Schaefer, M. K, Horre, K, Depboylu, C, ...
Regulated intramembrane proteolysis by gamma-secretase cleaves proteins in their transmembrane domain and is involved in important signaling pathways. At least four different gamma-secretase...
Singular minimization problems (2007)
This paper is concerned with the existence of ground state solutions of degenerate elliptic equations on R
Macrocyclic statine-based inhibitors of BACE-1 (2007)
Barazza, A., Gotz, M., Cadamuro, S. A., Goettig, P., Willem, M., Steuber, H., ...
Guo, C., Willem, M., Werner, A., Raivich, G., Emerson, M., Neyses, L., ...
Both the dystrophin–glycoprotein complex and 7ß1 integrin have critical roles in the maintenance of muscle integrity via the provision of mechanical links between muscle fibres and the basement...
On multiple solutions of the exterior neumann problem involving critical sobolev exponent (2005)
In this paper we consider the exterior Neumann problem involving a critical Sobolev exponent. We establish the existence of two solutions having a prescribed limit at infinity.
Willem, M., Dewachter, I., Smyth, N., Dooren, T., Borghgraef, P., Haass, C., ...
The generation of amyloid peptides (Aß) from the amyloid precursor protein (APP) is initiated by ß-secretase (BACE), whereas subsequent {gamma}-secretase cleavage mediated by presenilin-1, produces...
Nawrotzki,R., Willem,M., Miosge,N., Brinkmeier,H., Mayer,U.
Force transmission at the myotendinous junction requires a strong link between the muscle cytoskeleton and the extracellular matrix. At the adult junction, two splice variants of the laminin-binding...
Fluhrer,R., Multhaup,G., Schlicksupp,A., Okochi,M., Takeda,M., Lammich,S., ...
The beta-amyloid precursor protein (betaAPP) is proteolytically processed by two secretase activities to produce the pathogenic amyloid beta-peptide (Abeta). N-terminal cleavage is mediated by...
Nawrotzki, R., Willem, M., Miosge, N., Brinkmeier, H., Mayer, U.
Force transmission at the myotendinous junction requires a strong link between the muscle cytoskeleton and the extracellular matrix. At the adult junction, two splice variants of the laminin-binding...
Fluhrer, R., Multhaup, G., Schlicksupp, A., Okochi, M., Takeda, M., Lammich, S., ...
The beta-amyloid precursor protein (betaAPP) is proteolytically processed by two secretase activities to produce the pathogenic amyloid beta-peptide (Abeta). N-terminal cleavage is mediated by...
Remarks on a Sobolev-Hardy inequality (2002)
Secchi, S., Smets, D., Willem, M.
We compute the optimal constant for a generalized Hardy-Sobolev inequality, and using the product of two symmetrizations we present an elementary proof of the symmetries of some optimal functions....
Least energy solutions of a critical Neumann problem with a weight (2002)
We investigate the effect of the coefficient of the critical nonlinearity for the Neumann problem on the existence of least energy solutions. As a by-product we establish a Sobolev inequality with...
A critical function of the pial basement membrane in cortical histogenesis (2002)
Halfter,W., Dong,S. C., Yip,Y. P., Willem,M., Mayer,U.
Mice with a targeted deletion of the nidogen-binding site of laminin gamma1 were used to study the function of the pial basement membrane in cortical histogenesis. The pial basement membrane in the...
Willem, M., Miosge, N., Halfter, W., Smyth, N., Jannetti, I., Burghart, E., ...
Basement membrane assembly is of crucial importance in the development and function of tissues and during embryogenesis. Nidogen 1 was thought to be central in the assembly processes, connecting the...
Willem,M., Miosge,N., Halfter,W., Smyth,N., Jannetti,I., Burghart,E., ...
Basement membrane assembly is of crucial importance in the development and function of tissues and during embryogenesis. Nidogen 1 was thought to be central in the assembly processes, connecting the...
Willem, M., Miosge, N., Halfter, W., Smyth, N., Jannetti, I., Burghart, E., ...
Basement membrane assembly is of crucial importance in the development and function of tissues and during embryogenesis. Nidogen 1 was thought to be central in the assembly processes, connecting the...
A critical function of the pial basement membrane in cortical histogenesis (2002)
Halfter, W., Dong, S. C., Yip, Y. P., Willem, M., Mayer, U.
Mice with a targeted deletion of the nidogen-binding site of laminin gamma1 were used to study the function of the pial basement membrane in cortical histogenesis. The pial basement membrane in the...
Least energy solutions of a critical Neumann problem with a weight (2002)
We investigate the effect of the coefficient of the critical nonlinearity for the Neumann problem on the existence of least energy solutions. As a by-product we establish a Sobolev inequality with...
Least energy solutions of a critical Neumann problem with a weight (2002)
We investigate the effect of the coefficient of the critical nonlinearity for the Neumann problem on the existence of least energy solutions. As a by-product we establish a Sobolev inequality with...
Solution structure of the main a-amylase inhibitor from amaranth seeds. (2001)
Martins, José, ENASSAR, M, WILLEM, M, WIERUSZESKI, J, LIPPENS, G, WODAK, S
Multiple Critical Points of Invariant Functionals and Applications. (1998)
This paper deals with some multiplicity results of periodic orbits of Hamiltonian systems and for solution of a non-linear Dirichlet problem. These results follow from an abstract theorem of...
Density, spectral theory and homoclinics for singular sturm-liouville systems (1994)
We consider the singular system -(P(t)u')' + Q(t)u = lambda R(t)u. We give boundary conditions corresponding to the weak formulation, density results and conditions under which the set of...
Dejaegere, T., Serneels, L., Schäfer, M. K., Van Biervliet, J., Horré, K., Depboylu, C., ...
Regulated intramembrane proteolysis by γ-secretase cleaves proteins in their transmembrane domain and is involved in important signaling pathways. At least four different γ-secretase complexes have...