Oishi, Kimihiko, Zhang, Hui, Gault, William J., Wang, Cindy J., Tan, Cheryl C., Kim, In-Kyong, ...
Missense mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase SHP-2, cause clinically similar but distinctive disorders, LEOPARD (LS) and Noonan (NS) syndromes. The LS is an...
Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations (2006)
Oishi, Kimihiko, Gaengel, Konstantin, Krishnamoorthy, Srinivasan, Kamiya, Kenichi, Kim, In-Kyong, Ying, Huiwen, ...
Mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase SHP-2, causes Noonan syndrome (NS), an autosomal dominant disorder with pleomorphic developmental abnormalities. Certain...
Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations (2006)
Oishi, Kimihiko, Gaengel, Konstantin, Krishnamoorthy, Srinivasan, Kamiya, Kenichi, Kim, In-Kyong, Ying, Huiwen, ...
Mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase SHP-2, causes Noonan syndrome (NS), an autosomal dominant disorder with pleomorphic developmental abnormalities. Certain...
Jun Wu, Thomas J. Klein, Marek Mlodzik
Differential subcellular localization of Fz1 and Fz2 receptors contributes to signaling specificity within the Wnt/Fz signaling pathways.
Jun Wu, Thomas J. Klein, Marek Mlodzik
The Frizzled (Fz; called here Fz1) and Fz2 receptors have distinct signaling specificities activating either the canonical Wnt/β-catenin pathway or Fz/planar cell polarity (PCP) signaling in...
Das, Gishnu, Jenny, Andreas, Klein, Thomas J, Eaton, Suzanne, Mlodzik, Marek
Planar cell polarity (PCP) in the Drosophila eye is established by the distinct fate specifications of photoreceptors R3 and R4, and is regulated by the Frizzled (Fz)/PCP signaling pathway. Before...
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites (2001)
Ciapponi, Laura, Jackson, David B., Mlodzik, Marek, Bohmann, Dirk
Diss. Naturwiss. Basel (kein Austausch).
The planar polarity gene strabismus regulates convergent extension movements in Xenopus
Darken, Rachel S., Scola, Adriane M., Rakeman, Andrew S., Das, Gishnu, Mlodzik, Marek, Wilson, Paul A.
The signaling mechanisms that specify, guide and coordinate cell behavior during embryonic morphogenesis are poorly understood. We report that a Xenopus homolog of the Drosophila planar cell polarity...
Jenny, Andreas, Darken, Rachel S., Wilson, Paul A., Mlodzik, Marek
Frizzled (Fz) signaling regulates the establishment of planar cell polarity (PCP). The PCP genes prickle (pk) and strabismus (stbm) are thought to antagonize Fz signaling. We show that they act in...
Goberdhan, Deborah C.I., Paricio, Nuria, Goodman, Emma C., Mlodzik, Marek, Wilson, Clive
The human tumor suppressor gene PTEN encodes a putative cytoskeleton-associated molecule with both protein phosphatase and phosphatidylinositol 3,4,5-trisphosphate (PIP3) 3-phosphatase activities. In...
Wu, Jun, Klein, Thomas J, Mlodzik, Marek
The Frizzled (Fz; called here Fz1) and Fz2 receptors have distinct signaling specificities activating either the canonical Wnt/β-catenin pathway or Fz/planar cell polarity (PCP) signaling in...
Mlodzik, Marek, Fjose, Anders, Gehring, Walter J.
We report the isolation and characterization of caudal (cad), a previously unknown Drosophila homeo box-containing gene from the 38E region on the left arm of the second chromosome. This homeo box...
Domingos, Pedro M., Mlodzik, Marek, Mendes, César S., Brown, Samara, Steller, Hermann, Mollereau, Bertrand
The establishment of planar cell polarity in the Drosophila eye requires correct specification of the R3/R4 pair of photoreceptor cells. In response to a polarizing factor, Frizzled signaling...
Planar cell polarity signalling couples cell division and morphogenesis during neurulation
Ciruna, Brian, Jenny, Andreas, Lee, Diana, Mlodzik, Marek, Schier, Alexander F.
Environmental and genetic aberrations lead to neural tube closure defects (NTDs) in 1 in every 1000 births1. Mouse and frog models for these birth defects have suggested that Van Gogh-like 2 (Vangl2,...
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites
Ciapponi, Laura, Jackson, David B., Mlodzik, Marek, Bohmann, Dirk
During Drosophila development Fos acts downstream from the JNK pathway. Here we show that it can also mediate ERK signaling in wing vein formation and photoreceptor differentiation. Drosophila JNK...
The planar polarity gene strabismus regulates convergent extension movements in Xenopus
Darken, Rachel S., Scola, Adriane M., Rakeman, Andrew S., Das, Gishnu, Mlodzik, Marek, Wilson, Paul A.
The signaling mechanisms that specify, guide and coordinate cell behavior during embryonic morphogenesis are poorly understood. We report that a Xenopus homolog of the Drosophila planar cell polarity...
Jenny, Andreas, Darken, Rachel S., Wilson, Paul A., Mlodzik, Marek
Frizzled (Fz) signaling regulates the establishment of planar cell polarity (PCP). The PCP genes prickle (pk) and strabismus (stbm) are thought to antagonize Fz signaling. We show that they act in...
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites
Ciapponi, Laura, Jackson, David B., Mlodzik, Marek, Bohmann, Dirk
During Drosophila development Fos acts downstream from the JNK pathway. Here we show that it can also mediate ERK signaling in wing vein formation and photoreceptor differentiation. Drosophila JNK...
Goberdhan, Deborah C.I., Paricio, Nuria, Goodman, Emma C., Mlodzik, Marek, Wilson, Clive
The human tumor suppressor gene PTEN encodes a putative cytoskeleton-associated molecule with both protein phosphatase and phosphatidylinositol 3,4,5-trisphosphate (PIP3) 3-phosphatase activities. In...
Wu, Jun, Klein, Thomas J, Mlodzik, Marek
The Frizzled (Fz; called here Fz1) and Fz2 receptors have distinct signaling specificities activating either the canonical Wnt/β-catenin pathway or Fz/planar cell polarity (PCP) signaling in...
Mlodzik, Marek, Fjose, Anders, Gehring, Walter J.
We report the isolation and characterization of caudal (cad), a previously unknown Drosophila homeo box-containing gene from the 38E region on the left arm of the second chromosome. This homeo box...
Diversin regulates heart formation and gastrulation movements in development
Moeller, Heinz, Jenny, Andreas, Schaeffer, Hans-Joerg, Schwarz-Romond, Thomas, Mlodzik, Marek, Hammerschmidt, Matthias, ...
Canonical and noncanonical Wnt signaling regulate crucial events in the development of vertebrates and invertebrates. In this work we show that vertebrate Diversin, a potential orthologue of...
Cooperative control of Drosophila immune responses by the JNK and NF-κB signaling pathways
Delaney, Joseph R, Stöven, Svenja, Uvell, Hanna, Anderson, Kathryn V, Engström, Ylva, Mlodzik, Marek
Jun N-terminal kinase (JNK) signaling is a highly conserved pathway that controls both cytoskeletal remodeling and transcriptional regulation in response to a wide variety of signals. Despite the...