Williams-Gray, Caroline H., Evans, Jonathan R., Goris, An, Foltynie, Thomas, Ban, Maria, Robbins, Trevor W., ...
Cognitive abnormalities are common in Parkinson's disease, with important social and economic implications. Factors influencing their evolution remain unclear but are crucial to the development of...
Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Vannberg, Fredrik, Hill, Adrian V.S., Bradbury, Linda A., ...
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis ( AS), autoimmune thyroid disease...
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease (2007)
Clark, Graeme R, Foltynie, Thomas, Lewis, Simon J. G, Brown, Joanne, ...
Objective: Parkinson's disease (PD) is a neurodegenerative condition that typically presents as a movement disorder but is known to be associated with variable degrees of cognitive impairment...
Cardon, Lon R, Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P, ...
There is increasing evidence that genome-wide association ( GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study...
A second major histocompatibility complex susceptibility locus for multiple sclerosis (2007)
Gregory, Simon G, Barcellos, Lisa F, Walton, Amie, ...
Objective: Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the...
Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Vannberg, Fredrik, Hill, Adrian V. S., Bradbury, Linda A., ...
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis ( AS), autoimmune thyroid disease...
Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Vannberg, Fredrik, Hill, Adrian V. S., Bradbury, Linda A., ...
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis ( AS), autoimmune thyroid disease...
CD24 Ala/Val polymorphism and multiple sclerosis (2006)
Maranian, Melanie, Walton, Amie, Yeo, Tai Wai, Ban, Maria, Gray, Julia, ...
CD24 is expressed on a broad range of cells in the immune and central nervous systems and appears to be required for development of experimental autoimmune encephalomyelitis in mice. Association of a...
SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis (2006)
Galimberti, Daniela, Ban, Maria, Maranian, Mel, Scalabrini, Diego, Venturelli, Eliana, ...
P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a critical event in the pathogenesis of...
Investigation of the Role of Mitochondrial DNA in Multiple Sclerosis Susceptibility
Ban, Maria, Elson, Joanna, Walton, Amie, Turnbull, Douglas, Compston, Alastair, Chinnery, Patrick, ...
Several lines of evidence suggest that mitochondrial genetic factors may influence susceptibility to multiple sclerosis. To explore this hypothesis further, we re-sequenced the mitochondrial genome...
Jones, Joanne L., Phuah, Chia-Ling, Cox, Amanda L., Thompson, Sara A., Ban, Maria, Shawcross, Jacqueline, ...
Phase II clinical trials revealed that the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath-1H) is highly effective in the treatment of early relapsing-remitting multiple...