Eiriz, Maria Francisca, Carreto, Laura, Gomes, Ana Catarina, Pereira, Patricia, Schuller, Dorit, Santos, Manuel A. S.
Background: Genome variability generates phenotypic heterogeneity and is of relevance for adaptation to environmental change, but the extent of such variability in natural populations is still poorly...
GeneBrowser: an approach for integration and functional classification of genomic data (2007)
Arrais, Joel, Santos, Bruno, Fernandes, João, Carreto, Laura, Santos, Manuel A. S., Oliveira, José Luis
The aim of any high-throughput technique for genome analysis is to provide a direct link between the data produced and the hypothesis that originated the experiment. And so, tools for functional mRNA...
Yeast as a model organism for studying the evolution of nonstandard genetic codes (2004)
Silva, Raquel M., Miranda, Isabel, Moura, Gabriela, Santos, Manuel A. S.
During the last 30 years, a number of alterations to the standard genetic code have been uncovered both in prokaryotes and eukaryotic nuclear and mitochondrial genomes. But, the study of the...
Massey, Steven E., Moura, Gabriela, Beltrão, Pedro, Almeida, Ricardo, Garey, James R., Tuite, Mick F., ...
Using the (near) complete genome sequences of the yeasts Candida albicans, Saccharomyces cerevisiae, and Schizosaccharomyces pombe, we address the evolution of a unique genetic code change, which...
The CUG codon is decoded in vivo as serine and not leucine in Candida albicans (1995)
Santos, Manuel A.S., Tuite, Mick F.
Previous studies have shown that the yeast Candida albicans encodes a unique seryl-tRNACAG that should decode the leucine codon CUG as serine. However, In vitro translation of several different...
Empadinhas, Nuno, Albuquerque, Luciana, Costa, Joana, Zinder, Stephen H., Santos, Manuel A. S., Santos, Helena, ...
Mannosylglycerate (MG) is a common compatible solute found in thermophilic and hyperthermophilic prokaryotes. In this study we characterized a mesophilic and bifunctional mannosylglycerate synthase...
Massey, Steven E., Moura, Gabriela, Beltrão, Pedro, Almeida, Ricardo, Garey, James R., Tuite, Mick F., ...
Using the (near) complete genome sequences of the yeasts Candida albicans, Saccharomyces cerevisiae, and Schizosaccharomyces pombe, we address the evolution of a unique genetic code change, which...
Empadinhas, Nuno, Albuquerque, Luciana, Costa, Joana, Zinder, Stephen H., Santos, Manuel A. S., Santos, Helena, ...
Mannosylglycerate (MG) is a common compatible solute found in thermophilic and hyperthermophilic prokaryotes. In this study we characterized a mesophilic and bifunctional mannosylglycerate synthase...
Massey, Steven E., Moura, Gabriela, Beltrão, Pedro, Almeida, Ricardo, Garey, James R., Tuite, Mick F., ...
Using the (near) complete genome sequences of the yeasts Candida albicans, Saccharomyces cerevisiae, and Schizosaccharomyces pombe, we address the evolution of a unique genetic code change, which...
Moura, Gabriela, Pinheiro, Miguel, Arrais, Joel, Gomes, Ana Cristina, Carreto, Laura, Freitas, Adelaide, ...
A Genetic Code Alteration Is a Phenotype Diversity Generator in the Human Pathogen Candida albicans
Miranda, Isabel, Rocha, Rita, Santos, Maria C., Mateus, Denisa D., Moura, Gabriela R., Carreto, Laura, ...
Surfactants as Microbicides and Contraceptive Agents: A Systematic In Vitro Study
Vieira, Otilia V., Hartmann, Diego O., Cardoso, Carla M. P., Oberdoerfer, Daniel, Baptista, Marta, Santos, Manuel A. S., ...
Critical roles for a genetic code alteration in the evolution of the genus Candida
Silva, Raquel M, Paredes, João A, Moura, Gabriela R, Manadas, Bruno, Lima-Costa, Tatiana, Rocha, Rita, ...
During the last 30 years, several alterations to the standard genetic code have been discovered in various bacterial and eukaryotic species. Sense and nonsense codons have been reassigned or...
The Yeast PNC1 Longevity Gene Is Up-Regulated by mRNA Mistranslation
Silva, Raquel M., Duarte, Iven C. N., Paredes, João A., Lima-Costa, Tatiana, Perrot, Michel, Boucherie, Hélian, ...
Translation fidelity is critical for protein synthesis and to ensure correct cell functioning. Mutations in the protein synthesis machinery or environmental factors that increase synthesis of...