Perroud, Nader, Uher, Rudolf, Marusic, Andrej, Rietschel, Marcella, Mors, Ole, Henigsberg, Neven, ...
Abstract Background Suicidal thoughts and behaviours during antidepressant treatment, especially during the first weeks of treatment, have prompted warnings by regulatory bodies. The aim of the...
Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects (2009)
Jansen, Andreas, Krach, Sören, Krug, Axel, Markov, Valentin, Eggermann, Thomas, Zerres, Klaus, ...
Abstract Background In the last years, several susceptibility genes for psychiatric disorders have been identified, among others G72 (also named D-amino acid oxidase activator, DAOA). Typically, the...
Common variants conferring risk of schizophrenia (2009)
Stefansson, Hreinn, Ophoff, Roel A, Steinberg, Stacy, Andreassen, Ole A, Cichon, Sven, Rujescu, Dan, ...
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Wüst, Stefan, Kumsta, Robert, Treutlein, Jens, Frank, Josef, Entringer, Sonja, Schulze, Thomas G., ...
Objective: A key regulator of serotonergic neurotransmission is the serotonin transporter (5-HTT) and a common 5HTT gene promoter polymorphism, termed 5HTTLPR, is associated with phenotypes related...
Disruption of the neurexin 1 gene is associated with schizophrenia (2009)
Rujescu, Dan, Ingason, Andres, Cichon, Sven, Pietiläinen, Olli P H, Barnes, Michael R, Toulopoulou, Timothea, ...
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Disruption of the neurexin 1 gene is associated with schizophrenia (2009)
Rujescu, Dan, Ingason, Andres, Cichon, Sven, Pietiläinen, Olli P.H., Barnes, Michael R., Toulopoulou, Timothea, ...
Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We examined NRXN1, and the closely related NRXN2 and...
Schumacher, Johannes, Laje, Gonzalo, Jamra, Rami Abou, Becker, Tim, Mühleisen, Thomas W., Vasilescu, Catalina, ...
Association studies, as well as the initial translocation family study, identified the gene Disrupted-In-Schizophrenia-1 (DISC1) as a risk factor for schizophrenia. DISC1 encodes a multifunctional...
Large recurrent microdeletions associated with schizophrenia (2008)
Stefansson, Hreinn, Rujescu, Dan, Cichon, Sven, Pietiläinen, Olli P H, Ingason, Andres, Steinberg, Stacy, ...
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Rietschel, Marcella, Beckmann, Lars, Strohmeier, Jana, Georgi, Alexander, Karpushova, Anna, Schirmbeck, Frederike, ...
OBJECTIVE: G72 is among the most frequently replicated vulnerability genes for schizophrenia and bipolar disorder. The authors previously found identical haplotypes of markers M23 and M24 to be...
Identification of loci associated with schizophrenia by genome-wide association and follow-up (2008)
Donovan, Michael C., Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, ...
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong...
Cichon, Sven, Winge, Ingeborg, Mattheisen, Manuel, Georgi, Alexander, Karpushova, Anna, Freudenberg, Jan, ...
The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] controls a broad range of biological functions that are disturbed in affective disorder. In the brain, 5-HT production is controlled by...
Etain, Bruno, Mathieu, Flavie, Rietschel, Marcella, Maier, Wolfgang, Albus, Margot, Mckeon, Patrick, ...
Preliminary studies suggested that age at onset (AAO) may help to define homogeneous bipolar affective disorder (BPAD) subtypes. This candidate symptom approach might be useful to identify...
Etain, Bruno, Mathieu, Flavie, Rietschel, Marcella, Maier, Wolfgang, Albus, Margot, Mckeon, Patrick, ...
Preliminary studies suggested that age at onset (AAO) may help to define homogeneous bipolar affective disorder (BPAD) subtypes. This candidate symptom approach might be useful to identify...
Etain, Bruno, Mathieu, Flavie, Rietschel, Marcella, Maier, Wolfgang, Albus, Margot, Mckeon, Patrick, ...
Preliminary studies suggested that age at onset (AAO) may help to define homogeneous bipolar affective disorder (BPAD) subtypes. This candidate symptom approach might be useful to identify...
Abou Jamra, Rami, Schmael, Christine, Cichon, Sven, Rietschel, Marcella, Schumacher, Johannes, Nöthen, Markus M.
In follow-up from evidence obtained in linkage studies, systematic linkage disequilibrium mapping within chromosomal region 13q33 has led to the identification of a schizophrenia susceptibility locus...
The G72/G30 Gene Locus in Psychiatric Disorders: A Challenge to Diagnostic Boundaries? (2006)
Abou Jamra, Rami, Schmael, Christine, Cichon, Sven, Rietschel, Marcella, Schumacher, Johannes, Nöthen, Markus M.
In follow-up from evidence obtained in linkage studies, systematic linkage disequilibrium mapping within chromosomal region 13q33 has led to the identification of a schizophrenia susceptibility locus...
Whole genome linkage scan of recurrent depressive disorder from the depression network study (2005)
McGuffin, Peter, Knight, Jo, Breen, Gerome, Brewster, Shyama, Boyd, Peter R., Craddock, Nick, ...
Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where...
Farmer, Anne, Breen, Gerome, Brewster, Shyama, Craddock, Nick, Gill, Mike, Korszun, Ania, ...
Abstract Background The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in...
Familiarity of symptom dimensions in depression. (2004)
Korszun, Ania, Moskvina, Valentina, Brewster, Shyama, Craddock, Nicholas John, Ferrero, Francois, Gill, Michael, ...
Familiarity of symptom dimensions in depression. (2004)
Korszun, Ania, Moskvina, Valentina, Brewster, Shyama, Craddock, Nicholas John, Ferrero, Francois, Gill, Michael, ...
The Depression Network (DeNT) Study: methodology and (2004)
Anne Farmer, Gerome Breen, Shyama Brewster, Nick Craddock, Mike Gill, Ania Korszun, ...
Research article
Can long-range microsatellite data be used to predict short-range linkage disequilibrium? (2002)
Schulze, Thomas G., Chen, Yu-Sheng, Akula, Nirmala, Hennessy, Kathleen, Badner, Judith A., McInnis, Melvin G., ...
The distribution of linkage disequilibrium (LD) across the genome is highly complex. Little is known about the relationship between long-range and short-range LD in a genomic region. We assessed...
Cichon, Sven, Schumacher, Johannes, Müller, Daniel J., Hürter, Martina, Windemuth, Christine, Strauch, Konstantin, ...
Cichon, Sven, Schumacher, Johannes, Müller, Daniel J., Hürter, Martina, Windemuth, Christine, Strauch, Konstantin, ...
Bipolar affective disorder (BPAD), also known as manic depressive illness, is a severe psychiatric disorder characterized by episodes of mania and depression. It has a lifetime prevalence of...
Bonn, Univ., Habil.-Schr., 2000 (Nicht für den Austausch).
McQueen, Matthew B., Devlin, B., Faraone, Stephen V., Nimgaonkar, Vishwajit L., Sklar, Pamela, Smoller, Jordan W., ...
Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis...
Schumacher, Johannes, Kaneva, Radka, Jamra, Rami Abou, Diaz, Guillermo Orozco, Ohlraun, Stephanie, Milanova, Vihra, ...
We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian...
Schwab, Sibylle G., Knapp, Michael, Mondabon, Stephanie, Hallmayer, Joachim, Borrmann-Hassenbach, Margitta, Albus, Margot, ...
Genetic variants in a gene on 6p22.3, dysbindin, have been shown recently to be associated with schizophrenia (Straub et al. 2002a). There is no doubt that replication in other independent samples...
The DTNBP1 (Dysbindin) Gene Contributes to Schizophrenia, Depending on Family History of the Disease
Van Den Bogaert, Ann, Schumacher, Johannes, Schulze, Thomas G., Otte, Andreas C., Ohlraun, Stephanie, Kovalenko, Svetlana, ...
We have investigated the gene for dystrobrevin-binding protein 1 (DTNBP1), or dysbindin, which has been strongly suggested as a positional candidate gene for schizophrenia, in three samples of...
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder
Segurado, Ricardo, Detera-Wadleigh, Sevilla D., Levinson, Douglas F., Lewis, Cathryn M., Gill, Michael, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
McQueen, Matthew B., Devlin, B., Faraone, Stephen V., Nimgaonkar, Vishwajit L., Sklar, Pamela, Smoller, Jordan W., ...
Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis...
Schumacher, Johannes, Kaneva, Radka, Jamra, Rami Abou, Diaz, Guillermo Orozco, Ohlraun, Stephanie, Milanova, Vihra, ...
We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian...
Abou Jamra, Rami, Schmael, Christine, Cichon, Sven, Rietschel, Marcella, Schumacher, Johannes, Nöthen, Markus M.
In follow-up from evidence obtained in linkage studies, systematic linkage disequilibrium mapping within chromosomal region 13q33 has led to the identification of a schizophrenia susceptibility locus...