The immunotherapy of Alzheimer's disease (2004)
Abstract Only a small percentage of patients with Alzheimer's disease benefit from current drug therapy and for only a relatively short time. This is not surprising as the goal of these drugs is to...
Dysregulation of the humoral immune response in old mice (1995)
Zhao, Ke-sheng, Wang, Ya-fang, GuÈret, Roland, Weksler, Marc E., Doria, G.
The increase in autoantibodies with age of both experimental animals and humans has been thought to reflect a shift in the antibody repertoire from foreign to self antigens. In mice, before...
Cellular basis for the age-associated increase in autoimmune reactions (1990)
Weksler, Marc E., Schwab, Rise, Huetz, Francois, Kim, Young Tai, Coutinho, Antonio
The mechanisms that lead to the increased expression of autoantibodies with age are poorly understood. We have studied the number, size, and density of spleen and peritoneal cells from young and old...
Defective expression of high affinity IL-2 receptors on activated T cells from aged humans (1990)
Schwab, Risë, Pfeffer, Lawrence M., Szabo, Paul, Gamble, David, Schnurr, Christine M., Weksler, Marc E.
The proliferative response of T cells from aged humans to a number of mitogens is significantly reduced. We report here that there is a decrease in high affinity IL-2 receptor (IL-2R) expression on...
Impaired Lymphocyte Function in Aged Humans
Weksler, Marc E., Hütteroth, Thomas H.
The response of lymphocytes from young and old persons to phytohemagglutinin, pokeweed mitogen, or allogeneic lymphocytes has been measured. Lymphocytes from old persons incorporated significantly...
Weksler, Marc E., Bull, Geoffrey, Schwartz, Gabriel H., Stenzel, Kurt H., Rubin, Albert L.
The immunologic response of graft recipients to antilymphocyte globulin has been studied. The clearance from the serum of 125I-labeled antilymphocyte globulin was studied in 15 graft recipients...
Lymphocyte Transformation Induced by Autologous Cells: Stimulation by Cultured Lymphoblast Lines
Weksler, Marc E., Birnbaum, Gary
The ability of cultured lymphoblasts to stimulate autologous lymphocyte transformation in “one-way” mixed leukocyte culture has been studied. Intact, cultured lymphoblasts required physical...
The immunotherapy of Alzheimer's disease
Only a small percentage of patients with Alzheimer's disease benefit from current drug therapy and for only a relatively short time. This is not surprising as the goal of these drugs is to enhance...
Impaired Lymphocyte Function in Aged Humans
Weksler, Marc E., Hütteroth, Thomas H.
The response of lymphocytes from young and old persons to phytohemagglutinin, pokeweed mitogen, or allogeneic lymphocytes has been measured. Lymphocytes from old persons incorporated significantly...
Weksler, Marc E., Bull, Geoffrey, Schwartz, Gabriel H., Stenzel, Kurt H., Rubin, Albert L.
The immunologic response of graft recipients to antilymphocyte globulin has been studied. The clearance from the serum of 125I-labeled antilymphocyte globulin was studied in 15 graft recipients...
Lymphocyte Transformation Induced by Autologous Cells: Stimulation by Cultured Lymphoblast Lines
Weksler, Marc E., Birnbaum, Gary
The ability of cultured lymphoblasts to stimulate autologous lymphocyte transformation in “one-way” mixed leukocyte culture has been studied. Intact, cultured lymphoblasts required physical...
The immunotherapy of Alzheimer's disease
Only a small percentage of patients with Alzheimer's disease benefit from current drug therapy and for only a relatively short time. This is not surprising as the goal of these drugs is to enhance...
Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the...