Chk1 and Claspin potentiate PCNA ubiquitination (2008)
Yang, Xiaohong H., Shiotani, Bunsyo, Classon, Marie, Zou, Lee
Chk1 is a kinase crucial for genomic integrity and an effector of ATR (ATM and Rad3-realated) in DNA damage response. Here, we show that Chk1 regulates the DNA damage-induced ubiquitination of...
Nuclear organization of DNA replication in primary mammalian cells (2000)
Kennedy, Brian K., Barbie, David A., Classon, Marie, Dyson, Nicholas, Harlow, Ed
Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control
Classon, Marie, Salama, Sofie, Gorka, Carolyn, Mulloy, Roseann, Braun, Pascal, Harlow, Ed
Numerous studies have implicated the pRB family of nuclear proteins in the control of cell cycle progression. Although over-expression experiments have revealed that each of these proteins, pRB,...
Opposing roles of pRB and p107 in adipocyte differentiation
Classon, Marie, Kennedy, Brian K., Mulloy, Roseann, Harlow, Ed
The retinoblastoma (RB) family of proteins, pRB, p107, and p130, have been postulated to be partially redundant in their ability to regulate progression through the G1 phase of the cell cycle....
NPAT Expression Is Regulated by E2F and Is Essential for Cell Cycle Progression
Gao, Guang, Bracken, Adrian P., Burkard, Karina, Pasini, Diego, Classon, Marie, Attwooll, Claire, ...
NPAT is an in vivo substrate of cyclin E-Cdk2 kinase and is thought to play a critical role in coordinated transcriptional activation of histone genes during the G1/S-phase transition and in S-phase...
Nuclear organization of DNA replication in primary mammalian cells
Kennedy, Brian K., Barbie, David A., Classon, Marie, Dyson, Nicholas, Harlow, Ed
Using methods that conserve nuclear architecture, we have reanalyzed the spatial organization of the initiation of mammalian DNA synthesis. Contrary to the commonly held view that replication begins...
The Retinoblastoma Protein Is Required for Ras-Induced Oncogenic Transformationâ€
Williams, Jonathan P., Stewart, Timothy, Li, Bihua, Mulloy, Roseann, Dimova, Dessislava, Classon, Marie
Most human cancers involve either mutational activation of the Ras oncogenic pathway and/or inactivation of the retinoblastoma tumor suppressor (RB) pathway. Paradoxically, tumors that harbor Ras...
Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control
Classon, Marie, Salama, Sofie, Gorka, Carolyn, Mulloy, Roseann, Braun, Pascal, Harlow, Ed
Numerous studies have implicated the pRB family of nuclear proteins in the control of cell cycle progression. Although over-expression experiments have revealed that each of these proteins, pRB,...
Opposing roles of pRB and p107 in adipocyte differentiation
Classon, Marie, Kennedy, Brian K., Mulloy, Roseann, Harlow, Ed
The retinoblastoma (RB) family of proteins, pRB, p107, and p130, have been postulated to be partially redundant in their ability to regulate progression through the G1 phase of the cell cycle....
NPAT Expression Is Regulated by E2F and Is Essential for Cell Cycle Progression
Gao, Guang, Bracken, Adrian P., Burkard, Karina, Pasini, Diego, Classon, Marie, Attwooll, Claire, ...
NPAT is an in vivo substrate of cyclin E-Cdk2 kinase and is thought to play a critical role in coordinated transcriptional activation of histone genes during the G1/S-phase transition and in S-phase...
Nuclear organization of DNA replication in primary mammalian cells
Kennedy, Brian K., Barbie, David A., Classon, Marie, Dyson, Nicholas, Harlow, Ed
Using methods that conserve nuclear architecture, we have reanalyzed the spatial organization of the initiation of mammalian DNA synthesis. Contrary to the commonly held view that replication begins...
The Retinoblastoma Protein Is Required for Ras-Induced Oncogenic Transformationâ€
Williams, Jonathan P., Stewart, Timothy, Li, Bihua, Mulloy, Roseann, Dimova, Dessislava, Classon, Marie
Most human cancers involve either mutational activation of the Ras oncogenic pathway and/or inactivation of the retinoblastoma tumor suppressor (RB) pathway. Paradoxically, tumors that harbor Ras...
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation
Sarmento, Leonor M., Huang, Hui, Limon, Ana, Gordon, William, Fernandes, Jacquenilson, Tavares, Maria J., ...
Cyclin-dependent kinase inhibitors (CKIs) and Notch receptor activation have been shown to influence adult stem cells and progenitors by altering stem cell self-renewal and proliferation. Yet, no...
Chk1 and Claspin potentiate PCNA ubiquitination
Yang, Xiaohong H., Shiotani, Bunsyo, Classon, Marie, Zou, Lee
Chk1 is a kinase crucial for genomic integrity and an effector of ATR (ATM and Rad3-realated) in DNA damage response. Here, we show that Chk1 regulates the DNA damage-induced ubiquitination of...