Madeleine Durbeej

Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis (2006)

Anderson, Per, Durbeej, Madeleine, Van Rooijen, Nico, Ivars, Fredrik, ...

The endothelial cell monolayer of cerebral vessels and its basement membrane (BM) are ensheathed by the astrocyte endfeet, the leptomeningeal cells, and their associated parenchymal BM, all of which...

Laminin {alpha}1 chain improves laminin {alpha}2 chain deficient peripheral neuropathy (2006)

Gawlik, Kinga I., Li, Jia-Yi, Petersén, Åsa, Durbeej, Madeleine

Absence of laminin α2 chain leads to a severe form of congenital muscular dystrophy (MDC1A) associated with peripheral neuropathy. Hence, future therapies should be aimed at alleviating both muscle...

Laminin {alpha}1 chain improves laminin {alpha}2 chain deficient peripheral neuropathy (2006)

Gawlik, Kinga I., Li, Jia-Yi, Petersén, Åsa, Durbeej, Madeleine

Absence of laminin α2 chain leads to a severe form of congenital muscular dystrophy (MDC1A) associated with peripheral neuropathy. Hence, future therapies should be aimed at alleviating both muscle...

Laminin {alpha}1 chain reduces muscular dystrophy in laminin {alpha}2 chain deficient mice (2004)

Gawlik, Kinga, Miyagoe-Suzuki, Yuko, Ekblom, Peter, Takeda, Shin'ichi, Durbeej, Madeleine

Laminin α2 chain deficiency in humans and mice leads to severe forms of congenital muscular dystrophy. Here, we investigated whether laminin α1 chain in mice can compensate for the absence of...

Laminin {alpha}1 chain reduces muscular dystrophy in laminin {alpha}2 chain deficient mice (2004)

Gawlik, Kinga, Miyagoe-Suzuki, Yuko, Ekblom, Peter, Takeda, Shin'ichi, Durbeej, Madeleine

Laminin (LN) α2 chain deficiency in humans and mice leads to severe forms of congenital muscular dystrophy (CMD). Here, we investigated whether LNα1 chain in mice can compensate for the absence of...

Laminin {alpha}1 chain reduces muscular dystrophy in laminin {alpha}2 chain deficient mice (2004)

Gawlik, Kinga, Miyagoe-Suzuki, Yuko, Ekblom, Peter, Takeda, Shin'ichi, Durbeej, Madeleine

Laminin α2 chain deficiency in humans and mice leads to severe forms of congenital muscular dystrophy. Here, we investigated whether laminin α1 chain in mice can compensate for the absence of...

Nulp1, a novel basic helix-loop-helix protein expressed broadly during early embryonic organogenesis and prominently in developing dorsal root ganglia. (2002)

Olsson, Magnus, Durbeej, Madeleine, Ekblom, Peter, Hjalt, Tord

The basic helix-loop-helix (bHLH) proteins control differentiation and development of a variety of organs. We have isolated the complementary DNA (cDNA) of a novel class of bHLH transcription...

Opposing Roles of Integrin α6Aβ1 and Dystroglycan in Laminin-mediated Extracellular Signal-regulated Kinase Activation

Ferletta, Maria, Kikkawa, Yamato, Yu, Hao, Talts, Jan F., Durbeej, Madeleine, Sonnenberg, Arnoud, ...

Laminin–integrin interactions can in some settings activate the extracellular signal-regulated kinases (ERKs) but the control mechanisms are poorly understood. Herein, we studied ERK activation in...

Gene transfer establishes primacy of striated vs. smooth muscle sarcoglycan complex in limb-girdle muscular dystrophy

Durbeej, Madeleine, Sawatzki, Shanna M., Barresi, Rita, Schmainda, Kathleen M., Allamand, Valérie, Michele, Daniel E., ...

Limb-girdle muscular dystrophy types 2E and F are characterized by skeletal muscle weakness and often cardiomyopathy and are due to mutations in the genes encoding β- and δ-sarcoglycan. We...

Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex

Cohn, Ronald D., Durbeej, Madeleine, Moore, Steven A., Coral-Vazquez, Ramón, Prouty, Sally, Campbell, Kevin P.

Cardiomyopathy is a multifactorial disease, and the dystrophin-glycoprotein complex has been implicated in the pathogenesis of both hereditary and acquired forms of the disease. Using mouse models of...

Opposing Roles of Integrin α6Aβ1 and Dystroglycan in Laminin-mediated Extracellular Signal-regulated Kinase Activation

Ferletta, Maria, Kikkawa, Yamato, Yu, Hao, Talts, Jan F., Durbeej, Madeleine, Sonnenberg, Arnoud, ...

Laminin–integrin interactions can in some settings activate the extracellular signal-regulated kinases (ERKs) but the control mechanisms are poorly understood. Herein, we studied ERK activation in...

Gene transfer establishes primacy of striated vs. smooth muscle sarcoglycan complex in limb-girdle muscular dystrophy

Durbeej, Madeleine, Sawatzki, Shanna M., Barresi, Rita, Schmainda, Kathleen M., Allamand, Valérie, Michele, Daniel E., ...

Limb-girdle muscular dystrophy types 2E and F are characterized by skeletal muscle weakness and often cardiomyopathy and are due to mutations in the genes encoding β- and δ-sarcoglycan. We...

Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex

Cohn, Ronald D., Durbeej, Madeleine, Moore, Steven A., Coral-Vazquez, Ramón, Prouty, Sally, Campbell, Kevin P.

Cardiomyopathy is a multifactorial disease, and the dystrophin-glycoprotein complex has been implicated in the pathogenesis of both hereditary and acquired forms of the disease. Using mouse models of...

Laminin α1 Chain Corrects Male Infertility Caused by Absence of Laminin α2 Chain

Häger, Mattias, Gawlik, Kinga, Nyström, Alexander, Sasaki, Takako, Durbeej, Madeleine

Laminins are important for basement membrane structure and function. The laminin α2 chain is a major component of muscle basement membranes, and mutations in the laminin α2 gene lead to congenital...

Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis

Agrawal, Smriti, Anderson, Per, Durbeej, Madeleine, Van Rooijen, Nico, Ivars, Fredrik, Opdenakker, Ghislain, ...

The endothelial cell monolayer of cerebral vessels and its basement membrane (BM) are ensheathed by the astrocyte endfeet, the leptomeningeal cells, and their associated parenchymal BM, all of which...

Progressive Muscular Dystrophy in α-Sarcoglycan–deficient Mice

Duclos, Franck, Straub, Volker, Moore, Steven A., Venzke, David P., Hrstka, Ron F., Crosbie, Rachelle H., ...

Limb-girdle muscular dystrophy type 2D (LGMD 2D) is an autosomal recessive disorder caused by mutations in the α-sarcoglycan gene. To determine how α-sarcoglycan deficiency leads to muscle fiber...