Studies in patients and chimpanzees that spontaneously clear Hepatitis C Virus (HCV) have demonstrated that natural immunity to the virus is induced during primary infections and that this immunity...
Isao Nakano, Geert Maertens, Marian E. Major, Ludmila Vitvitski, Jean Dubuisson, Anne Fournillier, ...
Plasmids expressing different domains of the hepatitis C virus (HCV) envelope E2 glycoprotein from a genotype 1a isolate were constructed to compare the immunogenic potential of E2 in nucleic...
Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...
DNA vaccines express antigens intracellularly and effectively induce cellular immune responses. Because only chimpanzees can be used to model human hepatitis C virus (HCV) infections, we developed a...
Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...
Long-Term Follow-Up of Chimpanzees Inoculated with the First Infectious Clone for Hepatitis C Virus
Major, Marian E., Mihalik, Kathleen, Fernandez, Javier, Seidman, Jessica, Kleiner, David, Kolykhalov, Alexander A., ...
Two chimpanzees (Ch1535 and Ch1536) became infected with hepatitis C virus (HCV) following intrahepatic inoculation with RNA transcribed from a full-length cDNA clone of the virus. Both animals were...
Major, Marian E., Mihalik, Kathleen, Puig, Montserrat, Rehermann, Barbara, Nascimbeni, Michelina, Rice, Charles M., ...
Responses in three chimpanzees were compared following challenge with a clonal hepatitis C virus (HCV) contained in plasma from an animal that had received infectious RNA transcripts. Two of the...
Nascimbeni, Michelina, Mizukoshi, Eishiro, Bosmann, Markus, Major, Marian E., Mihalik, Kathleen, Rice, Charles M., ...
The immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood. Antibodies to HCV structural proteins do not appear to play a key role in clearance of the virus and...
Fernandez, Javier, Taylor, Deborah, Morhardt, Duncan R., Mihalik, Kathleen, Puig, Montserrat, Rice, Charles M., ...
Two chimpanzees, 1535 and 1536, became persistently infected following inoculation with RNA transcripts from cDNA clones of hepatitis C virus (HCV). Analysis of the HCV genomes from both animals...
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
Lindenbach, Brett D., Meuleman, Philip, Ploss, Alexander, Vanwolleghem, Thomas, Syder, Andrew J., McKeating, Jane A., ...
Hepatitis C virus (HCV) is a major cause of chronic liver disease, frequently progressing to cirrhosis and increased risk of hepatocellular carcinoma. Current therapies are inadequate and progress in...
Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...
DNA vaccines express antigens intracellularly and effectively induce cellular immune responses. Because only chimpanzees can be used to model human hepatitis C virus (HCV) infections, we developed a...
Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...
Long-Term Follow-Up of Chimpanzees Inoculated with the First Infectious Clone for Hepatitis C Virus
Major, Marian E., Mihalik, Kathleen, Fernandez, Javier, Seidman, Jessica, Kleiner, David, Kolykhalov, Alexander A., ...
Two chimpanzees (Ch1535 and Ch1536) became infected with hepatitis C virus (HCV) following intrahepatic inoculation with RNA transcribed from a full-length cDNA clone of the virus. Both animals were...
Major, Marian E., Mihalik, Kathleen, Puig, Montserrat, Rehermann, Barbara, Nascimbeni, Michelina, Rice, Charles M., ...
Responses in three chimpanzees were compared following challenge with a clonal hepatitis C virus (HCV) contained in plasma from an animal that had received infectious RNA transcripts. Two of the...
Nascimbeni, Michelina, Mizukoshi, Eishiro, Bosmann, Markus, Major, Marian E., Mihalik, Kathleen, Rice, Charles M., ...
The immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood. Antibodies to HCV structural proteins do not appear to play a key role in clearance of the virus and...
Fernandez, Javier, Taylor, Deborah, Morhardt, Duncan R., Mihalik, Kathleen, Puig, Montserrat, Rice, Charles M., ...
Two chimpanzees, 1535 and 1536, became persistently infected following inoculation with RNA transcripts from cDNA clones of hepatitis C virus (HCV). Analysis of the HCV genomes from both animals...
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
Lindenbach, Brett D., Meuleman, Philip, Ploss, Alexander, Vanwolleghem, Thomas, Syder, Andrew J., McKeating, Jane A., ...
Hepatitis C virus (HCV) is a major cause of chronic liver disease, frequently progressing to cirrhosis and increased risk of hepatocellular carcinoma. Current therapies are inadequate and progress in...