Volbracht, Christiane, Penzkofer, Stephan, Mansson, David, Vielsted Christensen, Kenneth, Fog, Karina, Schildknecht, Stefan, ...
Amyloid-β peptide (Aβ), a putatively causative agent of Alzheimers disease (AD), is proteolytically derived from β-amyloid precursor protein (APP). Here we describe cellular assays...
Kirkeby, Agnete, Torup, Lars, Bochsen, Louise, Kjalke, Marianne, Abel, Kristin, Theilgaard-Monch, Kim, ...
The haematopoietic hormone erythropoietin (EPO) has neuroprotective properties and is currently being explored for treatment of stroke and other neurological disorders. Short-term, high-dose...
The dawning of a new age of toxicology (2008)
Leist, Marcel, Hartung, Thomas, Nicotera, Pierluigi
Toxicology faces enormous challenges in a world in which we are exposed to thousands of chemicals and millions of mixtures thereof. Radically new approaches to this problem need to be developed. A...
Vor- und Nachdenkliches ... zum wahren Erfolg des 3R-Prinzips (2008)
Leist, Marcel, Kadereit, Suzanne, Schildknecht, Stefan
Ist es möglich, den "Wert" einer wissenschaftlichen Disziplin zu bemessen? Wie kann diese Disziplin dann in einem Gesamtrahmen eingeordnet werden, und nicht zuletzt, ist eine solche Überlegung...
Leist, Marcel, Bremer, Susanne, Brundin, Patrik, Hescheler, Jürgen, Kirkeby, Agnete, Krause, Karl-Heinz, ...
Human embryonic stem cells (hESC) are now routinely cultured in many laboratories, and differentiation protocols are available to generate a large variety of cell types. In an ongoing ethical debate...
Food for Thought ... on the Real Success of 3R Approches (2008)
Leist, Marcel, Kadereit, Suzanne, Schildknecht, Stefan
Can the value of a scientific discipline be gauged? Where does the discipline stand? Is such a consideration important at all? Some may have doubts about the usefulness of asking such questions. Some...
Vor- und Nachdenkliches ... zur Evolution der Toxikologie und dem Ausstieg aus Tierversuchen (2008)
Hartung, Thomas, Leist, Marcel
Auf dem Gebiet der Toxikologie tut sich etwas: Die Vision und Strategie der US National Academy of Sciences (NRC, 2007) aus dem letzten Jahr hat viele Toxikologen auf beiden Seiten des Atlantiks...
Food for thought on the evolution of toxicology and the phasing out of animal testing (2008)
Hartung, Thomas, Leist, Marcel
There is something brewing in the field of toxicology: Last year's vision and strategy document published by the US National Academy of Sciences (NRC, 2007) has excited many toxicologists on both...
Vergo, Sandra, Johansen, Jens Leander, Leist, Marcel, Lotharius, Julie
An abnormal accumulation of cytosolic dopamine resulting in reactive oxygen species and dopaminequinone productsmay play an important role in the rather selective degeneration of substantia nigra...
Kirkeby, Agnete, Beek, Johan Van, Nielsen, Jacob, Leist, Marcel, Helboe, Lone
Since it was discovered that the hematopoietic hormone erythropoetin (EPO) exerts neuroprotective effects in the CNS, many studies on the EPO receptor (EPOR) function and localisation in the CNS have...
Villa, Pia, Beek, Johan Van, Larsen, Anna Kirstine, Gerwien, Jens, Christensen, Søren, Cerami, Anthony, ...
Carbamylerythropoietin (CEPO) does not bind to the classical erythropoietin (EPO) receptor. Nevertheless, similarly to EPO, CEPO promotes neuroprotection on the histologic level in short-term stroke...
Pathological apoptosis in the developing brain (2007)
Blomgren, Klas, Leist, Marcel, Groc, Laurent
More than half of the initially-formed neurons are deleted in certain brain regions during normal development. This process, whereby cells are discretely removed without interfering with the further...
Volbracht, Christiane, Beek, Johan Van, Zhu, Changlian, Blomgren, Klas, Leist, Marcel
The pathogenesis of stroke, trauma and chronic degenerative diseases, such as Alzheimers disease (AD), has been linked to excitotoxic processes due to inappropriate stimulation of the...
Increased erythropoietin production after myocardial infarction in mice (2006)
Mengozzi, M., Latini, Renato, Salio, M., Sfacteria, Alessandra, Piedimonte, G., Gammeltoft Gerwien, Jens, ...
In addition to its role as the main regulator of erythropoiesis, erythropoietin has a wide range of protective, antiapoptotic activities in vitro and in vivo, particularly in the brain and, as more...
Mennini, Tiziana, Paola, Massimiliano De, Bigini, Paolo, Mastrotto, Cristina, Fumagalli, Elena, Barbera, Sara, ...
Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the...
Montero, Maria, Rom Poulsen, Frantz, Noraberg, Jens, Kirkeby, Agnete, Beek, Johan Van, Leist, Marcel, ...
In addition to its well-known hematopoietic effects, erythropoietin (EPO) also has neuroprotective properties. However, hematopoietic side effects are unwanted for neuroprotection, underlining the...
A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption (2006)
Müller, Georg Johannes, Geist, Marie Aavang, Veng, Lone Merete, Willesen, Mette Georgi, Johansen, Flemming Fryd, Leist, Marcel, ...
Microtubule disruption by colchicine induces apoptosis in selected neuronal populations. However, little is known about the upstream death signalling events mediating the neurotoxicity. We...
Lund, Søren, Vielsted Christensen, Kenneth, Hedtjärn, Maj, Mortensen, Anne-Louise, Hagberg, Henrik, Falsig, Jeppe, ...
Overall, the inflammatory potential of lipopolysaccharide (LPS) in vitro and in vivo was investigated using different omics technologies. We investigated the hippocampal response to...
Falsig, Jeppe, Pörzgen, Peter, Lund, Søren, Schrattenholz, André, Leist, Marcel
Upon injury, astrocytes assume an activated state associated with the release of inflammatory mediators. To model this, we stimulated murine primary astrocytes with a complete inflammatory cytokine...
Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection (2006)
Erythropoietin is well known to possess erythropoietic activity, but also tissue protection. Here, we present examples on how to separate these two activities. One possibility is to generate a...
Lotharius, Julie, Falsig, Jeppe, Beek, Johan Van, Payne, Sarah, Dringen, Ralf, Brundin, Patrik, ...
Models of Parkinson's disease (PD) based on selective neuronal death have been used to study pathogenic mechanisms underlying nigral cell death and in some instances to develop symptomatic therapies....
Berliocchi, Laura, Fava, Eugenio, Leist, Marcel, Horvat, Volker, Dinsdale, David, Read, David, ...
Clostridial neurotoxins are bacterial endopeptidases that cleave the major SNARE proteins in peripheral motorneurons. Here, we show that disruption of synaptic architecture by botulinum neurotoxin C1...
Inhibition of microglial inflammation by the MLK inhibitor CEP-1347 (2005)
Lund, Søren, Porzgen, Peter, Mortensen, Anna-Louise, Hasseldam, Henrik, Bozyczko-Coyne, Donna, Morath, Siegfried, ...
CEP-1347 is a potent inhibitor of the mixed lineage kinases (MLKs), a distinct family of mitogen-activated protein kinase kinase kinases (MAPKKK). It blocks the activation of the c-Jun/JNK apoptotic...
Asialoerythropoetin is not effective in the R6/2 line of Huntington's disease mice (2004)
Gil, Joana MAC, Leist, Marcel, Popovic, Natalija, Brundin, Patrik, Petersén, Åsa
Abstract Background Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. Both excitotoxicity and oxidative stress have been proposed...
Wang, Xiaoyang, Zhu, Changlian, Wang, Xinhua, Gerwien, Jens Gammeltoft, Schrattenholz, Andre, Sandberg, Mats, ...
Recently, erythropoietin (EPO) and the nonerythropoietic derivative asialoEPO have been linked to tissue protection in the nervous system. In this study, we tested their effects in a model of...
Asialoerythropoetin is not effective in the R6/2 line of Huntington's disease mice (2004)
Gil, Joana MAC, Leist, Marcel, Popovic, Natalija, Brundin, Patrik, Petersén, Åsa
Background: Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. Both excitotoxicity and oxidative stress have been proposed to play...
Falsig, Jeppe, Hofman Christiansen, Søren, Feuerhahn, Sascha, Bürkle, Alexander, Li Oei, Shiao, Keil, Claudia, ...
Poly(ADP-ribose) glycohydrolase (PARG) is being considered as a therapeutic target for the prevention of neurodegeneration. Here, we assessed the pharmacological tools available for target...
Lysosomes in cell death (2004)
Guicciardi, Maria Eugenia, Leist, Marcel, Gores, Gregory J.
For many years apoptosis research has focused on caspases and their putative role as sole executioners of programmed cell death. Accumulating information now suggests that lysosomal cathepsins are...
Modification of apoptosis-related genes and CD95 signaling in cytokine-treated astrocytes (2004)
Falsig, Jeppe, Pörzgen, Peter, Leist, Marcel
Inflammatory activation of astrocytes with a complete cytokine mix consisting of tumor necrosis factor, interleukin-1 and interferon-gamma renders these otherwise resistant cells highly susceptible...
Falsig, Jeppe, Latta, Markus, Leist, Marcel
A complete cytokine mix (CCM) or its individual components tumour necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ) were used to switch resting...
Falsig, Jeppe, Pörzgen, Peter, Lotharius, Julie, Leist, Marcel
Inflammatory conversion of murine astrocytes correlates with the activation of various MAPK, and inhibition of terminal MAPKs like JNK or p38 dampens the inflammatory reaction. Mixed lineage kinases...
Sensitization to the Lysosomal Cell Death Pathway upon Immortalization and Transformation (2004)
Fehrenbacher, Nicole, Gyrd-Hansen, Mads, Poulsen, Birgit, Felbor, Ute, Kallunki, Tuula, Boes, Marianne, ...
Tumorigenesis is associated with several changes that alter the cellular susceptibility to programmed cell death. Here, we show that immortalization and transformation sensitize cells in particular...
Hansson, Oskar, Nylandsted, Jesper, Castilho, Roger F, Leist, Marcel, Jäättelä, Marja, Brundin, Patrik
Abstract is not available
Erbayraktar, Serhat, Grasso, Giovanni, Sfacteria, Alessandra, Xie, Qiao-Wen, Coleman, Thomas, Kreilgaard, Mads, ...
Erythropoietin (EPO) is a tissue-protective cytokine preventing vascular spasm, apoptosis, and inflammatory responses. Although best known for its role in hematopoietic lineages, EPO also affects...
Hansson, Oskar, Nylandsted, Jesper, Castilho, Roger F., Leist, Marcel, Jäätela, Marja, Brundin, Patrik
Huntingtons disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine tract in a protein called huntingtin. The inducible form of heat shock protein 70 (Hsp70) has been...
Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells (2003)
In pathological situations, different modes of cell death are observed, and information on the role and uptake of nonapoptotic corpses is scarce. Here, we modeled two distinct forms of death in human...
Caspase-independent cell death (2002)
Leist, Marcel, Jäättelä, Marja
Caspase-mediated apoptosis is the death program of choice in many developmental and physiologic settings. It would, however, be very dangerous for the organism to depend on a single protease family...
Lehner, Martin D., Schwoebel, Frank, Kotlyarov, Alexey, Leist, Marcel, Gaestel, Matthias, Hartung, Thomas
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) is one of several kinases activated through direct phosphorylation by p38 mitogen-activated protein kinase. MK2 regulates LPS-induced...
Burning up TNF toxicity for cancer therapy (2002)
Leist, Marcel, Jäättelä, Marja
The tumor-killing capacity and the systemic toxicity of the cytokine tumor necrosis factor (TNF) have appeared inseparable. Now a study shows that TNF loses its toxicity but still kills tumors in...
Eradication of Glioblastoma, and Breast and Colon Carcinoma Xenografts by Hsp70 Depletion (2002)
Nylandsted, Jesper, Wick, Wolfgang, Hirt, Ulrich A., Brand, Karsten, Rohde, Mikkel, Leist, Marcel, ...
Heat shock protein 70 (Hsp70) is an antiapoptotic chaperone protein highly expressed in human tumors. Here we demonstrate that locoregional application of adenovirus expressing antisense Hsp70 cDNA...
Calpain inhibitors prevent nitric oxidetriggered excitotoxic apoptosis (2001)
Volbracht, Christiane, Fava, Eugenio, Leist, Marcel, Nicotera, Pierluigi
The pathogenesis of some neurodegenerative disorders has been linked to excitotoxicity, excess generation of nitric oxide (NO) and apoptosis. Here, we used a model of NO-triggered neuronal apoptosis...
Apoptosis in Caspase-inhibited Neurons (2001)
Volbracht, Christiane, Leist, Marcel, Kolb, Stefan A., Nicotera, Pierluigi
Background: There is growing evidence of apoptosis in neurodegenerative disease. However, it is still unclear whether the pathological manifestations observed in slow neurodegenerative diseases are...
Foghsgaard, Lasse, Wissing, Dorte, Mauch, Daniel, Boes, Marianne, Elling, Folmer, Leist, Marcel, ...
Death receptors can trigger cell demise dependent or independent of caspases. In WEHI-S fibrosarcoma cells, tumor necrosis factor (TNF) induced an increase in cytosolic cathepsin B activity followed...
Castro-Palomino, Julio C., Simon, Bernadett, Speer, Oliver, Leist, Marcel, Schmidt, Richard R.
2,3-Dehydroneuraminic acid derivative 5 was transformed in five efficient steps into sialyl donor 2, which has a phenylthio group on the b-side of the 3-position for anchimeric assistance and a...
Härter, Luc, Keel, Marius, Hentze, Hannes, Leist, Marcel, Ertel, Wolfgang
Loss of neurons after traumatic brain injury (TBI) might involve dysregulated apoptosis. Activation of caspase-3 is one hallmark of apoptosis. Therefore, caspase-3 activity (cleavage of DEVD-afc) was...
Latta, Markus, Künstle, Gerald, Leist, Marcel, Wendel, Albrecht
Hepatocyte apoptosis is crucial in several forms of liver disease. Here, we examined in different models of murine liver injury whether and how metabolically induced alterations of hepatocyte ATP...
Suter, Marianne, Remé, Charlotte, Grimm, Christian, Wenzel, Andreas, Jäättela, Marja, Esser, Peter, ...
1020% of individuals over the age of 65 suffer from agerelated macular degeneration (AMD), the leading cause of severe visual impairment in humans living in developed countries. The pathogenesis of...
Energy Requirement for Caspase Activation and Neuronal Cell Death (2000)
Nicotera, Pierluigi, Leist, Marcel, Fava, Eugenio, Berliocchi, Laura, Volbracht, Christiane
Recent work has shown that execution of the apoptotic program involves a relatively limited number of pathways. According to a general view, these would converge to activate the caspase family of...
Phagocytosis of Nonapoptotic Cells Dying by Caspase-Independent Mechanisms (2000)
Hirt, Ulrich, Gantner, Florian, Leist, Marcel
Caspase activation, exposure of phosphatidylserine (PS) on the outer surface of the plasma membrane, and rapid phagocytic removal of dying cells are key features of apoptosis. Nonapoptotic/necrotic...
ATP Controls Neuronal Apoptosis Triggered by Microtubule Breakdown or Potassium (1999)
Volbracht, Christiane, Leist, Marcel, Nicotera, Pierluigi
Background: Early loss of neurites followed by delayed damage of neuronal somata is a feature of several neurodegenerative diseases. Death by apoptosis would ensure the rapid removal of injured...
Leist, Marcel, Ullrich, Volker, Zou, Ming-Hui
Prostacyclin synthase (PCS) is an enzyme with antithrombotic, antiproliferative, and dilatory functions in the normal vasculature, and inactivation of PCS by tyrosine nitration may favor...
Guerini, Danilo, García-Martin, Elena, Gerber, Andreas, Volbracht, Christiane, Leist, Marcel, Gutiérrez Merino, Carlos, ...
Plasma membrane Ca²+ ATPase (PMCA) pump isoforms 2, 3, and 1CII are expressed in large amounts in the cerebellum of adult rats but only minimally in neonatal cerebellum. These isoforms were almost...
Leist, Marcel, Single, Barbara, Naumann, Heike, Fava, Eugenio, Simon, Bernadett, Kühnle, Simone
The endogenous mediator nitric oxide (NO) blocked apoptosis of Jurkat cells elicited by staurosporine, anti-CD95 or chemotherapeutics, and switched death to necrosis. The switch in the mode of cell...
Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik
Huntingtons disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...
Tributyltin-Induced Apoptosis Requires Glycolytic Adenosine Trisphosphate Production (1999)
Stridh, Hélène, Fava, Eugenio, Single, Barbara, Nicotera, Pierluigi, Orrenius, Sten, Leist, Marcel
The toxicity of tributyltin chloride (TBT) involves Ca2+ overload, cytoskeletal damage, and mitochondrial failure leading to cell death by apoptosis or necrosis. Here, we examined whether the...
Leist, Marcel, Volbracht, Christiane, Fava, Eugenio, Nicotera, Pierluigi
The pathogenesis of several neurodegenerative diseases may involve indirect excitotoxic mechanisms, where glutamate receptor overstimulation is a secondary consequence of initial functional defects...
Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice (1998)
Steinbach, Joachim P., Müller, Ulrike, Leist, Marcel, Li, Zhi-Wei, Nicotera, Pierluigi, Aguzzi, Adriano
Secreted forms of the β-amyloid precursor protein (β-APP) have neuroprotective properties in vitro and may be involved in the containment of neuronal excitation. To test whether loss of...
Simultaneous release of adenylate kinase and cytochrome c in cell death (1998)
Single, Barbara, Leist, Marcel, Nicotera, Pierluigi
Cytochrome c (Cyt c) is located within the mitochondrial intermembrane space, and it is an essential constituent of the respiratory chain. The translocation of Cyt c from mitochondria to the cytosol...
Leist, Marcel, Kühnle, Simone, Single, Barbara, Nicotera, Pierluigi
Apoptosis and necrosis are two forms of cell death that have been defined on the basis of distinguishable morphological criteria. However, these different types of cell death may involve several...
Cytokine-Mediated Hepatic Apoptosis (1998)
Leist, Marcel, Gantner, Florian, Künstle, Gerald, Wendel, Albrecht
Thirty years ago liver pathology defined apoptosis as a novel mode of cell death. Recently, experimental models of liver injury have been made available for examining the signaling molecules and...
Leist, Marcel, Single, Barbara, Castoldi, Anna F., Kühnle, Simone, Nicotera, Pierluigi
Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death. Here, we report that demise of human T cells caused by two classic apoptotic triggers...
Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide (1997)
Leist, Marcel, Volbracht, Christiane, Kühnle, Simone, Fava, Eugenio, Ferrando-May, Elisa, Nicotera, Pierluigi
BACKGROUND: Excitotoxicity and excess generation of nitric oxide (NO) are believed to be fundamental mechanisms in many acute and chronic neurodegenerative disorders. Disturbance of Ca2+ homeostasis...
Leist, Marcel, Fava, Eugenio, Montecucco, Cesare, Nicotera, Pierluigi
Endogenous generation of nitric oxide and its congeners, including peroxynitrite (ONOO-), has been implicated in the mechanism of neuron loss in neurodegenerative diseases. Accordingly, nitric oxide...
Göhring, Frank, Schwab, Birgit L., Nicotera, Pierluigi, Leist, Marcel, Fackelmayer, Frank O.
The scaffold attachment factor A (SAF-A) is an abundant component of the nuclear scaffold and of chromatin, and also occurs in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes. Evidence from...
Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury (1997)
Ertel, Wolfgang, Keel, Marius, Stocker, Reto, Imhof, Hans-Georg, Leist, Marcel, Steckholzer, Ursula, ...
When the cell surface molecule Fas is triggered by its agonist Fas ligand the result is apoptosis of these cells and tissue destruction. To elucidate the pathophysiological relevance of Fas ligand in...
Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins (1997)
Leist, Marcel, Gantner, Florian, Naumann, Heike, Bluethmann, Horst, Vogt, Kathrin, Brigelius-Flohe, Regina, ...
BACKGROUND & AIMS: Treatment with tumor necrosis factor (TNF) induces murine hepatocyte apoptosis in vitro and in vivo when sensitizing concentrations of toxins are present. The aim of this study was...
Energy supply and the shape of death in neurons and lymphoid cells (1997)
Nicotera, Pierluigi, Leist, Marcel
Apoptosis and necrosis are considered as conceptually distinct forms of cell death. Nevertheless, there is increasing evidence that classical apoptosis and necrosis represent only the extreme ends of...
The Shape of Cell Death (1997)
Leist, Marcel, Nicotera, Pierluigi
Cell death, a scheduled event during development and tissue turnover, or the ultimate consequence of toxic or pathologic insults seems to involve a relatively limited number of execution pathways....
Künstle, Gerald, Leist, Marcel, Uhlig, Stefan, Revesz, Laszlo, Feifel, Roland, MacKenzie, Andrew, ...
The two apoptosis receptors of mammalian cells, i.e. the 55 kDa TNF receptor (TNF-R1) and CD95 (Fas/APO1) are activated independently of each other, however, their signaling involves a variety of...
Bonfoco, Emanuela, Leist, Marcel, Zhivotovsky, Boris, Orrenius, Sten, Lipton, Stuart A., Nicotera, Pieriuigi
We have recently demonstrated that nitric oxide (NO) donors can trigger either apoptosis or necrosis of neurons as a function of the intensity of the exposure. Here, we show that the apoptosis...
A novel mechanism of murine hepatocyte death inducible by Concanavalin A (1996)
Leist, Marcel, Wendel, Albrecht
Background: Concanavalin A (Con A) is a plant lectin that polyclonally activates T-cells. When given intravenously to mice it induces a selective liver failure. Hepatotoxicity following Con A...
Leist, Marcel, Auer-Barth, Sigrid, Wendel, Albrecht
The liver contains the largest pool of cytokine-producing macrophages in the body and may therefore play an important role in the development and outcome of systemic inflammatory response syndromes....
DNA Fragmentation In Mouse Organs during Endotoxic Shock (1996)
Bohlinger, Ines, Leist, Marcel, Gantner, Florian, Angermüller, Sabine, Tiegs, Gisa, Wendel, Albrecht
The systemic inflammatory response syndrome has still an unpredictable outcome, and patients often die of multiple organ failure despite circulatory stabilization therapy. The still incompletely...
Gantner, Florian, Leist, Marcel, Küsters, Sabine, Vogt, Katrin, Volk, Hans-Dieter, Tiegs, Gisa
Polyclonal T cell stimulation in humans leads to a cytokine burst syndrome that may result in organ failure or lethality. Mechanisms of such cytokine-dependent morbidity can be studied in mice...
Jilg, Sabine, Barsig, Johannes, Leist, Marcel, Küsters, Sabine, Volk, Hans-Dieter, Wendel, Albrecht
The immunomodulating capacity of the methylxanthine A802715 (5-hydroxy- 5-methyl)hexyl-3-methyl-7-propylxanthin) was investigated in various murine models of endotoxemia and compared with that of the...
Gantner, Florian, Leist, Marcel, Lohse, Ansgar Wilhelm, Germann, Paul Georg, Tiegs, Gisa
Concanavalin A activates T lymphocytes in vitro and causes T-cell-dependent hepatic injury in mice. T lymphocytes were previously identified as effector cells of concanavalin A-induced liver injury....
Leist, Marcel, Gantner, Florian, Bohlinger, Ines, Tiegs, Gisa, Germann, Paul Georg, Wendel, Albrecht
We investigated the role of hepatocyte apoptosis in four different murine models of acute inflammatory liver failure. Liver damage induced in D-galactosamine-sensitized mice by endotoxin infection...
Tunicamycin potently inhibits tumor necrosis factor-induced hepatocyte apoptosis (1995)
Leist, Marcel, Wendel, Albrecht
The protein glycosylation inhibitor tunicamycin protected male BALB/c mice from tumor necrosis factor α-induced liver failure. Tunicamycin also inhibited tumor necrosis factor-induced cell death...
Bohlinger, Ines, Leist, Marcel, Barsig, Johannes, Uhlig, Stefan, Tiegs, Gisa, Wendel, Albrecht
D-Galactosamine-sensitized mice challenged with tumor necrosis factor α (TNF) developed severe apoptotic and secondary necrotic liver injury as assessed by histology, measurement of cytosolic...
Bohlinger, Ines, Leist, Marcel, Barsig, Johannes, Uhlig, Stefan, Tiegs, Gisa, Wendel, Albrecht
Mice sensitized with D-galactosamine (GalN) and challenged with recombinant murine tumor necrosis factor α (TNFα) developed severe apoptotic and secondary necrotic liver injury as assessed...
Isolation and characterization of rat primary lung cells (1995)
Bundschuh, Daniela S., Uhlig, Stefan, Leist, Marcel, Sauer, Achim, Wendel, Albrecht
Lung cell culture may be useful as anin vitro alternative to study the susceptibility of the lung to various toxic agents. Lungs from female Wistar rats were enzymatically digested by recirculating...
Leist, Marcel, Gantner, Florian, Jilg, Sabine, Wendel, Albrecht
The systemic inflammatory response is characterized by release of circulating TNF which may cause multiorgan failure including septic liver failure. We studied TNF signaling in an appropriate in...
Leist, Marcel, Gantner, Florian, Bohlinger, Ines, Germann, Paul G., Tiegs, Gisa, Wendel, Albrecht
Freshly isolated mouse hepatocytes were essentially insensitive to TNF- alpha cytotoxicity. However, TNF-alpha induced a concentration- dependent cell death in hepatocytes that had been pretreated...
Inflammatory stimuli and mediators in the mouse liver /--vorgelegt von Marcel Leist. (1993)
Thesis (doctoral)--Universität Konstanz, 1993.
Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik
Huntington’s disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
Erbayraktar, Serhat, Grasso, Giovanni, Sfacteria, Alessandra, Xie, Qiao-wen, Coleman, Thomas, Kreilgaard, Mads, ...
Erythropoietin (EPO) is a tissue-protective cytokine preventing vascular spasm, apoptosis, and inflammatory responses. Although best known for its role in hematopoietic lineages, EPO also affects...
Asialoerythropoetin is not effective in the R6/2 line of Huntington's disease mice
Gil, Joana MAC, Leist, Marcel, Popovic, Natalija, Brundin, Patrik, Petersén, Åsa
Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo
Mennini, Tiziana, De Paola, Massimiliano, Bigini, Paolo, Mastrotto, Cristina, Fumagalli, Elena, Barbera, Sara, ...
Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the...
Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik
Huntington’s disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
Erbayraktar, Serhat, Grasso, Giovanni, Sfacteria, Alessandra, Xie, Qiao-wen, Coleman, Thomas, Kreilgaard, Mads, ...
Erythropoietin (EPO) is a tissue-protective cytokine preventing vascular spasm, apoptosis, and inflammatory responses. Although best known for its role in hematopoietic lineages, EPO also affects...
Asialoerythropoetin is not effective in the R6/2 line of Huntington's disease mice
Gil, Joana MAC, Leist, Marcel, Popovic, Natalija, Brundin, Patrik, Petersén, Åsa
Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo
Mennini, Tiziana, De Paola, Massimiliano, Bigini, Paolo, Mastrotto, Cristina, Fumagalli, Elena, Barbera, Sara, ...
Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the...
Zou, Ming-Hui, Leist, Marcel, Ullrich, Volker
Prostacyclin synthase (PCS) is an enzyme with antithrombotic, antiproliferative, and dilatory functions in the normal vasculature, and inactivation of PCS by tyrosine nitration may favor...
Berliocchi, Laura, Fava, Eugenio, Leist, Marcel, Horvat, Volker, Dinsdale, David, Read, David, ...
Clostridial neurotoxins are bacterial endopeptidases that cleave the major SNARE proteins in peripheral motorneurons. Here, we show that disruption of synaptic architecture by botulinum neurotoxin C1...
Leist, Marcel, Single, Barbara, Castoldi, Anna F., Kühnle, Simone, Nicotera, Pierluigi
Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death. Here, we report that demise of human T cells caused by two classic apoptotic triggers...
Latta, Markus, Künstle, Gerald, Leist, Marcel, Wendel, Albrecht
Hepatocyte apoptosis is crucial in several forms of liver disease. Here, we examined in different models of murine liver injury whether and how metabolically induced alterations of hepatocyte ATP...
Foghsgaard, Lasse, Wissing, Dorte, Mauch, Daniel, Lademann, Ulrik, Bastholm, Lone, Boes, Marianne, ...
Death receptors can trigger cell demise dependent or independent of caspases. In WEHI-S fibrosarcoma cells, tumor necrosis factor (TNF) induced an increase in cytosolic cathepsin B activity followed...