Margaret A. Stanley

HPV & head and neck cancer: a descriptive update (2009)

Goon, Peter KC, Stanley, Margaret A, Ebmeyer, Jörg, Steinsträsser, Lars, Upile, Tahwinder, Jerjes, Waseem, ...

Abstract The incidence of head and neck squamous cell carcinoma (HNSCC) has been gradually increasing over the last three decades. Recent data have now attributed a viral aetiology to a subset of...

Acquisition of High-Level Chromosomal Instability Is Associated with Integration of Human Papillomavirus Type 16 in Cervical Keratinocytes (2008)

Mark R. Pett, Ian Roberts, Sally Dowen, David I. Smith, Margaret A. Stanley, ...

Whereas two key steps in cervical carcinogenesis are integration of high-risk human papillomavirus (HR-HPV) and acquisition of an unstable host genome, the temporal association between these events...

Interferon-{beta} treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrants (2006)

Herdman, M. Trent, Pett, Mark R., Roberts, Ian, Alazawi, William O. F., Teschendorff, Andrew E., Zhang, Xiao-Yin, ...

Following integration of human papillomavirus (HPV) into the host genome, overexpression of the viral oncogenes E6 and E7 requires loss of the transcriptional repressor functions of E2. A key step in...

Interferon-{beta} treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrants (2006)

Herdman, M.Trent, Pett, Mark R., Roberts, Ian, Alazawi, William O.F., Teschendorff, Andrew E., Zhang, Xiao-Yin, ...

Following integration of human papillomavirus (HPV) into the host genome, overexpression of the viral oncogenes E6 and E7 requires loss of the transcriptional repressor functions of E2. A key step in...

Cytokine Profile of Mouse Vaginal and Uterus Lymphocytes at Estrus and Diestrus (2005)

Maria C. Lopez, Margaret A. Stanley

It is known that sex hormones regulate IgA and IgG levels in the female reproductive tract. Moreover, antigen presentation by uterine and vaginal epithelial cells is also under strict hormonal...

Cytokine Profile of Mouse Vaginal and Uterus Lymphocytes at Estrus and Diestrus (2005)

Maria C. Lopez, Margaret A. Stanley

It is known that sex hormones regulate IgA and IgG levels in the female reproductive tract. Moreover, antigen presentation by uterine and vaginal epithelial cells is also under strict hormonal...

Intraepithelial DNA immunisation with a plasmid encoding a codon optimised COPV E1 gene sequence, but not the wild-type gene sequence completely protects against mucosal challenge with infectious COPV in beagles (2002)

Moore, Richard A., Parmar, Vanita, Walcott, Sarah P., Gough, Gerry W., Stanley, Margaret A., Santos, Elmer B., ...

DNA plasmids encoding the open reading frames of canine oral papillomavirus (COPV) nonstructural early genes E1, E2, or E7 protein were delivered into both oral mucosal and cutaneous epithelial sites...

A C-Terminal Helicase Domain of the Human Papillomavirus E1 Protein Binds E2 and the DNA Polymerase α-Primase p68 Subunit

Masterson, Philip J., Stanley, Margaret A., Lewis, Alan P., Romanos, Michael A.

The human papillomavirus (HPV) E1 and E2 proteins bind cooperatively to the viral origin of replication (ori), forming an E1-E2-ori complex that is essential for initiation of DNA replication. All...

Human Papillomavirus Type 16 E6 Amino Acid 83 Variants Enhance E6-Mediated MAPK Signaling and Differentially Regulate Tumorigenesis by Notch Signaling and Oncogenic Ras

Chakrabarti, Oishee, Veeraraghavalu, Karthikeyan, Tergaonkar, Vinay, Liu, Yun, Androphy, Elliot J., Stanley, Margaret A., ...

Oncogenically high-risk human papillomaviruses (HPVs) are causally associated with the progression of major human neoplasia-like cancers of the cervix. Several studies have defined functions of the...

Papillomavirus-Mediated Neoplastic Progression Is Associated with Reciprocal Changes in Jagged1 and Manic Fringe Expression Linked to Notch Activation†

Veeraraghavalu, Karthikeyan, Pett, Mark, Kumar, Rekha V., Nair, Pradip, Rangarajan, Annapoorni, Stanley, Margaret A., ...

Infection by high-risk human papillomaviruses (HPV) and persistent expression of viral oncogenes E6 and E7 are causally linked to the development of cervical cancer. These oncogenes are necessary but...

Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response

Pett, Mark R., Herdman, M. Trent, Palmer, Roger D., Yeo, Giles S. H., Shivji, Mahmud K., Stanley, Margaret A., ...

Integration of high-risk human papillomavirus (HRHPV) into the host genome is a key event in cervical neoplastic progression. Integration is associated with deregulated expression of the viral...

A C-Terminal Helicase Domain of the Human Papillomavirus E1 Protein Binds E2 and the DNA Polymerase α-Primase p68 Subunit

Masterson, Philip J., Stanley, Margaret A., Lewis, Alan P., Romanos, Michael A.

The human papillomavirus (HPV) E1 and E2 proteins bind cooperatively to the viral origin of replication (ori), forming an E1-E2-ori complex that is essential for initiation of DNA replication. All...

Human Papillomavirus Type 16 E6 Amino Acid 83 Variants Enhance E6-Mediated MAPK Signaling and Differentially Regulate Tumorigenesis by Notch Signaling and Oncogenic Ras

Chakrabarti, Oishee, Veeraraghavalu, Karthikeyan, Tergaonkar, Vinay, Liu, Yun, Androphy, Elliot J., Stanley, Margaret A., ...

Oncogenically high-risk human papillomaviruses (HPVs) are causally associated with the progression of major human neoplasia-like cancers of the cervix. Several studies have defined functions of the...

Papillomavirus-Mediated Neoplastic Progression Is Associated with Reciprocal Changes in Jagged1 and Manic Fringe Expression Linked to Notch Activation†

Veeraraghavalu, Karthikeyan, Pett, Mark, Kumar, Rekha V., Nair, Pradip, Rangarajan, Annapoorni, Stanley, Margaret A., ...

Infection by high-risk human papillomaviruses (HPV) and persistent expression of viral oncogenes E6 and E7 are causally linked to the development of cervical cancer. These oncogenes are necessary but...

Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response

Pett, Mark R., Herdman, M. Trent, Palmer, Roger D., Yeo, Giles S. H., Shivji, Mahmud K., Stanley, Margaret A., ...

Integration of high-risk human papillomavirus (HRHPV) into the host genome is a key event in cervical neoplastic progression. Integration is associated with deregulated expression of the viral...

Cytokine Profile of Mouse Vaginal and Uterus Lymphocytes at Estrus and Diestrus

Lopez, Maria C., Stanley, Margaret A.

It is known that sex hormones regulate IgA and IgG levels in the female reproductive tract. Moreover, antigen presentation by uterine and vaginal epithelial cells is also under strict hormonal...

HPV & head and neck cancer: a descriptive update

Goon, Peter KC, Stanley, Margaret A, Ebmeyer, Jörg, Steinsträsser, Lars, Upile, Tahwinder, Jerjes, Waseem, ...

The incidence of head and neck squamous cell carcinoma (HNSCC) has been gradually increasing over the last three decades. Recent data have now attributed a viral aetiology to a subset of head and...