Towne, Charles Fenton, York, Ian A., Neijssen, Joost J., Karow, Margaret L., Murphy, Andrew J., Valenzuela, David M., ...
Previous experiments using enzyme inhibitors, cell lysates, and purified enzyme have suggested that puromycin-sensitive aminopeptidase (PSA) plays a role in creating and destroying MHC class...
Towne, Charles Fenton, York, Ian A., Neijssen, Joost J., Karow, Margaret L., Murphy, Andrew J., Valenzuela, David M., ...
To detect viral infections and tumors, CD8+ T lymphocytes monitor cells for the presence of antigenic peptides bound to MHC class I molecules. The majority of MHC class I-presented peptides are...
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor
Carpenter, Laura Rocco, Farruggella, Thomas J., Symes, Aviva, Karow, Margaret L., Yancopoulos, George D., Stahl, Neil
Leptin is an adipocyte-derived cytokine that regulates food intake and body weight via interaction with its Ob receptor (ObR). Serum leptin levels are chronically elevated in obese humans, suggesting...
Suppression of TGA Mutations in the Bacillus subtilis spoIIR Gene by prfB Mutations
Karow, Margaret L., Rogers, Elizabeth J., Lovett, Paul S., Piggot, Patrick J.
An unexpectedly high proportion of TGA nonsense mutations was obtained in a collection of chemically induced mutations in the spoIIR locus of Bacillus subtilis. Of 11 different mutations obtained,...
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor
Carpenter, Laura Rocco, Farruggella, Thomas J., Symes, Aviva, Karow, Margaret L., Yancopoulos, George D., Stahl, Neil
Leptin is an adipocyte-derived cytokine that regulates food intake and body weight via interaction with its Ob receptor (ObR). Serum leptin levels are chronically elevated in obese humans, suggesting...
Suppression of TGA Mutations in the Bacillus subtilis spoIIR Gene by prfB Mutations
Karow, Margaret L., Rogers, Elizabeth J., Lovett, Paul S., Piggot, Patrick J.
An unexpectedly high proportion of TGA nonsense mutations was obtained in a collection of chemically induced mutations in the spoIIR locus of Bacillus subtilis. Of 11 different mutations obtained,...