Reckamp, Karen L, Figlin, Robert A, Burdick, Marie D, Dubinett, Steven M, Elashoff, Robert M, Strieter, Robert M
Abstract Background The CXC chemokine, CXCL12, and its receptor, CXCR4 promote metastases of a variety of solid tumors, including non-small cell lung cancer (NSCLC). The expression of CXCR4 on tumor...
Burdick, Marie D, Peeters, Elke, Van Den Broeck, Karolien, Dillen, Chris, ...
The platelet factor-4 variant, designated PF-4var/CXCL4L1, is a recently described natural non-allelic gene variant of the CXC chemokine platelet factor-4/CXCL4. PF-4var/CXCL4L1 was cloned, and the...
Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis (2006)
Pan, Judong, Mestas, Javier, Burdick, Marie D, Phillips, Roderick J, Thomas, George V, Reckamp, Karen, ...
Abstract Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate...
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection (2005)
Londhe, Vedang A, Belperio, John A, Keane, Michael P, Burdick, Marie D, Xue, Ying, Strieter, Robert M
Abstract Background Respiratory viral infections are characterized by the infiltration of leukocytes, including activated neutrophils into the lung that can lead to sustained lung injury and...
Burdick, Marie D, Strieter, Robert M
Platelet factor-4 (PF-4)/CXCL4 was the first chemokine described to inhibit neovascularization. Here, the product of the nonallelic variant gene of CXCL4, PF-4var1/PF-4alt, designated CXCL4L1, was...
Addison, Christina L, Belperio, John A, Burdick, Marie D, Strieter, Robert M
Abstract Background The Duffy antigen receptor for chemokines (DARC) is known to be a promiscuous chemokine receptor that binds a variety of CXC and CC chemokines in the absence of any detectable...
SLC/CCL21-mediated anti-tumor responses require IFNγ, MIG/CXCL9 and IP-10/CXCL10 (2003)
Sharma, Sherven, Yang, Seok-Chul, Hillinger, Sven, Zhu, Li X, Huang, Min, Batra, Raj K, ...
Abstract Background SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously...
Strieter, Robert M., White, Eric S., Burdick, Marie D., Strom, Scott R. B., Arenberg, Douglas A.
Tumor growth requires angiogenesis, which in turn requires an imbalance in the presence of angiogenic and angiostatic factors. We have shown that the CXC chemokine family, consisting of members that...
Burdick, Marie D., Strieter, Robert M., Arenberg, Douglas A., Zlotnick, Albert, Strom, Scott R. B.
The recently described CC chemokine, 6C-kine, is unique in that it contains -six rather than the usual four conserved cysteines typical of this family. Furthermore, murine 6C-kine binds to one of the...
Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines (2000)
DiGiovine, Bruno, Burdick, Marie D., Arenberg, Douglas A., Kunkel, Steven L., Strieter, Robert M., Strom, Scott R. B., ...
Bronchogenic carcinoma is the leading cause of malignancy-related mortality in the United States, with an overall 5-year survival rate of less than 15%. This aggressive behavior reflects, among...
Orens, Jonathan B., Lukacs, Nicholas W., Kunkel, Steven L., Burdick, Marie D., Wilke, Carol A., Walz, Alfred, ...
Previous studies have shown that during the development of a mixed lymphocyte reaction (MLR) levels of the chemotactic cytokines IL-8 and MCP-1 (members of the C-X-C and C-C supergene families,...
Lukacs, Nicholas W., Strieter, Robert M., Evanoff, Holly L., Burdick, Marie D., Kunkel, Steven L.
The allogeneic mixed lymphocyte reaction (MLR) is regarded as an effective model for examining the events which occur during an allospecific immune response. Numerous studies have delineated the role...
Hodge-Dufour, Jennifer, Marino, Michael W., Horton, Maureen R., Jungbluth, Achim, Burdick, Marie D., Strieter, Robert M., ...
Inflammation is associated with production of cytokines and chemokines that recruit and activate inflammatory cells. Interleukin (IL) 12 produced by macrophages in response to various stimuli is a...
IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis
Huang, Min, Sharma, Sherven, Zhu, Li X., Keane, Michael P., Luo, Jie, Zhang, Ling, ...
Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-γ–dependent and independent manner. Here, we have evaluated the antifibrotic...
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
Belperio, John A., Keane, Michael P., Burdick, Marie D., Londhe, Vedang, Xue, Ying Ying, Li, Kewang, ...
Mortality related to adult respiratory distress syndrome (ARDS) ranges from 35% to 65%. Lung-protective ventilator strategies can reduce mortality during ARDS. The protective strategies limit tidal...
SLC/CCL21-mediated anti-tumor responses require IFNγ, MIG/CXCL9 and IP-10/CXCL10
Sharma, Sherven, Yang, Seok-Chul, Hillinger, Sven, Zhu, Li X, Huang, Min, Batra, Raj K, ...
Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Lynch, Joseph P., Xue, Ying Ying, Berlin, Aaron, ...
Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival after lung transplantation. Acute rejection, its main risk factor, is characterized by perivascular/bronchiolar leukocyte...
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, Roderick J., Burdick, Marie D., Hong, Kurt, Lutz, Marin A., Murray, Lynne A., Xue, Ying Ying, ...
Previous reports have identified a circulating pool of CD45+ collagen I+ CXCR4+ (CD45+Col I+CXCR4+) cells, termed fibrocytes, that traffic to areas of fibrosis. No studies have demonstrated that...
Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Gomperts, Brigitte, Xue, Ying Ying, Hong, Kurt, ...
Angiogenesis and vascular remodeling support fibroproliferative processes; however, no study has addressed the importance of angiogenesis during fibro-obliteration of the allograft airway during...
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
Londhe, Vedang A, Belperio, John A, Keane, Michael P, Burdick, Marie D, Xue, Ying Ying, Strieter, Robert M
Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
Pan, Judong, Mestas, Javier, Burdick, Marie D, Phillips, Roderick J, Thomas, George V, Reckamp, Karen, ...
Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate organ-specific...
Hodge-Dufour, Jennifer, Marino, Michael W., Horton, Maureen R., Jungbluth, Achim, Burdick, Marie D., Strieter, Robert M., ...
Inflammation is associated with production of cytokines and chemokines that recruit and activate inflammatory cells. Interleukin (IL) 12 produced by macrophages in response to various stimuli is a...
IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis
Huang, Min, Sharma, Sherven, Zhu, Li X., Keane, Michael P., Luo, Jie, Zhang, Ling, ...
Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-γ–dependent and independent manner. Here, we have evaluated the antifibrotic...
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
Belperio, John A., Keane, Michael P., Burdick, Marie D., Londhe, Vedang, Xue, Ying Ying, Li, Kewang, ...
Mortality related to adult respiratory distress syndrome (ARDS) ranges from 35% to 65%. Lung-protective ventilator strategies can reduce mortality during ARDS. The protective strategies limit tidal...
SLC/CCL21-mediated anti-tumor responses require IFNγ, MIG/CXCL9 and IP-10/CXCL10
Sharma, Sherven, Yang, Seok-Chul, Hillinger, Sven, Zhu, Li X, Huang, Min, Batra, Raj K, ...
Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Lynch, Joseph P., Xue, Ying Ying, Berlin, Aaron, ...
Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival after lung transplantation. Acute rejection, its main risk factor, is characterized by perivascular/bronchiolar leukocyte...
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, Roderick J., Burdick, Marie D., Hong, Kurt, Lutz, Marin A., Murray, Lynne A., Xue, Ying Ying, ...
Previous reports have identified a circulating pool of CD45+ collagen I+ CXCR4+ (CD45+Col I+CXCR4+) cells, termed fibrocytes, that traffic to areas of fibrosis. No studies have demonstrated that...
Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Gomperts, Brigitte, Xue, Ying Ying, Hong, Kurt, ...
Angiogenesis and vascular remodeling support fibroproliferative processes; however, no study has addressed the importance of angiogenesis during fibro-obliteration of the allograft airway during...
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
Londhe, Vedang A, Belperio, John A, Keane, Michael P, Burdick, Marie D, Xue, Ying Ying, Strieter, Robert M
Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
Pan, Judong, Mestas, Javier, Burdick, Marie D, Phillips, Roderick J, Thomas, George V, Reckamp, Karen, ...
Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate organ-specific...
Distinct CXC Chemokines Mediate Tumorigenicity of Prostate Cancer Cells
Moore, Bethany B., Arenberg, Douglas A., Stoy, Kevin, Morgan, Tamara, Addison, Christina L., Morris, Susan B., ...
Prostate cancer is the second leading cause of malignancy-related mortality in males in the United States. As a solid tumor, clinically significant tumor growth and metastasis are dependent on...
The Role of MIG/CXCL9 in Cardiac Allograft Vasculopathy
Yun, James J., Fischbein, Michael P., Whiting, David, Irie, Yoshihito, Fishbein, Michael C., Burdick, Marie D., ...
T lymphocytes play a critical role in chronic rejection of transplanted hearts, or cardiac allograft vasculopathy (CAV). However, the molecular mediators of T lymphocyte recruitment in CAV are...
The Production of lnterleukin-1 Receptor Antagonist by Human Bronchogenic Carcinoma
Smith, Daniel R., Kunkel, Steven L., Standiford, Theodore J., Chensue, Stephen W., Rolfe, Mark W., Orringer, Mark B., ...
Bronchogenic carcinoma displays an aggressive clinical course that may reflect a capacity to evade host defenses. We postulated that tumors may elaborate interleukin-1 receptor antagonist protein...
Keratinocyte Growth Factor Improves Repair in the Injured Tracheal Epithelium
Gomperts, Brigitte N., Belperio, John A., Fishbein, Michael C., Keane, Michael P., Burdick, Marie D., Strieter, Robert M.
Keratinocyte growth factor (KGF) is a critical growth factor in lung development and is a protective agent after lung injury, although the exact mechanisms of this protective effect have not yet been...
Reckamp, Karen L, Figlin, Robert A, Burdick, Marie D, Dubinett, Steven M, Elashoff, Robert M, Strieter, Robert M
The Role of Circulating Mesenchymal Progenitor Cells, Fibrocytes, in Promoting Pulmonary Fibrosis
Strieter, Robert M., Keeley, Ellen C., Burdick, Marie D., Mehrad, Borna
The resident fibroblast has been traditionally viewed as the primary cell involved in promoting pulmonary fibrosis. However, contemporary findings now support the concept of a circulating cell...
Crawford, Matthew A., Zhu, Yinghua, Green, Candace S., Burdick, Marie D., Sanz, Patrick, Alem, Farhang, ...
Based on previous studies showing that host chemokines exert antimicrobial activities against bacteria, we sought to determine whether the interferon-inducible Glu-Leu-Arg-negative CXC chemokines...