Derudder, Emmanuel, Cadera, Emily J., Val, J. Christoph, Wang, Jing, Fox, Casey J., Zha, Shan, ...
By genetically ablating I kappa B kinase (IKK)-mediated activation of the transcription factor NF-kappa B in the B cell lineage and by analyzing a mouse mutant in which immunoglobulin...
Yin Yang 1 is a critical regulator of B-cell development (2007)
Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, ...
The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the...
Nenci, Arianna, Huth, Marion, Funteh, Alfred, Schmidt-Supprian, Marc, Bloch, Wilhelm, Metzger, Daniel, ...
NF-κB essential modulator (NEMO), the regulatory subunit of the IκB kinase, is essential for NF-κB activation. Mutations disrupting the X-linked NEMO gene cause incontinentia pigmenti (IP), a...
Nenci, Arianna, Huth, Marion, Funteh, Alfred, Schmidt-Supprian, Marc, Bloch, Wilhelm, Metzger, Daniel, ...
NF-κB Essential Modulator (NEMO), the regulatory subunit of the IκB kinase, is essential for NF-κB activation. Mutations disrupting the X-linked NEMO gene cause incontinentia pigmenti (IP), a...
Analysis of the Function of NF- kappaB Activation in vivo (2003)
Ziel dieser Arbeit war es, die Funktion der Aktivierung der Transkriptionsfaktor- Familie NF-kB durch den IkB-Kinase Komplex (IKK) im Immunsystem der Maus zu untersuchen. Zu diesem Zweck wurde ein...
Analysis of the function of NF-kB [NF-kappaB] activation in vivo / (2002)
Köln, Univ., Diss., 2003 (Nicht für den Austausch).
Analysis of the function of NF-kB [NF-kappaB] activation in vivo [Elektronische Ressource] / (2002)
Köln, Univ., Diss., 2003.
Schmidt-Supprian, Marc, Tian, Jane, Grant, Ethan P., Pasparakis, Manolis, Maehr, René, Ovaa, Huib, ...
Natural killer-like (NK) T, regulatory T (TR), and memory type T cells display surface phenotypes reminiscent of activated T cells. Previously, we reported that the generation of TR cells and, to a...
Schmidt-Supprian, Marc, Tian, Jane, Grant, Ethan P., Pasparakis, Manolis, Maehr, René, Ovaa, Huib, ...
Natural killer-like (NK) T, regulatory T (TR), and memory type T cells display surface phenotypes reminiscent of activated T cells. Previously, we reported that the generation of TR cells and, to a...
Yin Yang 1 is a critical regulator of B-cell development
Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, ...
The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the...
IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells
Pasparakis, Manolis, Schmidt-Supprian, Marc, Rajewsky, Klaus
Nuclear factor (NF)-κB proteins play crucial roles in immune responses and cellular survival. Activation of NF-κB is mediated by the IκB kinase (IKK) complex, which is composed of two kinases,...
Wunderlich, F. Thomas, Luedde, Tom, Singer, Stephan, Schmidt-Supprian, Marc, Baumgartl, Julia, Schirmacher, Peter, ...
Development of obesity-associated insulin resistance and diabetes mellitus type 2 has been linked to activation of proinflammatory pathways in the liver, leading to impaired insulin signal...
Sasaki, Yoshiteru, Calado, Dinis P., Derudder, Emmanuel, Zhang, Baochun, Shimizu, Yuri, Mackay, Fabienne, ...
BAFF-R-dependent activation of the alternative NF-κB pathway plays an essential role in mature B cell survival. Mutations leading to overexpression of NIK and deletion of the TRAF3 gene are...
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells
Otipoby, Kevin L., Sasaki, Yoshiteru, Schmidt-Supprian, Marc, Patke, Alina, Gareus, Ralph, Pasparakis, Manolis, ...
B cell activating factor (BAFF) signals through BAFF-R to promote mature B cell survival. Recent analyses of BAFF-induced signaling revealed direct association between augmented B cell metabolic...