Spanel-Borowski, Katharina, Smith, Mark A., Simone, Cristiano, Simonsen, Anne, Simon, Hans-Uwe, ...
Research in autophagy continues to accelerate, and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring...
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms (2005)
Rohde, Mikkel, Daugaard, Mads, Jensen, Mette Hartvig, Helin, Kristian, Nylandsted, Jesper, Jäättelä, Marja
Whereas the stress-inducible heat-shock protein 70 (Hsp70) has gained plenty of attention as a putative target for tumor therapy, little is known about the role of other Hsp70 proteins in cancer....
Sensitization to the Lysosomal Cell Death Pathway upon Immortalization and Transformation (2004)
Fehrenbacher, Nicole, Gyrd-Hansen, Mads, Poulsen, Birgit, Felbor, Ute, Kallunki, Tuula, Boes, Marianne, ...
Tumorigenesis is associated with several changes that alter the cellular susceptibility to programmed cell death. Here, we show that immortalization and transformation sensitize cells in particular...
Hansson, Oskar, Nylandsted, Jesper, Castilho, Roger F, Leist, Marcel, Jäättelä, Marja, Brundin, Patrik
Abstract is not available
Olsson, Tomas, Hansson, Oskar, Nylandsted, Jesper, Jäättelä, Marja, Smith, Maj-Lis, Wieloch, Tadeusz
Abstract is not available
Caspase-independent cell death (2002)
Leist, Marcel, Jäättelä, Marja
Caspase-mediated apoptosis is the death program of choice in many developmental and physiologic settings. It would, however, be very dangerous for the organism to depend on a single protease family...
Burning up TNF toxicity for cancer therapy (2002)
Leist, Marcel, Jäättelä, Marja
The tumor-killing capacity and the systemic toxicity of the cytokine tumor necrosis factor (TNF) have appeared inseparable. Now a study shows that TNF loses its toxicity but still kills tumors in...
Eradication of Glioblastoma, and Breast and Colon Carcinoma Xenografts by Hsp70 Depletion (2002)
Nylandsted, Jesper, Wick, Wolfgang, Hirt, Ulrich A., Brand, Karsten, Rohde, Mikkel, Leist, Marcel, ...
Heat shock protein 70 (Hsp70) is an antiapoptotic chaperone protein highly expressed in human tumors. Here we demonstrate that locoregional application of adenovirus expressing antisense Hsp70 cDNA...
Foghsgaard, Lasse, Wissing, Dorte, Mauch, Daniel, Boes, Marianne, Elling, Folmer, Leist, Marcel, ...
Death receptors can trigger cell demise dependent or independent of caspases. In WEHI-S fibrosarcoma cells, tumor necrosis factor (TNF) induced an increase in cytosolic cathepsin B activity followed...
Nylandsted, Jesper, Rohde, Mikkel, Brand, Karsten, Bastholm, Lone, Elling, Folmer, Jäättelä, Marja
Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. Here, we demonstrate that the mere inhibition of its synthesis by adenoviral...
Wissing, Dorte, Mouritzen, Helle, Egeblad, Mikala, Poirier, Guy G., Jäättelä, Marja
Tumor necrosis factor (TNF)-induced apoptosis is mediated by caspases, which are cysteine proteases related to interleukin 1β-converting enzyme. We report here that TNF-induced activation of...
Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja
The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...
Hsp70–RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor
Schneikert, Jean, Hübner, Susanne, Langer, Gernot, Petri, Thomas, Jäättelä, Marja, Reed, Jennifer, ...
Receptor-associating protein 46 (RAP46) is a cochaperone that regulates the transactivation function of several steroid receptors. It is transported into the nucleus by a liganded glucocorticoid...
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms
Rohde, Mikkel, Daugaard, Mads, Jensen, Mette Hartvig, Helin, Kristian, Nylandsted, Jesper, Jäättelä, Marja
Whereas the stress-inducible heat-shock protein 70 (Hsp70) has gained plenty of attention as a putative target for tumor therapy, little is known about the role of other Hsp70 proteins in cancer....
Nylandsted, Jesper, Rohde, Mikkel, Brand, Karsten, Bastholm, Lone, Elling, Folmer, Jäättelä, Marja
Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. Here, we demonstrate that the mere inhibition of its synthesis by adenoviral...
Wissing, Dorte, Mouritzen, Helle, Egeblad, Mikala, Poirier, Guy G., Jäättelä, Marja
Tumor necrosis factor (TNF)-induced apoptosis is mediated by caspases, which are cysteine proteases related to interleukin 1β-converting enzyme. We report here that TNF-induced activation of...
Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja
The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...
Hsp70–RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor
Schneikert, Jean, Hübner, Susanne, Langer, Gernot, Petri, Thomas, Jäättelä, Marja, Reed, Jennifer, ...
Receptor-associating protein 46 (RAP46) is a cochaperone that regulates the transactivation function of several steroid receptors. It is transported into the nucleus by a liganded glucocorticoid...
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms
Rohde, Mikkel, Daugaard, Mads, Jensen, Mette Hartvig, Helin, Kristian, Nylandsted, Jesper, Jäättelä, Marja
Whereas the stress-inducible heat-shock protein 70 (Hsp70) has gained plenty of attention as a putative target for tumor therapy, little is known about the role of other Hsp70 proteins in cancer....
Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9▿ †
Gyrd-Hansen, Mads, Farkas, Thomas, Fehrenbacher, Nicole, Bastholm, Lone, Høyer-Hansen, Maria, Elling, Folmer, ...
The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically...
Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
Nylandsted, Jesper, Gyrd-Hansen, Mads, Danielewicz, Agnieszka, Fehrenbacher, Nicole, Lademann, Ulrik, Høyer-Hansen, Maria, ...
Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by...
Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion
Boya, Patricia, Andreau, Karine, Poncet, Delphine, Zamzami, Naoufal, Perfettini, Jean-Luc, Metivier, Didier, ...
A number of diseases are due to lysosomal destabilization, which results in damaging cell loss. To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two...
Foghsgaard, Lasse, Wissing, Dorte, Mauch, Daniel, Lademann, Ulrik, Bastholm, Lone, Boes, Marianne, ...
Death receptors can trigger cell demise dependent or independent of caspases. In WEHI-S fibrosarcoma cells, tumor necrosis factor (TNF) induced an increase in cytosolic cathepsin B activity followed...
Cardoso, Carla M. P., Groth-Pedersen, Line, Høyer-Hansen, Maria, Kirkegaard, Thomas, Corcelle, Elizabeth, Andersen, Jens S., ...
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells
Herrero-Martín, Griselda, Høyer-Hansen, Maria, García-García, Celina, Fumarola, Claudia, Farkas, Thomas, López-Rivas, Abelardo, ...
Correction to: The EMBO Journal (2009) 28, 677–685. doi:10.1038/emboj.2009.8