Mario A. Bianchet

Mimicking damaged DNA with a small molecule inhibitor of human UNG2 (2006)

Krosky, Daniel J., Bianchet, Mario A., Seiple, Lauren, Chung, Suhman, Amzel, L. Mario, Stivers, James T.

Human nuclear uracil DNA glycosylase (UNG2) is a cellular DNA repair enzyme that is essential for a number of diverse biological phenomena ranging from antibody diversification to B-cell lymphomas...

Mimicking damaged DNA with a small molecule inhibitor of human UNG2 (2006)

Krosky, Daniel J., Bianchet, Mario A., Seiple, Lauren, Chung, Suhman, Amzel, L. Mario, Stivers, James T.

Human nuclear uracil DNA glycosylase (UNG2) is a cellular DNA repair enzyme that is essential for a number of diverse biological phenomena ranging from antibody diversification to B-cell lymphomas...

Mimicking damaged DNA with a small molecule inhibitor of human UNG2 (2006)

Krosky, Daniel J., Bianchet, Mario A., Seiple, Lauren, Chung, Suhman, Amzel, L. Mario, Stivers, James T.

Human nuclear uracil DNA glycosylase (UNG2) is a cellular DNA repair enzyme that is essential for a number of diverse biological phenomena ranging from antibody diversification to B-cell lymphomas...

Novel carbohydrate specificity of the 16-kDa galectin from Caenorhabditis elegans: binding to blood group precursor oligosaccharides (type 1, type 2, T{alpha}, and T{beta}) and gangliosides (2002)

Ahmed, Hafiz, Bianchet, Mario A., Amzel, L. Mario, Hirabayashi, Jun, Kasai, Ken-ichi, Giga-Hama, Yuko, ...

Galectins, a family of soluble &bgr;-galactosyl-binding lectins, are believed to mediate cell–cell and cell–extracellular matrix interactions during development, inflammation, apoptosis, and...

Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: Species comparison and structural changes with substrate binding and release

Faig, Margarita, Bianchet, Mario A., Talalay, Paul, Chen, Shiuan, Winski, Shannon, Ross, David, ...

NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. In...

The 2.8-Å structure of rat liver F1-ATPase: Configuration of a critical intermediate in ATP synthesis/hydrolysis

Bianchet, Mario A., Hullihen, Joanne, Pedersen, Peter L., Amzel, L. Mario

During mitochondrial ATP synthesis, F1-ATPase—the portion of the ATP synthase that contains the catalytic and regulatory nucleotide binding sites—undergoes a series of concerted conformational...

Structure of a Coenzyme A Pyrophosphatase from Deinococcus radiodurans: a Member of the Nudix Family

Kang, Lin-Woo, Gabelli, Sandra B., Bianchet, Mario A., Xu, Wen Lian, Bessman, Maurice J., Amzel, L. Mario

Gene Dr1184 from Deinococcus radiodurans codes for a Nudix enzyme (DR-CoAse) that hydrolyzes the pyrophosphate moiety of coenzyme A (CoA). Nudix enzymes with the same specificity have been found in...

Structure and activity of the axon guidance protein MICAL

Nadella, Mythili, Bianchet, Mario A., Gabelli, Sandra B., Barrila, Jennifer, Amzel, L. Mario

During development, neurons are guided to their targets by short- and long-range attractive and repulsive cues. MICAL, a large multidomain protein, is required for the combined action of semaphorins...

Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: Species comparison and structural changes with substrate binding and release

Faig, Margarita, Bianchet, Mario A., Talalay, Paul, Chen, Shiuan, Winski, Shannon, Ross, David, ...

NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. In...

The 2.8-Å structure of rat liver F1-ATPase: Configuration of a critical intermediate in ATP synthesis/hydrolysis

Bianchet, Mario A., Hullihen, Joanne, Pedersen, Peter L., Amzel, L. Mario

During mitochondrial ATP synthesis, F1-ATPase—the portion of the ATP synthase that contains the catalytic and regulatory nucleotide binding sites—undergoes a series of concerted conformational...

Structure of a Coenzyme A Pyrophosphatase from Deinococcus radiodurans: a Member of the Nudix Family

Kang, Lin-Woo, Gabelli, Sandra B., Bianchet, Mario A., Xu, Wen Lian, Bessman, Maurice J., Amzel, L. Mario

Gene Dr1184 from Deinococcus radiodurans codes for a Nudix enzyme (DR-CoAse) that hydrolyzes the pyrophosphate moiety of coenzyme A (CoA). Nudix enzymes with the same specificity have been found in...

Structure and activity of the axon guidance protein MICAL

Nadella, Mythili, Bianchet, Mario A., Gabelli, Sandra B., Barrila, Jennifer, Amzel, L. Mario

During development, neurons are guided to their targets by short- and long-range attractive and repulsive cues. MICAL, a large multidomain protein, is required for the combined action of semaphorins...

Mimicking damaged DNA with a small molecule inhibitor of human UNG2

Krosky, Daniel J., Bianchet, Mario A., Seiple, Lauren, Chung, Suhman, Amzel, L. Mario, Stivers, James T.

Human nuclear uracil DNA glycosylase (UNG2) is a cellular DNA repair enzyme that is essential for a number of diverse biological phenomena ranging from antibody diversification to B-cell lymphomas...

Compensatory Interactions between Sir3p and the Nucleosomal LRS Surface Imply Their Direct Interaction

Norris, Anne, Bianchet, Mario A., Boeke, Jef D.

The previously identified LRS (Loss of rDNA Silencing) domain of the nucleosome is critically important for silencing at both ribosomal DNA and telomeres. To understand the function of the LRS...