Genetics of gene expression and its effect on disease (2008)
Emilsson, Valur, Thorleifsson, Gudmar, Zhang, Bin, Leonardson, Amy S, Zink, Florian, Zhu, Jun, ...
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Life without white fat: a transgenic mouse (1998)
Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...
Torpor in mice is induced by both leptin-dependent and -independent mechanisms
Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...
We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...
Peters, Jeffrey M., Lee, Susanna S. T., Li, Wen, Ward, Jerrold M., Gavrilova, Oksana, Everett, Carrie, ...
To determine the physiological roles of peroxisome proliferator-activated receptor β (PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of the murine PPARβ...
Matsusue, Kimihiko, Haluzik, Martin, Lambert, Gilles, Yim, Sun-Hee, Gavrilova, Oksana, Ward, Jerrold M., ...
To elucidate the function of PPARγ in leptin-deficient mouse (ob/ob) liver, a PPARγ liver-null mouse on an ob/ob background, ob/ob-PPARγ(fl/fl)AlbCre+, was produced using a floxed PPARγ allele,...
Yu, Shuhua, Gavrilova, Oksana, Chen, Hui, Lee, Randy, Liu, Jie, Pacak, Karel, ...
Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein α subunit (Gsα), leads to distinct phenotypes depending on whether the maternal (m–/+) or paternal (+/p–) allele is...
Life without white fat: a transgenic mouse
Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...
We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...
In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...
Chao, Lily, Marcus-Samuels, Bernice, Mason, Mark M., Moitra, Jaideep, Vinson, Charles, Arioglu, Elif, ...
There is uncertainty about the site(s) of action of the antidiabetic thiazolidinediones (TZDs). These drugs are agonist ligands of the transcription factor PPARγ, which is abundant in adipose tissue...
Torpor in mice is induced by both leptin-dependent and -independent mechanisms
Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...
We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...
Peters, Jeffrey M., Lee, Susanna S. T., Li, Wen, Ward, Jerrold M., Gavrilova, Oksana, Everett, Carrie, ...
To determine the physiological roles of peroxisome proliferator-activated receptor β (PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of the murine PPARβ...
Matsusue, Kimihiko, Haluzik, Martin, Lambert, Gilles, Yim, Sun-Hee, Gavrilova, Oksana, Ward, Jerrold M., ...
To elucidate the function of PPARγ in leptin-deficient mouse (ob/ob) liver, a PPARγ liver-null mouse on an ob/ob background, ob/ob-PPARγ(fl/fl)AlbCre+, was produced using a floxed PPARγ allele,...
Yu, Shuhua, Gavrilova, Oksana, Chen, Hui, Lee, Randy, Liu, Jie, Pacak, Karel, ...
Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein α subunit (Gsα), leads to distinct phenotypes depending on whether the maternal (m–/+) or paternal (+/p–) allele is...
Life without white fat: a transgenic mouse
Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...
We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...
In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...
Chao, Lily, Marcus-Samuels, Bernice, Mason, Mark M., Moitra, Jaideep, Vinson, Charles, Arioglu, Elif, ...
There is uncertainty about the site(s) of action of the antidiabetic thiazolidinediones (TZDs). These drugs are agonist ligands of the transcription factor PPARγ, which is abundant in adipose tissue...
Pharmacogenetics of metformin response: a step in the path toward personalized medicine
Reitman, Marc L., Schadt, Eric E.
Type 2 diabetes mellitus affects 9.6% of the adults in the United States and more than 200 million people worldwide. Diabetes can be a devastating disease, but it can now be treated with nine classes...