Chintalapudi, Mastan R., Markiewicz, Margaret, Kose, Nurgun, Dammai, Vincent, Champion, Kristen J., Hoda, Rana S., ...
The von Hippel–Lindau (VHL) protein serves as a negative regulator of hypoxia-inducible factor (HIF)-α subunits. Since HIF regulates critical angiogenic factors such as vascular endothelial growth...
Genetic factors in systemic sclerosis (2007)
Mayes, Maureen D, Trojanowska, Maria
Abstract A number of genetic loci have been identified that appear to be associated with systemic sclerosis (SSc; scleroderma). There is mounting evidence suggesting that these genetic associations...
Czuwara-Ladykowska, Joanna, Makiela, Barbara, Smith, Edwin A, Trojanowska, Maria, Rudnicka, Lidia
Abstract The main manifestation of systemic sclerosis (SSc) is the overproduction of extracellular matrix, predominantly type I collagen. This study was undertaken to evaluate the effects of...
Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway. (2001)
Czuwara-Ladykowska, Joanna, Shirasaki, Fumiaki, Jackers, Pascale, Watson, Dennis K., Trojanowska, Maria
Fibrosis is characterized by the excessive deposition of extracellular matrix (ECM), especially collagen. Because Ets factors are implicated in physiological and pathological ECM remodeling, the aim...
The bacteriophage T4 regA gene: primary sequence of a translational repressor (1984)
Trojanowska, Maria, Miller, Eric S., Karam, Jim, Stormo, Gary, Gold, Larry
The regA gene product of bacteriophage T4 is an autogenously controlled translational regulatory protein that plays a role In differential inhibition (translational repression) of a subpopulation of...
Czuwara-Ladykowska, Joanna, Makiela, Barbara, Smith, Edwin A, Trojanowska, Maria, Rudnicka, Lidia
The main manifestation of systemic sclerosis (SSc) is the overproduction of extracellular matrix, predominantly type I collagen. This study was undertaken to evaluate the effects of noncytotoxic...
Czuwara-Ladykowska, Joanna, Makiela, Barbara, Smith, Edwin A, Trojanowska, Maria, Rudnicka, Lidia
The main manifestation of systemic sclerosis (SSc) is the overproduction of extracellular matrix, predominantly type I collagen. This study was undertaken to evaluate the effects of noncytotoxic...
Kubo, Masahide, Czuwara-Ladykowska, Joanna, Moussa, Omar, Markiewicz, Margaret, Smith, Edwin, Silver, Richard M., ...
The molecular and cellular mechanisms that maintain proper collagen homeostasis in healthy human skin and are responsible for the dysregulated collagen synthesis in scleroderma remain primarily...
Genetic factors in systemic sclerosis
Mayes, Maureen D, Trojanowska, Maria
A number of genetic loci have been identified that appear to be associated with systemic sclerosis (SSc; scleroderma). There is mounting evidence suggesting that these genetic associations may in...
Transcription Factor Fli1 Regulates Collagen Fibrillogenesis in Mouse Skin ▿
Asano, Yoshihide, Markiewicz, Margaret, Kubo, Masahide, Szalai, Gabor, Watson, Dennis K., Trojanowska, Maria
Biosynthesis of fibrillar collagen in the skin is precisely regulated to maintain proper tissue homeostasis; however, the molecular mechanisms involved in this process remain largely unknown....
Asano, Yoshihide, Trojanowska, Maria
Previous studies have shown that transforming growth factor β (TGF-β)-induced collagen gene expression involves acetylation-dependent dissociation from the human α2(I) collagen (COL1A2) promoter...