Shuji Ogino, Margaret L. Gulley, Robert B. Wilson
To translate basic research findings into clinical practice, it is essential that information about mutations and variations in the human genome are communicated easily and unequivocally....
Feng, Wen-hai, Westphal, Eva, Mauser, Amy, Raab-Traub, Nancy, Gulley, Margaret L., Busson, Pierre, ...
The Epstein-Barr virus (EBV) genome is present in a variety of tumor types, including virtually all undifferentiated nasopharyngeal carcinomas (NPC) and a portion of gastric carcinomas. The uniform...
Hong, Gregory K., Kumar, Pawan, Wang, Ling, Damania, Blossom, Gulley, Margaret L., Delecluse, Henri-Jacques, ...
Although Epstein-Barr virus (EBV)-associated malignancies are primarily composed of cells with one of the latent forms of EBV infection, a small subset of tumor cells containing the lytic form of...
Epstein-Barr Virus Lytic Infection Contributes to Lymphoproliferative Disease in a SCID Mouse Model
Hong, Gregory K., Gulley, Margaret L., Feng, Wen-Hai, Delecluse, Henri-Jacques, Holley-Guthrie, Elizabeth, Kenney, Shannon C.
Most Epstein-Barr virus (EBV)-positive tumor cells contain one of the latent forms of viral infection. The role of lytic viral gene expression in EBV-associated malignancies is unknown. Here we show...
Feng, Wen-hai, Westphal, Eva, Mauser, Amy, Raab-Traub, Nancy, Gulley, Margaret L., Busson, Pierre, ...
The Epstein-Barr virus (EBV) genome is present in a variety of tumor types, including virtually all undifferentiated nasopharyngeal carcinomas (NPC) and a portion of gastric carcinomas. The uniform...
Hong, Gregory K., Kumar, Pawan, Wang, Ling, Damania, Blossom, Gulley, Margaret L., Delecluse, Henri-Jacques, ...
Although Epstein-Barr virus (EBV)-associated malignancies are primarily composed of cells with one of the latent forms of EBV infection, a small subset of tumor cells containing the lytic form of...
Epstein-Barr Virus Lytic Infection Contributes to Lymphoproliferative Disease in a SCID Mouse Model
Hong, Gregory K., Gulley, Margaret L., Feng, Wen-Hai, Delecluse, Henri-Jacques, Holley-Guthrie, Elizabeth, Kenney, Shannon C.
Most Epstein-Barr virus (EBV)-positive tumor cells contain one of the latent forms of viral infection. The role of lytic viral gene expression in EBV-associated malignancies is unknown. Here we show...
Ryan, Julie L., Fan, Hongxin, Glaser, Sally L., Schichman, Steven A., Raab-Traub, Nancy, Gulley, Margaret L.
Epstein-Barr Virus (EBV) infects nearly all humans and then persists for the life of the host. In some people who later develop cancer, EBV DNA is present within malignant cells and circulates at...
Fan, Hongxin, Civalier, Chris, Booker, Jessica K., Gulley, Margaret L., Prior, Thomas W., Farber, Rosann A.
The 3243A>G mutation in the MTTL1 (tRNALeu) gene and the 8344A>G mutation in the MTTK (tRNALys) gene are the most common mutations found in mitochondrial encephalomyopathy, lactic acidosis with...
Scanga, Lori, Chaing, Shu, Powell, Cynthia, Aylsworth, Arthur S., Harrell, Lizzie J., Henshaw, Nancy G., ...
Congenital human cytomegalovirus (HCMV) infection affects 1% of children and is the most common infectious cause of sensorineural hearing loss. Due to the difficulty of diagnosing deafness and other...
Lymphoid Tissues from Patients with Infectious Mononucleosis Lack Monoclonal B and T Cells
Plumbley, Julie A., Fan, Hongxin, Eagan, Phyllis A., Ehsan, Aamir, Schnitzer, Bertram, Gulley, Margaret L.
In typical cases of infectious mononucleosis (IM), lymphoid tissue is rarely submitted for pathological examination. When lymphoid tissues from IM cases are examined, the histological appearance of...
Clinical Applications of BCR-ABL Molecular Testing in Acute Leukemia
Nashed, Amgad L., Rao, Kathleen W., Gulley, Margaret L.
Recent advances in molecular genetics impact the health care and outcome of patients with acute lymphoblastic leukemia (ALL). BCR-ABL, a common molecular defect in adult ALL, is a valuable tumor...
Molecular Diagnosis of Epstein-Barr Virus-Related Diseases
Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis, and it may also be found in a wide variety of benign and malignant lesions including oral hairy leukoplakia, inflammatory...
Gulley, Margaret L., Fan, Hongxin, Elmore, Sandra H.
Epstein-Barr virus (EBV) is associated with a wide range of benign and malignant diseases, including infectious mononucleosis, lymphoma, posttransplant lymphoproliferative disorder, and...
Standard Mutation Nomenclature in Molecular Diagnostics : Practical and Educational Challenges
Ogino, Shuji, Gulley, Margaret L., Den Dunnen, Johan T., Wilson, Robert B.
To translate basic research findings into clinical practice, it is essential that information about mutations and variations in the human genome are communicated easily and unequivocally....
Laboratory Assays for Epstein-Barr Virus-Related Disease
Gulley, Margaret L., Tang, Weihua
Epstein-Barr virus (EBV) infects various cell types in a wide spectrum of benign and malignant diseases. Laboratory tests for EBV have improved and are increasingly used in diagnosis, prognosis,...