McCormick, David L., Johnson, William D., Kozub, Nicole M., Rao, K.V.N., Lubet, Ronald A., Steele, Vernon E., ...
Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats. However, concerns related to the possible androgenicity of DHEA may preclude its use for chemoprevention of...
Steinetz, Bernard G., Gordon, Terry, Lasano, Salamia, Horton, Lori, Ng, Sheung Pui, Zelikoff, Judith T., ...
Early pregnancy is a powerful negative risk factor for breast cancer (BCa) in women. Pregnancy also protects rats against induction of BCa by carcinogens such as N-methyl-N-nitrosourea (MNU), making...
Steinetz, Bernard G., Gordon, Terry, Lasano, Salamia, Horton, Lori, Ng, Sheung Pui, Zelikoff, Judith T., ...
Early pregnancy is a powerful negative risk factor for breast cancer (BCa) in women. Pregnancy also protects rats against induction of BCa by carcinogens such as N-methyl-N-nitrosourea (MNU), making...
McCormick, David L., Johnson, William D., Kozub, Nicole M., Rao, K. V. N., Lubet, Ronald A., Steele, Vernon E., ...
Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats. However, concerns related to the possible androgenicity of DHEA may preclude its use for chemoprevention of...
Cavalieri, Ercole L., Devanesan, Prabu, Bosland, Maarten C., Badawi, Alaa F., Rogan, Eleanor G.
Prostate carcinomas arise in 100% of Noble rats treated with estradiol and testosterone. We hypothesize that estrogens initiate prostate cancer mainly by formation of 4-catechol estrogens (CE),...
Chapter 2: The Role of Steroid Hormones in Prostate Carcinogenesis (2000)
Carcinoma of the prostate is the most frequently diagnosed malignancy and the second leading cause of death as a result of cancer in men in the United States and in many other Western countries....
Dietary Fat, Calories, and Prostate Cancer Risk (1999)
Bosland, Maarten C., Oakley-Girvan, Ingrid, Whittemore, Alice S.
Bosland, Maarten C., Ford, Helen, Horton, Lori
This study determined the incidence of prostate adenocarcinoma following long-term treatment of NBL and Sprague-Dawley rats with estradiol-17β or diethylstilbestrol (DES) plus testosterone and it...
Han, Xueliang, Liehr, Joachim G., Bosland, Maarten C.
Treatment with estradiol-17β and testosterone induces epithelial dysplasia and, subsequently, adenocarcinoma in the dorsolateral prostate of NBL rats. The purpose of this study was to determine...
Bosland, Maarten C., Prinsen, Menk K., Rivenson, Abraham, Weisburger, John H.
The purpose of this study was to determine the carcinogenic effect in male rats of a single i.v. injection of N-methyl-N-nitrosourea (MNU) after sequential treatment with cyproterone acetate (for 21...
Arsenite cocarcinogenesis: an animal model derived from genetic toxicology studies.
Rossman, Toby G, Uddin, Ahmed N, Burns, Fredric J, Bosland, Maarten C
Although epidemiologic evidence shows an association between inorganic arsenic in drinking water and increased risk of skin, lung, and bladder cancers, no animal model for arsenic carcinogenesis has...
The Role of Estrogens in Prostate Carcinogenesis: A Rationale for Chemoprevention
Estrogens as hormonal therapy, particularly diethylstilbestrol, are effective against androgen-dependent prostate cancer, but paradoxically estrogens might also be involved in the causation of this...
Arsenite cocarcinogenesis: an animal model derived from genetic toxicology studies.
Rossman, Toby G, Uddin, Ahmed N, Burns, Fredric J, Bosland, Maarten C
Although epidemiologic evidence shows an association between inorganic arsenic in drinking water and increased risk of skin, lung, and bladder cancers, no animal model for arsenic carcinogenesis has...
The Role of Estrogens in Prostate Carcinogenesis: A Rationale for Chemoprevention
Estrogens as hormonal therapy, particularly diethylstilbestrol, are effective against androgen-dependent prostate cancer, but paradoxically estrogens might also be involved in the causation of this...
Liang, Feng-Xia, Bosland, Maarten C., Huang, Hongying, Romih, Rok, Baptiste, Solange, Deng, Fang-Ming, ...
Although the epithelial lining of much of the mammalian urinary tract is known simply as the urothelium, this epithelium can be divided into at least three lineages of renal pelvis/ureter,...
Disruption of Growth Hormone Signaling Retards Prostate Carcinogenesis in the Probasin/TAg Rat
Wang, Zhuohua, Luque, Raul M., Kineman, Rhonda D., Ray, Vera H., Christov, Konstantin T., Lantvit, Daniel D., ...
We asked whether down-regulation of GH signaling could block carcinogenesis in the Probasin/TAg rat, a model of aggressive prostate cancer. The Spontaneous Dwarf rat, which lacks GH due to a mutation...