Stuart Parkinson, Vanessa Spedding, Tim Berners-lee, Alan Cottey, Tim Foxon, Mae Wan Ho, ...
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Gaucher's Disease: Deficiency of “cid”β-Glucosidase and Reconstitution of Enzyme Activity In Vitro
The spleen from a patient with adult Gaucher's disease was shown to be deficient in a β-glucosidase (EC 3.2.1.21) isoenzyme that has optimal activity at pH 4.0-4.3, and is stimulated by 0.02% Triton...
Hydrolysis of GM1-ganglioside by human liver β-galactosidase isoenzymes
Ho, Mae Wan, Cheetham, Peter, Robinson, Donald
1. GM1-ganglioside, specifically tritiated in the terminal galactose, was hydrolysed by two forms of `acid' methylumbelliferyl β-galactosidase isolated on gel filtration. 2. Identification of...
Identity of `acid' β-glucosidase and glucocerebrosidase in human spleen
1. Glucocerebrosidase, in association with a membrane-bound `acid' β-glucosidase, was separated from a soluble `neutral' β-glucosidase that had no activity towards glucocerebroside as substrate. 2....
Ho, Mae Wan, Light, Nicholas D.
The reconstitution of glucocerebrosidase activity from its inactive macromolecular components depended on acidic membrane phospholipids.
Glucocerebrosidase: reconstitution of activity from macromolecular components. (Short Communication)
Ho, Mae Wan, O'Brien, John S., Radin, Norman S., Erickson, John S.
Glucocerebrosidase activity was reconstituted in vitro from a soluble glycoprotein factor (P) and a particle-bound factor (C). The physiological significance of the system is discussed.
Hydrolysis of ceramide trihexoside by a specific α-galactosidase from human liver
1. Partially purified ceramide trihexoside α-galactosidase from human liver was studied by using ceramide trihexoside specifically tritiated in the terminal galactose. 2. The hydrolysis of ceramide...
Gaucher's Disease: Deficiency of “cid”β-Glucosidase and Reconstitution of Enzyme Activity In Vitro
The spleen from a patient with adult Gaucher's disease was shown to be deficient in a β-glucosidase (EC 3.2.1.21) isoenzyme that has optimal activity at pH 4.0-4.3, and is stimulated by 0.02% Triton...
Hydrolysis of GM1-ganglioside by human liver β-galactosidase isoenzymes
Ho, Mae Wan, Cheetham, Peter, Robinson, Donald
1. GM1-ganglioside, specifically tritiated in the terminal galactose, was hydrolysed by two forms of `acid' methylumbelliferyl β-galactosidase isolated on gel filtration. 2. Identification of...
Identity of `acid' β-glucosidase and glucocerebrosidase in human spleen
1. Glucocerebrosidase, in association with a membrane-bound `acid' β-glucosidase, was separated from a soluble `neutral' β-glucosidase that had no activity towards glucocerebroside as substrate. 2....
Ho, Mae Wan, Light, Nicholas D.
The reconstitution of glucocerebrosidase activity from its inactive macromolecular components depended on acidic membrane phospholipids.
Glucocerebrosidase: reconstitution of activity from macromolecular components. (Short Communication)
Ho, Mae Wan, O'Brien, John S., Radin, Norman S., Erickson, John S.
Glucocerebrosidase activity was reconstituted in vitro from a soluble glycoprotein factor (P) and a particle-bound factor (C). The physiological significance of the system is discussed.
Hydrolysis of ceramide trihexoside by a specific α-galactosidase from human liver
1. Partially purified ceramide trihexoside α-galactosidase from human liver was studied by using ceramide trihexoside specifically tritiated in the terminal galactose. 2. The hydrolysis of ceramide...