Manuel Baca

Protein Mimetics: Total Chemical Synthesis of an Active HIV-1 Protease Analog Containing a Rigid Bicyclic Beta-Turn Mimic, (9999)

Baca, Manuel, Jones, Alun, Dragar, Charles, Alewood, Paul F., Kent, Stephen B.

This Article is from 'Peptides, Chemistry and Biology: Proceedings of the American Peptide Symposium (12th) Held in Cambridge, Massachusetts on 16-21 June 1991', AD-A256 113, p732-733.

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

Nicholson, Sandra E., De Souza, David, Fabri, Louis J., Corbin, Jason, Willson, Tracy A., Zhang, Jian-Guo, ...

Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among others, the common receptor subunit...

Phage display of a catalytic antibody to optimize affinity for transition-state analog binding

Baca, Manuel, Scanlan, Thomas S., Stephenson, Robert C., Wells, James A.

Catalytic antibodies have shown great promise for catalyzing a tremendously diverse set of natural and unnatural chemical transformations. However, few catalytic antibodies have efficiencies that...

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Zhang, Jian-Guo, Farley, Alison, Nicholson, Sandra E., Willson, Tracy A., Zugaro, Lisa M., Simpson, Richard J., ...

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of...

SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation

Krebs, Danielle L., Uren, Rachel T., Metcalf, Donald, Rakar, Steven, Zhang, Jian-Guo, Starr, Robyn, ...

SOCS-6 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS-1 to SOCS-7 and CIS) which each contain a central SH2 domain and a carboxyl-terminal SOCS box. SOCS-1,...

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP

Silke, John, Ekert, Paul G., Day, Catherine L., Hawkins, Christine J., Baca, Manuel, Chew, Joanne, ...

XIAP is a mammalian inhibitor of apoptosis protein (IAP). To determine residues within the second baculoviral IAP repeat (BIR2) required for inhibition of caspase 3, we screened a library of BIR2...

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.

Fairlie, W Douglas, De Souza, David, Nicola, Nicos A, Baca, Manuel

Cytokines of the interleukin-6 family utilize the shared cytokine receptor gp130 in the formation of active signalling complexes. Tyrosine-757 (Y757) on this receptor is critical for negative...

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

Nicholson, Sandra E., De Souza, David, Fabri, Louis J., Corbin, Jason, Willson, Tracy A., Zhang, Jian-Guo, ...

Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among others, the common receptor subunit...

Phage display of a catalytic antibody to optimize affinity for transition-state analog binding

Baca, Manuel, Scanlan, Thomas S., Stephenson, Robert C., Wells, James A.

Catalytic antibodies have shown great promise for catalyzing a tremendously diverse set of natural and unnatural chemical transformations. However, few catalytic antibodies have efficiencies that...

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Zhang, Jian-Guo, Farley, Alison, Nicholson, Sandra E., Willson, Tracy A., Zugaro, Lisa M., Simpson, Richard J., ...

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of...

SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation

Krebs, Danielle L., Uren, Rachel T., Metcalf, Donald, Rakar, Steven, Zhang, Jian-Guo, Starr, Robyn, ...

SOCS-6 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS-1 to SOCS-7 and CIS) which each contain a central SH2 domain and a carboxyl-terminal SOCS box. SOCS-1,...

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP

Silke, John, Ekert, Paul G., Day, Catherine L., Hawkins, Christine J., Baca, Manuel, Chew, Joanne, ...

XIAP is a mammalian inhibitor of apoptosis protein (IAP). To determine residues within the second baculoviral IAP repeat (BIR2) required for inhibition of caspase 3, we screened a library of BIR2...

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.

Fairlie, W Douglas, De Souza, David, Nicola, Nicos A, Baca, Manuel

Cytokines of the interleukin-6 family utilize the shared cytokine receptor gp130 in the formation of active signalling complexes. Tyrosine-757 (Y757) on this receptor is critical for negative...

FINE STRUCTURE OF THE HUMAN OVUM IN THE PRONUCLEAR STAGE

Zamboni, Luciano, Mishell, Daniel R., Bell, James H., Baca, Manuel

A penetrated ovum was recovered from the oviduct of a 33 year old surgical patient who had had sexual intercourse 26 hr before the operation. The ovum was in the pronuclear stage. The ooplasmic...

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy

White, Christine A., Zhang, Jian-Guo, Salamonsen, Lois A., Baca, Manuel, Fairlie, W. Douglas, Metcalf, Donald, ...

Blastocyst implantation is a critical stage in the establishment of pregnancy. Leukemia inhibitory factor (LIF) is essential for mouse blastocyst implantation and also plays a role in human...