Sakurai,T., Sundaralingam,M., Jeffrey,G. A.
The crystal structure of 2,5-dichloroaniline, C6H3Cl2NH2, was determined by the combined application of nuclear quadrupole resonance and X-ray diffraction. The molecule is planar, except for the...
Chen, X, Mitra, S N, Rao, S T, Sekar, K, Sundaralingam, M
Netropsin is bound to the DNA decamer d(CCCCCIIIII)2, the C-4 bromo derivative d(CCCBr5CCIIIII)2and the C-2 bromo derivative d(CBr5CCCCIIIII)2in a novel 2:1 mode. Complexes of the native decamer and...
Crystal structure of an RNA octamer duplex r(CCCIUGGG)2 incorporating tandem I.U wobbles.
Pan, B, Mitra, S N, Sun, L, Hart, D, Sundaralingam, M
The crystal structure of the RNA octamer duplex r(CCCIUGGG)2has been elucidated at 2.5 A resolution. The crystals belong to the space group P21and have unit cell constants a = 33.44 A, b = 43.41 A, c...
Crystal structure of an RNA duplex r(G GCGC CC)2 with non-adjacent G*U base pairs.
Shi, K, Wahl, M, Sundaralingam, M
The crystal structure of a self-complementary RNA duplex r(GGGCGCUCC)2with non-adjacent G*U and U*G wobble pairs separated by four Watson-Crick base pairs has been determined to 2.5 A resolution....
Sundaralingam, M., Arora, S. K.
The elucidation of puromycin structure represents the first case where both a nucleic acid and a protein fragment are found together in a crystal. The molecule displays an elongated conformation with...
Biological Membrane Structure, II. A Detailed Model for the Retinal Rod Outer Segment Membrane
Vanderkooi, G., Sundaralingam, M.
A model, based on the available chemical, electron microscopic, and x-ray diffraction data, has been developed for the structure of the retinal rod outer segment membranes. The model consists of a...
Brennan, R G, Kondo, N S, Sundaralingam, M
The anionic oxygen atoms of the phosphodiester backbone of RNA and DNA are particularly susceptible to esterification by many mutagenic and carcinogenic alkylating agents. To better understand the...
Rubin, J R, Sabat, M, Sundaralingam, M
A comparative study of the binding of square planar cis- and trans-[Pt(NH3)2Cl2] complexes and the octahedral [Ru(NH3)5(H2O)]3+ complex to tRNAphe from yeast was carried out by X-ray crystallography....
Ban, C, Ramakrishnan, B, Sundaralingam, M
The crystal structure of the self-complementary chimeric decamer duplex r(C)d(CGGCGCCG)r(G), with RNA base pairs at both termini, has been solved at 1.9 A resolution by the molecular replacement...
Bingman, C, Jain, S, Zon, G, Sundaralingam, M
The crystal structure of the alternating dodecamer d(GCGTACGTACGC) (5'-GC) has been determined to a resolution of 2.55A using oscillation film data. The crystals belong to space group P6(1) 22, a = b...
Zwitterionic character of nucleotides: possible significance in the evolution of nucleic acids.
X-ray crystallography has shown that the free acids of adenosine 5'- and 3'-monophosphates and of cytidine 5'- and 3'-monophosphates exist as zwiterions in the solid state with protonation of the...
The occurrence of the noncomplementary G-U base pair at the end of a helix is found to be governed by stacking interactions. As a rule, a G-U pair with G on the 5'-side of a Watson-Crick base pair...
Yathindra, N, Sundaralingam, M
The two helical parameters n and h where n is the number of nucleotide residues per turn and h is the height per nucleotide residue have been evaluated for single stranded helical polynucleotide...
Stout, C D, Mizuno, H, Rubin, J, Brennan, T, Rao, S T, Sundaralingam, M
The atomic coordinates of yeast tRNA(Phe) in the monoclinic crystal form have been determined by an independent analysis from a model built into a 3 A MIR map. The overall molecular structure is...
Sundaralingam, M, Mizuno, H, Stout, C D, Rao, S T, Liedman, M, Yathindra, N
The (omega', omega) polot depicting the internucleotide P-O bond rotation angles in yeast phenylalanyl transfer RNA has established the interdependence of the phosphodiesters and the nucleotide...
Structure of transfer RNA molecules containing the long variable loop
Brennan, T., Sundaralingam, M.
A structure is proposed for the type II tRNA molecules containing the long variable loop and the tertiary base interactions here are compared with type I tRNAs having the short variable loop. The...
The non-self-complementary dinucleoside monophosphate cytidylyl-3',5'-adenosine (CpA) forms a base-paired parallel-chain dimer with an intercalated proflavine. The dimer complex possesses a...
Sundaralingam, M, Drendel, W, Greaser, M
The unusual dumbbell shape of troponin C is due to the presence of a long alpha-helix of nine turns that connects the amino- and carboxyl-terminal calcium-binding domains. The center of the long...
Sundaralingam, M., Beddell, C.
A detailed conformational analysis of the known crystal structures of vitamin A, carotenoid, and xanthenoid derivatives has been made. These studies suggest that the visual chromophore 11-cis retinal...
Liebman, M, Rubin, J, Sundaralingam, M
X-ray diffraction studies at 4.5-A resolution on crystals of a complex of ethidium bromide and yeast phenylalanine tRNA reveal a nonintercalative model of binding of the ethidium within the tertiary...
Yathindra, N., Sundaralingam, M.
The possible backbone phosphodiester conformations in a dinucleoside monophosphate and a dinucleoside triphosphate have been investigated by semiempirical energy calculations. Conformational energies...
Smith, S G, Lewis, M, Aschaffenburg, R, Fenna, R E, Wilson, I A, Sundaralingam, M, ...
The crystal structure of baboon alpha-lactalbumin has been determined at 6 A and at 4.5 A (0.6 nm and 0.45 nm) resolution by the method of isomorphous replacement. The principal derivative was...
Crystal structure of d(GCGCGCG) with 5'-overhang G residues.
Pan, B, Ban, C, Wahl, M C, Sundaralingam, M
The crystal structure of the DNA heptamer d(GCGCGCG) has been solved at 1.65 A resolution by the molecular replacement method and refined to an R-value of 0.184 for 3598 reflections. The heptamer...
Crystal structure of the B-DNA hexamer d(CTCGAG): model for an A-to-B transition.
Wahl, M C, Rao, S T, Sundaralingam, M
The crystal structure of the B-DNA hexamer d(CTCGAG) has been solved at 1.9 A resolution by iterative single isomorphous replacement, using the brominated derivative d(CG5BrCGAG), and refined to an...
Ban, C, Ramakrishnan, B, Sundaralingam, M
Alternating self-complementary oligonucleotides starting with a 5'-pyrimidine usually form left-handed Z-DNA; however, with a 5'-purine start sequence they form the right-handed A-DNA. Here we report...
The crystal structure of the alternating 5'-purine start decamer d(GCGCGCGCGC) was found to be in the left-handed Z-DNA conformation. Inasmuch as the A.T base pair is known to resist Z-DNA formation,...
Ramakrishnan, B, Sundaralingam, M
The crystal structure of the self-complementary decamer d(CCIGGCCm5CGG), where I and m5C replace A and T, respectively, in the Watson-Crick B-DNA decamer d(CCAGGCCTGG) is in the A-DNA conformation....
Two crystal forms of helix II of Xenopus laevis 5S rRNA with a cytosine bulge.
The crystal structure of r(GCCACCCUG).r(CAGGGUCGGC), helix II of the Xenopus laevis 5S rRNA with a cytosine bulge (underlined), has been determined in two forms at 2.2 A (Form I, space group...
Deng, J, Xiong, Y, Sudarsanakumar, C, Shi, K, Sundaralingam, M
The RNA/DNA 14-mer, (gguauuucgguaCc)2 with consecutive uridine bulges (underlined) on each strand has been determined in two crystal forms, spermine bound (Sp-form) and spermine free (Sp-free). The...
Chen, X, Mitra, S N, Rao, S T, Sekar, K, Sundaralingam, M
Netropsin is bound to the DNA decamer d(CCCCCIIIII)2, the C-4 bromo derivative d(CCCBr5CCIIIII)2and the C-2 bromo derivative d(CBr5CCCCIIIII)2in a novel 2:1 mode. Complexes of the native decamer and...
Crystal structure of an RNA octamer duplex r(CCCIUGGG)2 incorporating tandem I.U wobbles.
Pan, B, Mitra, S N, Sun, L, Hart, D, Sundaralingam, M
The crystal structure of the RNA octamer duplex r(CCCIUGGG)2has been elucidated at 2.5 A resolution. The crystals belong to the space group P21and have unit cell constants a = 33.44 A, b = 43.41 A, c...
Crystal structure of an RNA duplex r(G GCGC CC)2 with non-adjacent G*U base pairs.
Shi, K, Wahl, M, Sundaralingam, M
The crystal structure of a self-complementary RNA duplex r(GGGCGCUCC)2with non-adjacent G*U and U*G wobble pairs separated by four Watson-Crick base pairs has been determined to 2.5 A resolution....
Sundaralingam, M., Arora, S. K.
The elucidation of puromycin structure represents the first case where both a nucleic acid and a protein fragment are found together in a crystal. The molecule displays an elongated conformation with...
Biological Membrane Structure, II. A Detailed Model for the Retinal Rod Outer Segment Membrane
Vanderkooi, G., Sundaralingam, M.
A model, based on the available chemical, electron microscopic, and x-ray diffraction data, has been developed for the structure of the retinal rod outer segment membranes. The model consists of a...
Brennan, R G, Kondo, N S, Sundaralingam, M
The anionic oxygen atoms of the phosphodiester backbone of RNA and DNA are particularly susceptible to esterification by many mutagenic and carcinogenic alkylating agents. To better understand the...
Rubin, J R, Sabat, M, Sundaralingam, M
A comparative study of the binding of square planar cis- and trans-[Pt(NH3)2Cl2] complexes and the octahedral [Ru(NH3)5(H2O)]3+ complex to tRNAphe from yeast was carried out by X-ray crystallography....
Ban, C, Ramakrishnan, B, Sundaralingam, M
The crystal structure of the self-complementary chimeric decamer duplex r(C)d(CGGCGCCG)r(G), with RNA base pairs at both termini, has been solved at 1.9 A resolution by the molecular replacement...
Bingman, C, Jain, S, Zon, G, Sundaralingam, M
The crystal structure of the alternating dodecamer d(GCGTACGTACGC) (5'-GC) has been determined to a resolution of 2.55A using oscillation film data. The crystals belong to space group P6(1) 22, a = b...
Zwitterionic character of nucleotides: possible significance in the evolution of nucleic acids.
X-ray crystallography has shown that the free acids of adenosine 5'- and 3'-monophosphates and of cytidine 5'- and 3'-monophosphates exist as zwiterions in the solid state with protonation of the...
The occurrence of the noncomplementary G-U base pair at the end of a helix is found to be governed by stacking interactions. As a rule, a G-U pair with G on the 5'-side of a Watson-Crick base pair...
Yathindra, N, Sundaralingam, M
The two helical parameters n and h where n is the number of nucleotide residues per turn and h is the height per nucleotide residue have been evaluated for single stranded helical polynucleotide...
Stout, C D, Mizuno, H, Rubin, J, Brennan, T, Rao, S T, Sundaralingam, M
The atomic coordinates of yeast tRNA(Phe) in the monoclinic crystal form have been determined by an independent analysis from a model built into a 3 A MIR map. The overall molecular structure is...
Sundaralingam, M, Mizuno, H, Stout, C D, Rao, S T, Liedman, M, Yathindra, N
The (omega', omega) polot depicting the internucleotide P-O bond rotation angles in yeast phenylalanyl transfer RNA has established the interdependence of the phosphodiesters and the nucleotide...
Structure of transfer RNA molecules containing the long variable loop
Brennan, T., Sundaralingam, M.
A structure is proposed for the type II tRNA molecules containing the long variable loop and the tertiary base interactions here are compared with type I tRNAs having the short variable loop. The...
The non-self-complementary dinucleoside monophosphate cytidylyl-3',5'-adenosine (CpA) forms a base-paired parallel-chain dimer with an intercalated proflavine. The dimer complex possesses a...
Sundaralingam, M, Drendel, W, Greaser, M
The unusual dumbbell shape of troponin C is due to the presence of a long alpha-helix of nine turns that connects the amino- and carboxyl-terminal calcium-binding domains. The center of the long...
Sundaralingam, M., Beddell, C.
A detailed conformational analysis of the known crystal structures of vitamin A, carotenoid, and xanthenoid derivatives has been made. These studies suggest that the visual chromophore 11-cis retinal...
Liebman, M, Rubin, J, Sundaralingam, M
X-ray diffraction studies at 4.5-A resolution on crystals of a complex of ethidium bromide and yeast phenylalanine tRNA reveal a nonintercalative model of binding of the ethidium within the tertiary...
Yathindra, N., Sundaralingam, M.
The possible backbone phosphodiester conformations in a dinucleoside monophosphate and a dinucleoside triphosphate have been investigated by semiempirical energy calculations. Conformational energies...
Smith, S G, Lewis, M, Aschaffenburg, R, Fenna, R E, Wilson, I A, Sundaralingam, M, ...
The crystal structure of baboon alpha-lactalbumin has been determined at 6 A and at 4.5 A (0.6 nm and 0.45 nm) resolution by the method of isomorphous replacement. The principal derivative was...
Crystal structure of d(GCGCGCG) with 5'-overhang G residues.
Pan, B, Ban, C, Wahl, M C, Sundaralingam, M
The crystal structure of the DNA heptamer d(GCGCGCG) has been solved at 1.65 A resolution by the molecular replacement method and refined to an R-value of 0.184 for 3598 reflections. The heptamer...
Crystal structure of the B-DNA hexamer d(CTCGAG): model for an A-to-B transition.
Wahl, M C, Rao, S T, Sundaralingam, M
The crystal structure of the B-DNA hexamer d(CTCGAG) has been solved at 1.9 A resolution by iterative single isomorphous replacement, using the brominated derivative d(CG5BrCGAG), and refined to an...
Ban, C, Ramakrishnan, B, Sundaralingam, M
Alternating self-complementary oligonucleotides starting with a 5'-pyrimidine usually form left-handed Z-DNA; however, with a 5'-purine start sequence they form the right-handed A-DNA. Here we report...
The crystal structure of the alternating 5'-purine start decamer d(GCGCGCGCGC) was found to be in the left-handed Z-DNA conformation. Inasmuch as the A.T base pair is known to resist Z-DNA formation,...
Ramakrishnan, B, Sundaralingam, M
The crystal structure of the self-complementary decamer d(CCIGGCCm5CGG), where I and m5C replace A and T, respectively, in the Watson-Crick B-DNA decamer d(CCAGGCCTGG) is in the A-DNA conformation....
Two crystal forms of helix II of Xenopus laevis 5S rRNA with a cytosine bulge.
The crystal structure of r(GCCACCCUG).r(CAGGGUCGGC), helix II of the Xenopus laevis 5S rRNA with a cytosine bulge (underlined), has been determined in two forms at 2.2 A (Form I, space group...
Deng, J, Xiong, Y, Sudarsanakumar, C, Shi, K, Sundaralingam, M
The RNA/DNA 14-mer, (gguauuucgguaCc)2 with consecutive uridine bulges (underlined) on each strand has been determined in two crystal forms, spermine bound (Sp-form) and spermine free (Sp-free). The...
Sekharudu, C., Ramakrishnan, B., Huang, B., Jiang, R. T., Dupureur, C. M., Tsai, M. D., ...
The enzyme phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 ester bond of membrane phospholipids. The highly conserved Tyr residues 52 and 73 in the enzyme form hydrogen bonds to the...
Sekharudu, C. Y., Sundaralingam, M.
In the crystal structure of troponin C, the holo C-domain is bound in a head-to-tail fashion to the A-helix of the apo N-domain of a symmetry-related molecule. Using this interaction, we have...
Structure of Paramecium tetraurelia calmodulin at 1.8 A resolution.
Rao, S. T., Wu, S., Satyshur, K. A., Ling, K. Y., Kung, C., Sundaralingam, M.
The crystal structure of calmodulin (CaM; M(r) 16,700, 148 residues) from the ciliated protozoan Paramecium tetraurelia (PCaM) has been determined and refined using 1.8 A resolution area detector...
Kumar, A., Sekharudu, C., Ramakrishnan, B., Dupureur, C. M., Zhu, H., Tsai, M. D., ...
To probe the role of the Asp-99 ... His-48 pair in phospholipase A2 (PLA2) catalysis, the X-ray structure and kinetic characterization of the mutant Asp-99-->Asn-99 (D99N) of bovine pancreatic PLA2...