Marc Lecuit

Multidisciplinary Prospective Study of Mother-to-Child Chikungunya Virus Infections on the Island of La Réunion (2008)

Patrick Gérardin, Georges Barau, Alain Michault, Marc Bintner, Hanitra Randrianaivo, Ghassan Choker, ...

BackgroundAn outbreak of chikungunya virus affected over one-third of the population of La Réunion Island between March 2005 and December 2006. In June 2005, we identified the first case of...

A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease (2008)

Thérèse Couderc, Fabrice Chrétien, Clémentine Schilte, Olivier Disson, Madly Brigitte, Florence Guivel-Benhassine, ...

Chikungunya virus (CHIKV) is a re-emerging arbovirus responsible for a massive outbreak currently afflicting the Indian Ocean region and India. Infection from CHIKV typically induces a mild disease...

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. (2007)

Boneca, Ivo G, Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...

Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. (2007)

Boneca, Ivo G, Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...

Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. (2007)

Boneca, Ivo G, Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...

Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....

ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion. (2005)

Sousa, Sandra, Cabanes, Didier, Archambaud, Cristel, Colland, Frédéric, Lemichez, Emmanuel, Popoff, Michel, ...

E-cadherin mediates the formation of adherens junctions between epithelial cells. It serves as a receptor for Listeria monocytogenes, a bacterial pathogen that enters epithelial cells. The L....

A role for α- and β-catenins in bacterial uptake

Lecuit, Marc, Hurme, Reini, Pizarro-Cerdá, Javier, Ohayon, Hélène, Geiger, Benjamin, Cossart, Pascale

Interaction of internalin with E-cadherin promotes entry of Listeria monocytogenes into human epithelial cells. This process requires actin cytoskeleton rearrangements. Here we show, by using a...

Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin–catenins complex

Küssel-Andermann, Polonca, El-Amraoui, Aziz, Safieddine, Saaid, Nouaille, Sylvie, Perfettini, Isabelle, Lecuit, Marc, ...

Defects in myosin VIIA are responsible for deafness in the human and mouse. The role of this unconventional myosin in the sensory hair cells of the inner ear is not yet understood. Here we show that...

Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: Role of internalin interaction with trophoblast E-cadherin

Lecuit, Marc, Nelson, D. Michael, Smith, Steve D., Khun, Huot, Huerre, Michel, Vacher-Lavenu, Marie-Cécile, ...

Listeria monocytogenes produces severe fetoplacental infections in humans. How it targets and crosses the maternofetal barrier is unknown. We used immunohistochemistry to examine the location of L....

Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein

Cabanes, Didier, Sousa, Sandra, Cebriá, Antonio, Lecuit, Marc, Cossart, Pascale

By comparative genomics, we have identified a gene of the intracellular pathogen Listeria monocytogenes that encodes an LPXTG surface protein absent from nonpathogenic Listeria species. This gene,...

LPXTG Protein InlJ, a Newly Identified Internalin Involved in Listeria monocytogenes Virulence

Sabet, Christophe, Lecuit, Marc, Cabanes, Didier, Cossart, Pascale, Bierne, Hélène

Listeria monocytogenes expresses surface proteins covalently anchored to the peptidoglycan by sortase enzymes. Inactivation of srtA attenuates Listeria virulence in mice (H. Bierne, S. K. Mazmanian,...

A role for α- and β-catenins in bacterial uptake

Lecuit, Marc, Hurme, Reini, Pizarro-Cerdá, Javier, Ohayon, Hélène, Geiger, Benjamin, Cossart, Pascale

Interaction of internalin with E-cadherin promotes entry of Listeria monocytogenes into human epithelial cells. This process requires actin cytoskeleton rearrangements. Here we show, by using a...

Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin–catenins complex

Küssel-Andermann, Polonca, El-Amraoui, Aziz, Safieddine, Saaid, Nouaille, Sylvie, Perfettini, Isabelle, Lecuit, Marc, ...

Defects in myosin VIIA are responsible for deafness in the human and mouse. The role of this unconventional myosin in the sensory hair cells of the inner ear is not yet understood. Here we show that...

Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: Role of internalin interaction with trophoblast E-cadherin

Lecuit, Marc, Nelson, D. Michael, Smith, Steve D., Khun, Huot, Huerre, Michel, Vacher-Lavenu, Marie-Cécile, ...

Listeria monocytogenes produces severe fetoplacental infections in humans. How it targets and crosses the maternofetal barrier is unknown. We used immunohistochemistry to examine the location of L....

Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein

Cabanes, Didier, Sousa, Sandra, Cebriá, Antonio, Lecuit, Marc, Cossart, Pascale

By comparative genomics, we have identified a gene of the intracellular pathogen Listeria monocytogenes that encodes an LPXTG surface protein absent from nonpathogenic Listeria species. This gene,...

LPXTG Protein InlJ, a Newly Identified Internalin Involved in Listeria monocytogenes Virulence

Sabet, Christophe, Lecuit, Marc, Cabanes, Didier, Cossart, Pascale, Bierne, Hélène

Listeria monocytogenes expresses surface proteins covalently anchored to the peptidoglycan by sortase enzymes. Inactivation of srtA attenuates Listeria virulence in mice (H. Bierne, S. K. Mazmanian,...

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

Boneca, Ivo G., Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...

Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....

Multidisciplinary Prospective Study of Mother-to-Child Chikungunya Virus Infections on the Island of La Réunion

Gérardin, Patrick, Barau, Georges, Michault, Alain, Bintner, Marc, Randrianaivo, Hanitra, Choker, Ghassan, ...

In a prospective study on the island of La Réunion, Marc Lecuit and colleagues find frequent transmission of Chikungunya virus by viremic mothers giving birth during an outbreak, resulting in...

A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

Couderc, Thérèse, Chrétien, Fabrice, Schilte, Clémentine, Disson, Olivier, Brigitte, Madly, Guivel-Benhassine, Florence, ...

Chikungunya virus (CHIKV) is a re-emerging arbovirus responsible for a massive outbreak currently afflicting the Indian Ocean region and India. Infection from CHIKV typically induces a mild disease...

The Listeria monocytogenes Virulence Factor InlJ Is Specifically Expressed In Vivo and Behaves as an Adhesin▿

Sabet, Christophe, Toledo-Arana, Alejandro, Personnic, Nicolas, Lecuit, Marc, Dubrac, Sarah, Poupel, Olivier, ...

The food-borne pathogen Listeria monocytogenes is adapted to a diversity of environments, such as soil, food, body fluids, and the cytosol of eukaryotic cells. The transition between saprophytic and...

A New Perspective on Listeria monocytogenes Evolution

Ragon, Marie, Wirth, Thierry, Hollandt, Florian, Lavenir, Rachel, Lecuit, Marc, Le Monnier, Alban, ...

Listeria monocytogenes is a model organism for cellular microbiology and host–pathogen interaction studies and an important food-borne pathogen widespread in the environment, thus representing an...

Antifungal Therapy of Aspergillus Invasive Otitis Externa: Efficacy of Voriconazole and Review▿

Parize, Perrine, Chandesris, Marie-Olivia, Lanternier, Fanny, Poirée, Sylvain, Viard, Jean-Paul, Bienvenu, Boris, ...

Invasive otitis externa (IOE) due to Aspergillus is a rare, potentially life-threatening, invasive fungal infection affecting immunocompromised patients. The invasive process may lead to skull base...

Listeria monocytogenes Internalin and E-cadherin: From Bench to Bedside

Bonazzi, Matteo, Lecuit, Marc, Cossart, Pascale

Listeria monocytogenes is a Gram-positive bacterium responsible for a severe infection associated with different clinical features (gastroenteritis, meningoencephalitis, and abortion in pregnant...