Scientific Commons: Manfred Uhr

Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol - A double-blind multicenter trial (2009)

CONTEXT: The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3 patients does not fully recover even after several treatment trials. Genetic factors and clinical...

Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder (2008)

Unschuld, Paul G., Ising, Marcus, Erhardt, Angelika, Lucae, Susanne, Kohli, Martin, Kloiber, Stefan, ...

Polymorphisms in the drug transporter Gene ABCB1 predict antidepressant treatment response in depression (2008)

Uhr, Manfred, Tontsch, Alina, Namendorf, Christian, Ripke, Stephan, Lucae, Susanne, Ising, Marcus, ...

Polymorphisms in the FKBP5 gene region modulates recovery from psychosocial stress in healthy controls (2008)

Ising, Marcus, Depping, Anna-Mareike, Siebertz, Anna, Lucae, Susannr, Unschuld, Paul G., Kloiber, Stefan, ...

Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls (2007)

Uhr, Manfred, Grauer, Markus T., Yassouridis, Alexander, Ebinger, Martin

Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major-depression-A potential biomarker? (2007)

Ising, Marcus, Horstmann, Sonja, Kloiber, Stefan, Lucae, Susanne, Binder, Elisabeth B., Kern, Nikola, ...

Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks (2007)

Thoeringer, Christoph K., Binder, Elisabeth B., Salyakina, Daria, Erhardt, Angelika, Ising, Marcus, Unschuld, Paul G., ...

Ghrelin Suppresses Secretion of Luteinizing Hormone in Humans (2007)

Kluge, Michael, Schüssler, Petra, Uhr, Manfred, Yassouridis, Alexander, Steiger, Axel

Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep (2007)

Kluge, Michael, Schüssler, Petra, Zuber, Verena, Kleyer, Sara, Yassouridis, Alexander, Dresler, Martin, ...

Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations (2006)

Then Bergh, Florian, Kümpfel, Tania, Schumann, Erina, Held, Ulrike, Schwan, Michaela, Blazevic, Mirjana, ...

Abstract Background Intravenous methylprednisolone (IV-MP) is an established treatment for multiple sclerosis (MS) relapses, accompanied by rapid, though transient reduction of gadolinium enhancing...

Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder (2006)

Erhardt, Angelika, Ising, Marcus, Unschuld, Paul Gerson, Kern, Nikola, Lucae, Susanne, Pütz, Benno, ...

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder (2006)

Lucae, Susanne, Salyakina, Daria, Barden, Nicholas, Harvey, Mario, Gagné, Bernard, Labbé, Michel, ...

Successful antidepressant therapy restores the disturbed interplay between TNF-α system and HPA axis (2006)

Himmerich, Hubertus, Binder, Elisabeth B., Künzel, Heike E., Schuld, Andreas, Lucae, Susanne, Uhr, Manfred, ...

ABC drug transporter at the blood-brain barrier. Effects on drug metabolism and drug response (2006)

Ebinger, Martin, Uhr, Manfred

Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders (2006)

Erhardt, Angelika, Lucae, Susanne, Unschuld, Paul G., Ising, Marcus, Kern, Nikola, Salyakina, Daria, ...

Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations (2006)

Then Bergh, Florian, Kümpfel, Tania, Schumann, Erina, Held, Ulrike, Schwan, Michaela, Blazevic, Mirjana, ...

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder (2006)

Lucae, Susanne, Salyakina, Daria, Barden, Nicholas, Harvey, Mario, Gagné, Bernard, Labbé, Michel, ...

The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified as a susceptibility locus for affective disorders by linkage and association studies. P2RX7 is a purinergic...

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder (2006)

Lucae, Susanne, Salyakina, Daria, Barden, Nicholas, Harvey, Mario, Gagné, Bernard, Labbé, Michel, ...

The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified as a susceptibility locus for affective disorders by linkage and association studies. P2RX7 is a purinergic...

The anti-Parkinson drug budipine is exported actively out of the brain by P-glycoprotein in mice (2005)

Uhr, Manfred, Ebinger, Martin, Rosenhagen, Marcus C., Grauer, Markus T.

Ghrelin Stimulates Appetite, Imagination of Food, GH, ACTH, and Cortisol, but does not Affect Leptin in Normal Controls (2005)

Schmid, Dagmar A., Held, Katja, Ising, Marcus, Uhr, Manfred, Weikel, Jutta C., Steiger, Axel

Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains (2005)

Eisensamer, Brigitte, Uhr, Manfred, Meyr, Sabrina, Gimpl, Gerald, Deiml, Tobias, Rammes, Gerhard, ...

Elevated plasma ghrelin levels in night-eating syndrome (2005)

Rosenhagen, Marcus C., Uhr, Manfred, Schüssler, Petra, Steiger, Axel

Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolaction, melatonin, ghrelin and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine (2005)

Schmid, Dagmar A., Wichniak, Adam, Uhr, Manfred, Ising, Marcus, Brunner, Hans, Held, Katja, ...

Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters (2005)

Brunner, Jürgen, Bronisch, Thomas, Uhr, Manfred, Ising, Marcus, Binder, Elisabeth, Holsboer, Florian, ...

Nocturnal ghrelin levels - relationship to sleep EEG, the levels of growth hormone, ACTH and cortisol - and gender differences (2005)

Schüssler, Petra, Uhr, Manfred, Ising, Marcus, Schmid, Dagmar, Weikel, Jutta, Steiger, Axel

P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood-brain barrier in mice after a 10-day administration of amitriptyline (2004)

Grauer, Markus T., Uhr, Manfred

Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers (2004)

Frieboes, Ralf-Michael, Antonijevic, Irina A., Held, Katja, Murck, Harald, Pollmächer, Thomas, Uhr, Manfred, ...

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment (2004)

Binder, Elisabeth B., Salyakina, Daria, Lichtner, Peter, Wochnik, Gabriele M., Ising, Marcus, Pütz, Benno, ...

abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice (2003)

Uhr, Manfred, Grauer, Markus T.

Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) p-glycoprotein gene disruption (2003)

Uhr, Manfred, Grauer, Markus T., Holsboer, Florian

ABCBI (MDRI)- type P-Glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder (2003)

Müller, Marianne B., Keck, Martin E., Binder, Elisabeth B., Kresse, Adelheid E., Hagemeyer, Thomas P., Landgraf, Rainer, ...

Steroid synthesis inhibition with ketoconazole and its effects upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans (2003)

Deuschle, Michael, Lecei, Olivera, Stalla, Günther K., Landgraf, Rainer, Hamann, Bettina, Lederbogen, Florian, ...

Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevate behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model (2003)

Keck, Martin E., Welt, Tobias, Müller, Marianne B., Uhr, Manfred, Ohl, Frauke, Wigger, Alexandra, ...

Einfluss des P-Glykoproteins auf die Blut-Hirn-Schrankenfunktion (2002)

Uhr, Manfred

Die vorliegende Arbeit zeigt den Einfluss und die Bedeutung des P-Glykoproteins auf die Blut-Hirn-Schrankenfunktion von zentral wirksamen Medikamenten und Steroiden. Das P-Glykoprotein ist das...

Einfluss des P-Glykoproteins auf die Blut-Hirn-Schrankenfunktion [Elektronische Ressource] / (2002)

Uhr, Manfred.

Bielefeld, Univ., Diss., 2002.

Einfluss des P-Glykoproteins auf die Blut-Hirn-Schrankenfunktion (2002)

Uhr, Manfred

Die Blut-Liquor-Schrankenfunktion für Vitamin E / (1995)

Uhr, Manfred.

Göttingen, Univ., Diss., 1996.

Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study

Otto, Markus, Wiltfang, Jens, Schütz, Ekkehard, Zerr, Inga, Otto, Anke, Pfahlberg, Annette, ...

Objective: To analyse serum concentrations of brain specific S100 protein in patients with Creutzfeldt-Jakob disease and in controls.

Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations