Suzaku Detection of Super-hard X-ray Emission from the Classical Nova V2491 Cygni (2009)
Takei, D., Tsujimoto, M., Kitamoto, S., Drake, J. J., Takahashi, H., ...
We report the detection of super-hard (>10 keV) X-ray emission extending up to 70 keV from the classical nova V2491 Cygni using the Suzaku observatory. We conducted two ~20 ks target-of-opportunity...
Swift X-ray and UV monitoring of the Classical Nova V458 Vul (Nova Vul 2007) (2009)
Drake, J. J., Beardmore, A. P., Boyd, D., Bode, M. F., Brady, S., ...
We describe the highly variable X-ray and UV emission of V458 Vul (Nova Vul 2007), observed by Swift between 1 and 422 days after outburst. Initially bright only in the UV, V458 Vul became a variable...
Detection of a Rare Supersoft Outburst Event during a Suzaku Observation of 1E0102.2-7219 (2007)
Takei, D., Tsujimoto, M., Kitamoto, S., Morii, M., Ebisawa, K., Maeda, Y., ...
We report the detection of a transient X-ray source toward the Small Magellanic Cloud (SMC) using the X-ray Imaging Spectrometer (XIS) onboard the Suzaku telescope. The source was detected at the...
An X-ray Imaging Study of the Stellar Population in RCW49 (2007)
Tsujimoto, M., Feigelson, E. D., Townsley, L. K., Broos, P. S., Getman, K. V., Wang, J., ...
We present the results of a high-resolution X-ray imaging study of the stellar population in the Galactic massive star-forming region RCW49 and its central OB association Westerlund 2. We obtained a...
Nomura, H., Aikawa, Y., Tsujimoto, M., Nakagawa, Y., Millar, T. J.
Detailed models for the density and temperature profiles of gas and dust in protoplanetary disks are constructed by taking into account X-ray and ultraviolet (UV) irradiation from a central T Tauri...
Pressure-induced intermetallic valence transition in BiNiO3 (2007)
Azuma, M, Carlsson, S, Rodgers, J, Tucker, MG, Tsujimoto, M, Ishiwata, S, ...
Hard X-rays from Ultra-Compact HII Regions in W49A (2006)
Tsujimoto, M., Hosokawa, T., Feigelson, E. D., Getman, K. V., Broos, P. S.
We report the Chandra detection of hard X-ray emission from the Welch ring in W49A, an organized structure of ultra-compact (UC) HII regions containing a dozen nascent early-type stars. Two UC HII...
Suzaku Spectroscopy Study of Hard X-Ray Emission in the Arches Cluster (2006)
Tsujimoto, M., Hyodo, Y., Koyama, K.
We present the results of a Suzaku study of the Arches cluster. A high S/N spectrum in the 3-12 keV band was obtained with the XIS. We found that the spectrum consists of a thermal plasma, a hard...
Ebisawa, K., Tsujimoto, M., Paizis, A., Hamaguchi, K., Bamba, A., Cutri, R., ...
Using the Chandra Advanced CCD Imaging Spectrometer Imaging array (ACIS-I), we have carried out a deep hard X-ray observation of the Galactic plane region at (l,b) ~ (28.5, 0.0), where no discrete...
X-ray and Near-infrared Studies of a Star-forming Cloud; L1448 (2005)
Tsujimoto, M., Kobayashi, N., Tsuboi, Y.
We present the results of X-ray and near-infrared (NIR) observations of L1448, a star-forming region in the Perseus cloud complex using the Chandra X-ray Observatory and the 4 m telescope at the Kitt...
Chandra Orion Ultradeep Project : Observations and source lists (2005)
Getman, K. V., Flaccomio, E., Broos, P. S., Grosso, N., Tsujimoto, M., Townsley, L., ...
Iron Fluorescent Line Emission from Young Stellar Objects in the Orion Nebula (2004)
Tsujimoto, M., Feigelson, E. D., Grosso, N., Micela, G., Tsuboi, Y., Favata, F., ...
We present the result of a systematic search for the iron Kalpha fluorescent line at 6.4 keV among 1616 X-ray sources detected by ultra-deep Chandra observations of the Orion Nebula Cluster and the...
Favata, F., Micela, G., Silva, B., Sciortino, S., Tsujimoto, M.
We report the results of a search for 6.4 keV Fe fluorescent emission in Young Stellar Objects (YSOs) with measured accretion luminosities in the rho Oph cloud, using all existing chandra and...
Chandra Orion Ultradeep Project: Observations and Source Lists (2004)
Getman, K. V., Flaccomio, E., Broos, P. S., Grosso, N., Tsujimoto, M., Townsley, L., ...
We present a description of the data reduction methods and the derived catalog of more than 1600 X-ray point sources from the exceptionally deep January 2003 Chandra X-ray Observatory observation of...
A Chandra Deep X-ray Exposure on the Galactic Plane and Near Infrared Identification (2004)
Ebisawa, K., Paizis, A., Couvoisier, T. J. -L., Dubath, P., Tsujimoto, M., Hamaguchi, K., ...
Using the Chandra ACIS-I instruments, we have carried out a deep X-ray observation on the Galactic plane region at (l,b) ~ (28.5, 0.0), where no discrete X-ray sources have been known previously. We...
Tsujimoto, M., Koyama, K., Kobayashi, N., Saito, M., Tsuboi, Y., Chandler, C. J.
Using the Very Large Array (VLA) in the A-configuration, we have obtained a high-resolution 3.6 cm map of a hard X-ray source detected by the Chandra X-ray Observatory in a protostellar clump in...
Imanishi, K., Nakajima, H., Tsujimoto, M., Koyama, K., Tsuboi, Y.
We report on the results of a systematic study of X-ray flares from low-mass young stellar objects, using Chandra observations of the main region of the Rho Oph. From 195 X-ray sources, including...
Tsujimoto, M., Koyama, K., Kobayashi, N., Goto, M., Tsuboi, Y., Tokunaga, A. T.
We conducted deep NIR imaging observations of the Orion molecular cloud 2 and 3 using QUIRC on the 88-inch telescope of the University of Hawaii. Our purposes are 1) to generate a comprehensive NIR...
Tsujimoto, M., Koyama, K., Tsuboi, Y., Chartas, G., Goto, M., Kobayashi, N., ...
We obtained near infrared (NIR) imaging with the Subaru Telescope of the class 0 protostar candidates in the Orion Molecular Cloud-3, two of which were discovered to have X-ray emission by the...
Tsujimoto, M., Koyama, K., Tsuboi, Y., Goto, M., Kobayashi, N.
We report X-ray results of the Chandra observation of Orion Molecular Cloud 2 and 3. A deep exposure of \sim 100 ksec detects \sim 400 X-ray sources in the field of view of the ACIS array, providing...
Transcriptional regulation of human placental leucine aminopeptidase/oxytocinase gene (2001)
Ito, T., Nomura, S., Okada, M., Katsumata, Y., Iwase, A., Kikkawa, F., ...
Human placental leucine aminopeptidase (P-LAP) plays a major role in the clearance of oxytocin, which is a key hormone in regulating labour pain. To explore the transcriptional regulation of P-LAP...
Murakami, H., Koyama, K., Tsujimoto, M., Maeda, Y., Sakano, M.
We present an ASCA discovery of diffuse hard X-ray emission from the Sgr C complex with its peak in the vicinity of the molecular cloud core. The X-ray spectrum is characterized by a strong 6.4-keV...
ASCA Observations of the Sgr B2 Cloud: An X-Ray Reflection Nebula (1999)
Murakami, H., Koyama, K., Sakano, M., Tsujimoto, M., Maeda, Y.
We present the ASCA results of imaging spectroscopy of the giant molecular cloud Sgr B2. The X-ray spectrum is found to be very peculiar; it exhibits a strong emission line at 6.4 keV, a low energy...
Sugimoto, Y, Yatsunami, K, Tsujimoto, M, Khorana, H G, Ichikawa, A
cDNA clones encoding a glutamic acid-rich protein were isolated from a bovine retina cDNA expression library. The cDNA sequence contained an open reading frame of 1770 base pairs encoding a protein...
Immunobiological activities of synthetic lipid A analogs with low endotoxicity.
Kotani, S, Takada, H, Takahashi, I, Ogawa, T, Tsujimoto, M, Shimauchi, H, ...
Synthetic lipid A analogs, beta(1-6)glucosamine disaccharide 1,4'-bisphosphates, which possesses four tetradecanoyl groups at the 2- and 2'-amino, and 3- and 3'-hydroxyl groups (LA-17-PP), and each...
Takahashi, I, Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Shiba, T, ...
Several synthetic acylated glucosamine monophosphates, with structures corresponding to the nonreducing or reducing moiety of the lipid A of the Escherichia coli or Salmonella minnesota type, and a...
Tsujimoto, M, Kotani, S, Kinoshita, F, Kanoh, S, Shiba, T, Kusumoto, S
Thirteen 6-O-acyl-N-acetylmuramyl-L-alanyl-D-isoglutamines (6-O-acyl-MDPs), including four inactive D-isoasparagine and L-isoglutamine analogs, were tested for their pyrogenicity and...
Tsujimoto, M, Kotani, S, Shiba, T, Kusumoto, S
6-O-(2-Tetradecylhexadecanoyl)-N-acetylmuramyl-L-alanyl-D-isoglutamine (B3O-MDP) and 6-O-(3-hydroxy-2-docosylhexacosanoyl)-MDP (BH48-MDP) were examined for immunopotentiating activity in stimulating...
Kotani, S, Takada, H, Takahashi, I, Tsujimoto, M, Ogawa, T, Ikeda, T, ...
A synthetic lipid A (Salmonella type, compound 516), beta (1-6)-linked D-glucosamine disaccharide 1,4'-bisphosphate, with three acyloxyacyl groups and one hydroxyacyl group, i.e.,...
Takada, H, Kotani, S, Tsujimoto, M, Ogawa, T, Takahashi, I, Harada, K, ...
Synthetic lipid A analogs (compounds 404 through 406) were examined for their immunopharmacological activities. These compounds had two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Takahashi, I, Ikeda, T, ...
A synthetic compound (506), beta (1-6) D-glucosamine disaccharide 1,4'-bisphosphate, which is acylated at 2'-amino and 3'-hydroxyl groups with (R)-3-dodecanoyloxytetradecanoyl and...
Emori, K, Nagao, S, Shigematsu, N, Kotani, S, Tsujimoto, M, Shiba, T, ...
Muramyl dipeptide, which does not induce epithelioid granuloma when injected alone dissolved in phosphate-buffered saline, could induce extensive granulomas in guinea pigs when chemically conjugated...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Harada, K, Mori, Y, ...
Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Mori, Y, Sakuta, M, ...
Thirteen acylated and phosphorylated derivatives of beta-1,6-linked glucosamine disaccharide (lipid A analogs), which were synthesized after the structural model of Salmonella-type lipid A, and seven...
Production of human interferon-gamma in serum-free medium.
Tsujimoto, M, Tarutani, T, Ogawa, K, Akashi, K, Okubo, Y, Higashi, N
Interferon (IFN)-gamma was produced with a high yield in cultures of human peripheral mononuclear cells by combined stimulation with OK-432 and staphylococcal enterotoxin B. Human mononuclear cells...
Expression in Escherichia coli of chemically synthesized gene for the human immune interferon.
Tanaka, S, Oshima, T, Ohsuye, K, Ono, T, Mizono, A, Ueno, A, ...
A 454 base pair fragment of double stranded DNA consisting of a gene for a human immune interferon (hIFN-gamma), initiation and termination signals plus appropriate restriction endonuclease sites,...
Liberation of serotonin from rabbit blood platelets by bacterial cell walls and related compounds.
Harada, K, Kotani, S, Takada, H, Tsujimoto, M, Hirachi, Y, Kusumoto, S, ...
A study was made on the activity of various bacterial cell walls and peptidoglycans to liberate serotonin from rabbit blood platelets. All of the test cell walls or peptidoglycans prepared from 27...
Ogawa, T, Kotani, S, Tsujimoto, M, Kusumoto, S, Shiba, T, Kawata, S, ...
Cell walls isolated from four bacterial species (Streptococcus pyogenes, Lactobacillus plantarum, Streptomyces gardneri, and Nocardia corynebacteriodes), which exhibited the adjuvant effect of...
Chemical and biological properties of a peptidoglycan isolated from Treponema pallidum kazan.
Umemoto, T, Ota, T, Sagawa, H, Kato, K, Takada, H, Tsujimoto, M, ...
A peptidoglycan layer of Treponema pallidum kazan was isolated by solubilization of whole cells with 1% warm sodium dodecyl sulfate and subsequent digestion of an insoluble residue with proteases....
Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.
Tsujimoto, M, Yip, Y K, Vilcek, J
Highly purified, Escherichia coli-derived recombinant human tumor necrosis factor (TNF) was labeled with 125I and employed to determine receptor binding, internalization, and intracellular...
Macrophage activation by bacterial cell walls and related synthetic compounds.
Takada, H, Tsujimoto, M, Kato, K, Kotani, S, Kusumoto, S, Inage, M, ...
Activation of peritoneal macrophages from guinea pigs by various bacterial cell walls, M-1 endo-N-acetylmuramidase enzymatically digested bacterial cell walls and synthetic muramyl dipeptides was...
Kohno, M, Nishizawa, N, Tsujimoto, M, Nomoto, H
Tumour necrosis factor (TNF) is a potent mitogen for some fibroblast cell lines. Here we have examined the TNF-mediated changes in protein phosphorylation in Swiss 3T3 and human FS-4 fibroblasts, and...
Immunological activities of Capnocytophaga cellular components.
Murayama, Y, Muranishi, K, Okada, H, Kato, K, Kotani, S, Takada, H, ...
Whole cells of a clinical isolate (strain S-3) of the genus Capnocytophaga were divided into cell envelope (CE) and cytoplasm (CP) fractions by mechanical disintegration followed by differential...
Sugimoto, Y, Yatsunami, K, Tsujimoto, M, Khorana, H G, Ichikawa, A
cDNA clones encoding a glutamic acid-rich protein were isolated from a bovine retina cDNA expression library. The cDNA sequence contained an open reading frame of 1770 base pairs encoding a protein...
Immunobiological activities of synthetic lipid A analogs with low endotoxicity.
Kotani, S, Takada, H, Takahashi, I, Ogawa, T, Tsujimoto, M, Shimauchi, H, ...
Synthetic lipid A analogs, beta(1-6)glucosamine disaccharide 1,4'-bisphosphates, which possesses four tetradecanoyl groups at the 2- and 2'-amino, and 3- and 3'-hydroxyl groups (LA-17-PP), and each...
Takahashi, I, Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Shiba, T, ...
Several synthetic acylated glucosamine monophosphates, with structures corresponding to the nonreducing or reducing moiety of the lipid A of the Escherichia coli or Salmonella minnesota type, and a...
Tsujimoto, M, Kotani, S, Kinoshita, F, Kanoh, S, Shiba, T, Kusumoto, S
Thirteen 6-O-acyl-N-acetylmuramyl-L-alanyl-D-isoglutamines (6-O-acyl-MDPs), including four inactive D-isoasparagine and L-isoglutamine analogs, were tested for their pyrogenicity and...
Tsujimoto, M, Kotani, S, Shiba, T, Kusumoto, S
6-O-(2-Tetradecylhexadecanoyl)-N-acetylmuramyl-L-alanyl-D-isoglutamine (B3O-MDP) and 6-O-(3-hydroxy-2-docosylhexacosanoyl)-MDP (BH48-MDP) were examined for immunopotentiating activity in stimulating...
Kotani, S, Takada, H, Takahashi, I, Tsujimoto, M, Ogawa, T, Ikeda, T, ...
A synthetic lipid A (Salmonella type, compound 516), beta (1-6)-linked D-glucosamine disaccharide 1,4'-bisphosphate, with three acyloxyacyl groups and one hydroxyacyl group, i.e.,...
Takada, H, Kotani, S, Tsujimoto, M, Ogawa, T, Takahashi, I, Harada, K, ...
Synthetic lipid A analogs (compounds 404 through 406) were examined for their immunopharmacological activities. These compounds had two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Takahashi, I, Ikeda, T, ...
A synthetic compound (506), beta (1-6) D-glucosamine disaccharide 1,4'-bisphosphate, which is acylated at 2'-amino and 3'-hydroxyl groups with (R)-3-dodecanoyloxytetradecanoyl and...
Emori, K, Nagao, S, Shigematsu, N, Kotani, S, Tsujimoto, M, Shiba, T, ...
Muramyl dipeptide, which does not induce epithelioid granuloma when injected alone dissolved in phosphate-buffered saline, could induce extensive granulomas in guinea pigs when chemically conjugated...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Harada, K, Mori, Y, ...
Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Mori, Y, Sakuta, M, ...
Thirteen acylated and phosphorylated derivatives of beta-1,6-linked glucosamine disaccharide (lipid A analogs), which were synthesized after the structural model of Salmonella-type lipid A, and seven...
Production of human interferon-gamma in serum-free medium.
Tsujimoto, M, Tarutani, T, Ogawa, K, Akashi, K, Okubo, Y, Higashi, N
Interferon (IFN)-gamma was produced with a high yield in cultures of human peripheral mononuclear cells by combined stimulation with OK-432 and staphylococcal enterotoxin B. Human mononuclear cells...
Expression in Escherichia coli of chemically synthesized gene for the human immune interferon.
Tanaka, S, Oshima, T, Ohsuye, K, Ono, T, Mizono, A, Ueno, A, ...
A 454 base pair fragment of double stranded DNA consisting of a gene for a human immune interferon (hIFN-gamma), initiation and termination signals plus appropriate restriction endonuclease sites,...
Liberation of serotonin from rabbit blood platelets by bacterial cell walls and related compounds.
Harada, K, Kotani, S, Takada, H, Tsujimoto, M, Hirachi, Y, Kusumoto, S, ...
A study was made on the activity of various bacterial cell walls and peptidoglycans to liberate serotonin from rabbit blood platelets. All of the test cell walls or peptidoglycans prepared from 27...
Ogawa, T, Kotani, S, Tsujimoto, M, Kusumoto, S, Shiba, T, Kawata, S, ...
Cell walls isolated from four bacterial species (Streptococcus pyogenes, Lactobacillus plantarum, Streptomyces gardneri, and Nocardia corynebacteriodes), which exhibited the adjuvant effect of...
Chemical and biological properties of a peptidoglycan isolated from Treponema pallidum kazan.
Umemoto, T, Ota, T, Sagawa, H, Kato, K, Takada, H, Tsujimoto, M, ...
A peptidoglycan layer of Treponema pallidum kazan was isolated by solubilization of whole cells with 1% warm sodium dodecyl sulfate and subsequent digestion of an insoluble residue with proteases....
Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.
Tsujimoto, M, Yip, Y K, Vilcek, J
Highly purified, Escherichia coli-derived recombinant human tumor necrosis factor (TNF) was labeled with 125I and employed to determine receptor binding, internalization, and intracellular...
Macrophage activation by bacterial cell walls and related synthetic compounds.
Takada, H, Tsujimoto, M, Kato, K, Kotani, S, Kusumoto, S, Inage, M, ...
Activation of peritoneal macrophages from guinea pigs by various bacterial cell walls, M-1 endo-N-acetylmuramidase enzymatically digested bacterial cell walls and synthetic muramyl dipeptides was...
Immunological activities of Capnocytophaga cellular components.
Murayama, Y, Muranishi, K, Okada, H, Kato, K, Kotani, S, Takada, H, ...
Whole cells of a clinical isolate (strain S-3) of the genus Capnocytophaga were divided into cell envelope (CE) and cytoplasm (CP) fractions by mechanical disintegration followed by differential...
Kohno, M, Nishizawa, N, Tsujimoto, M, Nomoto, H
Tumour necrosis factor (TNF) is a potent mitogen for some fibroblast cell lines. Here we have examined the TNF-mediated changes in protein phosphorylation in Swiss 3T3 and human FS-4 fibroblasts, and...
Regulation by cytokines of eosinophilopoiesis and immunoglobulin E production in mice.
Takenaka, T, Kuribayashi, K, Nakamine, H, Tsujimoto, M, Fukuhara, Y, Maeda, J, ...
Certain clinical disorders are associated with eosinophilia and hyperimmunoglobulinaemia of the immunoglobulin (Ig) E class, but others give rise to eosinophilia without hyperimmunoglobulinaemia. To...
Shichikawa, K., Inoue, K., Hirota, S., Maeda, A., Ota, H., Kimura, M., ...
OBJECTIVE—To evaluate secular trends in the incidence and prevalence of rheumatoid arthritis (RA) in Japan. METHODS—The incidence and prevalence of RA were determined in a longitudinal...
Tatsumura, T., Koyama, S., Tsujimoto, M., Kitagawa, M., Kagamimori, S.
Nebulisation chemotherapy, a chemotherapeutic method for the treatment of lung cancer that involves the administration of anticancer agents through the inhalation of nebulised aerosols, has been...
Tatsumura, T., Tsujimoto, M., Koyama, S., Furuno, T., Komori, Y., Sato, H., ...
4, 6-0-Benzylidene-D-glucopyranose (BG), a derivative of benzaldehyde (BA), whose anti-tumour action has often been reported, showed responses in 10 out of 24 patients (41.7%). These patients...
Expression of p21 (WAF1/CIP1) protein in clinical thyroid tissues.
Ito, Y., Kobayashi, T., Takeda, T., Komoike, Y., Wakasugi, E., Tamaki, Y., ...
p21 (WAF1/CIP1) protein expression in various thyroid tissues, including thyroid carcinoma, was studied by means of immunohistochemistry using anti-p21 monoclonal antibody. Normal follicles and...
Ito, Y, Matsuura, N, Sakon, M, Takeda, T, Umeshita, K, Nagano, H, ...
In this study, we investigated the proliferating cell index by the percentage of Ki-67 expressing cells (Ki-67 LI) and the apoptotic index (AI) by the number of morphologically apoptotic cells per...
The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma
Ito, Y, Monden, M, Takeda, T, Eguchi, H, Umeshita, K, Nagano, H, ...
The status of Fas and Fas ligand (Fas L) expression was investigated in this study for 103 hepatocellular carcinomas (HCC). We studied the expression of the following three factors, Fas and Fas L...
Munakata*, S, Enomoto, T, Tsujimoto, M, Otsuki, Y, Miwa, H, Kanno, H, ...
SummaryExpression of apoptosis-related proteins, bcl-2, Bax, Fas and Fas ligand (L), in ovarian epithelial neoplasms together with its clinical relevance was examined by immunohistochemistry. They...
Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma
Ito, Y, Takeda, T, Sakon, M, Tsujimoto, M, Higashiyama, S, Noda, K, ...
In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the...