Wedderburn, Lucy R., Maini, Mala K., Patel, Alka, Beverley, Peter C. L., Woo, Patricia
We have demonstrated a stable expansion of CD8+ T cells in the peripheral blood of a child with chronic arthritis. The expanded TCRBV family (TCRBV14) was enriched for CD57hiCD28– T cells....
Franzese, Ornella, Kennedy, Patrick T. F., Gehring, Adam J., Gotto, Jim, Williams, Roger, Maini, Mala K., ...
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell...
Franzese, Ornella, Kennedy, Patrick T. F., Gehring, Adam J., Gotto, Jim, Williams, Roger, Maini, Mala K., ...
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell...
The Level of Viral Antigen Presented by Hepatocytes Influences CD8 T-Cell Function▿
Gehring, Adam J., Sun, Dianxing, Kennedy, Patrick T. F., Lim, Seng Gee, Wasser, Shanthi, ...
CD8 T cells exert their antiviral function through cytokines and lysis of infected cells. Because hepatocytes are susceptible to noncytolytic mechanisms of viral clearance, CD8 T-cell antiviral...
Dunn, Claire, Brunetto, Maurizia, Reynolds, Gary, Christophides, Theodoros, Kennedy, Patrick T., Lampertico, Pietro, ...
Hepatitis B virus (HBV) causes chronic infection in more than 350 million people worldwide. It replicates in hepatocytes but is non-cytopathic; liver damage is thought to be immune mediated. Here, we...
Maini, Mala K., Boni, Carolina, Lee, Chun Kyon, Larrubia, Juan R., Reignat, Stephanie, Ogg, Graham S., ...
Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes by HBV-specific CD8 cells has been assumed to be the central mechanism causing both liver damage and...
Reignat, Stephanie, Webster, George J.M., Brown, David, Ogg, Graham S., King, Abigail, Seneviratne, Suranjith L., ...
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in...
Bim-mediated deletion of antigen-specific CD8+ T cells in patients unable to control HBV infection
Lopes, A. Ross, Kellam, Paul, Das, Abhishek, Dunn, Claire, Kwan, Antonia, Turner, Joanna, ...
HBV-specific CD8+ T cells are critical for a successful immune response to HBV infection. They are markedly diminished in number in patients who fail to control the virus, but the mechanisms...
Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
Das, Abhishek, Hoare, Matthew, Davies, Nathan, Lopes, A. Ross, Dunn, Claire, Kennedy, Patrick T.F., ...
The inflamed liver in chronic hepatitis B virus (HBV) infection (CHB) is characterized by a large influx of non–virus-specific CD8 T cells. Little is known about the functional capacity of these...