Monrad, Seetha U, Rea, Kristine, Thacker, Seth, Kaplan, Mariana J
Abstract Introduction There is a growing body of evidence implicating aberrant dendritic cell function as a crucial component in the immunopathogenesis of systemic lupus erythematosus. The purpose of...
The role of aldosterone blockade in murine lupus nephritis (2008)
Monrad, Seetha U, Killen, Paul D, Anderson, Marc R, Bradke, Amanda, Kaplan, Mariana J
Abstract Background The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZB × NZW) F 1 murine lupus...
Rajagopalan, Sanjay, Pfenninger, Dana, Kehrer, Christine, Chakrabarti, Anjan, Somers, Emily C., Pavlic, Robert, ...
Objective To compare microvascular and macrovascular functions in a cohort of patients with primary and secondary Raynaud's phenomenon (RP) who were matched for demographic, risk factor, and severity...
Kaplan, Mariana J, Ike, Robert W
Abstract Background The autoimmune destruction of exocrine glands that defines primary Sjögren's syndrome (1°SS) often extends to non-exocrine organs including the liver. We aimed to determine the...
Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus (2002)
Lu, Qianjin, Kaplan, Mariana J., Ray, Donna, Ray, Doreen, Zacharek, Sima, Gutsch, David, ...
Objective Inhibition of T cell DNA methylation causes autoreactivity in vitro and a lupus-like disease in vivo, suggesting that T cell DNA hypomethylation may contribute to autoimmunity. The...
Deng, Chun, Kaplan, Mariana J., Yang, Jun, Ray, Donna, Zhang, Zhiyong, McCune, William Joseph, ...
Objective Previous studies have shown that inhibiting T cell DNA methylation causes a lupus-like disease by modifying gene expression. T cells from patients with lupus exhibit diminished levels of...
Crofford, Leslie J., Oates, James C., McCune, William Joseph, Gupta, Samardeep, Kaplan, Mariana J., Catella-Lawson, Francesca, ...
Specific inhibitors of cyclooxygenase 2 (COX-2) have been approved for the treatment of osteoarthritis and rheumatoid arthritis. Unlike nonsteroidal anti-inflammatory drugs, specific COX-2 inhibitors...
Grolleau, Annabelle, Kaplan, Mariana J., Hanash, Samir M., Beretta, Laura, Richardson, Bruce
Activation of peripheral blood T cells results in a rapid and substantial rise in translation rates and proliferation, but proliferation in response to mitogen stimulation is impaired in systemic...
Grolleau, Annabelle, Kaplan, Mariana J., Hanash, Samir M., Beretta, Laura, Richardson, Bruce
Activation of peripheral blood T cells results in a rapid and substantial rise in translation rates and proliferation, but proliferation in response to mitogen stimulation is impaired in systemic...
The role of aldosterone blockade in murine lupus nephritis
Monrad, Seetha U, Killen, Paul D, Anderson, Marc R, Bradke, Amanda, Kaplan, Mariana J
Denny, Michael F., Thacker, Seth, Mehta, Hemal, Somers, Emily C., Dodick, Todd, Barrat, Franck J., ...
Individuals with systemic lupus erythematosus (SLE) have a striking increase in premature atherosclerosis of unclear etiology. Accelerated endothelial cell apoptosis occurs in SLE and correlates with...
Cardiometabolic risk in psoriasis: differential effects of biologic agents
Psoriasis is associated to an increased risk of cardiovascular (CV) complications. Overall, the pathogenic mechanisms involved in premature CV complications in psoriasis appear to be complex and...