Rose, Kirsten L., Paixao-Cavalcante, Danielle, Fish, Jennifer, Manderson, Anthony P., Malik, Talat, Bygrave, Anne E., ...
The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) is associated with dysregulation. of the alternative pathway of complement activation. MPGN2 is characterized...
Giacomin, Paul, Gordon, David L., Botto, Marina, Daha, Mohamed R., Sanderson, Sam D., Taylor, Stephen M., ...
Copyright © 2007 Elsevier Ltd All rights reserved.
Giacomin, Paul, Gordon, David L., Botto, Marina, Daha, Mohamed R., Sanderson, Sam D., Taylor, Stephen M., ...
Copyright © 2007 Elsevier Ltd All rights reserved.
Serum Amyloid P Aids Complement-Mediated Immunity to Streptococcus pneumoniae (2007)
Jose Yuste, Marina Botto, Stephen E. Bottoms, Jeremy S. Brown
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been...
Pickering, Matthew C., Goicoechea De Jorge, Elena, Martinez-Barricarte, Rubén, Recalde, Sergio, Garcia-Layana, Alfredo, Rose, Kirsten L., ...
We are grateful to all patients and the collaborating clinicians for their participation in this study. We thank Mr. Ian Shore for his technical assistance with the preparation of tissue for electron...
Rose, Kirsten L., Paixao-Cavalcante, Danielle, Fish, Jennifer, Manderson, Anthony P., Malik, Talat, Bygrave, Anne E., ...
No abstract
Manderson, Anthony P, Carlucci, Francesco, Lachmann, Peter J, Lazarus, Robert A, Festenstein, Richard J, Cook, H Terence, ...
Abstract Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Evidence makes it clear that the...
Manderson, Anthony P., Carlucci,Francesco, Lachmann, J., Lazarus, Robert A ., Festenstein,Richard J, Cook, Terence, ...
Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Evidence makes it clear that the development of...
Anne E. Bygrave, Kirsten L. Rose, Josefina Cortes-Hernandez, Joanna Warren, Robert J. Rigby, H. Terence Cook, ...
Several strains of gene-targeted mice develop systemic lupus erythematosus (SLE). Analysis of these strains demonstrates that the genetic background profoundly influences the development of...
Anne E. Bygrave, Kirsten L. Rose, Josefina Cortes-Hernandez, Joanna Warren, Robert J. Rigby, H. Terence Cook, ...
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop...
Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal (2004)
Abstract Apoptosis, a physiological process of controlled cell death, is essential during embryonic development and for the maintenance of tissue homeostasis. In recent years the view has emerged...
Celik, Ilhan, Stover, Cordula M., Botto, Marina, Thiel, Steffen, Tzima, Sotiria, Künkel, Dieter, ...
Also available from http://iai.asm.org/ and from PubMed Central.
Links between complement deficiency and apoptosis (2001)
Abstract Deficiency in the classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). In addition, SLE causes consumption...
MT1-MMP-deficient mice develop connective tissue abnormalities (1999)
No abstract available.
Taylor, Philip R., Seixas, Elsa, Walport, Mark J., Langhorne, Jean, Botto, Marina
We have studied the impact of deficiency of the complement system on the progression and control of the erythrocyte stages of the malarial parasite Plasmodium chabaudi chabaudi. C1q-deficient mice...
Celik, Ilhan, Stover, Cordula, Botto, Marina, Thiel, Steffen, Tzima, Sotiria, Künkel, Dieter, ...
The complement system and the natural antibody repertoire provide a critical first-line defense against infection. The binding of natural antibodies to microbial surfaces opsonizes invading...
Increased Susceptibility of C1q-Deficient Mice to Salmonella enterica Serovar Typhimurium Infection
Warren, Joanna, Mastroeni, Pietro, Dougan, Gordon, Noursadeghi, Mahdad, Cohen, Jonathan, Walport, Mark J., ...
The role of the complement system in host defense against Salmonella infection is poorly defined. Bacterial cell wall O-antigen polysaccharide can activate the alternative pathway in vitro. No...
Links between complement deficiency and apoptosis
Deficiency in the classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). In addition, SLE causes consumption of...
Brown, Jeremy S., Hussell, Tracy, Gilliland, Sarah M., Holden, David W., Paton, James C., Ehrenstein, Michael R., ...
The complement system is an important component of the innate immune response to bacterial pathogens, including Streptococcus pneumoniae. The classical complement pathway is activated by...
Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal
Apoptosis, a physiological process of controlled cell death, is essential during embryonic development and for the maintenance of tissue homeostasis. In recent years the view has emerged that dying...
Bygrave, Anne E, Rose, Kirsten L, Cortes-Hernandez, Josefina, Warren, Joanna, Rigby, Robert J, Cook, H. Terence, ...
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop...
Giacomin, Paul R., Wang, Hui, Gordon, David L., Botto, Marina, Dent, Lindsay A.
Complement activation and C3 deposition on the surface of parasitic helminths may be important for recruitment of leukocytes and for damage to the target organism via cell-mediated mechanisms....
Manderson, Anthony P, Carlucci, Francesco, Lachmann, Peter J, Lazarus, Robert A, Festenstein, Richard J, Cook, H Terence, ...
Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Evidence makes it clear that the development of...
Taylor, Philip R., Seixas, Elsa, Walport, Mark J., Langhorne, Jean, Botto, Marina
We have studied the impact of deficiency of the complement system on the progression and control of the erythrocyte stages of the malarial parasite Plasmodium chabaudi chabaudi. C1q-deficient mice...
Celik, Ilhan, Stover, Cordula, Botto, Marina, Thiel, Steffen, Tzima, Sotiria, Künkel, Dieter, ...
The complement system and the natural antibody repertoire provide a critical first-line defense against infection. The binding of natural antibodies to microbial surfaces opsonizes invading...
Increased Susceptibility of C1q-Deficient Mice to Salmonella enterica Serovar Typhimurium Infection
Warren, Joanna, Mastroeni, Pietro, Dougan, Gordon, Noursadeghi, Mahdad, Cohen, Jonathan, Walport, Mark J., ...
The role of the complement system in host defense against Salmonella infection is poorly defined. Bacterial cell wall O-antigen polysaccharide can activate the alternative pathway in vitro. No...
Links between complement deficiency and apoptosis
Deficiency in the classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). In addition, SLE causes consumption of...
Brown, Jeremy S., Hussell, Tracy, Gilliland, Sarah M., Holden, David W., Paton, James C., Ehrenstein, Michael R., ...
The complement system is an important component of the innate immune response to bacterial pathogens, including Streptococcus pneumoniae. The classical complement pathway is activated by...
Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal
Apoptosis, a physiological process of controlled cell death, is essential during embryonic development and for the maintenance of tissue homeostasis. In recent years the view has emerged that dying...
Bygrave, Anne E, Rose, Kirsten L, Cortes-Hernandez, Josefina, Warren, Joanna, Rigby, Robert J, Cook, H. Terence, ...
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop...
Giacomin, Paul R., Wang, Hui, Gordon, David L., Botto, Marina, Dent, Lindsay A.
Complement activation and C3 deposition on the surface of parasitic helminths may be important for recruitment of leukocytes and for damage to the target organism via cell-mediated mechanisms....
Manderson, Anthony P, Carlucci, Francesco, Lachmann, Peter J, Lazarus, Robert A, Festenstein, Richard J, Cook, H Terence, ...
Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Evidence makes it clear that the development of...
Hutchinson, Winston L, Herbert, Jeff, Botto, Marina, Pepys, Mark B
During induction of reactive systemic amyloid A protein (AA) amyloidosis in mice, either by chronic inflammation or by severe acute inflammation following injection of amyloid enhancing factor, the...
Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice
Trendelenburg, Marten, Manderson, Anthony P, Fossati-Jimack, Liliane, Walport, Mark J, Botto, Marina
C1q deficiency has been shown to accelerate spontaneous autoimmunity in mice. We studied the time course of activation of monocytes and lymphocytes in autoimmune and non-autoimmune mice in the...
CD59a Deficiency Exacerbates Ischemia-Reperfusion Injury in Mice
Turnberg, Daniel, Botto, Marina, Lewis, Margarita, Zhou, Wuding, Sacks, Steven H., Morgan, B. Paul, ...
The terminal complement components C5a and the membrane attack complex are involved in the pathogenesis of ischemia-reperfusion injury in many organs. CD59 is the major regulator of membrane attack...
Woodman, Michael E., Cooley, Anne E., Miller, Jennifer C., Lazarus, John J., Tucker, Kathryn, Bykowski, Tomasz, ...
The causative agent of Lyme disease, Borrelia burgdorferi, is naturally resistant to its host's alternative pathway of complement-mediated killing. Several different borrelial outer surface proteins...
Fossati-Jimack, Liliane, Cortes-Hernandez, Josefina, Norsworthy, Peter J., Walport, Mark J., Cook, H. Terence, Botto, Marina
C1q-deficient mice have been shown to develop a lupus-like disease and to display an impaired clearance of apoptotic cells that are enriched in lupus autoantigens. However, the role of C1q in the...
Pickering, Matthew C., De Jorge, Elena Goicoechea, Martinez-Barricarte, Rubén, Recalde, Sergio, Garcia-Layana, Alfredo, Rose, Kirsten L., ...
Factor H (FH) is an abundant serum glycoprotein that regulates the alternative pathway of complement-preventing uncontrolled plasma C3 activation and nonspecific damage to host tissues. Age-related...
Rose, Kirsten L., Paixao-Cavalcante, Danielle, Fish, Jennifer, Manderson, Anthony P., Malik, Talat H., Bygrave, Anne E., ...
The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) is associated with dysregulation of the alternative pathway of complement activation. MPGN2 is characterized...
Available carbon source influences the resistance of Neisseria meningitidis against complement
Exley, Rachel M., Shaw, Jonathan, Mowe, Eva, Sun, Yao-hui, West, Nicholas P., Williamson, Michael, ...
Neisseria meningitidis is an important cause of septicaemia and meningitis. To cause disease, the bacterium must acquire essential nutrients for replication in the systemic circulation, while...
Stokol, Tracy, O'Donnell, Peter, Xiao, Ling, Knight, Sara, Stavrakis, George, Botto, Marina, ...
Inflammation induced by circulating immunoglobulin G–immune complexes (ICs) characterizes many immune-mediated diseases. In this work, the molecular requirements for the deposition of circulating...
Serum Amyloid P Aids Complement-Mediated Immunity to Streptococcus pneumoniae
Yuste, Jose, Botto, Marina, Bottoms, Stephen E, Brown, Jeremy S
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been...
Taylor, Philip R., Carugati, Anna, Fadok, Valerie A., Cook, H. Terence, Andrews, Mark, Carroll, Michael C., ...
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease...
Da Silveira, Samareh Azeredo, Kikuchi, Shuichi, Fossati-Jimack, Liliane, Moll, Thomas, Saito, Takashi, Verbeek, J. Sjef, ...
By generating four IgG isotype-switch variants of the high affinity 34–3C anti-erythrocyte autoantibody, and comparing them to the IgG variants of the low affinity 4C8 anti-erythrocyte autoantibody...
Continual Low-Level Activation of the Classical Complement Pathway
Manderson, Anthony P., Pickering, Matthew C., Botto, Marina, Walport, Mark J., Parish, Christopher R.
There is evidence that the classical complement pathway may be activated via a “C1-tickover” mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and...
Cutler, Antony J., Botto, Marina, Van Essen, Dominic, Rivi, Roberta, Davies, Kevin A., Gray, David, ...
The role of the classical complement pathway in humoral immune responses was investigated in gene-targeted C1q-deficient mice (C1qA−/−). Production of antigen-specific immunoglobulin (Ig)G2a and...
Yuste, Jose, Sen, Ashwin, Truedsson, Lennart, Jönsson, Göran, Tay, Liang-Seah, Hyams, Catherine, ...
Results from studies using mice deficient in specific complement factors and clinical data on patients with an inherited deficiency of the classical complement pathway component C2 suggest that the...
Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice
Fossati-Jimack, Liliane, Cortes-Hernandez, Josefina, Norsworthy, Peter J, Cook, H Terence, Walport, Mark J, Botto, Marina
Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase
Paixão-Cavalcante, Danielle, Hanson, Steven, Botto, Marina, Cook, H. Terence, Pickering, Matthew C.
Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh−/−) mice spontaneously develop C3...
Chevrier, Stéphane, Genton, Céline, Kallies, Axel, Karnowski, Alexander, Otten, Luc A., Malissen, Bernard, ...
Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93,...