homologous chromosomes.

Sparkes, R S, Simon, M, Cohn, V H, Fournier, R E, Lem, J, Klisak, I, ...

Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious...

Association of mitochondria with microtubules in cultured cells.

Heggeness, M H, Simon, M, Singer, S J

By indirect immunofluorescence techniques, microtubules and mitochondria were localized in normal rat kidney cells, human WI38 fibroblasts, mouse peritoneal macrophages, and a putative smooth muscle...

Legumin Synthesis in Developing Cotyledons of Vicia faba L. 1

Millerd, Adele, Simon, M., Stern, H.

The synthesis of legumin in developing cotyledons of Vicia faba L. has been examined as a potential system for approaching the problem of differential gene expression. The pattern of legumin...

Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III.

Boulet, A, Simon, M, Faye, G, Bauer, G A, Burgers, P M

Saccharomyces cerevisiae cdc2 mutants arrest in the S-phase of the cell cycle when grown at the non-permissive temperature, implicating this gene product as essential for DNA synthesis. The CDC2 gene...

Antigenic Nature of Bacterial Flagellar Hook Structures

Dimmitt, K., Simon, M.

The bacterial flagellar hook is antigenically distinct from the remainder of the flagellum. This conclusion is based on electron microscopic observation of intact flagella coated with antisera...

The identification of the mot gene product with Escherichia coli-lambda hybrids.

Silverman, M, Matsumura, P, Simon, M

Molecular cloning techniques were used to construct lambda-E. coli hybrid bacteriophage carrying genes involved in bacterial flagellar motility (mot) and chemotaxis (cheA). A series of hybrid...

The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.

Simon, M, Giot, L, Faye, G

In Saccharomyces cerevisiae, DNA polymerase delta (POLIII), the product of the CDC2 (POL3) gene, possesses, in its N-terminal half, the well conserved 3-domain 3' to 5' exonuclease site. Strains...

MSS18, a yeast nuclear gene involved in the splicing of intron aI5 beta of the mitochondrial cox1 transcript.

Séraphin, B, Simon, M, Faye, G

We have isolated and characterized a nuclear gene, MSS18, which is implicated in the splicing of intron aI5 beta of the mitochondrial cox1 transcript (subunit 1 of the cytochrome c oxidase). Northern...

Enterotoxin B: Serological Assay in Cultures by Passive Hemagglutination

Johnson, H. M., Hall, H. E., Simon, M.

Bis-diazotized benzidine hemagglutination with Formalinized sheep erythrocytes was adapted to the rapid and specific detection of enterotoxin B in staphylococcal culture fluids. There was complete...

Characterization of the prosome from Drosophila and its similarity to the cytoplasmic structures formed by the low molecular weight heat-shock proteins.

Arrigo, A P, Darlix, J L, Khandjian, E W, Simon, M, Spahr, P F

We have identified and characterized a ribonucleoprotein structure from the cytoplasm of Drosophila melanogaster tissue culture cells which is equivalent to the prosome, a recently described...

Radiation Sterilization of Bacon for Military Feeding

Anellis, A., Grecz, N., Huber, D. A., Berkowitz, D., Schneider, M. D., Simon, M.

Sliced, cured bacon, packed in cans and seeded with 6 × 105 spores per can of Clostridium botulinum strains 33A or 41B, or with 3 × 106 spores per can of strains 36A, 12885A, 9B, or 53B, was...

KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28.

Simon, M, Seraphin, B, Faye, G

We have isolated, in yeast, a nuclear gene named KIN28 which presents significant sequence homology with the cell-division-cycle CDC28 gene, with members of the protein-tyrosine kinase family (src,...

Involvement of the Yeast DNA Polymerase δ in DNA Repair in Vivo

Giot, L., Chanet, R., Simon, M., Facca, C., Faye, G.

The POL3 encoded catalytic subunit of DNA polymerase δ possesses a highly conserved C-terminal cysteine-rich domain in Saccharomyces cerevisiae. Mutations in some of its cysteine codons display a...

Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis.

Simon, M, Haftek, M, Sebbag, M, Montézin, M, Girbal-Neuhauser, E, Schmitt, D, ...

Cornified cell envelope (CE) is generated during the late stages of epidermal differentiation and is made up of proteins covalently linked together by transglutaminases. To determine whether...

Significance of Bacteriophages for Controlling Bacterioplankton Growth in a Mesotrophic Lake

Hennes, K. P., Simon, M.

Bacterium-specific viruses have attracted much interest in aquatic microbial ecology because they have been shown to be about 10 times more abundant than planktonic bacteria. So far most of the...

Absence of a single repeat from the coding region of the human involucrin gene leading to RFLP.

Simon, M, Phillips, M, Green, H, Stroh, H, Glatt, K, Burns, G, ...

The human involucrin gene has been mapped to the region q21-q22 of chromosome 1. Three of six Utah families examined were polymorphic for a PstI fragment of the involucrin gene. In one individual,...

A study of 609 HLA haplotypes marking for the hemochromatosis gene: (1) mapping of the gene near the HLA-A locus and characters required to define a heterozygous population and (2) hypothesis concerning the underlying cause of hemochromatosis-HLA association.

Simon, M, Le Mignon, L, Fauchet, R, Yaouanq, J, David, V, Edan, G, ...

We compared 609 haplotypes carrying the idiopathic hemochromatosis allele with 475 control haplotypes. Four haplotypes were more frequent in hemochromatosis: A3, B7 (actually A3, CW., B7, Bfs, DR2);...

Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information.

Lalouel, J M, Le Mignon, L, Simon, M, Fauchet, R, Bourel, M, Rao, D C, ...

An ongoing family study of idiopathic hemochromatosis in Brittany, France, allowed us to investigate the segregation of this trait and its linkage and association to the HLA-A locus in 147 pedigrees,...

Recombinations between IRP and cystic fibrosis.

Farrall, M, Wainwright, B J, Feldman, G L, Beaudet, A, Sretenovic, Z, Halley, D, ...

A candidate gene for cystic fibrosis was recently isolated by selective cloning of HpaII-tiny-fragment islands; it maps considerably closer to CF than does MET or D7S8 (pJ3.11), and DNA polymorphisms...

Characterisation of the rat oesophagus epithelium antigens defined by the so-called 'antikeratin antibodies', specific for rheumatoid arthritis.

Girbal, E, Sebbag, M, Gomès-Daudrix, V, Simon, M, Vincent, C, Serre, G

OBJECTIVES--An attempt was made to characterise the antigens recognised by serum IgG antibodies directed to the stratum corneum of rat oesophagus epithelium, the so-called 'antikeratin antibodies',...

Immunoblotting detection of so-called 'antikeratin antibodies': a new assay for the diagnosis of rheumatoid arthritis.

Gomès-Daudrix, V, Sebbag, M, Girbal, E, Vincent, C, Simon, M, Rakotoarivony, J, ...

OBJECTIVES--To assess the diagnostic value for rheumatoid arthritis (RA), of an immunoblotting assay based on the rat oesophagus epithelium antigens recognised by the so-called 'antikeratin...

Optimum duration of antithyroid drug treatment determined by assay of thyroid stimulating antibody in patients with Graves' disease.

Edan, G., Massart, C., Hody, B., Poirier, J. Y., Lé Reun, M., Hespel, J. P., ...

OBJECTIVE--To determine the optimal duration of antithyroid drug treatment by monitoring serum thyroid stimulating antibody values in patients with Graves' disease. DESIGN--Prospective longitudinal...

Automated high-resolution polymerase chain reaction fragment analysis: a method for detecting T-cell receptor gamma-chain gene rearrangements in lymphoproliferative diseases.

Simon, M., Kind, P., Kaudewitz, P., Krokowski, M., Graf, A., Prinz, J., ...

Southern blot analysis and the polymerase chain reaction (PCR) are powerful tools for detecting clonal antigen receptor gene rearrangements. However, a number of limitations restrict the predictive...

Mesenchymal cell activation is the rate-limiting step of granulation tissue induction.

McClain, S. A., Simon, M., Jones, E., Nandi, A., Gailit, J. O., Tonnesen, M. G., ...

During wound repair a 3-day lag occurs between injury and granulation tissue development. When full-thickness, 8-mm-round, excisional wounds were made in the paravertebral skin of outbred Yorkshire...

Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy.

Ksiezak-Reding, H., Tracz, E., Yang, L. S., Dickson, D. W., Simon, M., Wall, J. S.

Paired helical filaments (PHFs) accumulate in the brains of subjects affected with Alzheimer's disease (AD) and certain other neurodegenerative disorders, including corticobasal degeneration (CBD)....

Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.

Simon, M, Bourel, M, Fauchet, R, Genetet, B

The frequency of HLA-A3 and HLA-B14 antigens was significantly higher in a series of 51 patients with idiopathic haemochromatosis than in a control group, being respectively 78-4 versus 27-0% and...

Serum and tumour ferritins in primary liver cancer.

Kew, M C, Torrance, J D, Derman, D, Simon, M, Macnab, G M, Charlton, R W, ...

Serum ferritin concentrations were found to be raised, often considerably, in 58 of 76 black patients with primary liver cancer (PLC). No correlation could be demonstrated between the serum ferritin...

Impact of microvascular integrity and local viability on left ventricular remodelling after reperfused acute myocardial infarction

Garot, P, Pascal, O, Simon, M, Monin, J L, Teiger, E, Garot, J, ...

Objective: To assess left ventricular remodelling in patients with reperfused acute myocardial infarction and to study its relation to microvascular damage.

Hyperhomocyst(e)inaemia, but not MTHFR C677T mutation, as a risk factor for non-arteritic ischaemic optic neuropathy

Weger, M., Stanger, O., Deutschmann, H., Simon, M., Renner, W., Schmut, O., ...

BACKGROUND/AIMS—Hyperhomocyst(e)inaemia has been identified as a strong risk factor for stroke, myocardial infarction, and deep vein thrombosis. A point mutation of methylene tetrahydrofolate...

The rheumatoid arthritis-associated autoantibodies to filaggrin label the fibrous matrix of the cornified cells but not the profilaggrin-containing keratohyalin granules in human epidermis.

Simon, M, Vincent, C, Haftek, M, Girbal, E, Sebbag, M, Gomès-Daudrix, V, ...

Since they were first described, serum IgG antibodies to the stratum corneum of rat oesophagus epithelium, highly specific for rheumatoid arthritis (RA), have been consensually called antikeratin...

Immune biology of macaque lymphocyte populations during mycobacterial infection

LAI, X, SHEN, Y, ZHOU, D, SEHGAL, P, SHEN, L, SIMON, M, ...

Immune responses of lymphocyte populations during early phases of mycobacterial infection and reinfection have not been well characterized in humans. A non-human primate model of Mycobacterium bovis...

Ex Vivo Stability of the Rodent-Borne Hantaan Virus in Comparison to That of Arthropod-Borne Members of the Bunyaviridae Family▿

Hardestam, J., Simon, M., Hedlund, K. O., Vaheri, A., Klingström, J., Lundkvist, Å.

The possible effect of virus adaptation to different transmission routes on virus stability in the environment is not well known. In this study we have compared the stabilities of three viruses...

Pharmacokinetics and renal elimination of desferrioxamine and ferrioxamine in healthy subjects and patients with haemochromatosis.

Allain, P, Mauras, Y, Chaleil, D, Simon, P, Ang, K S, Cam, G, ...

1 Desferrioxamine mesylate (DM) (10 mg kg-1 = 15.24 mumol kg-1) was given by intramuscular injection to five healthy subjects and to six patients with haemochromatosis, after informed consent. 2...

A pharmacological profile of the novel, peripherally-selective κ-opioid receptor agonist, EMD 61753

Barber, A., Bartoszyk, G.D., Bender, H.M., Gottschlich, R., Greiner, H.E., Harting, J., ...

1 The pharmacological properties of the novel diarylacetamide κ-opioid receptor agonist, EMD 61753, have been compared with those of ICI 197067 (a centrally-acting κ agonist) and ICI 204448 (a...

Central and peripheral actions of the novel kappa-opioid receptor agonist, EMD 60400.

Barber, A., Bartoszyk, G. D., Greiner, H. E., Mauler, F., Murray, R. D., Seyfried, C. A., ...

1. The pharmacological characteristics of the kappa-opioid receptor agonist, EMD 60400, have been investigated, with particular reference to its central and peripheral sites of action and its ability...

Normal human epidermal keratinocytes express in vitro specific molecular forms of (pro)filaggrin recognized by rheumatoid arthritis-associated antifilaggrin autoantibodies.

Girbal-Neuhauser, E., Montézin, M., Croute, F., Sebbag, M., Simon, M., Durieux, J. J., ...

BACKGROUND: The so-called antikeratin antibodies and the antiperinuclear factor are the most specific serological markers of rheumatoid arthritis (RA). They were recently shown to be largely the same...

Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green

Terborg, C, Bramer, S, Harscher, S, Simon, M, Witte, O

Objective: To detect perfusion reductions in patients with acute cerebral infarcts using near-infrared spectroscopy (NIRS) with indocyanine green (ICG) as tracer.

Expression of N-cadherin and alpha-catenin in astrocytomas and glioblastomas.

Shinoura, N., Paradies, N. E., Warnick, R. E., Chen, H., Larson, J. J., Tew, J. J., ...

We examined levels of mRNA and protein for N-cadherin, the predominant cadherin in neural tissues, and mRNA levels for the cadherin-associated protein, alpha-catenin, in a series of gliomas and in...