Mario Losen

Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis (2005)

Losen, Mario, Stassen, Maurice H. W., Martínez-Martínez, Pilar, Machiels, Barbie M., Duimel, Hans, Frederik, Peter, ...

Myasthenia gravis is usually caused by autoantibodies to the acetylcholine receptor (AChR). The AChR is clustered and anchored in the postsynaptic membrane of the neuromuscular junction (NMJ) by a...

Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis (2005)

Losen, Mario, Stassen, Maurice H. W., Martínez-Martínez, Pilar, Machiels, Barbie M., Duimel, Hans, Frederik, Peter, ...

Myasthenia gravis is usually caused by autoantibodies to the acetylcholine receptor (AChR). The AChR is clustered and anchored in the postsynaptic membrane of the neuromuscular junction (NMJ) by a...

Overexpression of Rapsyn in Rat Muscle Increases Acetylcholine Receptor Levels in Chronic Experimental Autoimmune Myasthenia Gravis

Martínez-Martínez, Pilar, Losen, Mario, Duimel, Hans, Frederik, Peter, Spaans, Frank, Molenaar, Peter, ...

The primary autoantigen in myasthenia gravis, the acetylcholine receptor (AChR), is clustered and anchored in the postsynaptic membrane of the neuromuscular junction by rapsyn. Previously, we found...

Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding

Martinez-Martinez, Pilar, Phemambucq, Marko, Steinbusch, Laura, Schaeffer, Laurent, Berrih-Aknin, Sonia, Duimel, Hans, ...

The receptor-associated protein of the synapse (rapsyn) is required for anchoring and stabilizing the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane of the neuromuscular...

Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding

Martinez-Martinez, Pilar, Phemambucq, Marko, Steinbusch, Laura, Schaeffer, Laurent, Berrih-Aknin, Sonia, Duimel, Hans, ...

The receptor-associated protein of the synapse (rapsyn) is required for anchoring and stabilizing the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane of the neuromuscular...

Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil

Janssen, Sofie P. M., Phernambucq, Marko, Martinez-Martinez, Pilar, DE BAETS, Marc, Losen, Mario

Currently used non-specific immunosuppresive drugs often require intervention in myasthenia gravis (MG) and clinical improvement varies widely. To analyze the therapeutic effect of mycophenolate...