TNF{alpha} shedding and epidermal inflammation are controlled by Jun proteins (2009)
Guinea-Viniegra, Juan, Zenz, Rainer, Scheuch, Harald, Hnisz, Denes, Holcmann, Martin, Bakiri, Latifa, ...
Inducible epidermal deletion of JunB and c-Jun in adult mice causes a psoriasis-like inflammatory skin disease. Increased levels of the proinflammatory cytokine TNFα play a major role in this...
Behrens, Axel, Sibilia, Maria, David, Jean-Pierre, Möhle-Steinlein, Uta, Tronche, François, Schütz, Günther, ...
Mice lacking the AP-1 transcription factor c-jun die at mid-gestation showing heart defects and impaired hepatogenesis. To inactivate c-jun in hepatocytes, mice carrying a floxed c-jun allele were...
Stoll, Stefan W, Kansra, Sanjay, Peshick, Scott, Fry, David W, Leopold, Wilbur R, Wiesen, Jane F, ...
Induction of heparin-binding epidermal growth factor-like growth factor (HB-EGF) mRNA in mouse skin organ culture was blocked by two pan-ErbB receptor tyrosine kinase (RTK) inhibitors but not by...
Behrens, Axel, Sibilia, Maria, David, Jean-Pierre, Möhle-Steinlein, Uta, Tronche, François, Schütz, Günther, ...
Mice lacking the AP-1 transcription factor c-jun die at mid-gestation showing heart defects and impaired hepatogenesis. To inactivate c-jun in hepatocytes, mice carrying a floxed c-jun allele were...
Stoll, Stefan W, Kansra, Sanjay, Peshick, Scott, Fry, David W, Leopold, Wilbur R, Wiesen, Jane F, ...
Induction of heparin-binding epidermal growth factor-like growth factor (HB-EGF) mRNA in mouse skin organ culture was blocked by two pan-ErbB receptor tyrosine kinase (RTK) inhibitors but not by...
Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes
Wagner, Bettina, Natarajan, Anuradha, Grünaug, Sabine, Kroismayr, Renate, Wagner, Erwin F, Sibilia, Maria
Mice lacking epidermal growth factor receptor (EGFR) develop a neurodegeneration of unknown etiology affecting exclusively the frontal cortex and olfactory bulbs. Here, we show that EGFR signaling...
Early Embryonic Lethality of Mice Lacking the Essential Protein SNEV▿ ‡
Fortschegger, Klaus, Wagner, Bettina, Voglauer, Regina, Katinger, Hermann, Sibilia, Maria, Grillari, Johannes
SNEV (Prp19, Pso4, NMP200) is a nuclear matrix protein known to be involved in pre-mRNA splicing, ubiquitylation, and DNA repair. In human umbilical vein endothelial cells, SNEV overexpression...
The EGF receptor is required for efficient liver regeneration
Natarajan, Anuradha, Wagner, Bettina, Sibilia, Maria
Mice lacking the EGF receptor (EGFR) die between midgestation and postnatal day 20 with various defects in neural and epithelial organs. Here, we generated mice carrying a floxed EGFR allele to...
Functions of c-Jun in Liver and Heart Development
Eferl, Robert, Sibilia, Maria, Hilberg, Frank, Fuchsbichler, Andrea, Kufferath, Iris, Guertl, Barbara, ...
Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is known about the cell types affected as well as the cause of embryonic lethality. Here we show that a...
Sibilia, Maria, Wagner, Erwin F.
Transgenic animals are organisms in which permanent gene modifications have been experimentally introduced into their germline. Most knowledge of modern biology relating to the tissue-specific...