Manlio Di Cristina

Interaction of proteins with the mRNA for ribosomal protein L1 in Xenopus: structural characterization of in vivo complexes and identification of proteins that bind in vivo to its 5'UTR (1993)

Cardinali, Beatrice, Di Cristina, Manlio, Pierandrei-Amaldi, Paola

Xenopus r-proteln mRNAs are known to be coordinately regulated at the translational level. To find out If RNA/protein Interactions are involved In this control mechanism, we have characterized the...

Two Conserved Amino Acid Motifs Mediate Protein Targeting to the Micronemes of the Apicomplexan Parasite Toxoplasma gondii

Di Cristina, Manlio, Spaccapelo, Roberta, Soldati, Dominique, Bistoni, Francesco, Crisanti, Andrea

The micronemal protein 2 (MIC2) of Toxoplasma gondii shares sequence and structural similarities with a series of adhesive molecules of different apicomplexan parasites. These molecules accumulate,...

Transformed Toxoplasma gondii Tachyzoites Expressing the Circumsporozoite Protein of Plasmodium knowlesi Elicit a Specific Immune Response in Rhesus Monkeys

Di Cristina, Manlio, Ghouze, Firman, Kocken, Clemens H. M., Naitza, Silvia, Cellini, Pamela, Soldati, Dominique, ...

Toxoplasma gondii tachyzoites were transformed with the coding sequence of the circumsporozoite (CS) protein of the primate malaria parasite Plasmodium knowlesi. A single inoculation of live...

Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii

Opitz, Corinna, Di Cristina, Manlio, Reiss, Matthias, Ruppert, Thomas, Crisanti, Andrea, Soldati, Dominique

Apicomplexan parasites actively secrete proteins at their apical pole as part of the host cell invasion process. The adhesive micronemal proteins are involved in the recognition of host cell...

Use of an Immunoglobulin G Avidity Assay Based on Recombinant Antigens for Diagnosis of Primary Toxoplasma gondii Infection during Pregnancy

Beghetto, Elisa, Buffolano, Wilma, Spadoni, Andrea, Del Pezzo, Mariassunta, Di Cristina, Manlio, Minenkova, Olga, ...

The objective of this work was to develop an antibody-specific immunoglobulin G (IgG) avidity assay to discriminate between acute and latent phases of Toxoplasma gondii infection by using recombinant...

Use of Recombinant Antigens for Early Postnatal Diagnosis of Congenital Toxoplasmosis

Buffolano, Wilma, Beghetto, Elisa, Del Pezzo, Mariassunta, Spadoni, Andrea, Di Cristina, Manlio, Petersen, Eskild, ...

The main objective of this work was to improve the early serologic diagnosis of toxoplasmosis in children at risk of congenital infection by using recombinant antigens. Serum samples from 104 infants...

Two Conserved Amino Acid Motifs Mediate Protein Targeting to the Micronemes of the Apicomplexan Parasite Toxoplasma gondii

Di Cristina, Manlio, Spaccapelo, Roberta, Soldati, Dominique, Bistoni, Francesco, Crisanti, Andrea

The micronemal protein 2 (MIC2) of Toxoplasma gondii shares sequence and structural similarities with a series of adhesive molecules of different apicomplexan parasites. These molecules accumulate,...

Transformed Toxoplasma gondii Tachyzoites Expressing the Circumsporozoite Protein of Plasmodium knowlesi Elicit a Specific Immune Response in Rhesus Monkeys

Di Cristina, Manlio, Ghouze, Firman, Kocken, Clemens H. M., Naitza, Silvia, Cellini, Pamela, Soldati, Dominique, ...

Toxoplasma gondii tachyzoites were transformed with the coding sequence of the circumsporozoite (CS) protein of the primate malaria parasite Plasmodium knowlesi. A single inoculation of live...

Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii

Opitz, Corinna, Di Cristina, Manlio, Reiss, Matthias, Ruppert, Thomas, Crisanti, Andrea, Soldati, Dominique

Apicomplexan parasites actively secrete proteins at their apical pole as part of the host cell invasion process. The adhesive micronemal proteins are involved in the recognition of host cell...

Use of an Immunoglobulin G Avidity Assay Based on Recombinant Antigens for Diagnosis of Primary Toxoplasma gondii Infection during Pregnancy

Beghetto, Elisa, Buffolano, Wilma, Spadoni, Andrea, Del Pezzo, Mariassunta, Di Cristina, Manlio, Minenkova, Olga, ...

The objective of this work was to develop an antibody-specific immunoglobulin G (IgG) avidity assay to discriminate between acute and latent phases of Toxoplasma gondii infection by using recombinant...

Use of Recombinant Antigens for Early Postnatal Diagnosis of Congenital Toxoplasmosis

Buffolano, Wilma, Beghetto, Elisa, Del Pezzo, Mariassunta, Spadoni, Andrea, Di Cristina, Manlio, Petersen, Eskild, ...

The main objective of this work was to improve the early serologic diagnosis of toxoplasmosis in children at risk of congenital infection by using recombinant antigens. Serum samples from 104 infants...

Identification and Characterization of an Escorter for Two Secretory Adhesins in Toxoplasma gondii

Reiss, Matthias, Viebig, Nicola, Brecht, Susan, Fourmaux, Marie-Noelle, Soete, Martine, Di Cristina, Manlio, ...

The intracellular protozoan parasite Toxoplasma gondii shares with other members of the Apicomplexa a common set of apical structures involved in host cell invasion. Micronemes are apical secretory...

Temporal and Spatial Distribution of Toxoplasma gondii Differentiation into Bradyzoites and Tissue Cyst Formation In Vivo▿

Di Cristina, Manlio, Marocco, Daniela, Galizi, Roberto, Proietti, Carla, Spaccapelo, Roberta, Crisanti, Andrea

During Toxoplasma gondii infection, a fraction of the multiplying parasites, the tachyzoites, converts into bradyzoites, a dormant stage, which form tissue cysts localized mainly in brain, heart, and...