Man-fung Yuen

Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutationson hepatocellular carcinoma: a case control study (2004)

Yuen, Man-Fung, Tanaka, Yasuhito, Mizokami, Masashi, Yuen, John Chi-Hang, Wong, Danny Ka-Ho, Yuan, He-Jun, ...

The role of hepatitis B virus (HBV) genotypes, core promoter (CP) and precore mutants on hepatocellular carcinoma (HCC) is still controversial. We aimed to determine their role on the development and...

Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study (2004)

Yuen, Man-Fung, Tanaka, Yasuhito, Mizokami, Masashi, Yuen, John Chi-Hang, Wong, Danny Ka-Ho, Yuan, He-Jun, ...

The role of hepatitis B virus (HBV) genotypes, core promoter (CP) and precore mutants on hepatocellular carcinoma (HCC) is still controversial. We aimed to determine their role on the development and...

Chronic hepatitis B virus infection in the Chinese : natural history, sequelae, treatment and prevention (2001)

Yuen, Man-fung

(Uncorrected OCR) Abstract of thesis entitled Chronic Hepatitis B Virus Infection in the Chinese: Natural History, Sequelae, Treatment and Prevention Submitted by Yuen Man Fung for the degree of...

Chronic hepatitis B virus infection in the Chinese : natural history, sequelae, treatment and prevention (2001)

Yuen, Man-fung

(Uncorrected OCR) Abstract of thesis entitled Chronic Hepatitis B Virus Infection in the Chinese: Natural History, Sequelae, Treatment and Prevention Submitted by Yuen Man Fung for the degree of...

Chronic hepatitis B virus infection in the Chinese : natural history, sequelae, treatment and prevention (2001)

Yuen, Man-fung

(Uncorrected OCR) Abstract of thesis entitled Chronic Hepatitis B Virus Infection in the Chinese: Natural History, Sequelae, Treatment and Prevention Submitted by Yuen Man Fung for the degree of...

Nucleic Acid-Based Cross-Linking Assay for Detection and Quantification of Hepatitis B Virus DNA

Lai, Vicky C. H., Guan, Richard, Wood, Michael L., Lo, Su Kong, Yuen, Man-Fung, Lai, Ching-Lung

A nucleic acid photo-cross-linking technology was used to develop a direct assay for the quantification of hepatitis B virus (HBV) DNA levels in serum. Cross-linker-modified DNA probes complementary...

Clinical Evaluation of the Digene Hybrid Capture II Test and the COBAS AMPLICOR Monitor Test for Determination of Hepatitis B Virus DNA Levels

Yuan, He-Jun, Yuen, Man-Fung, Wong, Danny Ka-Ho, Sum, Simon Siu-Man, Lai, Ching-Lung

The measurement of hepatitis B virus (HBV) DNA is important for the assessment of liver disease and treatment efficacy. Most commercially available assays for the determination of HBV DNA levels have...

Real-Time PCR Assay Using Molecular Beacon for Quantitation of Hepatitis B Virus DNA

Sum, Simon Siu-Man, Wong, Danny Ka-Ho, Yuen, Man-Fung, Yuan, He-Jun, Yu, Jian, Lai, Ching-Lung, ...

Levels of hepatitis B virus (HBV) DNA in the blood serve as an important marker in monitoring the disease progression and treatment efficacy of chronic HBV infection. Several commercial assays are...

Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis

Wong, Danny Ka-Ho, Yuen, Man-Fung, Tse, Eric, Yuan, HeJun, Sum, Simon Siu-Man, Hui, Chee-Kin, ...

Assessment of intrahepatic hepatitis B virus (HBV) DNA levels in patients with chronic hepatitis B is important in understanding the natural history of the disease and designing antiviral therapy...

Long-Term Follow-Up Study of Chinese Patients with YMDD Mutations: Significance of Hepatitis B Virus Genotypes and Characteristics of Biochemical Flares

Yuen, Man-Fung, Yuan, He-Jun, Sablon, Erwin, Wong, Danny Ka-Ho, Chan, Annie On-On, Wong, Benjamin Chun-Yu, ...

We sought to examine the role of hepatitis B virus (HBV) genotypes in virological breakthroughs and biochemical flares in patients with YMDD mutations during lamivudine therapy. Virologic...

HBsAg Seroclearance in Chinese Patients Receiving Lamivudine Therapy for Chronic Hepatitis B Virus Infection

Yuen, Man-Fung, Wong, Danny Ka-Ho, Yuan, He-Jun, Sum, Siu-Man, Lai, Ching-Lung

We report two Chinese patients in whom lamivudine treatment resulted in HBsAg seroclearance. One patient received lamivudine, and another patient received 12-week famciclovir treatment followed by...

Longitudinal Study of Hepatitis Activity and Viral Replication before and after HBeAg Seroconversion in Chronic Hepatitis B Patients Infected with Genotypes B and C

Yuen, Man-Fung, Fung, Scott K., Tanaka, Yasuhito, Kato, Takanobu, Mizokami, Masashi, Yuen, John Chi-Hang, ...

The aims of this study were to compare chronic hepatitis B (CHB) patients with genotypes B and C for the probability of HBeAg seroconversion, hepatitis activity, and viral replication before and...

Molecular Characterization of Human Immunodeficiency Virus Type 1 and Hepatitis C Virus in Paid Blood Donors and Injection Drug Users in China

Zhang, Linqi, Chen, Zhiwei, Cao, Yunzhen, Yu, Jian, Li, Guanghan, Yu, Wenjie, ...

China is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection due to large numbers of paid blood donors (PBD), injection drug users...

Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance

Yuan, He-Jun, Yuen, Man-Fung, Wong, Danny Ka-Ho, Sum, Siu-Man, Doutreloigne, Joke, Sablon, Erwin, ...

This study was performed to determine the factors for predicting the occurrence of acute exacerbation of hepatitis B virus infection in HBeAg-negative patients. Two hundred and sixteen patients with...

Nucleic Acid-Based Cross-Linking Assay for Detection and Quantification of Hepatitis B Virus DNA

Lai, Vicky C. H., Guan, Richard, Wood, Michael L., Lo, Su Kong, Yuen, Man-Fung, Lai, Ching-Lung

A nucleic acid photo-cross-linking technology was used to develop a direct assay for the quantification of hepatitis B virus (HBV) DNA levels in serum. Cross-linker-modified DNA probes complementary...

Clinical Evaluation of the Digene Hybrid Capture II Test and the COBAS AMPLICOR Monitor Test for Determination of Hepatitis B Virus DNA Levels

Yuan, He-Jun, Yuen, Man-Fung, Wong, Danny Ka-Ho, Sum, Simon Siu-Man, Lai, Ching-Lung

The measurement of hepatitis B virus (HBV) DNA is important for the assessment of liver disease and treatment efficacy. Most commercially available assays for the determination of HBV DNA levels have...

Real-Time PCR Assay Using Molecular Beacon for Quantitation of Hepatitis B Virus DNA

Sum, Simon Siu-Man, Wong, Danny Ka-Ho, Yuen, Man-Fung, Yuan, He-Jun, Yu, Jian, Lai, Ching-Lung, ...

Levels of hepatitis B virus (HBV) DNA in the blood serve as an important marker in monitoring the disease progression and treatment efficacy of chronic HBV infection. Several commercial assays are...

Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis

Wong, Danny Ka-Ho, Yuen, Man-Fung, Tse, Eric, Yuan, HeJun, Sum, Simon Siu-Man, Hui, Chee-Kin, ...

Assessment of intrahepatic hepatitis B virus (HBV) DNA levels in patients with chronic hepatitis B is important in understanding the natural history of the disease and designing antiviral therapy...

Long-Term Follow-Up Study of Chinese Patients with YMDD Mutations: Significance of Hepatitis B Virus Genotypes and Characteristics of Biochemical Flares

Yuen, Man-Fung, Yuan, He-Jun, Sablon, Erwin, Wong, Danny Ka-Ho, Chan, Annie On-On, Wong, Benjamin Chun-Yu, ...

We sought to examine the role of hepatitis B virus (HBV) genotypes in virological breakthroughs and biochemical flares in patients with YMDD mutations during lamivudine therapy. Virologic...

HBsAg Seroclearance in Chinese Patients Receiving Lamivudine Therapy for Chronic Hepatitis B Virus Infection

Yuen, Man-Fung, Wong, Danny Ka-Ho, Yuan, He-Jun, Sum, Siu-Man, Lai, Ching-Lung

We report two Chinese patients in whom lamivudine treatment resulted in HBsAg seroclearance. One patient received lamivudine, and another patient received 12-week famciclovir treatment followed by...

Longitudinal Study of Hepatitis Activity and Viral Replication before and after HBeAg Seroconversion in Chronic Hepatitis B Patients Infected with Genotypes B and C

Yuen, Man-Fung, Fung, Scott K., Tanaka, Yasuhito, Kato, Takanobu, Mizokami, Masashi, Yuen, John Chi-Hang, ...

The aims of this study were to compare chronic hepatitis B (CHB) patients with genotypes B and C for the probability of HBeAg seroconversion, hepatitis activity, and viral replication before and...

Molecular Characterization of Human Immunodeficiency Virus Type 1 and Hepatitis C Virus in Paid Blood Donors and Injection Drug Users in China

Zhang, Linqi, Chen, Zhiwei, Cao, Yunzhen, Yu, Jian, Li, Guanghan, Yu, Wenjie, ...

China is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection due to large numbers of paid blood donors (PBD), injection drug users...

Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance

Yuan, He-Jun, Yuen, Man-Fung, Wong, Danny Ka-Ho, Sum, Siu-Man, Doutreloigne, Joke, Sablon, Erwin, ...

This study was performed to determine the factors for predicting the occurrence of acute exacerbation of hepatitis B virus infection in HBeAg-negative patients. Two hundred and sixteen patients with...

Evolution of Primary and Compensatory Lamivudine Resistance Mutations in Chronic Hepatitis B Virus-Infected Patients during Long-Term Lamivudine Treatment, Assessed by a Line Probe Assay▿

Libbrecht, Evelien, Doutreloigne, Joke, Van De Velde, Hilde, Yuen, Man-Fung, Lai, Ching-Lung, Shapiro, Fred, ...

With the availability of more potent nucleotide/nucleoside analogues, the early detection of drug-resistant mutants of hepatitis B virus (HBV) is important for the strategic treatment of chronic...

Hepatitis B Virus Core-Related Antigens as Markers for Monitoring Chronic Hepatitis B Infection▿

Wong, Danny Ka-Ho, Tanaka, Yasuhito, Lai, Ching-Lung, Mizokami, Masashi, Fung, James, Yuen, Man-Fung

A sensitive chemiluminescence enzyme immunoassay has been developed for hepatitis B virus (HBV) core-related antigen (HBcrAg) detection. We aimed to investigate the usefulness of HBcrAg measurement...

Natural history of hepatitis-related hepatocellular carcinoma

But, David Yiu-Kuen, Lai, Ching-Lung, Yuen, Man-Fung

Hepatocellular carcinoma (HCC) is an important cause of cancer death in the world. It has great regional differences in the pathology and epidemiology. The variation is greatly influenced by the...

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)

Sarin, Shiv Kumar, Kumar, Ashish, Almeida, John A., Chawla, Yogesh Kumar, Fan, Sheung Tat, Garg, Hitendra, ...

The Asian Pacific Association for the Study of the Liver (APASL) set up a working party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus guidelines on various...

Pharmacokinetics of LB80331 and LB80317 following Oral Administration of LB80380, a New Antiviral Agent for Chronic Hepatitis B (CHB), in Healthy Adult Subjects, CHB Patients, and Mice▿

Yuen, Man-Fung, Lee, Sung-Hack, Kang, Hyang-Mi, Kim, Chung Ryeol, Kim, John, Ngai, Vincent, ...

LB80380, a dipivoxil ester prodrug of LB80331 (metabolite, LB80317), is a novel antiviral agent for chronic hepatitis B (CHB). The pharmacokinetics of LB80331/LB80317 were evaluated in two clinical...