Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death
Okada, Hitoshi, Bakal, Chris, Shahinian, Arda, Elia, Andrew, Wakeham, Andrew, Suh, Woong-Kyung, ...
Because survivin-null embryos die at an early embryonic stage, the role of survivin in thymocyte development is unknown. We have investigated the role by deleting the survivin gene only in the T...
Schmitt, Thomas M., Ciofani, Maria, Petrie, Howard T., Zúñiga-Pflücker, Juan Carlos
Notch signaling has been shown to play a pivotal role in inducing T lineage commitment. However, T cell progenitors are known to retain other lineage potential long after the first point at which...
The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival
Mandal, Malay, Borowski, Christine, Palomero, Teresa, Ferrando, Adolfo A., Oberdoerffer, Philipp, Meng, Fanyong, ...
The pre–T cell receptor (TCR) is expressed early during T cell development and imposes a tight selection for differentiating T cell progenitors. Pre-TCR–expressing cells are selected to survive...