Animal models of focal brain ischemia (2009)
Sicard, Kenneth M, Fisher, Marc
Abstract Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology of ischemic injury and developing therapies is an important endeavor that requires much...
Good laboratory practice: preventing introduction of bias at the bench (2009)
Macleod, Malcolm R., Fisher, Marc, O'Collins, Victoria, Sena, Emily S., Dirnagl, Ulrich, Bath, Philip M.W., ...
Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human...
Fuhai Li, Kai-feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, ...
values are reversible if reperfusion is rapidly performed after focal brain ischemia. We sought to determine if reperfusion-induced renormalization of initially abnormal values indicates reversal of...
ABSTRACT Automated Test Case Generation for Spreadsheets (2008)
Marc Fisher, Mingming Cao, Gregg Rothermel, Curtis R. Cook, Margaret M. Burnett
Spreadsheet languages, which include commercial spread-sheets and various research systems, have had a substantial impact on end-user computing. Research shows, however, that spreadsheets often...
Integrating automated test generation into the WYSIWYT spreadsheet testing methodology (2008)
Marc Fisher, Ii Mingming, Cao Gregg Rothermel
Spreadsheet languages, which include commercial spreadsheets and various research systems, have had a substantial impact on end-user computing. Research shows, however, that spreadsheets often...
Stroke and TIA: epidemiology, risk factors, and the need for early intervention (2008)
The risk of recurrent stroke in patients who have suffered a prior stroke or transient ischemic attack (TIA) is significant. It is imperative that individuals who report symptoms of a cerebrovascular...
Probing analysis of closed components (2008)
Software is increasingly being built through the composition of exisiting components, such as web services, where access to the source code, and in some cases even the executable code, is...
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Marc Fisher, Mingming Cao, Gregg Rothermel, Curtis R. Cook, Margaret M. Burnett
Savitz, Sean I., Lew, Robert A., Bluhmki, Erich, Hacke, Werner, Fisher, Marc
BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant NXY-059 used a novel outcome for acute ischemic stroke trials: a shift toward good functional...
Henninger, Nils, Sicard, Kenneth M., Li, Zhixin, Kulkarni, Praveen P., Dutzmann, Stephan, Urbanek, Christian, ...
OBJECTIVE: The relationship between cerebral integrity, recovery of brain function, and neurologic status after mild traumatic brain injury is incompletely characterized. DESIGN: Prospective and...
BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections from the sphenopalatine ganglion [SPG], henceforth referred to...
Prophylactic neuroprotection (2007)
Ischemic brain injury can be anticipated in a number of clinical settings such as procedures associated with a high-risk for stroke, patients with transient ischemic attacks or minor strokes who are...
The Virtual International Stroke Trials Archive (2007)
Myzoon, Ali, Bath, Philip M.W., Curram, John, Davis, Stephen M, Diener, Hans-Christoph, Donnan, Geoffrey A, ...
Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of...
The Virtual International Stroke Trials Archive (2007)
Myzoon, Ali, Bath, Philip M.W., Curram, John, Davis, Stephen M., Diener, Hans-Christoph, Donnan, Geoffrey A., ...
Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of...
Lampl, Yair, Zivin, Justin A., Fisher, Marc, Lew, Robert A., Welin, Lennart, Dahlof, Bjorn, ...
BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and preliminary effectiveness of the NeuroThera Laser System in the ability to improve...
The Virtual International Stroke Trials Archive (2007)
Ali, Myzoon, Bath, Philip M.W., Curram, John, Davis, Stephen M., Diener, Hans-Christoph, Donnan, Geoffrey A., ...
BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of...
Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (2007)
The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and improve functional outcome is based on sound scientific principles and extensive preclinical animal...
Henninger, Nils, Sicard, Kenneth M., Fisher, Marc
Almost no data is available on the serial changes in the brain after spectacular shrinking deficit (SSD) that may help understand this relatively rare clinical phenomenon. Quantitative...
Bardutzky, Juergen F., Shen, Qiang, Henninger, Nils, Schwab, Stefan, Duong, Timothy Q., Fisher, Marc
BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion on ischemic lesion evolution and pixel-by-pixel apparent diffusion coefficient-cerebral blood flow...
Bardutzky, Juergen F., Shen, Qiang, Henninger, Nils, Schwab, Stefan, Duong, Timothy Q., Fisher, Marc
BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion on ischemic lesion evolution and pixel-by-pixel apparent diffusion coefficient-cerebral blood flow...
Henninger, Nils, Bouley, James P., Nelligan, Julia M., Sicard, Kenneth M., Fisher, Marc
Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia. Employing diffusion (DWI)- and perfusion (PWI)-weighted magnetic resonance imaging (MRI), the...
Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain injury that could lead to enhanced therapy for this disorder. Among the more important...
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (2007)
Fisher, Marc, Hanley, Daniel F., Howard, George, Jauch, Edward C., Warach, Steven
Bouley, James P., Fisher, Marc, Henninger, Nils
Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO) in rats may considerably influence the results of experimental treatment studies. Using...
Perspectives on neuroprotective stroke therapy (2006)
Schabitz, Wolf-Rudiger, Fisher, Marc
After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of recent study results. We outline in this review how a neuroprotective candidate drug should be...
Handbook of Experimental Neurology: Methods and Techniques in Animal Research (2006)
Fisher, Marc, Tatlisumak, Turgut
This reference work covers every major methodology and disease model used in current neuroscience research. Divided into two major sections, the first deals with general methodologies in neuroscience...
Imaging in Experimental Neurology (2006)
Fisher, Marc, Lo, Eng H., Lev, Michael
No abstract available.
Dhib-Jalbut, Suhayl, Arnold, Douglas L., Cleveland, Don W., Fisher, Marc, Friedlander, Robert M., Mouradian, M. Maral, ...
Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic neuron depletion; ALS, a disease of motor neuron death; and Alzheimer's, a disease of...
Sicard, Kenneth M., Henninger, Nils, Fisher, Marc, Duong, Timothy Q., Ferris, Craig F.
BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical and experimental cerebral ischemia is incompletely characterized. We assessed the...
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (2006)
Padma, Vasantha, Fisher, Marc, Moonis, Majaz
The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin, or low molecular weight heparin have not been able to demonstrate undisputed...
The ischemic penumbra: a new opportunity for neuroprotection (2006)
The development of acute stroke therapies has yielded only limited success and many failures in multiple clinical trials. The target of acute stroke therapy is that portion of the ischemic region...
Henninger, Nils, Sicard, Kenneth M., Schmidt, Karl F., Bardutzky, Juergen F., Fisher, Marc
BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO) in rats may considerably influence the results of experimental...
Sicard, Kenneth M., Henninger, Nils, Fisher, Marc, Duong, Timothy Q., Ferris, Craig F.
The association between recovery of brain function and behavior after transient cerebral ischemia in animals and humans is incompletely characterized. Quantitative diffusion- (DWI), perfusion- (PWI),...
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (2006)
Henninger, Nils, Sicard, Kenneth M., Bouley, James P., Fisher, Marc, Stagliano, Nancy E.
The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral ischemia. For time-window assessment, male Wistar-Kyoto rats were treated with 0.2 mg/kg...
Walberer, Maureen, Stolz, Erwin, Muller, Clemens, Friedrich, C., Rottger, Carina, Blaes, F., ...
Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study was designed to evaluate the influence of early reperfusion and choice of rat strains on...
The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and the predominant current choices are aspirin, aspirin plus extended-release dipyridamole, and clopidogrel....
Warach, Steven, Kaufman, David, Chiu, David, Devlin, Thomas, Luby, Marie, Rashid, Ajaz, ...
BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the N-methyl-D-aspartate receptor. The safety and efficacy of GV150526 were studied in two phase III...
Developing and implementing future stroke therapies: the potential of telemedicine (2005)
Stroke is a major public health concern with few positive phase III clinical trials and a shortage of stroke care expertise. Drug development likely can be enhanced by adapting new outcome measures...
Bardutzky, Juergen F., Shen, Qiang, Henninger, Nils, Bouley, James P., Duong, Timothy Q., Fisher, Marc
BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO) in rats may considerably influence the results of experimental...
Fisher, Marc, Albers, Gregory W., Donnan, Geoffrey A., Furlan, Anthony J., Grotta, James, Kidwell, Chelsea S., ...
BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug efficacy and enhancing acute stroke trial design and performance. A fourth...
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (2005)
Moonis, Majaz, Kane, Kevin, Schwiderski, Ute, Sandage, Bobby W., Fisher, Marc
BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored. METHODS: We assessed...
Bardutzky, Juergen F., Shen, Qiang, Bouley, James P., Sotak, Christopher H., Duong, Timothy Q., Fisher, Marc
High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of normal, ischemic, and at-risk tissue. We compared the capability of...
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (2005)
Shen, Qiang, Ren, Hongxia, Cheng, Haiying, Fisher, Marc, Duong, Timothy Q.
Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30 mins was performed on permanent and transient focal ischemic brain injury in rats during...
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (2005)
Padma, Vasantha, Fisher, Marc, Moonis, Majaz
The current status of thrombolytic therapy approved by the US Food and Drug Administration is intravenous recombinant plasminogen activator given within 3 h of the onset of ischemic stroke....
Statistical prediction of tissue fate in acute ischemic brain injury (2005)
Shen, Qiang, Ren, Hongxia, Fisher, Marc, Duong, Timothy Q.
An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative high-resolution (200 x 200 microm) cerebral blood flow (CBF) and apparent diffusion...
Henning, Erica C., Meng, Xiangjun, Fisher, Marc, Sotak, Christopher H.
Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl to the exposed rat cortex. MEMRI signal increase in the ipsilateral cortex...
Bardutzky, Juergen F., Meng, Xiangjun, Bouley, James P., Duong, Timothy Q., Ratan, Rajiv, Fisher, Marc
Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant. We (1) tested the neuroprotective potential of DMSO at different time windows on infarct size...
Ren, Hongxia, Shen, Qiang, Bardutzky, Juergen F., Fisher, Marc, Duong, Timothy Q.
Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk tissues. Cerebral-blood-flow (CBF) and apparent diffusion coefficient (ADC) were...
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (2004)
Padma, Vasantha, Fisher, Marc, Moonis, Majaz
It is increasingly clear that even a small reduction in blood pressure results in a substantial risk reduction of vascular events including ischemic stroke. Recently, several comparative prospective...
Shen, Qiang, Ren, Hongxia, Fisher, Marc, Bouley, James P., Duong, Timothy Q.
High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) maps in stroke rats (permanent occlusion)...
Gerriets, Tibo, Stolz, Erwin, Walberer, Maureen, Muller, Clemens, Rottger, Carina, Kluge, Alexander, ...
BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human stroke. Complications and side effects are common among these models. The present study...
Duong, Timothy Q., Fisher, Marc
The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The increasing availability of novel magnetic resonance imaging (MRI) techniques, such as diffusion and...
Kazemi, Mark, Silva, Matthew D., Li, Fuhai, Fisher, Marc, Sotak, Christopher H.
Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative surrogate end-point for investigating the efficacy of drug treatment or...
Microsphere-induced embolic stroke: an MRI study (2004)
Mayzel-Oreg, Orna, Omae, Tsuyoshi, Kazemi, Mark, Li, Fuhai, Fisher, Marc, Cohen, Yoram, ...
Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for stroke is still lacking, emphasizing the need for further development and characterization of...
Shen, Qiang, Fisher, Marc, Sotak, Christopher H., Duong, Timothy Q.
The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain injury in rats were evaluated on a pixel-by-pixel basis using quantitative cerebral blood flow...
Gerriets, Tibo, Stolz, Erwin, Walberer, Maureen, Muller, Clemens, Kluge, Alexander, Kaps, Manfred, ...
Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental stroke is induced outside the magnet bore, preventing investigators from...
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (2004)
Meng, Xiangjun, Fisher, Marc, Shen, Qiang, Sotak, Christopher H., Duong, Timothy Q.
Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke patients. The PWI volume is typically substantially larger than the DWI...
Gerriets, Tibo, Stolz, Erwin, Walberer, Maureen, Muller, Clemens, Kluge, Alexander, Bachmann, A., ...
BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in...
The ischemic penumbra: identification, evolution and treatment concepts (2003)
The concept of the ischemic penumbra is an important one for both basic investigators of cerebral ischemia and for clinicians who treat stroke patients. The ischemic penumbra has been defined in a...
Shen, Qiang, Meng, Xiangjun, Fisher, Marc, Sotak, Christopher H., Duong, Timothy Q.
Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion and diffusion magnetic resonance imaging every 30 minutes for 3...
Gerriets, Tibo, Stolz, Erwin, Walberer, Maureen, Kaps, Manfred, Bachmann, Georg, Fisher, Marc
BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture technique causes hypothalamic damage with subsequent hyperthermia, which can confound...
Magnetic Resonance Imaging in Stroke (2003)
Fisher, Marc, Davis, Stephen, Warach, Steven
Magnetic resonance imaging (MRI) provides non-invasive information about the brain's blood flow, water movement and biochemical abnormalities following stroke. Advances in MRI are transforming the...
Using Diffusion-Perfusion MRI in Animal Models for Drug Development (2003)
No abstract provided.
BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with a few successful and many unsuccessful trials. New strategies need to be considered to enhance the chances...
Gerriets, Tibo, Li, Fuhai, Silva, Matthew D., Meng, Xiangjun, Brevard, Mathew E., Sotak, Christopher H., ...
BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for the simulation of focal cerebral ischemia in rats. This technique causes hypothalamic injury...
Shashoua, Victor E., Adams, David S., Boyer-Boiteau, Anne, Cornell-Bell, Ann, Li, Fuhai, Fisher, Marc
NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and 13.6 kDa, respectively) that are neuroprotective in the middle cerebral artery occlusion (MCAO)...
New perspectives on developing acute stroke therapy (2003)
The development of additional acute stroke therapies to complement and supplement intravenous recombinant tissue-type plasminogen activator within the first 3 hours after stroke onset remains an...
Combination Therapies, Restorative Therapies and Future Directions (2003)
No abstract provided.
Ongoing Trials and Future Directions for Acute Ischemic Stroke Treatment (2003)
No abstract provided.
Silva, Matthew D., Omae, Tsuyoshi, Helmer, Karl G., Li, Fuhai, Fisher, Marc, Sotak, Christopher H.
Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured in normal and ischemic rat brain. Selective T(1)-relaxation enhancement of...
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (2002)
BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered much controversy and discussion. Recent studies of low-molecular-weight heparins in...
Li, Fuhai, Liu, Kai-Feng, Silva, Matthew D., Meng, Xiangjun, Gerriets, Tibo, Helmer, Karl G., ...
BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is rapidly performed after focal brain ischemia. We sought to determine if...
Automated Test Case Generation for Spreadsheets (2002)
Marc Fisher, Mingming Cao, Gregg Rothermel, Curtis R. Cook, Margaret M. Burnett
Spreadsheet languages, which include commercial spreadsheets and various research systems, have had a substantial impact on end-user computing. Research shows, however, that spreadsheets often...
Liu, Kai-Feng, Li, Fuhai, Tatlisumak, Turgut, Garcia, Julio H., Sotak, Christopher H., Fisher, Marc, ...
BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue after cerebral artery occlusion. This acute drop is thought to be caused by the loss of...
Imaging of acute stroke (2001)
The utility of diagnostic imaging during the critical first few hours after stroke onset has many important applications. First and foremost, imaging technologies that can reliably detect and...
Li, Fuhai, Liu, Kai-Feng, Silva, Matthew D., Omae, Tsuyoshi, Sotak, Christopher H., Fenstermacher, Joseph D., ...
BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible. The purposes of this study were to determine whether resolution of...
Stroke Therapy (2nd ed.) (2001)
This second edition covers developments in the field regarding effective therapy for cerebrovascular disorders. It surveys methods for accurate stroke diagnosis necessary for therapeutic decisions...
Patients with acute stroke: recent developments in neuroimaging (2000)
Combremont, Pierre C., Fisher, Marc
The authors discuss recent developments in neuroimaging and their role in the evaluation of patients with acute stroke from diagnostic, therapeutic, and prognostic points of view. New techniques...
Tatlisumak, Turgut, Carano, Richard A.D., Takano, Kentaro, Meiler, Michael R., Li, Fuhai, Sotak, Christopher H., ...
Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution of focal ischemic injury. We studied the effects of a novel, broad-spectrum inhibitor of...
Li, Fuhai, Silva, Matthew D., Liu, Kai-Feng, Helmer, Karl G., Omae, Tsuyoshi, Fenstermacher, Joseph D., ...
This study was designed to characterize the initial and secondary changes of the apparent diffusion coefficient (ADC) of water with high temporal resolution measurements of ADC values and to...
Schabitz, Wolf-Rudiger, Li, Fuhai, Fisher, Marc
BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury and is probably amenable to pharmacological intervention. In this study we investigated whether an...
Li, Fuhai, Silva, Matthew D., Sotak, Christopher H., Fisher, Marc
OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within minutes after the onset of ischemia. This study was designed to determine...
Current Review of Cerebrovascular Disease (4th ed.) (2000)
Fisher, Marc, Bogousslavsky, Julien
Advances in the field of cerebrovascular medicine occur at a rapid pace. The fourth edition of Current Review of Cerebrovascular Disease provides an update on these rapidly evolving topics and gives...
Li, Fuhai, Omae, Tsuyoshi, Fisher, Marc
BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used in experimental stroke studies. The purposes of this study were to determine whether...
Li, Fuhai, Han, Sam S., Tatlisumak, Turgut, Liu, Kai-Feng, Garcia, Julio H., Sotak, Christopher H., ...
Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral artery occlusion (n = 5 per group) or sham occlusion (n = 2) in the magnetic resonance imaging unit....
Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke (1999)
Fisher, Marc, Albers, Gregory W.
Diffusion-weighted imaging (DWI) and perfusion imaging (PI) are two new magnetic resonance technologies that are becoming increasingly available for evaluation of acute ischemic stroke patients. DWI...
Antithrombotic and thrombolytic therapy for ischemic stroke (1999)
Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease. Aspirin modestly reduces the risk for subsequent ischemic stroke after a...
Schabitz, Wolf-Rudiger, Li, Fuhai, Irie, Katsumi, Sandage, Bobby W., Locke, Kenneth W., Fisher, Marc
BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous compound that stabilizes membrane function) have demonstrated...
Current Review of Cerebrovascular Disease (3rd ed.) (1999)
Fisher, Marc, Bogousslavsky, Julien
No abstract provided.
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (1998)
Carano, Richard A.D., Takano, Kentaro, Helmer, Karl G., Tatlisumak, Turgut, Irie, Katsumi, Petruccelli, Joseph D., ...
Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain after permanent middle cerebral arterial occlusion. MS analysis used a four-dimensional MS model...
Tatlisumak, Turgut, Takano, Kentaro, Carano, Richard A.D., Miller, Leonard P., Foster, Alan C., Fisher, Marc
BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels. This results in activation of cell surface adenosine receptors and some degree of...
Li, Fuhai, Han, Sam S., Tatlisumak, Turgut, Carano, Richard A.D., Irie, Katsumi, Sotak, Christopher H., ...
BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI data and to image ischemic changes immediately after occlusion. We have...
Takano, Kentaro, Carano, Richard A.D., Tatlisumak, Turgut, Meiler, Michael R., Sotak, Christopher H., Kleinert, H. D., ...
OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and i.v. delivery in a rat embolic stroke model, using diffusion (DWI) and perfusion...
Further evolution toward effective therapy for acute ischemic stroke (1998)
Fisher, Marc, Bogousslavsky, Julien
The effective treatment of acute ischemic stroke remains an important goal of modern medicine and substantive advances are occurring. Recently, thrombolytic therapy with tissue-type plasminogen...
Tatlisumak, Turgut, Carano, Richard A.D., Takano, Kentaro, Opgenorth, Terry J., Sotak, Christopher H., Fisher, Marc
BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain ischemia and may worsen the ischemic damage. Diffusion-weighted MRI (DWI) and...
Takano, Kentaro, Tatlisumak, Turgut, Bergmann, Andreas G., Gibson, Daniel G., Fisher, Marc
The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture remains unsettled, regarding the usefulness of coated or uncoated sutures. Three...
Tatlisumak, Turgut, Takano, Kentaro, Meiler, Michael R., Fisher, Marc
BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion evolution. N-Methyl-D-aspartate (NMDA) antagonists inhibit SDs and reduce infarct...
Li, Fuhai, Irie, Katsumi, Anwer, M. Sawkat, Fisher, Marc
Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were subjected to immediate or 8-hour delayed 2,3,5-triphenyltetrazolium chloride (TTC) staining (n = 8...
Takano, Kentaro, Tatlisumak, Turgut, Formato, James E., Carano, Richard A.D., Bergmann, Andreas G., Pullan, Linda M., ...
BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic target for acute focal ischemia, potentially devoid of most side effects associated...
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (1997)
Onal, M. Zulkuf, Li, Fuhai, Tatlisumak, Turgut, Locke, Kenneth W., Sandage, Bobby W., Fisher, Marc
BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently being assessed in clinical trials. To evaluate potential synergistic...
Characterizing the target of acute stroke therapy (1997)
BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially salvageable ischemic tissue when therapy is initiated because it is widely assumed...
Acute ischemic stroke therapy. A clinical overview (1997)
Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy and protecting the brain from the harmfull cellular, and metabolic consequences...
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (1997)
Feuerstein, Giora Z., Fisher, Marc, Nunnari, John J., Ruffolo, Robert R.
The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel blocker, were investigated on aortic lipid deposition and the accumulation of...
Tatlisumak, Turgut, Takano, Kentaro, Carano, Richard A.D., Fisher, Marc
BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was performed to evaluate the effects of bFGF on infarct size when administered 30...
Hasegawa, Yasuhiro, Formato, James E., Latour, Lawrence L., Gutierrez, Jorge A., Liu, Kai-Feng, Garcia, Julio H., ...
BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary severe hypoglycemia on the apparent diffusion coefficient (ADC) acquired by diffusion-weighted MRI of brain...
Hematologic disorders associated with ischemic stroke (1996)
Tatlisumak, Turgut, Fisher, Marc
Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation abnormalities with ischemic stroke is not always clear. The etiology of stroke still...
Medical therapy for ischemic stroke (1996)
Silver, Brian, Weber, Johannes, Fisher, Marc
Therapy for stroke is undergoing major changes. Many of the changes parallel the advances made in the therapy for myocardial infarction. Acute intervention with cytoprotective and thrombolytic agents...
The role of spreading depression in focal ischemia evaluated by diffusion mapping (1996)
Takano, Kentaro, Latour, Lawrence L., Formato, James E., Carano, Richard A.D., Helmer, Karl G., Hasegawa, Yasuhiro, ...
This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution of focal ischemia in vivo. We induced focal ischemia in 12 rats using the middle cerebral artery...
Current Review of Cerebrovascular Disease (2nd ed.) (1996)
Fisher, Marc, Bogousslavsky, Julien
No abstract provided.
Acute and atypical presentations of syringomyelia (1996)
Anwer, Ursula E., Fisher, Marc
Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and syringobulbia demonstrates similar pathology in the brainstem. Both conditions typically present...
Acute stroke treatment trials in the United States. Rethinking strategies for success (1995)
Adams, Robert J., Fisher, Marc, Furlan, Anthony J., Del Zoppo, Gregory
In this editorial, we present some of the important issues facing those who design and implement acute stroke treatment studies. Our opinions pertain primarily to the medical environment in the...
Fisher, Marc, Meadows, Mary-Ellen, Do, Tuyen, Weise, Jens, Trubetskoy, Vladimir, Charette, Marc, ...
Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells (including neurons, glia, and endothelia) and protects neurons against a number of toxins and insults...
ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study (1995)
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (1995)
Hasegawa, Yasuhiro, Latour, Lawrence L., Formato, James E., Sotak, Christopher H., Fisher, Marc
Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion coefficient (ADC) of water in eight contiguous coronal slices,...
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (1995)
Reith, W., Hasegawa, Yasuhiro, Latour, Lawrence L., Dardzinski, Bernard J., Sotak, Christopher H., Fisher, Marc
Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset of ischemia. The use of a DWI echo-planar multislice technique in...
Potentially effective therapies for acute ischemic stroke (1995)
Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the basic pathophysiology has expanded, rational approaches to therapy have evolved. The frequent...
Cohen, Ronald A., Hasegawa, Yasuhiro, Fisher, Marc
We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia induced by permanent occlusion of the right middle cerebral artery in rats. A...
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (1994)
Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of an intracranial aneurysm. Advances have occurred in the areas of epidemiology,...
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (1994)
Hasegawa, Yasuhiro, Fisher, Marc, Latour, Lawrence L., Dardzinski, Bernard J., Sotak, Christopher H.
The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic insult is thought to reflect intracellular water accumulation (cytotoxic edema) related to...
Latour, Lawrence L., Hasegawa, Yasuhiro, Formato, James E., Fisher, Marc, Sotak, Christopher H.
A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading depression (SD) was elicited in rats by topical application of potassium chloride to the...
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (1994)
Hasegawa, Yasuhiro, Fisher, Marc, Baron, Bruce M., Metcalf, Geoffrey
BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective effect is demonstrable when the drug is administered beginning 30...
Prophylactic neuroprotection for cerebral ischemia (1994)
Fisher, Marc, Jonas, Saran, Sacco, Ralph L.
BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic brain injury has advanced. Treatment strategies under development are aimed at...
Hasegawa, Yasuhiro, Latour, Lawrence L., Sotak, Christopher H., Dardzinski, Bernard J., Fisher, Marc
To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in brain tissue, the ADC values of normal rat brain were measured over a range of body temperatures...
Minematsu, Kazuo, Fisher, Marc, Li, Limin, Sotak, Christopher H.
BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's...
Fisher, Marc, Plante, Gregory M., Doyle, Elizabeth M.
Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute and chronic central nervous system (CNS) disorders. The 21-aminosteroids are novel derivatives of...
Dardzinski, Bernard J., Sotak, Christopher H., Fisher, Marc, Hasegawa, Yasuhiro, Li, Lirnin, Minematsu, Kazuo
Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient (ADC) during experimental focal ischemia in the rat brain following permanent...
Evolving toward effective therapy for acute ischemic stroke (1993)
Fisher, Marc, Bogousslavsky, Julien
Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the pathophysiology of ischemic brain injury have led to the development of rational...
Hypermagnesemic pseudocoma (1993)
Rizzo, Marco A., Fisher, Marc, Lock, J. Paul
We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome. Hypermagnesemia (magnesium level, 9.85 mmol/L [24 mg/dL]) can cause parasympathetic...
Minematsu, Kazuo, Fisher, Marc, Li, L., Davis, Michael A., Knapp, A. G., Cotter, R. E., ...
We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first 3 hours after permanent occlusion of the middle cerebral artery in rats. Using DWI as early as 30...
Current Review of Cerebrovascular Disease (1993)
Fisher, Marc, Bogousslavsky, Julien
No abstract provided.
Nunnari, John J., Fisher, Marc, White, Stanley D. T.
We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of lipid in the aorta, (2) on the level of plasma lipids, and (3) on the number of adherent intimal monocytes...
Antithrombotic therapy for cerebrovascular disorders (1992)
Sherman, David G., Dyken, Mark L., Fisher, Marc, Gent, Michael, Harrison, Michael J. G., Hart, Robert G.
Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (1992)
Goodnight, Scott H., Cairns, John A., Fisher, Marc, FitzGerald, Garret A.
Minematsu, Kazuo, Li, Limin, Sotak, Christopher H., Davis, Michael A., Fisher, Marc
BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within minutes after the onset of ischemia. We performed the present...
New magnetic resonance techniques for evaluating cerebrovascular disease (1992)
Fisher, Marc, Sotak, Christopher H., Minematsu, Kazuo, Li, Limin
Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel MR technologies, now in preclinical and clinical development, will contribute to stroke...
Fisher, Marc, Arpano, Margaret M.
Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system (CNS) focal ischemia or trauma. Inhibiting oxygen free radicals has improved outcome in...
Minematsu, Kazuo, Li, L., Fisher, Marc, Sotak, Christopher H., Davis, Michael A., Fiandaca, M. S.
We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes to 3 hours after intraluminal suture occlusion of the middle cerebral artery (MCA) in eight...
Fisher, Marc, Levine, Peter H., Doyle, Elizabeth M., Arpano, Margaret M., Hoogasian, James J.
Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages and foam cell formation. Inhibiting LDL oxidation may impede these processes and offers a new...
Thrombosis in a congenitally bifurcated superior sagittal sinus (1991)
Hosley, Mark A., Fisher, Marc, Lingley, James F.
A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The initial thrombus was present only in the right channel of a congenitally bifurcated superior...
Ischemic cerebral vascular disease: an overview (1991)
The management of patients with cerebrovascular ischemic disease (ICD) is rapidly changing due to newer diagnostic approaches and therapies being developed. In the present article, the author reviews...
Fisher, Marc, Levine, Peter H., Doyle, Elizabeth M., Arpano, Margaret M., Bergeron, D. A., Cohen, Ronald A., ...
Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local tissue injury by generating an inflammatory response, mediated in part by the production of...
Atherosclerosis: cellular aspects and potential interventions (1991)
The pathogenesis of atherosclerosis has been extensively studied and the cellular aspects increasingly characterized. This review will focus on the basic pathology, presumed cellular events, cellular...
Fisher, Marc, Levine, Peter H., Cohen, Ronald A.
Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their ability to promote inflammation. A novel group of drugs, the 21-aminosteroids, have been observed...
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (1990)
Phillips, David A., Fisher, Marc, Davis, Michael A., Smith, Thomas W., Pang, Roy H.L.
Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are under way. We evaluated two fibrinolytic agents, an analogue of tissue plasminogen activator...
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (1990)
Kase, Carlos S., O'Neal, Angela M., Fisher, Marc, Girgis, Gigi N., Ordia, Joe I.
Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report the cases of six patients with intracranial hemorrhage after tPA treatment for acute...
Cardiogenic brain embolism and lupus anticoagulant (1989)
Young, Seymour M., Fisher, Marc, Sigsbee, Ann, Errichetti, Annmarie
The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been linked to the occurrence of cerebral ischemia presumably related to in situ...
Atherosclerosis: current concepts on pathogenesis and interventional therapies (1989)
Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus of epidemiological, basic, and clinical investigations. Since these studies have...
Amantadine treatment of fatigue associated with multiple sclerosis (1989)
Cohen, Ronald A., Fisher, Marc
Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment. A double-blind, controlled study of fatigue treatment was conducted to evaluate the efficacy of...
Levine, Peter H., Fisher, Marc, Schneider, Peter B., Whitten, Richard H., Weiner, Bonnie H., Ockene, Ira S., ...
Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence of atherothrombotic disorders. This effect may be mediated in part through suppression of in vivo...
Phillips, David A., Fisher, Marc, Smith, Thomas W., Davis, Michael A., Pang, Roy H.L.
Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be both angiographically and clinically effective when employed in animal stroke models....
Brain tumor presenting as an acute pure motor hemiparesis (1989)
Fisher, Marc, Recht, Lawrence D.
Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar infarction, although other etiologies have been described. We recently encountered three...
Antithrombotic therapy for cerebrovascular disorders (1989)
Sherman, David G., Dyken, Mark L., Fisher, Marc, Harrison, Michael J. G., Hart, Robert G.
Phillips, David A., Davis, Michael A., Fisher, Marc
We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and digital arteriography. The internal carotid arteries of 14 rabbits were catheterized selectively and...
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (1988)
Fisher, Marc, Kase, Carlos S., Stelle, Barbara, Mills, Roger M.
The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial, but stroke after pacemaker insertion has not been well studied. We observed 10 sick sinus...
Fisher, Marc, Levine, Peter H., Weiner, Bonnie H., Vaudreuil, Christine H., Natale, Anita M., Johnson, Mark H., ...
Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active multiple sclerosis demyelination and are assumed to be involved in the demyelinating...
Phillips, David A., Fisher, Marc, Smith, Thomas W., Davis, Michael A.
Thrombolysis with tissue plasminogen activator (tPA) has been used to treat myocardial infarction and pulmonary embolism in humans. This plasminogen activator may also be useful in treating certain...
Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (1988)
Fisher, Marc, Smith, Thomas W., Jacobs, Richard
Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with small infarctions in the contralateral internal capsule or basis pontis. Pure motor...
The importance of carotid artery plaque disruption and hemorrhage (1987)
Fisher, Marc, Blumenfeld, Andrew M., Smith, Thomas W.
The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains uncertain. Analysis of carotid endarterectomy surgical specimens from symptomatic...
Fisher, Marc, Johnson, Mark H., Natale, Anita M., Levine, Peter H.
We found a small but statistically significant reduction in the linoleic acid concentration of white blood cells and platelets in MS patients. The percent linoleic acid concentration (mean +/- S.D.)...
Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (1987)
Wytrzes, Lydia, Markley, Herbert G., Fisher, Marc, Alfred, Howard J.
Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic patients who developed pain, paresthesias, and weakness in the...
Fisher, Marc, Upchurch, Katherine S., Levine, Peter H., Johnson, Mark H., Vaudreuil, Christine H., Natale, Anita M., ...
Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of the pathophysiology of many human diseases. We assessed the effect of fish oil on PMNL...
Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (1986)
Weiner, Bonnie H., Ockene, Ira S., Levine, Peter H., Cuenoud, Henri F., Fisher, Marc, Johnson, Brian F., ...
We studied the effect of cod-liver oil on the development and progression of coronary artery disease in swine subjected to coronary balloon abrasion and fed an atherogenic diet for eight months....
The effect of vegetarian diets on plasma lipid and platelet levels (1986)
Fisher, Marc, Levine, Peter H., Weiner, Bonnie H., Ockene, Ira S., Johnson, Brian F., Johnson, Mark H., ...
Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This may be secondary to dietary effects of plasma lipids and lipoproteins, but platelets, which...
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (1986)
Przelomski, Monica M., Fisher, Marc, Davidson, Robin I., Jones, H. Royden, Marcus, Elliott M.
Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from an unruptured intracranial aneurysm. Follow-up data in 12 such patients revealed no ischemic strokes,...
Tissue plasminogen activator reduces neurological damage after cerebral embolism (1985)
Zivin, Justin A., Fisher, Marc, DeGirolami, Umberto, Hemenway, Carl C., Stashak, Joan A.
Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots into the carotid circulation in rabbit embolic stroke model animals caused a...
Russell, James, Fisher, Marc, Zivin, Justin A., Sullivan, John L., Drachman, David A.
Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus (EBV) encephalopathy. Clinical findings of infectious mononucleosis were absent and...
Selective thromboxane inhibition: a new approach to antiplatelet therapy (1984)
Fisher, Marc, Weiner, Bonnie H., Ockene, Ira S., Hoogasian, James S., Natale, Anita M., Arsenault, John R., ...
Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the formation of both the potent platelet aggregator, thromboxane A2 and the potent...
Hand muscle atrophy in multiple sclerosis (1983)
Fisher, Marc, Long, Randall R., Drachman, David A.
The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically has been ascribed to disease involving the motor unit. Nine patients with MS in a single...
Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (1983)
Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease (ICVD) is an apparent complication of MVP. We report the concordance of MVP...
Neurologic complications in patients with Hereditary Hemorrhagic Telangiectasia (HHT) occur as a consequence of a variety of vascular malformations. One type of intracranial malformation, saccular...
Platelet activation and mitral valve prolapse (1983)
Fisher, Marc, Weiner, Bonnie H., Ockene, Ira S., Forsberg, Ann D., Duffy, Celeste P., Levine, Peter H.
Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults. Cerebral embolization of intracardiac thrombi is the probable mechanism in many cases....
Marker proteins of platelet activation in patients with cerebrovascular disease (1982)
Fisher, Marc, Levine, Peter H., Fullerton, Albert L., Forsberg, Ann D., Duffy, Celeste P., Hoogasian, James J., ...
Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks (TIAs). Determination of this activity can now be measured by assaying the platelet-specific...
Intramedullary spinal cord metastasis (1981)
Sebastian, Peter R., Fisher, Marc, Smith, Thomas W., Davidson, Robin I.
Intramedullary spinal cord metastases are rarely the presenting manifestation of a previously undiagnosed neoplasms. We report such a case in which a subacutely progressive motor and sensory spinal...
Levine, Peter H., Fisher, Marc, Fullerton, Albert L., Duffy, Celeste P., Hoogasian, James J.
Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and the cells of recently outdated platelet concentrates. Following purification by affinity...
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (1981)
Fisher, Marc, McQuillen, James B.
Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary lesion. A patient had these signs, but at autopsy, bilateral cortical border-zone infarcts and...
Fisher, Marc, Davidson, Robin I., Marcus, Elliott M.
Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral aneurysms. This study presents seven patients with TIA who had aneurysms in a...
Familial inverted choreoathetosis (1979)
Fisher, Marc, Sargent, Jane, Drachman, David A.
We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs predominantly and also impaired gait. No dementia, seizures, or rigidity was noted....
Holter monitoring in patients with transient focal cerebral ischemia (1978)
The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is well established, but its value in transient focal neurological deficits is less...
Roman, Gustavo, Fisher, Marc, Perl, Daniel P., Poser, Charles M.
Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had multiple vascular malformations including telangiectasias of the brain, medulla,...
Syphilitic meningomyelitis. A case report (1977)
Fisher, Marc, Poser, Charles M.
A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a previous syphilitic infection, but spinal fluid examination disclosed a lymphocytic...