B Cell Antigen Receptor Signaling and Internalization Are Mutually Exclusive Events (2006)
Ping Hou, Elizabeth Araujo, Tong Zhao, Miao Zhang, Don Massenburg, Margaret Veselits, ...
The B cell receptor (BCR) is responsible for both the internalization of pathogens by B cells and for B cell activation signaling; internalization and activation signaling are mutually exclusive...
B Cell Antigen Receptor Signaling and Internalization Are Mutually Exclusive Events (2006)
Ping Hou, Elizabeth Araujo, Tong Zhao, Miao Zhang, Don Massenburg, Margaret Veselits, ...
Engagement of the B cell antigen receptor initiates two concurrent processes, signaling and receptor internalization. While both are required for normal humoral immune responses, the relationship...
Kabak, Shara, Skaggs, Brian J., Gold, Michael R., Affolter, Michael, West, Kelly L., Foster, Mark S., ...
Following B-cell antigen receptor (BCR) ligation, the cytoplasmic domains of immunoglobulin α (Igα) and Igβ recruit Syk to initiate signaling cascades. The coupling of Syk to several distal...
Wang, Leo D., Lopes, Jared, Cooper, A. Byron, Dang-Lawson, May, Matsuuchi, Linda, Clark, Marcus R.
Within the B cell antigen receptor (BCR), the cytoplasmic tails of both Igα and Igβ are required for normal B cell development and maturation. To dissect the mechanisms by which each tail...
B Cell Antigen Receptor Signaling and Internalization Are Mutually Exclusive Events
Hou, Ping, Araujo, Elizabeth, Zhao, Tong, Zhang, Miao, Massenburg, Don, Veselits, Margaret, ...
Engagement of the B cell antigen receptor initiates two concurrent processes, signaling and receptor internalization. While both are required for normal humoral immune responses, the relationship...
Kabak, Shara, Skaggs, Brian J., Gold, Michael R., Affolter, Michael, West, Kelly L., Foster, Mark S., ...
Following B-cell antigen receptor (BCR) ligation, the cytoplasmic domains of immunoglobulin α (Igα) and Igβ recruit Syk to initiate signaling cascades. The coupling of Syk to several distal...
Wang, Leo D., Lopes, Jared, Cooper, A. Byron, Dang-Lawson, May, Matsuuchi, Linda, Clark, Marcus R.
Within the B cell antigen receptor (BCR), the cytoplasmic tails of both Igα and Igβ are required for normal B cell development and maturation. To dissect the mechanisms by which each tail...
B Cell Antigen Receptor Signaling and Internalization Are Mutually Exclusive Events
Hou, Ping, Araujo, Elizabeth, Zhao, Tong, Zhang, Miao, Massenburg, Don, Veselits, Margaret, ...
Engagement of the B cell antigen receptor initiates two concurrent processes, signaling and receptor internalization. While both are required for normal humoral immune responses, the relationship...
B-cell antigen-receptor signalling in lymphocyte development
Signalling through the B-cell antigen receptor (BCR) is required throughout B-cell development and peripheral maturation. Targeted disruption of BCR components or downstream effectors indicates that...
Smith, Judith A., Tso, J. Yun, Clark, Marcus R., Cole, Michael S., Bluestone, Jeffrey A.
Anti-CD3 monoclonal antibodies (mAbs) are potent immunosuppressive agents used in clinical transplantation. However, the activation-related adverse side effects associated with these mAbs have...
Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells
O'Neill, Shannon K., Veselits, Margaret L., Zhang, Miao, Labno, Christine, Cao, Yanxia, Finnegan, Alison, ...
In autoimmune prone murine strains, sequential engagement of the B cell antigen receptor (BCR) on the cell surface and toll-like receptors (TLRs) in late endosomes is necessary and sufficient for...
Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid
Mandal, Malay, Crusio, Kelly M., Meng, Fanyong, Liu, Suqing, Kinsella, Marcus, Clark, Marcus R., ...
On their entry into the thymus, developing lymphocyte progenitors depend on signaling from the pre-T cell receptor (pre-TCR), which orchestrates differentiation, cell proliferation, and survival. The...