Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells (2005)
Lina E. Tze, Brian R. Schram, Kong-Peng Lam, Kristin A. Hogquist, Keli L. Hippen, Jiabin Liu, ...
Gene rearrangement is a hallmark of B cell maturation. By interrupting basal cell signaling through the rearranged IgM receptor, immature B cells "back-differentiate" to an earlier stage in their...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells (2005)
Lina E. Tze, Brian R. Schram, Kong-Peng Lam, Kristin A. Hogquist, Keli L. Hippen, Jiabin Liu, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Blanco, Gonzalo, Coulton, GaryR., Biggin, Andrew, Grainge, Christopher, Moss, Jill, Barrett, Michael, ...
The ky mouse mutant exhibits a primary degenerative myopathy preceding chronic thoraco-lumbar kyphoscoliosis. The histopathology of the ky mutant suggests that Ky protein activity is crucial for...
Blanco, Gonzalo, Coulton, Gary R., Biggin, Andrew, Grainge, Christopher, Moss, Jill, Barrett, Michael, ...
The ky mouse mutant exhibits a primary degenerative myopathy preceding chronic thoraco-lumbar kyphoscoliosis. The histopathology of the ky mutant suggests that Ky protein activity is crucial for...
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Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
Tze, Lina E, Schram, Brian R, Lam, Kong-Peng, Hogquist, Kristin A, Hippen, Keli L, Liu, Jiabin, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
Tze, Lina E, Schram, Brian R, Lam, Kong-Peng, Hogquist, Kristin A, Hippen, Keli L, Liu, Jiabin, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Waisman, Ari, Kraus, Manfred, Seagal, Jane, Ghosh, Snigdha, Melamed, Doron, Song, Jian, ...
We describe a mouse strain in which B cell development relies either on the expression of membrane-bound immunoglobulin (Ig) γ1 or μ heavy chains. Progenitor cells expressing γ1 chains from the...
Reichlin, Amy, Gazumyan, Anna, Nagaoka, Hitoshi, Kirsch, Kathrin H., Kraus, Manfred, Rajewsky, Klaus, ...
B cell receptor (BCR) signaling is mediated through immunoglobulin (Ig)α and Igβ a membrane-bound heterodimer. Igα and Igβ are redundant in their ability to support early B cell development, but...
Kraus, Manfred, Pao, Lily I., Reichlin, Amy, Hu, Yun, Canono, Beth, Cambier, John C., ...
To determine the function of immunoglobulin (Ig)α immunoreceptor tyrosine–based activation motif (ITAM) phosphorylation, we generated mice in which Igα ITAM tyrosines were replaced by...
Reichlin, Amy, Hu, Yun, Meffre, Eric, Nagaoka, Hitoshi, Gong, Shiaoching, Kraus, Manfred, ...
The B cell receptor (BCR) regulates B cell development and function through immunoglobulin (Ig)α and Igβ, a pair of membrane-bound Ig superfamily proteins, each of which contains a single...