Tritapepe, L., De Santis, V., Vitale, D., Guarracino, F., Pellegrini, F., Pietropaoli, P., ...
Background The calcium sensitizer levosimendan has anti-ischaemic effects mediated via the opening of sarcolemmal and mitochondrial ATP-sensitive potassium channels. These properties suggest...
Denke, C, Deja, M, Carstens, S, Sprung, CL, Annane, D, Briegel, J, ...
No abstract available.
Severe sepsis: international and specialty variations in initial management (2008)
Reade, MC, Huang, DT, Bell, D, Coats, TJ, Cross, AM, Peake, SL, ...
No abstract available.
Wilson, A.P., Hayman, S., Whitehouse, T., Cepeda, J., Kibbler, C., Shaw, S., ...
Objective: To assess the degree of environmental contamination with methicillin-resistant Staphylococcus aureus (MRSA) in critical care and the likelihood of subsequent new patient acquisition if...
Extremal metrics on blow ups (2006)
Arezzo, C., Pacard, F., Singer, M.
Given a compact Kahler manifold with an extremal metric (M,\omega), we give sufficient conditions on finite sets points p_1,...,p_n and weights a_1,...a_n for which the blow up of M at p_1,...,p_n...
Miller, R.F., Allen, E., Copas, A., Singer, M., Edwards, S.G.
Background: Despite a decline in incidence of Pneumocystis jirovecii pneumonia (PCP), severe PCP continues to be a common cause of admission to the intensive care unit (ICU) where mortality remains...
Preconditioning effects of levosimendan in coronary artery bypass grafting--a pilot study (2006)
Tritapepe, L., De Santis, V., Vitale, D., Santulli, M., Morelli, A., Nofroni, I., ...
Background. The calcium sensitizer levosimendan protects against myocardial ischaemia and reperfusion injury in animal models. Methods. The present pilot study investigated whether a short infusion...
Harvey, S., Harrison, D.A., Singer, M., Ashcroft, J., Jones, C.M., Elbourne, D., ...
Background: Over the past 30 years the pulmonary artery catheter (PAC) has become a widely used haemodynamic monitoring device in the management of critically ill patients, though doubts exist about...
Ng, J., Finney, S.J., Shulman, R., Bellingan, G.J., Singer, M., Glynne, P.A.
Use of inhaled nitric oxide for treatment of pulmonary hypertension in adult critical illness is limited by its mode of delivery and high costs, prompting evaluation of alternative therapies. We...
Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide (2005)
Singer, M., Coluzzi, F., O'Brien, A., Clapp, L.H.
We describe three critically ill patients who received drugs with KATP channel-opening properties and subsequently developed severe life-threatening complications, including hyperkalaemia and...
Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide (2005)
Singer, M., Coluzzi, F., O'Brien, A., Clapp, L.H.
We describe three critically ill patients who received drugs with KATP channel-opening properties and subsequently developed severe life-threatening complications, including hyperkalaemia and...
Clapp, B.R., Hirschfield, G.M., Storry, C., Gallimore, J.R., Stidwill, R.P., Singer, M., ...
Background: Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when...
Cepeda, J.A., Whitehouse, T., Cooper, B., Hails, J., Jones, K., Kwaku, F., ...
Background: Hospital-acquired infection due to meticillin-resistant Staphylococcus aureus (MRSA) is common within intensive-care units. Single room or cohort isolation of infected or colonised...
Nitrosyl heme production compared in endotoxemic and hemorrhagic shock (2005)
Davies, N.A., Brealey, D.A., Stidwill, R., Singer, M., Svistunenko, D.A., Cooper, C.E.
We compared nitric oxide production and nitrosyl hemoglobin steady state concentrations during the early phases of endotoxemic and hemorrhagic shock of equivalent severity. Sprague–Dawley rats were...
COMBINATORIAL CRITERIA FOR GRÖBNER BASES (2005)
John Edward Perry, E. Kaltofen, A. Szanto, M. Singer
the direction of Hoon Hong.) Both the computation and the detection of Gröbner bases require a criterion that decides whether a set of polynomials is a Gröbner basis. The most funda-mental decision...
Medication errors: comparison of electronic and hand-written prescribing in the ICU (2004)
Shulman, R, Bellingan, G, Singer, M
No abstract available.
Triplet-sensitized photodeprotection of oligonucleotides in solution and on microarray chips (2004)
Walbert, S, Stengele, KP, Albert, TJ, Richmond, T, Norton, J, ...
Conditions and kinetics of triplet sensitization as a method for increasing the light sensitivity of photolabile protecting groups used for the photolithographic synthesis of oligonucleotide...
Lonely in the crowd: Recollections of bullying (2004)
Hunter, Simon C, Schäefer, M., Korn, S., Smith, P., Mora-Merchán, J., ...
This study examined the long-term correlates of victimization in school with aspects of functioning in adult life, using a specially designed Retrospective Bullying Questionnaire, which also included...
Lonely in the crowd: Recollections of bullying (2004)
Hunter, Simon C., Schäefer, M., Korn, S., Smith, P., Mora-Merchán, J., ...
This study examined the long-term correlates of victimization in school with aspects of functioning in adult life, using a specially designed Retrospective Bullying Questionnaire, which also included...
Lonely in the crowd: Recollections of bullying (2004)
Hunter, Simon C., Schäefer, M., Korn, S., Smith, P., Mora-Merchán, J., ...
This study examined the long-term correlates of victimization in school with aspects of functioning in adult life, using a specially designed Retrospective Bullying Questionnaire, which also included...
Linezolid resistance in clinical isolates of Staphylococcus aureus (2003)
Wilson, Peter, Andrews, J. A., Charlesworth, R., Walesby, R., Singer, M., Farrell, D. J., ...
Association between mitochondrial dysfunction and severity and outcome of septic shock (2002)
Brealey, D., Brand, M., Hargreaves, I., Heales, S., Land, J., Smolenski, R., ...
Summary: Background: Sepsis-induced multiple organ failure is the major cause of mortality and morbidity in critically ill patients. However, the precise mechanisms by which this dysfunction is...
Association between mitochondrial dysfunction and severity and outcome of septic shock (2002)
Brealey, D., Brand, M., Hargreaves, I., Heales, S., Land, J., Smolenski, R., ...
Background: Sepsis-induced multiple organ failure is the major cause of mortality and morbidity in critically ill patients. However, the precise mechanisms by which this dysfunction is caused remain...
Terlipressin for norepinephrine-resistant septic shock (2002)
O'Brien, A., Clapp, L., Singer, M.
Norepinephrine-resistant hypotension when associated with septic shock has a high rate of mortality, which might possibly be reduced by infusion of low-dose vasopressin. However, rebound hypotension...
Spanagel, R, Siegmund, S, Cowen, M, Schroff, KC, Schumann, G, Fiserova, M, ...
In the present study, we describe a new role of the neuronal nitric oxide synthase (nNOS) gene in the regulation of alcohol drinking behavior. Mice deficient in the nNOS gene (nNOS-/-) and wild-type...
Linezolid resistance in clinical isolates of Staphylococcus aureus (2002)
Wilson, Peter, Andrews, J. A., Charlesworth, R., Walesby, R., Singer, M., Farrell, D. J., ...
Linezolid resistance in clinical isolates of Staphylococcus aureus (2002)
Wilson, Peter, Andrews, J. A., Charlesworth, R., Walesby, R., Singer, M., Farrell, D. J., ...
Bradshaw, CJ, Venn, RM, Spencer, R, Brealey, D, Caudwell, E, Singer, M, ...
No abstract available.
The oxygen trail: tissue oxygenation (1999)
Aerobic cellular respiration depends on the efficient supply of oxygen and substrate to the mitochondria. There is an oxygen cascade from the environment to the subcellular environment. Efficient...
Stanney, K., Salvendy, G., Deisinger, J., DiZio, P., Ellis, S., Ellison, J., ...
This report represents a committee summary of the current state of knowledge regarding aftereffects and sense of presence in virtual environments (VEs). The work presented in this article, and the...
KLINGSIEK, S., SINGER, M., WENK, H., ELEFTHERIADIS, S., KUPPE, H., ...
We have compared the Doppler against the thermodilution technique for measurement of cardiac output in six patients during aortic surgery. The correlation coefficient between the two methods was...
Endoscopie opératoire, diagnostique et thérapeutique du tube digestif (1977)
OTTENJANN, R., BARTELHEIMER, W., BUSSE, R., LUX, G., SINGER, M.
Enhanced c-myc gene expression during forelimb regenerative outgrowth in the young Xenopus laevis.
Géraudie, J, Hourdry, J, Vriz, S, Singer, M, Méchali, M
Analysis of the expression of the c-myc protooncogene has been carried out in the forelimb regenerate of the Xenopus laevis froglet. Northern blot hybridization analysis revealed the presence of a...
Singer, M, Rossmiessl, P, Cali, B M, Liebke, H, Gross, C A
The ts8 mutant of Escherichia coli has previously been shown to preferentially inhibit stable RNA synthesis when shifted to the nonpermissive temperature. We demonstrate in this report that the ts8...
Singer, M, Walter, W A, Cali, B M, Rouviere, P, Liebke, H H, Gourse, R L, ...
The conditional lethal mutations ts8 and h8 are located in fda, the gene encoding aldolase, and they inhibit RNA synthesis upon shift to the nonpermissive temperature. We demonstrate that both...
In vivo metabolic intermediates of phospholipid biosynthesis in Rhodopseudomonas sphaeroides.
Cain, B D, Singer, M, Donohue, T J, Kaplan, S
The in vivo metabolic pathways of phospholipid biosynthesis in Rhodopseudomonas sphaeroides have been investigated. Rapid pulse-chase-labeling studies indicated that phosphatidylethanolamine and...
Recent work suggests that one or more members of the highly repeated LINE-1 (L1) DNA family found in all mammals may encode one or more proteins. Here we report the sequence of a portion of an L1...
Asakura, T, Ohnishi, S T, Adachi, K, Ozguc, M, Hashimoto, K, Singer, M, ...
The antisickling effect of cetiedil, alpha-cyclohexyl-3-thiopheneacetic acid 2-(hexahydro-1H-azepin-1-yl)-ethyl ester, has been investigated. The concentration of cetiedil required for 50% inhibition...
Singer, M, Baker, T A, Schnitzler, G, Deischel, S M, Goel, M, Dove, W, ...
We present a collection of 182 isogenic strains containing genetically linked antibiotic resistance elements located at approximately 1-min intervals around the Escherichia coli chromosome. At most...
Analysis of the effects of forelimb amputation and denervation on [35S]methionine incorporation into the protein of newt brachial plexus nerve ganglia showed that amputation increases the level of...
Expression and function of neural cell adhesion molecule during limb regeneration.
Maier, C E, Watanabe, M, Singer, M, McQuarrie, I G, Sunshine, J, Rutishauser, U
The neural cell adhesion molecule (NCAM) has been detected in regenerating limb bud of adult newts in addition to brain and peripheral nerves. In the regenerating tissue, NCAM was found primarily on...
Singer, M, Baer, H A, Scott, G, Horowitz, S, Weinstein, B
OBJECTIVE: To break the link between drug use and the human immunodeficiency virus (HIV), in 1992 the state of Connecticut rescinded a 14-year ban on pharmacy sales of syringes without a physician's...
Singer, M, Stopka, T, Siano, C, Springer, K, Barton, G, Khoshnood, K, ...
While significant gains have been achieved in understanding and reducing AIDS and hepatitis risks among injection drug users (IDUs), it is necessary to move beyond individual-level characteristics to...
Enhanced c-myc gene expression during forelimb regenerative outgrowth in the young Xenopus laevis.
Géraudie, J, Hourdry, J, Vriz, S, Singer, M, Méchali, M
Analysis of the expression of the c-myc protooncogene has been carried out in the forelimb regenerate of the Xenopus laevis froglet. Northern blot hybridization analysis revealed the presence of a...
Singer, M, Rossmiessl, P, Cali, B M, Liebke, H, Gross, C A
The ts8 mutant of Escherichia coli has previously been shown to preferentially inhibit stable RNA synthesis when shifted to the nonpermissive temperature. We demonstrate in this report that the ts8...
Singer, M, Walter, W A, Cali, B M, Rouviere, P, Liebke, H H, Gourse, R L, ...
The conditional lethal mutations ts8 and h8 are located in fda, the gene encoding aldolase, and they inhibit RNA synthesis upon shift to the nonpermissive temperature. We demonstrate that both...
In vivo metabolic intermediates of phospholipid biosynthesis in Rhodopseudomonas sphaeroides.
Cain, B D, Singer, M, Donohue, T J, Kaplan, S
The in vivo metabolic pathways of phospholipid biosynthesis in Rhodopseudomonas sphaeroides have been investigated. Rapid pulse-chase-labeling studies indicated that phosphatidylethanolamine and...
Recent work suggests that one or more members of the highly repeated LINE-1 (L1) DNA family found in all mammals may encode one or more proteins. Here we report the sequence of a portion of an L1...
Asakura, T, Ohnishi, S T, Adachi, K, Ozguc, M, Hashimoto, K, Singer, M, ...
The antisickling effect of cetiedil, alpha-cyclohexyl-3-thiopheneacetic acid 2-(hexahydro-1H-azepin-1-yl)-ethyl ester, has been investigated. The concentration of cetiedil required for 50% inhibition...
Singer, M, Baker, T A, Schnitzler, G, Deischel, S M, Goel, M, Dove, W, ...
We present a collection of 182 isogenic strains containing genetically linked antibiotic resistance elements located at approximately 1-min intervals around the Escherichia coli chromosome. At most...
Analysis of the effects of forelimb amputation and denervation on [35S]methionine incorporation into the protein of newt brachial plexus nerve ganglia showed that amputation increases the level of...
Expression and function of neural cell adhesion molecule during limb regeneration.
Maier, C E, Watanabe, M, Singer, M, McQuarrie, I G, Sunshine, J, Rutishauser, U
The neural cell adhesion molecule (NCAM) has been detected in regenerating limb bud of adult newts in addition to brain and peripheral nerves. In the regenerating tissue, NCAM was found primarily on...
Singer, M, Baer, H A, Scott, G, Horowitz, S, Weinstein, B
OBJECTIVE: To break the link between drug use and the human immunodeficiency virus (HIV), in 1992 the state of Connecticut rescinded a 14-year ban on pharmacy sales of syringes without a physician's...
Singer, M, Stopka, T, Siano, C, Springer, K, Barton, G, Khoshnood, K, ...
While significant gains have been achieved in understanding and reducing AIDS and hepatitis risks among injection drug users (IDUs), it is necessary to move beyond individual-level characteristics to...
OBJECTIVE--To assess oesophageal Doppler ultrasonography as a convenient means of optimising positive end expiratory pressure for maximal delivery of oxygen to tissues. DESIGN--Measurements of blood...
Hanck, C, Manigold, T, Bocker, U, Kurimoto, M, Kolbel, C, Singer, M, ...
BACKGROUND—Most patients with alcohol induced cirrhosis (AC) and chronic endotoxinaemia are not suffering from clinically evident systemic inflammatory reactions. This may be due to altered gene...
Haemodynamic evidence for cardiac stress during transurethral prostatectomy.
Evans, J. W., Singer, M., Chapple, C. R., Macartney, N., Walker, J. M., Milroy, E. J.
OBJECTIVE--To compare haemodynamic performance during transurethral prostatectomy and non-endoscopic control procedures similar in duration and surgical trauma. DESIGN--Controlled comparative study....
Cardiac stress during transurethral prostatectomy: Authors' reply
Evans, J W H, Macartney, N, Singer, M, Walker, J M, Chapple, C R, Milroy, E J G
O'Brien, A J, Wilson, A J, Sibbald, R, Singer, M, Clapp, L H
Endotoxin-induced vascular hyporeactivity to phenylephrine (PE) is well described in rodent aorta, but has not been investigated in smaller vessels in vitro.Segments of rat superior mesenteric artery...
Sinclair, S., James, S., Singer, M.
OBJECTIVES: To assess whether intraoperative intravascular volume optimisation improves outcome and shortens hospital stay after repair of proximal femoral fracture. DESIGN: Prospective, randomised...
Carr, C. S., Ling, K. D., Boulos, P., Singer, M.
OBJECTIVES: To assess whether immediate post-operative enteral feeding in patients who have undergone gastrointestinal resection is safe and effective. DESIGN: Randomised trial of immediate...
Immunotherapy in the management of sepsis.
The pathophysiological effects of severe sepsis, septic shock and related syndromes result from tissues damaged by the uncontrolled production of the mediators of inflammation. Early deaths are...
High dependency units in the UK: variable size, variable character, few in number.
An exploratory descriptive survey was conducted to determine the size and character of high dependency units (HDUs) in the UK. A telephone survey and subsequent postal questionnaire was sent to the...
Nisoldipine, a new dihydropyridine calcium antagonist, was examined for its dose-related haemodynamic effects using exercise-induced changes in aortic blood flow as measured by Doppler ultrasound....