Drosophila Stoned Proteins Regulate the Rate and Fidelity of Synaptic Vesicle Internalization (2008)
Daniel T. Stimson, Patricia S. Estes, Sujata Rao, K. S. Krishnan, Leonard E. Kelly, Mani Ramaswami
At an initial step during synaptic vesicle recycling, dynamin and adaptor proteins mediate the endocytosis of synaptic vesicle components from the plasma membrane. StonedA and stonedB, novel synaptic...
Synaptic and genomic responses to JNK and AP-1 signaling in Drosophilaneurons (2005)
Etter, Paul D, Narayanan, Radhakrishnan, Navratilova, Zaneta, Patel, Chirag, Bohmann, Dirk, Jasper, Heinrich, ...
Abstract Background The transcription factor AP-1 positively controls synaptic plasticity at the Drosophila neuromuscular junction. Although in motor neurons, JNK has been shown to activate AP-1, a...
Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail (2003)
Sudarslal, S, Majumdar, Sriparna, Ramasamy, P, Dhawan, Ritu, Pal, Prajna P, Ramaswami, Mani, ...
A 26 residue peptide (Am 2766) with the sequence CKQAGESCDIFSQNCCVG-TCAFICIE-NH2 has been isolated and purified from the venom of the molluscivorous snail, Conus amadis, collected off the...
Evidence for cell autonomous AP1 function in regulation of Drosophilamotor-neuron plasticity (2003)
Sanyal, Subhabrata, Narayanan, Radhakrishnan, Consoulas, Christos, Ramaswami, Mani
Abstract Background The transcription factor AP1 mediates long-term plasticity in vertebrate and invertebrate central nervous systems. Recent studies of activity-induced synaptic change indicate that...
Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail (2003)
Sudarslal, S, Majumdar, Sriparna, Ramasamy, P, Dhawan, Ritu, Pal, Prajna P, Ramaswami, Mani, ...
A 26 residue peptide (Am 2766) with the sequence CKQAGESCDIFSQNCCVG-TCAFICIE-NH2 has been isolated and purified from the venom of the molluscivorous snail, Conus amadis, collected off the...
Kamb, Alexander, Ramaswami, Mani
Abstract Background Microarray experiments offer a potent solution to the problem of making and comparing large numbers of gene expression measurements either in different cell types or in the same...
Ito, Kei, Suzuki, Kazumi, Estes, Patricia, Ramaswami, Mani, Yamamoto, Daisuke, Strausfeld, Nicholas J.
Two Sodium-Channel Genes in Drosophila: Implications for Channel Diversity (1989)
Ramaswami, Mani, Tanouye, Mark A.
We describe two Drosophila melanogaster transcription units that are highly homologous to a rat Na+-channel cDNA. They appear to encode the major subunits of two distinct Na+-channel proteins. One of...
Evidence for cell autonomous AP1 function in regulation of Drosophila motor-neuron plasticity
Sanyal, Subhabrata, Narayanan, Radhakrishnan, Consoulas, Christos, Ramaswami, Mani
Ito, Kei, Suzuki, Kazumi, Estes, Patricia, Ramaswami, Mani, Yamamoto, Daisuke, Strausfeld, Nicholas J.
Although the importance of the Drosophila mushroom body in olfactory learning and memory has been stressed, virtually nothing is known about the brain regions to which it is connected. Using Golgi...
Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons
Etter, Paul D, Narayanan, Radhakrishnan, Navratilova, Zaneta, Patel, Chirag, Bohmann, Dirk, Jasper, Heinrich, ...
Estes, Patricia S, Jackson, Taryn C, Stimson, Daniel T, Sanyal, Subhabrata, Kelly, Leonard E, Ramaswami, Mani
The dicistronic Drosophila stoned mRNA produces two proteins, stonedA and stonedB, that are localized at nerve terminals. While the stoned locus is required for synaptic-vesicle cycling in neurons,...
Rikhy, Richa, Ramaswami, Mani, Krishnan, K S
Rapidly reversible, temperature-sensitive (ts) paralytic mutants of Drosophila have been useful in delineating immediate in vivo functions of molecules involved in synaptic transmission. Here we...
Evidence for cell autonomous AP1 function in regulation of Drosophila motor-neuron plasticity
Sanyal, Subhabrata, Narayanan, Radhakrishnan, Consoulas, Christos, Ramaswami, Mani
Ito, Kei, Suzuki, Kazumi, Estes, Patricia, Ramaswami, Mani, Yamamoto, Daisuke, Strausfeld, Nicholas J.
Although the importance of the Drosophila mushroom body in olfactory learning and memory has been stressed, virtually nothing is known about the brain regions to which it is connected. Using Golgi...
Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons
Etter, Paul D, Narayanan, Radhakrishnan, Navratilova, Zaneta, Patel, Chirag, Bohmann, Dirk, Jasper, Heinrich, ...
Estes, Patricia S, Jackson, Taryn C, Stimson, Daniel T, Sanyal, Subhabrata, Kelly, Leonard E, Ramaswami, Mani
The dicistronic Drosophila stoned mRNA produces two proteins, stonedA and stonedB, that are localized at nerve terminals. While the stoned locus is required for synaptic-vesicle cycling in neurons,...
Rikhy, Richa, Ramaswami, Mani, Krishnan, K S
Rapidly reversible, temperature-sensitive (ts) paralytic mutants of Drosophila have been useful in delineating immediate in vivo functions of molecules involved in synaptic transmission. Here we...
Narayanan, Radhakrishnan, Leonard, Marilyn, Song, Byeong Doo, Schmid, Sandra L., Ramaswami, Mani
The mechanism by which the self-assembling GTPase dynamin functions in vesicle formation remains controversial. Point mutations in shibire, the Drosophila dynamin, cause temperature-sensitive (ts)...
The DEAD-Box RNA Helicase Ded1p Affects and Accumulates in Saccharomyces cerevisiae P-Bodies
Beckham, Carla, Hilliker, Angela, Cziko, Anne-Marie, Noueiry, Amine, Ramaswami, Mani, Parker, Roy
Recent results suggest that cytoplasmic mRNAs can form translationally repressed messenger ribonucleoprotein particles (mRNPs) capable of decapping and degradation, or accumulation into cytoplasmic...
GLD2 poly(A) polymerase is required for long-term memory
Kwak, Jae Eun, Drier, Eric, Barbee, Scott A., Ramaswami, Mani, Yin, Jerry C. P., Wickens, Marvin
The formation of long-term memory is believed to require translational control of localized mRNAs. In mammals, dendritic mRNAs are maintained in a repressed state and are activated upon repetitive...
Kim, Susy M., Kumar, Vimlesh, Lin, Yong-Qi, Karunanithi, Shanker, Ramaswami, Mani
In all nervous systems, short-term enhancement of transmitter release is achieved by increasing the weights of unitary synapses; in contrast, long-term enhancement, which requires nuclear gene...
Kumar, Vimlesh, Alla, Suneel Reddy, Krishnan, K.S., Ramaswami, Mani
Syndapin is a conserved dynamin-binding protein, with predicted function in synaptic-vesicle endocytosis. Here, we combine genetic mutational analysis with in vivo cell biological assays to ask...
Syndapin Promotes Formation of a Postsynaptic Membrane System in Drosophila
Kumar, Vimlesh, Fricke, Robert, Bhar, Debjani, Reddy-Alla, Suneel, Krishnan, K. S., Bogdan, Sven, ...
Syndapins belong to the F-BAR domain protein family whose predicted functions in membrane tubulation remain poorly studied in vivo. At Drosophila neuromuscular junctions, syndapin is associated...
Genetic Modifiers of dFMR1 Encode RNA Granule Components in Drosophila
Cziko, Anne-Marie J., McCann, Cathal T., Howlett, Iris C., Barbee, Scott A., Duncan, Rebecca P., Luedemann, Rene, ...
Mechanisms of neuronal mRNA localization and translation are of considerable biological interest. Spatially regulated mRNA translation contributes to cell-fate decisions and axon guidance during...