Scientific Commons: M. Zweckstetter

The voltage-dependent anion channel (VDAC), also known as mitochondrial porin, is the most abundant protein in the mitochondrial outer membrane (MOM). VDAC is the channel known to guide the metabolic...

Structure of the human voltage-dependent anion channel (2008)

Bayrhuber, M., Meins, T., Habeck, M., Becker, S., Giller, K., Villinger, S., ...

The C2A-C2B linker defines the high affinity Ca2+ binding mode of rabphilin-3A (2007)

Montaville, P., Schlicker, C., Leonov, A., Zweckstetter, M., Sheldrick, G. M., Becker, S.

Fast high-resolution protein structure determination by using unassigned NMR data (2007)

Korukottu, J., Bayrhuber, M., Montaville, P., Jung, Y. S., Vijayan, V., Becker, S., ...

Structural and microtubule binding properties of tau mutants of frontotemporal dementias (2007)

Fischer, D., Mukrasch, M., Von Bergen, M., Klos-Witkowska, A., Biernat, J., Griesinger, C., ...

Amino acid bulkiness defines the local conformations and dynamics of natively unfolded alpha-synuclein and tau (2007)

Cho, M. K., Kim, H. Y., Bernado, P., Fernandez, C. O., Blackledge, M., Zweckstetter, M.

The "jaws" of the tau-microtubule interaction (2007)

Mukrasch, M., Von Bergen, M., Biernat, J., Fischer, D., Griesinger, C., Mandelkow, E., ...

Highly populated turn conformations in natively unfolded Tau protein identified from residual dipolar couplings and molecular simulation (2007)

Mukrasch, M., Markwick, P., Biernat, J., Von Bergen, M., Bernado, P., Griesinger, C., ...

Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation (2007)

Bertoncini, C. W., Rasia, R. M., Lamberto, G. R., Binolfi, A., Zweckstetter, M., Griesinger, C., ...

Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein (2007)

Kim, H. Y., Heise, H., Fernandez, C. O., Baldus, M., Zweckstetter, M.

The "jaws" of the tau-microtubule interaction (2007)

Mukrasch, M. D., Von Bergen, M., Biernat, J., Fischer, D., Griesinger, C., Mandelkow, E., ...

Tau is the major microtubule-associated protein in neuronal axons. It aggregates into "neurofibrillary tangles" during the course of Alzheimer disease. Binding to microtubules and microtubule...

Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation (2007)

Mukrasch, M. D., Markwick, P., Biernat, J., Von Bergen, M., Bernado, P., Griesinger, C., ...

Tau, a natively unstructured protein that regulates the organization of neuronal microtubules, is also found in high concentrations in neurofibrillary tangles of Alzheimer's disease and other...

Structural and microtubule binding properties of tau mutants of frontotemporal dementias (2007)

Fischer, D., Mukrasch, M. D., Von Bergen, M., Klos-Witkowska, A., Biernat, J., Griesinger, C., ...

Several mutations in the gene encoding the microtubule-associated protein tau are responsible for the formation of neurofibrillary inclusions in frontotemporal dementia with Parkinsonism linked to...

Interaction of alpha-synuclein with divalent metal ions reveals key differences: A link between structure, binding specificity and fibrillation enhancement (2006)

Binolfi, A., Rasia, R. M., Bertoncini, C. W., Ceolin, M., Zweckstetter, M., Griesinger, C., ...

NMR in the SPINE structural proteomics project (2006)

Ab, E., Atkinson, A., Banci, L., Bertini, I., Ciofi-baffoni, S., Brunner, K., ...

Prion protein helix1 promotes aggregation but is not converted into beta-sheet (2006)

Watzlawik, J., Skora, L., Frense, D., Griesinger, C., Zweckstetter, M., Schulz-Schaeffer, W., ...

NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA (2006)

Iwahara, J., Zweckstetter, M., Clore, G. M.

Charge-induced molecular alignment of intrinsically disordered proteins (2006)

Skora, L., Cho, M. K., Kim, H. Y., Becker, S., Fernandez, C. O., Blackledge, M., ...

H-1, N-15, and C-13 resonance assignment of the C2A domain of rabphilin3A (2006)

Montaville, P., Kim, H. Y., Vijayan, V., Becker, S., Zweckstetter, M.

Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment (2006)

Jauch, R., Cho, M. K., Netter, C., Jaeckle, H., Zweckstetter, M., Wahl, M. C.

Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment (2006)

Jauch, R., Cho, M. K., Jaekel, S., Netter, C., Schreiter, K., Aicher, B., ...

Production of recombinat Conkunitzin-S1 in Escherichia coli. (2006)

Bayrhuber, M., Graf, R., Ferber, M., Zweckstetter, M., Imperial, J., Garrett, J. E., ...

Prediction of charge-induced molecular alignment: Residual dipolar couplings at pH 3 and alignment in surfactant liquid crystalline phases. (2006)

Zweckstetter, M.

NMR in the SPINE Structural Proteomics project (2006)

AB, E., Atkinson, A.R., Banci, L., Bertini, I., Ciofi-Baffoni, S., Brunner, K., ...

NMR in the SPINE Structural Proteomics project (2006)

Ab, E., Atkinson, A., Banci, L., Bertini, I., Ciofi-Baffoni, S., Brunner, Konrad, ...

This paper describes the developments, role and contributions of the NMR spectroscopy groups in the Structural Proteomics In Europe (SPINE) consortium. Focusing on the development of high-throughput...

Release of long-range tertiary interactions potentiates aggregation of natively unstructured α-synuclein (2005)

Bertoncini, C. W., Jung, Y. S., Fernandez, C. O., Hoyer, W., Griesinger, C., Jovin, T. M., ...

In idiopathic Parkinson’s disease, intracytoplasmic neuronal inclusions (Lewy bodies) containing aggregates of the protein α-synuclein (αS) are deposited in the pigmented nuclei of the brainstem....

Structural characterization of copper(II) binding to α-Synuclein: Insights into the bioinorganic chemistry of Parkinson's disease (2005)

Rasia, R. M., Bertoncini, C. W., Marsh, D., Hoyer, W., Cherny, D. I., Zweckstetter, M., ...

The aggregation of α -synuclein (AS) is characteristic of Parkinson’s disease and other neurodegenerative synucleinopathies. We demonstrate here that Cu(II) ions are effective in accelerating AS...

Familial mutants of α-synuclein with increased neurotoxicity have a destabilized conformation (2005)

Bertoncini, C. W., Fernandez, C. O., Griesinger, C., Jovin, T. M., Zweckstetter, M.

A30P and A53T mutations of the presynaptic protein α-synuclein are associated with familial forms of Parkinson’s disease. NMR spectroscopy demonstrates that Parkinsonism-linked mutations greatly...

Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family - Structural and functional characterization (2005)

Bayrhuber, M., Vijayan, V., Ferber, M., Graf, R., Korukottu, J., Imperial, J., ...

Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings (2005)

Bernado, P., Bertoncini, C. W., Griesinger, C., Zweckstetter, M., Blackledge, M.

3D structure, ligand binding, autoinhibition, aggregation, and cellular distribution of wild-type, mutant, and labeled alpha-synuclein (2005)

Bertoncini, C. W., Cherny, D. I., Fernandez, C. O., Garfinkel, E., Griesinger, C., Hoyer, W., ...

Sites of tau important for aggregation populate beta-structure and bind to microtubules and polyanions (2005)

Mukrasch, M., Biernat, J., Von Bergen, M., Griesinger, C., Mandelkow, E., Zweckstetter, M.

Letter to the editor: Backbone resonance assignment of the homodimeric, 35 kDa chaperone CesT from enteropathogenic Escherichia coli (2005)

Rumpel, S., Kim, H. Y., Vijayan, V., Becker, S., Zweckstetter, M.

Simultaneous measurement of protein one-bond residual dipolar couplings without increased resonance overlap (2005)

Vijayan, V., Zweckstetter, M.

Determination of the packing mode of the coiled-coil domain of cGMP-Dependent protein kinase I alpha in solution using charge-predicted dipolar couplings (2005)

Zweckstetter, M., Schnell, J. R., Chou, J. J.

The nature of the stimulus and of the fumarate binding site of the fumarate sensor DcuS of Escherichia coli (2005)

Kneuper, H., Janausch, I. G., Vijayan, V., Zweckstetter, M., Bock, V., Griesinger, C., ...

Rapid and accurate structure determination of coiled-coil domains using NMR dipolar couplings: Application to cGMP-dependent protein kinase I alpha (2005)

Schnell, J. R., Zhou, G. P., Zweckstetter, M., Rigby, A. C., Chou, J. J.

Rapid and accurate structure determination of coiled-coil domains using NMR dipolar couplings: Application to cGMP-dependent protein kinase I alpha (2005)

Schnell, J. R., Zhou, G. P., Zweckstetter, M., Rigby, A. C., Chou, J. J.

Determination of the packing mode of the coiled-coil domain of cGMP-dependent protein kinase I alpha in solution using charge-predicted dipolar couplings (2005)

Zweckstetter, M., Schnell, J. R., Chou, J. J.

Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family - Structural and functional characterization (2005)

Bayrhuber, M., Vijayan, V., Ferber, M., Graf, R., Korukottu, J., Imperial, J., ...

Sites of tau important for aggregation populate beta structure and bind to microtubules and polyanions. (2005)

Mukrasch, M. D., Biernat, J., Von Bergen, M., Griesinger, C., Mandelkow, E., Zweckstetter, M.

Defining long-range order and local disorder in native α-synuclein using residual dipolar couplings. (2005)

Bernado, P., Bertonconi, C. W., Griesinger, C., Zweckstetter, M., Blackledge, M.

3D structure, ligand binding, autoinhibition, aggregation, and cellular distribution of wild-type, mutant, and labeled alpha-synuclein. (2005)

Bertoncini, C. W., Cherny, D., Fernandez, C. O., Garfinkel, E., Griesinger, C., Hoyer, W., ...

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation (2004)

Fernandez, C.O., Hoyer, W., Zweckstetter, M., Jares-Erijman, E.A., Subramaniam, V., Griesinger, C., ...

NMR of α-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation (2004)

Fernandez, C. O., Hoyer, W., Zweckstetter, M., Jares-Erijman, E. A., Subramaniam, V., Griesinger, C., ...

The aggregation of alpha-synuclein is characteristic of Parkinson’s disease (PD) and other neurodegenerative synucleinopathies. The 140-aa protein is natively unstructured; thus, ligands binding to...

Simultaneous assignment and structure determination of protein backbones by using NMR dipolar couplings (2004)

Jung, Y. S., Sharma, M., Zweckstetter, M.

Mars - robust automatic backbone assignment of proteins (2004)

Jung, Y. S., Zweckstetter, M.

Backbone assignment of proteins with known structure using residual dipolar couplings (2004)

Jung, Y. S., Zweckstetter, M.

Expression, purification, crystallization and preliminary crystallographic studies of the Enterococcus faecalis cytolysin repressor CylR2 (2004)

Razeto, A., Giller, K., Haas, W., Gilmore, M. S., Zweckstetter, M., Becker, S.

Structure and DNA-binding properties of the cytolysin regulator CylR2 from Enterococcus faecalis (2004)

Rumpel, S., Razeto, A., Pillar, C. M., Vijayan, V., Taylor, A., Giller, K., ...

Prediction of charge-induced molecular alignment of biomolecules dissolved in dilute liquid-crystalline phases. (2004)

Zweckstetter, M., Hummer, G., Bax, A.

Determination of molecular alignment tensors without backbone resonance assignment: Aid to rapid analysis of protein-protein interactions (2003)

Zweckstetter, M.

Measurement of long range H,C couplings in natural products in orienting media: a tool for structure elucidation of natural products (2003)

Verdier, L., Sakhaii, P., Zweckstetter, M., Griesinger, C.

The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli (2003)

Pappalardo, L., Janausch, I. G., Vijayan, V., Zientz, E., Junker, J., Peti, W., ...

Evaluation of uncertainty in alignment tensors obtained from dipolar couplings (2002)

Zweckstetter, M., Bax, A.

Residual dipolar couplings and their corresponding alignment tensors are useful for structural analysis of macromolecules. The error in an alignment tensor, derived from residual dipolar couplings on...

Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.

Kalus, W, Zweckstetter, M, Renner, C, Sanchez, Y, Georgescu, J, Grol, M, ...

Binding proteins for insulin-like growth factors (IGFs) IGF-I and IGF-II, known as IGFBPs, control the distribution, function and activity of IGFs in various cell tissues and body fluids....

Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.

Kalus, W, Zweckstetter, M, Renner, C, Sanchez, Y, Georgescu, J, Grol, M, ...

Binding proteins for insulin-like growth factors (IGFs) IGF-I and IGF-II, known as IGFBPs, control the distribution, function and activity of IGFs in various cell tissues and body fluids....

M. Zweckstetter

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