Manfred Hergenhahn

Human p53 knock-in (HUPKI) mice do not differ in liver tumor response from their counterparts with murine p53 (2005)

Jaworski, Maike, Hailfinger, Stephan, Buchmann, Albrecht, Hergenhahn, Manfred, Hollstein, Monica, Ittrich, Carina, ...

Mouse models are important tools in toxicologic research. Differences between species in pathways contributing to tumor development, however, raise the question in how far mouse models are valid for...

Human p53 knock-in (HUPKI) mice do not differ in liver tumor response from their counterparts with murine p53 (2005)

Jaworski, Maike, Hailfinger, Stephan, Buchmann, Albrecht, Hergenhahn, Manfred, Hollstein, Monica, Ittrich, Carina, ...

Mouse models are important tools in toxicologic research. Differences between species in pathways contributing to tumor development, however, raise the question in how far mouse models are valid for...

Human p53 knock-in (hupki) mice do not differ in liver tumor response from their counterparts with murine p53 (2005)

Jaworski, Maike, Hailfinger, Stephan, Buchmann, Albrecht, Hergenhahn, Manfred, Hollstein, Monica, Ittrich, Carina, ...

Mouse models are important tools in toxicologic research. Differences between species in pathways contributing to tumor development, however, raise the question in how far mouse models are valid for...

Analysis of CREM-dependent gene expression during mouse spermatogenesis (2003)

Beißbarth,Tim, Borisevich,Igor, Hörlein,Andreas, Kenzelmann,Marc, Hergenhahn,Manfred, Klewe-Nebenius,Annette, ...

The transcription factors CREM, CREB, and ATF-1 constitute a subfamily of -Zip transcription factors. Several different kinase cascades regulate the activity of these proteins. The activator...

Analysis of CREM-dependent gene expression during mouse spermatogenesis (2003)

Beißbarth, Tim, Borisevich, Igor, Hörlein, Andreas, Kenzelmann, Marc, Hergenhahn, Manfred, Klewe-Nebenius, Annette, ...

The transcription factors CREM, CREB, and ATF-1 constitute a subfamily of -Zip transcription factors. Several different kinase cascades regulate the activity of these proteins. The activator...

Validation of two test systems for detecting tumor promoters and EBV inducers: comparative responses of several agents in DR-CAT Raji cells and in human granulocytes (1993)

Bouvier, Guy, Hergenhahn, Manfred, Polack, Axel, Bornkamm, Georg W., Bartsch, Helmut

The response to a number of agents has been compared in two short-term assays used for the detection of virus inducers and tumor promoters: (i) induction of the EBV-DR-promoter in Raji cells, as...

Specific binding of the tumor promoter TPA in various mouse organs as measured by a 'cold acetone-filter assay' (1981)

Hergenhahn, Manfred, Hecker, Erich

Rapid, specific, saturable and partially reversible binding of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate ([3H]TPA) to a particulate fraction of mouse brain can be demonstrated by means...

Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

Liu, Zhipei, Hergenhahn, Manfred, Schmeiser, Heinz H., Wogan, Gerald N., Hong, Amanda, Hollstein, Monica

To date, there has been no way to examine induced human p53 gene mutations in cell cultures exposed to mutagenic factors, other than by restriction site analysis. Here, we used embryonic cells from...

Expression Profiling of Human Hepatoma Cells Reveals Global Repression of Genes Involved in Cell Proliferation, Growth, and Apoptosis upon Infection with Parvovirus H-1†

Li, Jianhong, Werner, Ekkehard, Hergenhahn, Manfred, Poirey, Rémy, Luo, Zuyu, Rommelaere, Jean, ...

Autonomous parvoviruses are characterized by their stringent dependency on host cell S phase and their cytopathic effects on neoplastic cells. To better understand the interactions between the virus...

Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

Liu, Zhipei, Hergenhahn, Manfred, Schmeiser, Heinz H., Wogan, Gerald N., Hong, Amanda, Hollstein, Monica

To date, there has been no way to examine induced human p53 gene mutations in cell cultures exposed to mutagenic factors, other than by restriction site analysis. Here, we used embryonic cells from...

Expression Profiling of Human Hepatoma Cells Reveals Global Repression of Genes Involved in Cell Proliferation, Growth, and Apoptosis upon Infection with Parvovirus H-1†

Li, Jianhong, Werner, Ekkehard, Hergenhahn, Manfred, Poirey, Rémy, Luo, Zuyu, Rommelaere, Jean, ...

Autonomous parvoviruses are characterized by their stringent dependency on host cell S phase and their cytopathic effects on neoplastic cells. To better understand the interactions between the virus...

Decrease and Gain of Gene Expression Are Equally Discriminatory Markers for Prostate Carcinoma : A Gene Expression Analysis on Total and Microdissected Prostate Tissue

Ernst, Thomas, Hergenhahn, Manfred, Kenzelmann, Marc, Cohen, Clemens D., Bonrouhi, Mahnaz, Weninger, Annette, ...

Information on over- and underexpressed genes in prostate cancer in comparison to adjacent normal tissue was sought by DNA microarray analysis. Approximately 12,600 mRNA sequences were analyzed from...

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

Gotter, Jörn, Brors, Benedikt, Hergenhahn, Manfred, Kyewski, Bruno

Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene...

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

Derbinski, Jens, Gäbler, Jana, Brors, Benedikt, Tierling, Sascha, Jonnakuty, Sunitha, Hergenhahn, Manfred, ...

The role of central tolerance induction has recently been revised after the discovery of promiscuous expression of tissue-restricted self-antigens in the thymus. The extent of tissue representation...