Lewis, J.L., Chinswangwatanakul, W., Zheng, B., Marley, S.B., Nguyen, D.X., Cross, N.C., ...
This study investigated the influence of expression of proteins of the INK4 family, particularly p16, on the growth and self-renewal kinetics of hematopoietic cells. First, retrovirus-mediated gene...
Gordon, M Y, Powles, R L, Douglas, I D
An in vivo culture system, the agar diffusion chamber technique, has been used to measure the population of colony-forming precursor cells in the bone marrow of patients receiving immunotherapy...
Gordon, M Y, Marley, S B, Lewis, J L, Davidson, R J, Nguyen, D X, Grand, F H, ...
The biological target for interferon (IFN)-alpha in chronic myeloid leukemia (CML) is unknown, but one possibility is that amplification of granulocyte-macrophage colony-forming cells (CFU-GM) is...
Gordon, M Y, Powles, R L, Douglas, I D
An in vivo culture system, the agar diffusion chamber technique, has been used to measure the population of colony-forming precursor cells in the bone marrow of patients receiving immunotherapy...
Gordon, M Y, Marley, S B, Lewis, J L, Davidson, R J, Nguyen, D X, Grand, F H, ...
The biological target for interferon (IFN)-alpha in chronic myeloid leukemia (CML) is unknown, but one possibility is that amplification of granulocyte-macrophage colony-forming cells (CFU-GM) is...
The use of a T lymphocyte colony assay to measure mononuclear phagocyte function.
Gordon, M Y, King, J A, Gordon-Smith, E C
The control of colony formation of normal PHA-stimulated lymphocytes has been investigated using a liquid-on-agar culture system (Lowenberg & De Zeeuw, 1979). Optimal colony formation requires the...
Gordon, M Y, King, J A, Gordon-Smith, E C
The effect of levamisole on T lymphocyte colony-forming cells (TL-CFC) is determined by the numbers or function of plastic-adherent mononuclear cells in the culture. Using levamisole in cultures of...
Effects of levamisole on T lymphocyte colony formation by cells from bone marrow aspirates.
Levamisole has been added to cultures of bone marrow and peripheral blood mononuclear cells stimulated by phytohaemagglutinin (PHA). T lymphocytes colony-forming cells (TL-CFC) in the peripheral...
Hows, J. M., Mehta, A., Ward, L., Woods, K., Perez, R., Gordon, M. Y., ...
A prospective randomised study was carried out to compare the effect of mesna (2-mercaptoethane sulphonate sodium) with that of forced diuresis in preventing cyclophosphamide induced haemorrhagic...
Quantitation of Haemopoietic Cells from Normal and Leukaemic RFM Mice Using an In Vivo Colony Assay
The conventional diffusion chamber (CDC) as described by Benestad (1970) had been modified to assay the colony forming capacity of RFM bone marrow and spleen cells in agar diffusion chambers (ADCs)....
McElwain, T. J., Hedley, D. W., Burton, G., Clink, H. M., Gordon, M. Y., Jarman, M., ...
In a Phase I study, melphalan 140 mg/m2 was administered to 8 patients with disseminated malignant melanoma. Marrow was removed from the patients immediately before melphalan administration and...
Gordon, M. Y., Blackett, N. M.
The growth of mouse bone marrow colonies in agar diffusion chambers (ADCs) was evaluated using host mice injected with saline or with cyclophosphamide (CY) before chamber insertion. The mice...
Studies on the humoral regulation of granulopoiesis in leukaemic RFM mice.
Intraperitoneal diffusion chambers have been used to investigate changes in humoral factors during the development of myeloid leukaemia in mice. Normal mouse bone marrow cells form colonies of...
A colony-forming assay for human tumour xenografts using agar in diffusion chambers.
Smith, I. E., Courtenay, V. D., Gordon, M. Y.
A technique for growing colonies from single-cell suspensions of human tumour xenografts using agar in diffusion chambers is described. Modified Millipore diffusion chambers containing tumour cells...