遺伝的手法による関数近似を用いた時系列におけるジャンプ過程の推定とその予測と最適化への応用 (2009)
譚, 康融, 中西, 一, 時永, 祥三, Tan, Kangrong, Nakanishi, Makoto, Tokinaga, Shozo, ...
ジャンプ過程を含む変数で記述される評価関数の最適化とそのリアルオプション手法による事業評価分析への応用 (2008)
時永, 祥三, 中西 , 一, Tokinaga, Shozo, Nakanishi, Makoto, トキナガ, ショウゾウ, ナカニシ , マコト
応用一般均衡による社会基盤整備のモデル分析とその応用 (2008)
中西, 一, 時永, 祥三, Nakanishi, Makoto, Tokinaga, Shozo , ナカニシ. マコト, トキナガ, ショウゾウ
DNA damage checkpoints in mammals (2005)
Niida, Hiroyuki, Nakanishi, Makoto
DNA damage is a common event and probably leads to mutation or deletion within chromosomal DNA, which may cause cancer or premature aging. DNA damage induces several cellular responses including DNA...
地方予算の国際比較 : 現代公共経営における枠配分・責任予算の位置付け (2003)
中西, 一, Nakanishi, Makoto, ナカニシ, マコト
はじめに １．アメリカNPMと枠配分予算 ２．フランスの公的管理会計と責任センター ３．イギリスNPMとコスト・センター...
Nonstoichiometry of Epitaxial FeTiO(3+delta) Films (2003)
Fujii, Tatsuo, Sadai, Makoto, Kayano, Masakazu, Nakanishi, Makoto, Takada, Jun
Epitaxial thin films of (001)-oriented FeTiO(3+delta) were prepared on alpha-Al2O3(001) single crystalline substrates by helicon plasma sputtering technique. The FeTiO(3+delta) films had large oxygen...
Exchange Coupling and Spin-Flip Transition of CoFe2O4/alpha-Fe2O3 Bilayered Films (2002)
Fujii, Tatsuo, Yano, Takuya, Nakanishi, Makoto, Takada, Jun
CoFe2O4/alpha-Fe2O3 (ferrimagnetic/antiferromagnetism) bilayered films were prepared on alpha-Al2O3(102) single-crystalline substrates by helicon plasma sputtering. A well-crystallized epitaxial...
Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice (2000)
Takai, Hiroyuki, Tominaga, Kaoru, Motoyama, Noboru, Minamishima, Yohji A., Nagahama, Hiroyasu, Tsukiyama, Tadasuke, ...
Ogawa, Kumiko, Kimoto, Naoya, Asamoto, Makoto, Nakanishi, Makoto, Takahashi, Satoru, Shirai, Tomoyuki
Alteration in cell cycle regulators is considered to play an important role in carcinogenesis. In order to cast light on changes in reversible hyperplastic and irreversible tumorigenic lesions in the...
Yanagisawa, Ken, Kosaka, Akiko, Iwahana, Hiroyuki, Nakanishi, Makoto, Tominaga, Shin-ichi
Contact inhibition is a well-known phenomenon, but the details of its mechanism are poorly understood. Recently, cyclin-dependent kinase inhibitors have been studied intensively with respect to their...
Characterization of the Human Dihydropyrimidinase-Related Protein 2 (DRP-2) Gene (1999)
Kitamura, Kenzo, Takayama, Muneyuki, Hamajima, Naoki, Nakanishi, Makoto, Sasaki, Makoto, Endo, Yuichi, ...
The genes within the dihydropyrimidinase-related protein (DRP) family were originally identified in humans by their homology to dihydropyrimidinase (DHP). Four members of this gene family, DRP-1, -2,...
Nakanishi, Makoto, Moriyama, Akihiko, Narita, Yasuko, Sasaki, Makoto
Aminopeptidase M [EC 3.4.11.2] was purified 772-fold to homogeneity from the microsomal fraction of human liver, with a yield of 18.9%, by a combination of solubilization with 0.5%...
Nakanishi, Makoto, Moriyama, Akihiko, Narita, Yasuko, Sasaki, Makoto
The mechanism of inhibition of aminopeptidase M by bile acids was analyzed by application of the specific velocity plot that was introduced by Baici [Eur. J. Biochem. 119, 9–14 (1981)]. Kinetic...
Porcine Muscle Prolyl Endopeptidase and Its Endogenous Substrates (1988)
Moriyama, Akihiko, Nakanishi, Makoto, Sasaki, Makoto
Prolyl endopeptidase [EC 3.4.21.26] was purified 4,675-fold with a yield of 26.3% from porcine muscle.The purified enzyme was shown to be very similar to the liver enzyme with respect to its...
Chk2 Activation Dependence on Nbs1 after DNA Damage
Buscemi, Giacomo, Savio, Camilla, Zannini, Laura, Miccichè, Francesca, Masnada, Debora, Nakanishi, Makoto, ...
The checkpoint kinase Chk2 has a key role in delaying cell cycle progression in response to DNA damage. Upon activation by low-dose ionizing radiation (IR), which occurs in an ataxia telangiectasia...
Touitou, Robert, Richardson, Jo, Bose, Suchira, Nakanishi, Makoto, Rivett, Jennifer, Allday, Martin J.
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 is a key regulator of cell-cycle progression and its expression is tightly regulated at the level of transcription and by proteasome-dependent...
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
Takai, Hiroyuki, Naka, Kazuhito, Okada, Yuki, Watanabe, Miho, Harada, Naoki, Saito, Shin’ichi, ...
The mammalian Chk2 kinase is thought to mediate ATM-dependent signaling in response to DNA damage. The physiological role of mammalian Chk2 has now been investigated by the generation of...
Kobayashi, Yosuke, Watanabe, Miho, Okada, Yuki, Sawa, Hirofumi, Takai, Hiroyuki, Nakanishi, Makoto, ...
A growing number of DNA polymerases have been identified, although their physiological function and relation to human disease remain mostly unknown. DNA polymerase λ (Pol λ; also known as Pol β2)...
Fujita, Fumitaka, Taniguchi, Yuko, Kato, Takashi, Narita, Yasuko, Furuya, Akiko, Ogawa, Tatsuhiro, ...
The IκB kinase (IKK)-related kinase NAK (also known as TBK or T2K) contributes to the activation of NF-κB-dependent gene expression. Here we identify NAP1 (for NAK-associated protein 1), a protein...
Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− mice
Takai, Hiroyuki, Tominaga, Kaoru, Motoyama, Noboru, Minamishima, Yohji A., Nagahama, Hiroyasu, Tsukiyama, Tadasuke, ...
The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1 is thought to mediate signaling...
A checkpoint control linking meiotic S phase and recombination initiation in fission yeast
Tonami, Yuko, Murakami, Hiroshi, Shirahige, Katsuhiko, Nakanishi, Makoto
During meiosis, high levels of recombination initiated by DNA double-strand breaks (DSBs) occur only after DNA replication. However, how DSB formation is coupled to DNA replication is unknown. We...
Chk2 Activation Dependence on Nbs1 after DNA Damage
Buscemi, Giacomo, Savio, Camilla, Zannini, Laura, Miccichè, Francesca, Masnada, Debora, Nakanishi, Makoto, ...
The checkpoint kinase Chk2 has a key role in delaying cell cycle progression in response to DNA damage. Upon activation by low-dose ionizing radiation (IR), which occurs in an ataxia telangiectasia...
Touitou, Robert, Richardson, Jo, Bose, Suchira, Nakanishi, Makoto, Rivett, Jennifer, Allday, Martin J.
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 is a key regulator of cell-cycle progression and its expression is tightly regulated at the level of transcription and by proteasome-dependent...
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
Takai, Hiroyuki, Naka, Kazuhito, Okada, Yuki, Watanabe, Miho, Harada, Naoki, Saito, Shin’ichi, ...
The mammalian Chk2 kinase is thought to mediate ATM-dependent signaling in response to DNA damage. The physiological role of mammalian Chk2 has now been investigated by the generation of...
Kobayashi, Yosuke, Watanabe, Miho, Okada, Yuki, Sawa, Hirofumi, Takai, Hiroyuki, Nakanishi, Makoto, ...
A growing number of DNA polymerases have been identified, although their physiological function and relation to human disease remain mostly unknown. DNA polymerase λ (Pol λ; also known as Pol β2)...
Fujita, Fumitaka, Taniguchi, Yuko, Kato, Takashi, Narita, Yasuko, Furuya, Akiko, Ogawa, Tatsuhiro, ...
The IκB kinase (IKK)-related kinase NAK (also known as TBK or T2K) contributes to the activation of NF-κB-dependent gene expression. Here we identify NAP1 (for NAK-associated protein 1), a protein...
Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− mice
Takai, Hiroyuki, Tominaga, Kaoru, Motoyama, Noboru, Minamishima, Yohji A., Nagahama, Hiroyasu, Tsukiyama, Tadasuke, ...
The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1 is thought to mediate signaling...
A checkpoint control linking meiotic S phase and recombination initiation in fission yeast
Tonami, Yuko, Murakami, Hiroshi, Shirahige, Katsuhiko, Nakanishi, Makoto
During meiosis, high levels of recombination initiated by DNA double-strand breaks (DSBs) occur only after DNA replication. However, how DSB formation is coupled to DNA replication is unknown. We...
Specific Role of Chk1 Phosphorylations in Cell Survival and Checkpoint Activation▿ †
Niida, Hiroyuki, Katsuno, Yuko, Banerjee, Birendranath, Hande, M. Prakash, Nakanishi, Makoto
Chk1 is a multifunctional protein kinase that plays essential roles in cell survival and cell cycle checkpoints. Chk1 is phosphorylated at multiple sites by several protein kinases, but the precise...
Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast
Murakami-Tonami, Yuko, Yamada-Namikawa, Chisato, Tochigi, Akiko, Hasegawa, Norio, Kojima, Hisae, Kunimatsu, Mitoshi, ...
The kinase Cdc2p is a central regulator of entry into and progression through nuclear division during mitosis and meiosis in eukaryotes. Cdc2p is activated at the onset of mitosis by...
Cyclin E as a Coactivator of the Androgen Receptor
Yamamoto, Ayako, Hashimoto, Yoshihiro, Kohri, Kenjiro, Ogata, Etsuro, Kato, Shige-aki, Ikeda, Kyoji, ...
Androgens play an important role in the growth of prostate cancer, but the molecular mechanism that underlies development of resistance to antiandrogen therapy remains unknown. Cyclin E has now been...
Shimada, Midori, Yamada-Namikawa, Chisato, Murakami-Tonami, Yuko, Yoshida, Takashi, Nakanishi, Makoto, Urano, Takeshi, ...
In most eukaryotes, cyclin-dependent kinases (Cdks) play a central role in control of cell-cycle progression. Cdks are inactivated from the end of mitosis to the start of the next cell cycle as well...
Cyclin A–Cdk1 regulates the origin firing program in mammalian cells
Katsuno, Yuko, Suzuki, Ayumi, Sugimura, Kazuto, Okumura, Katsuzumi, Zineldeen, Doaa H., Shimada, Midori, ...
Somatic mammalian cells possess well-established S-phase programs with specific regions of the genome replicated at precise times. The ATR–Chk1 pathway plays a central role in these programs, but...