The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface. (2009)
Heikkinen, Sami, Argmann, Carmen, Feige, Jérôme N, Koutnikova, Hana, Champy, Marie-France, Dali-Youcef, Nassim, ...
The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated. We demonstrate, using a...
Genetic background determines metabolic phenotypes in the mouse. (2008)
Champy, Marie-France, Selloum, Mohammed, Zeitler, Valérie, Caradec, Claudia, Jung, Barbara, Rousseau, Stéphane, ...
To evaluate the contribution of genetic background to phenotypic variation, we compared a large range of biochemical and metabolic parameters at different ages of four inbred mice strains, C57BL/6J,...
Dali-Youcef, Nassim, Mataki, Chikage, Coste, Agnès, Messaddeq, Nadia, Giroud, Sylvain, Blanc, Stéphane, ...
The role of the tumor suppressor retinoblastoma protein (pRb) has been firmly established in the control of cell cycle, apoptosis, and differentiation. Recently, it was demonstrated that lack of pRb...
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. (2006)
Rodriguez, Angelina, Durán, Angeles, Selloum, Mohammed, Champy, Marie-France, Diez-Guerra, Francisco J, Flores, Juana María, ...
Signaling cascades that control adipogenesis are essential in the regulation of body weight and obesity. The adaptor p62 controls pathways that modulate cell differentiation. We report here that...
Mouse functional genomics requires standardization of mouse handling and housing conditions. (2004)
Champy, Marie-France, Selloum, Mohammed, Piard, Laetitia, Zeitler, Valerie, Caradec, Claudia, Chambon, Pierre, ...
The study of mouse models is crucial for the functional annotation of the human genome. The recent improvements in mouse genetics now moved the bottleneck in mouse functional genomics from the...
Koutnikova, Hana, Cock, Terrie-Anne, Watanabe, Mitsuhiro, Houten, Sander M, Champy, Marie-France, Dierich, Andreé, ...
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPAR gamma 2-specific exon...
SRC-1 and TIF2 control energy balance between white and brown adipose tissues. (2003)
Picard, Frédéric, Géhin, Martine, Annicotte, Jean- Sébastien, Rocchi, Stéphane, Champy, Marie-France, O'Malley, Bert W, ...
We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas...
Koutnikova, Hana, Cock, Terrie-Anne, Watanabe, Mitsuhiro, Houten, Sander M., Champy, Marie-France, Dierich, Andrée, ...
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPARγ2-specific exon B,...
Koutnikova, Hana, Cock, Terrie-Anne, Watanabe, Mitsuhiro, Houten, Sander M., Champy, Marie-France, Dierich, Andrée, ...
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPARγ2-specific exon B,...
Dali-Youcef, Nassim, Mataki, Chikage, Coste, Agnès, Messaddeq, Nadia, Giroud, Sylvain, Blanc, Stéphane, ...
The role of the tumor suppressor retinoblastoma protein (pRb) has been firmly established in the control of cell cycle, apoptosis, and differentiation. Recently, it was demonstrated that lack of pRb...