Carey, Andrew L., Steinberg, Gregory R., Macaulay, S. Lance, Thomas, Walter G., Holmes, Anna G., Ramm, Georg, ...
Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion...
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK (2006)
Watt, Matthew J., Dzamko, Nicolas, Thomas, Walter G., Rose-John, Stefan, Ernst, Matthias, Carling, David, ...
Ciliary neurotrophic factor (CNTF) induces weight loss and improves glucose tolerance in humans and rodents. CNTF is thought to act centrally by inducing hypothalamic neurogenesis to modulate food...
Lee, Jong Sam, Pinnamaneni, Srijan K., Eo, Su Ju, Cho, In Ho, Pyo, Jae Hwan, Kim, Chang Keun, ...
Consumption of a Western diet rich in saturated fats is associated with obesity and insulin resistance. In some insulin-resistant phenotypes this is associated with accumulation of skeletal muscle...
Carey, Andrew L., Steinberg, Gregory R., Macaulay, S. Lance, Thomas, Walter G., Holmes, Anna G., Ramm, Georg, ...
Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion...
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK (2006)
Watt, Matthew J., Dzamko, Nicolas, Thomas, Walter G., Rose-John, Stefan, Ernst, Matthias, Carling, David, ...
Ciliary neurotrophic factor (CNTF) induces weight loss and improves glucose tolerance in humans and rodents. CNTF is thought to act centrally by inducing hypothalamic neurogenesis to modulate food...
Lee, Jong Sam, Pinnamaneni, Srijan K., Eo, Su Ju, Cho, In Ho, Pyo, Jae Hwan, Kim, Chang Keun, ...
Consumption of a Western diet rich in saturated fats is associated with obesity and insulin resistance. In some insulin-resistant phenotypes this is associated with accumulation of skeletal muscle...
Askew, Christopher, Green, Simon C., Walker, Philip B., Kerr, Graham K., Green, Anita A., Williams, Andrew D., ...
Objective To better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius...
Askew, Christopher, Green, Simon C., Walker, Philip B., Kerr, Graham K., Green, Anita A., Williams, Andrew D., ...
ObjectiveTo better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius muscle...
Askew, Christopher, Green, Simon C., Walker, Philip B., Kerr, Graham K., Green, Anita A., Williams, Andrew D., ...
Objective To better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius...
Askew, Christopher, Green, Simon C., Walker, Philip B., Kerr, Graham K., Green, Anita A., Williams, Andrew D., ...
Objective To better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius...
Askew, Christopher, Green, Simon C., Walker, Philip B., Kerr, Graham K., Green, Anita A., Williams, Andrew D., ...
Objective To better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius...
Southgate, Robert J., Bruce, Clinton R., Carey, Andrew L., Steinberg, Gregory R., Walder, Ken, Monks, Robert, ...
Regulation of HSL serine phsohorylastion in skeletal muscle and adipose tissue (2005)
Watt, Matthew J., Holmes, Anna G., Pinnamaneni, Srijan K., Garnham, Andrew, Steinberg, Gregory R., Kemp, Bruce E., ...
Hormone-sensitive lipase (HSL) is important for the degradation of triacylglycerol in adipose and muscle tissue, but the tissue-specific regulation of this enzyme is not fully understood. We...
Askew, Christopher, Green, Simon C., Walker, Philip B., Kerr, Graham K., Green, Anita A., Williams, Andrew D., ...
Objective To better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius...
Askew, Christopher, Green, Simon C., Walker, Philip B., Kerr, Graham K., Green, Anita A., Williams, Andrew D., ...
Objective To better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius...
Askew, Christopher, Green, Simon C., Walker, Philip B., Kerr, Graham K., Green, Anita A., Williams, Andrew D., ...
Objective To better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius...
Regulation of HSL serine phsohorylastion in skeletal muscle and adipose tissue (2005)
Watt, Matthew J., Holmes, Anna G., Pinnamaneni, Srijan K., Garnham, Andrew, Steinberg, Gregory R., Kemp, Bruce E., ...
Hormone-sensitive lipase (HSL) is important for the degradation of triacylglycerol in adipose and muscle tissue, but the tissue-specific regulation of this enzyme is not fully understood. We...
Southgate, Robert J., Bruce, Clinton R., Carey, Andrew L., Steinberg, Gregory R., Walder, Ken, Monks, Robert, ...
Askew, Christopher, Green, Simon C., Walker, Philip B., Kerr, Graham K., Green, Anita A., Williams, Andrew D., ...
Objective To better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius...
Mark A. Febbraio, Jose L. Mesa, Jason Chung, Adam Steensberg, Charlotte Keller, Henning B. Nielsen, ...
ß- adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling (2004)
Watt, Matthew J., Steinberg, Gregory R., Chan, Stanley, Garnham, Andrew, Kemp, Bruce E., Febbraio, Mark A.
Hormone-sensitive lipase (HSL), an important regulatory enzyme for triacylglycerol hydrolysis within skeletal muscle, is controlled by β-adrenergic signaling as well as intrinsic factors related...
Chan, M.H. Stanley, McGee, Sean, Watt, Matthew J., Hargreaves, Mark, Febbraio, Mark A.
To determine the effect of glycogen availability and contraction on intracellular signaling and IL-6 gene transcription, eight males performed 60 min of exercise on two occasions: either with prior...
ß- adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling (2004)
Watt, Matthew J., Steinberg, Gregory R., Chan, Stanley, Garnham, Andrew, Kemp, Bruce E., Febbraio, Mark A.
Hormone-sensitive lipase (HSL), an important regulatory enzyme for triacylglycerol hydrolysis within skeletal muscle, is controlled by β-adrenergic signaling as well as intrinsic factors related...
Chan, M.H. Stanley, McGee, Sean, Watt, Matthew J., Hargreaves, Mark, Febbraio, Mark A.
To determine the effect of glycogen availability and contraction on intracellular signaling and IL-6 gene transcription, eight males performed 60 min of exercise on two occasions: either with prior...
Baldwin, Jacinta, Snow, Rod, Gibala, Martin J., Garnham, Andrew, Howarth, Krista, Febbraio, Mark A.
The hypothesis that fatigue during prolonged exercise arises from insufficient intramuscular glycogen, which limits tricarboxylic acid cycle (TCA) activity due to reduced TCA cycle intermediates...
Howlett, Kirsten, Watt, Matthew J., Hargreaves, Mark, Febbraio, Mark A.
This study examined the effect of combined α- and β-adrenergic blockade on glucose kinetics during intense exercise. Six endurance-trained men exercised for 20 minutes at approximately 78%...
Baldwin, Jacinta, Snow, Rod, Gibala, Martin J., Garnham, Andrew, Howarth, Krista, Febbraio, Mark A.
The hypothesis that fatigue during prolonged exercise arises from insufficient intramuscular glycogen, which limits tricarboxylic acid cycle (TCA) activity due to reduced TCA cycle intermediates...
Watt, Matthew J., Howlett, Kirsten, Febbraio, Mark A., Spriet, Lawrence L., Hargreaves, Mark
# 1. To evaluate the role of adrenaline in regulating carbohydrate metabolism during moderate exercise, 10 moderately trained men completed two 20 min exercise bouts at 58 ± 2 % peak pulmonary...
Watt, Matthew J., Howlett, Kirsten, Febbraio, Mark A., Spriet, Lawrence L., Hargreaves, Mark
# 1. To evaluate the role of adrenaline in regulating carbohydrate metabolism during moderate exercise, 10 moderately trained men completed two 20 min exercise bouts at 58 ± 2 % peak pulmonary...
Febbraio, Mark A., Mesa, Jose L., Chung, Jason, Steensberg, Adam, Keller, Charlotte, Nielsen, Henning B., ...
Heat shock protein (Hsp) 72 is a cytosolic stress protein that is highly inducible by several factors including exercise. Hsp60 is primarily mitochondrial in cellular location, plays a key role in...
Febbraio, Mark A., Mesa, Jose L., Chung, Jason, Steensberg, Adam, Keller, Charlotte, Nielsen, Henning B., ...
Heat shock protein (Hsp) 72 is a cytosolic stress protein that is highly inducible by several factors including exercise. Hsp60 is primarily mitochondrial in cellular location, plays a key role in...
gp130 receptor ligands as potential therapeutic targets for obesity
Obesity and its related cluster of pathophysiologic conditions including insulin resistance, glucose intolerance, dyslipidemia, and hypertension are recognized as growing threats to world health. It...
Hevener, Andrea L., Olefsky, Jerrold M., Reichart, Donna, Nguyen, M.T. Audrey, Bandyopadyhay, Gautam, Leung, Ho-Yin, ...
PPARγ is required for fat cell development and is the molecular target of antidiabetic thiazolidinediones (TZDs), which exert insulin-sensitizing effects in adipose tissue, skeletal muscle, and...
Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes
Watt, Matthew J, Steinberg, Gregory R, Chen, Zhi-Ping, Kemp, Bruce E, Febbraio, Mark A
We investigated the role of fatty acid availability on AMPK signalling and fatty acid oxidation in skeletal muscle. Incubating L6 skeletal muscle myotubes with palmitate (a saturated fatty acid) or...
Watt, Matthew J, Howlett, Kirsten F, Febbraio, Mark A, Spriet, Lawrence L, Hargreaves, Mark
To evaluate the role of adrenaline in regulating carbohydrate metabolism during moderate exercise, 10 moderately trained men completed two 20 min exercise bouts at 58 ± 2 % peak pulmonary oxygen...
Steensberg, Adam, Febbraio, Mark A, Osada, Takuya, Schjerling, Peter, Van Hall, Gerrit, Saltin, Bengt, ...
Prolonged exercise results in a progressive decline in glycogen content and a concomitant increase in the release of the cytokine interleukin-6 (IL-6) from contracting muscle. This study tests the...
Febbraio, Mark A, Steensberg, Adam, Walsh, Rory, Koukoulas, Irene, Van Hall, Gerrit, Saltin, Bengt, ...
To test the hypothesis that a decrease in intramuscular glycogen availability may stimulate heat shock protein expression, seven men depleted one leg of muscle glycogen the day before performing...
Steensberg, Adam, Van Hall, Gerrit, Keller, Charlotte, Osada, Takuya, Schjerling, Peter, Klarlund Pedersen, Bente, ...
There are many factors that can influence glucose uptake by contracting skeletal muscle during exercise and although one may be intramuscular glycogen content, this relationship is at present not...
Exercise induces hepatosplanchnic release of heat shock protein 72 in humans
Febbraio, Mark A, Ott, Peter, Nielsen, Henning Bay, Steensberg, Adam, Keller, Charlotte, Krustrup, Peter, ...
Physical exercise results in the appearance of heat shock protein (HSP) 72 in the circulation that precedes any increase in gene or protein expression in contracting skeletal muscle. In rodents,...
Steensberg, Adam, Fischer, Christian P, Sacchetti, Massimo, Keller, Charlotte, Osada, Takuya, Schjerling, Peter, ...
The cytokine interleukin (IL)-6 has recently been linked with type 2 diabetes mellitus and has been suggested to affect glucose metabolism. To determine whether acute IL-6 administration affects...
Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans
Febbraio, Mark A, Steensberg, Adam, Keller, Charlotte, Starkie, Rebecca L, Nielsen, Henning B, Krustrup, Peter, ...
To examine whether glucose ingestion during exercise affects the release of interleukin-6 (IL-6) from the contracting limb, seven men performed 120 min of semi-recumbent cycling on two occasions...
HSP72 protects against obesity-induced insulin resistance
Chung, Jason, Nguyen, Anh-Khoi, Henstridge, Darren C., Holmes, Anna G., Chan, M. H. Stanley, Mesa, Jose L., ...
Patients with type 2 diabetes have reduced gene expression of heat shock protein (HSP) 72, which correlates with reduced insulin sensitivity. Heat therapy, which activates HSP72, improves clinical...