Zhang, Junlong, Zhang, F. (Fang), Didelot, Xavier, Bruce, Kimberley D., Cagampang, Felino R., Vatish, Manu, ...
Background miRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-term effects on the offspring, but it is not known...
Burdge, Graham C., Lillycrop, Karen A., Phillips, Emma S., Slater-Jefferies, Joanne L., Jackson, Alan A., Hanson, Mark A.
Prenatal nutritional constraint is associated with increased risk of metabolic dysregulation in adulthood contingent on adult diet. In rats, folic acid supplementation of a protein-restricted (PR)...
Torrens, Christopher, Kelsall, Christopher J., Hopkins, Laura A., Anthony, Frederick W., Curzen, Nick P., Hanson, Mark A.
Maternal protein restriction in rats leads to endothelial dysfunction and decreased NO bioavailability in the offspring. Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) are...
Ebbing, Cathrine, Rasmussen, Svein, Godfrey, Keith M., Hanson, Mark A., Kiserud, Torvid
Objective: To establish longitudinal reference ranges for the fetal superior mesenteric artery (SMA) flow velocity and pulsatility index (PISMA). Also to examine the hemodynamic relationship to...
Torrens, Christopher, Snelling, Tristram H., Chau, Ryan, Shanmuganathan, Meena, Cleal, Jane K., Poore, Kirsten R., ...
The nutritional environment during development and even prior to conception may contribute to cardiovascular risk. In mature adult female sheep, we investigated the effect of preconceptional and...
Adam J. Watkins, Elizabeth Ursell, Rose Panton, Thomas Papenbrock, Colm Cunningham, Adrian Wilkins, ...
Short title: Embryo responses to diet lead to adult disease Summary sentence: Maternal low protein diet induces compensatory responses within mouse early embryos to enhance growth and nutrient...
Rodford, Joanne L., Torrens, Christopher, Siow, Richard C.M., Mann, Giovanni E., Hanson, Mark A., Clough, Geraldine F.
Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant...
Anthony T. Miller, Mark A. Hanson, James O. Church, Brian Palik, Shane E. Bowe, Malcolm G. Butler
Using data sets from two separate studies, we assessed within-year variation in aquatic invertebrate communities in 31 seasonally flooded (seasonal) wetlands in aspen (Populus spp.) – dominated...
Johnsen, Synnøve L, Wilsgaard, Tom, Rasmussen, Svein, Hanson, Mark A, Godfrey, Keith M, Kiserud, Torvid
Abstract Background Conventionally, the pregnancy duration is accepted to be 280–282 days. Fetuses determined by ultrasound biometry to be small in early pregnancy, have an increased risk of...
Costello, Paula M., Rowlerson, Anthea, Astaman, Nur Aida, Anthony, Fred Erick W., Sayer, Avan Aihie, Cooper, Cyrus, ...
Poor prenatal nutrition is associated with a greater risk of adult glucose intolerance and insulin insensitivity in the offspring. Skeletal muscle is the primary tissue for glucose utilization, and...
Predictive adaptive responses in perspective (2008)
Gluckman, Peter D., Hanson, Mark A., Beedle, Alan S., Spencer, Hamish G.
Watkins, Adam J., Wilkins, Adrian, Cunningham, Colm, Perry, V. Hugh, Seet, Meei J., Osmond, Clive, ...
Early embryonic development is known to be susceptible to maternal undernutrition, leading to a disease-related postnatal phenotype. To determine whether this sensitivity extended into oocyte...
Watkins, Adam J., Ursell, Elizabeth, Panton, Rose, Papenbrock, Thomas, Hollis, Lisa, Cunningham, Colm, ...
Poor maternal nutrition during pregnancy can alter postnatal phenotype and increase susceptibility to adult cardiovascular and metabolic diseases. However, underlying mechanisms are largely unknown....
Analysis of Covariance Models for Data From Observational Field Studies (2008)
Michael R. Riggs, Kurt J. Haroldson, Mark A. Hanson
We outline the features of a general class of statistical models (i.e., analysis of covariance [ANCOVA] models) that has proven to be effective for the analysis of data from observational studies. In...
Effect of in utero and early-life conditions on adult health and disease (2008)
Gluckman, Peter D., Hanson, Mark A., Cooper, Cyrus, Thornburg, Kent L.
A long latency period between an environmental trigger and the onset of subsequent disease is widely recognized in the etiology of certain cancers, yet this phenomenon is not generally considered in...
Bertram, Caroline, Khan, Omar, Ohri, Sunil, Phillips, David I., Matthews, Stephen G., Hanson, Mark A.
The perinatal environment is a powerful determinant of risk for developing disease in later life. Here, we have shown that maternal undernutrition causes dramatic changes in heart structure and...
Elahi, Maqsood M., Cagampang, Felino R., Anthony, Frederick W., Curzen, Nick, Ohri, Sunil K., Hanson, Mark A.
Increasing evidence suggests that hypercholesterolemia during pregnancy initiates pathogenic events in the fetus leading to increased risk of cardiovascular disease in the adult offspring. In this...
Herrera, Emilio A., Reyes, Roberto V., Giussani, Dino A., Riquelme, Raquel A., Sanhueza, Emilia M., Ebensperger, Germán, ...
Aims To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas. Methods and results We used neonatal...
Evolution, developmental plasticity, and metabolic disease (2007)
Kuzawa, Christopher W., Gluckman, Peter D., Hanson, Mark A., Beedle, Alan S.
Cleal, Jane K., Poore, Kirsten R., Newman, James P., Noakes, David E., Hanson, Mark A., Green, Lucy R.
In utero undernutrition in humans may result in cardiovascular (CV), metabolic, and growth adaptations. In sheep, maternal nutrient restriction during pregnancy, without effects on fetal or birth...
Evolving in thin air: lessons from the llama fetus in the altiplano (2007)
Llanos, Aníbal J., Riquelme, Raquel A., Herrera, Emilio A., Ebensperger, Germán, Krause, Bernardo, Reyes, Roberto V., ...
Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Cleal, Jane K., Brownbill, Paul, Godfrey, Keith M., Jackson, John M., Jackson, Alan A., Sibley, Colin P., ...
Fetal growth is dependent on both the quantity and relative composition of amino acids delivered to the fetal circulation, and impaired placental amino acid supply is associated with restricted fetal...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Herrera, Emilio A., Pulgar, Victor M., Riquelme, Raquel A., Sanhueza, Emilia M., Reyes, Roberto V., Ebensperger, German, ...
Perinatal exposure to chronic hypoxia induces sustained pulmonary hypertension and structural and functional changes in both pulmonary and systemic vascular beds. The aim of this study was to analyze...
Herrera, Emilio A., Pulgar, Víctor M., Riquelme, Raquel A., Sanhueza, Emilia M., Reyes, Roberto V., Ebensperger, Germán, ...
Perinatal exposure to chronic hypoxia induces sustained pulmonary hypertension and structural and functional changes in both pulmonary and systemic vascular beds. The aim of this study was to analyze...
Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, ...
The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit...
Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, ...
The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit...
Cleal, Jane K., Brownbill, Paul, Godfrey, Keith M., Jackson, John M., Jackson, Alan A., Sibley, Colin P., ...
Fetal growth is dependent on both the quantity and relative composition of amino acids delivered to the fetal circulation, and impaired placental amino acid supply is associated with restricted fetal...
Godfrey, Keith M., Lillycrop, Karen A., Burdge, Graham C., Gluckman, Peter D., Hanson, Mark A.
There is now considerable evidence that elements of the heritable or familial component of disease susceptibility are transmitted by nongenomic means, and that environmental influences acting during...
Burdge, Graham C., Slater-Jefferies, Jo, Torrens, Christopher, Phillips, Emma S., Hanson, Mark A., Lillycrop, Karen A.
Epidemiological studies and experimental models show that maternal nutritional constraint during pregnancy alters the metabolic phenotype of the offspring and that this can be passed to subsequent...
Gluckman, Peter D., Beedle, Alan S., Hanson, Mark A., Vickers, Mark H.
Events in early life are associated with changes in the risk of disease in later life. There is increasing evidence that these associations are mediated by permanent transcriptional changes in...
Poore, Kirsten R., Cleal, Jane K., Newman, James P., Boullin, Julian P., Noakes, David E., Hanson, Mark A., ...
The early-life environment has implications for risk of adult-onset diseases, such as glucose intolerance, insulin insensitivity, and obesity, effects that may occur with or without reduced birth...
Poore, Kirsten R., Cleal, Jane K., Newman, James P., Boullin, Julian P., Noakes, David E., Hanson, Mark A., ...
The early-life environment has implications for risk of adult-onset diseases such as glucose intolerance, insulin insensitivity and obesity, effects which may occur with or without reduced birth...
Low birthweight and subsequent obesity in Japan (2007)
Gluckman, Peter D., Seng, Chong Y., Fukuoka, Hideoki, Beedle, Alan S., Hanson, Mark A.
The Lancet's World Report (Feb 10, p 451)1 rightly highlights the growing epidemic of obesity in Japan—a pattern that is also seen in other Asian countries and which might be of concern for future...
Developmental perspectives on the origins of obesity (2007)
Kuzawa, Christopher W., Gluckman, Peter D., Hanson, Mark A.
This chapter reviews the developmental pathways contributing to the origin of obesity. Evolutionary considerations are emphasized. At birth more than half of a human baby’s metabolism is devoted to...
Herrera, Emilio A., Reyes, Roberto V., Giussani, Dino A., Riquelme, Raquel A., Sanhueza, Emilia M., Ebensperger, Germán, ...
Aims To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas. Methods and results We used neonatal...
Herrera, Emilio A., Reyes, Roberto V., Giussani, Dino A., Riquelme, Raquel A., Sanhueza, Emilia M., Ebensperger, Germán, ...
Aims To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas. Methods and results We used neonatal...
Mechanisms of disease: in utero programming in the pathogenesis of hypertension (2006)
Barker, David J.P., Bagby, Susan P., Hanson, Mark A.
Nutritional and other environmental cues during development can permanently alter the structure, homeostatic systems, and functions of the body. This phenomenon has been referred to as 'programming'....
Response to Wells: phenotypic responses to early environmental cues can be adaptive in adults (2006)
Musha, Yuka, Itoh, Shigeru, Hanson, Mark A., Kinoshita, Katsuyuki
It is established that there are gender-related differences in the effects on offspring blood pressure induced by maternal protein restriction in animal studies. Since such effects may depend on...
The developmental origins of health and disease: an overview (2006)
Gluckman, Peter D., Hanson, Mark A.
This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases....
Evolution, development and timing of puberty (2006)
Gluckman, Peter D., Hanson, Mark A.
The age of menarche has fallen as child health has improved. Although there is ample evidence of delayed puberty being associated with poorer childhood nutrition, menarche is also influenced by...
Evolution, development and timing of puberty (2006)
Gluckman, Peter D., Hanson, Mark A.
The age of menarche has fallen as child health has improved. Although there is ample evidence of delayed puberty being associated with poorer childhood nutrition, menarche is also influenced by...
Evolution, development and timing of puberty (2006)
Gluckman, Peter D., Hanson, Mark A.
The age of menarche has fallen as child health has improved. Although there is ample evidence of delayed puberty being associated with poorer childhood nutrition, menarche is also influenced by...
Torrens, Christopher, Brawley, Lee, Anthony, Frederick W., Dance, Caroline S., Dunn, Rebecca, Jackson, Alan A., ...
Dietary protein restriction in the rat compromises the maternal cardiovascular adaptations to pregnancy and leads to raised blood pressure and endothelial dysfunction in the offspring. In this study...
The conceptual basis for the developmental origins of health and disease (2006)
Gluckman, Peter D., Hanson, Mark A.
This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases....
Rodford, Joanne, Li, Francois Y., Siow, Richard C.M., Hanson, Mark A., Mann, Giovanni E., Clough, Geraldine F.
In rats, restriction of dietary protein during pregnancy leads to raised blood pressure, impaired vasodilatation (Brawley et al. 2003) and increased oxidative damage (increased protein carbonyl...
Torrens, Christopher, Rodford, Joanne L., Wheeler, Timothy, Hanson, Mark A., Clough, Geraldine F.
In the rat, the restriction of dietary protein during pregnancy leads to raised blood pressure and impaired endothelium-dependent vasodilatation in the male offspring (Brawley et al. 2003). Ageing is...
Predictive adaptive responses and human evolution (2005)
Gluckman, Peter D., Hanson, Mark A., Spencer, Hamish G.
The importance of a single genotype being able to produce different phenotypes in different environments (phenotypic plasticity) is widely recognized in evolutionary theory and its adaptive...
Mark A. Hanson, Kyle D. Zimmer, Malcolm G. Butler, Brian A. Tangen, Brian R. Herwig, Ned H. Euliss Jr.
Wetlands are abundant throughout the prairie pothole region (PPR), an area comprising over 700,000 km2 in central North America. Prairie wetland communities are strongly influenced by regional...
Vasodilator tone in the llama fetus: the role of nitric oxide during normoxemia and hypoxemia (2005)
Sanhueza, Emilia M., Riquelme, Raquel, Herrera, Emilio A., Giussani, Dino A., Blanco, Carlos E., Hanson, Mark A., ...
The fetal llama responds to hypoxemia, with a marked peripheral vasoconstriction but, unlike the sheep, with little or no increase in cerebral blood flow. We tested the hypothesis that the role of...
Lillycrop, Karen A., Phillips, Emma S., Jackson, Alan A., Hanson, Mark A., Burdge, Graham C.
Environmental constraints during early life result in phenotypic changes that can be associated with increased disease risk in later life. This suggests persistent alteration of gene transcription....
Gluckman, Peter D., Hanson, Mark A., Spencer, Hamish G., Bateson, Patrick
Early experience has a particularly great effect on most organisms. Normal development may be disrupted by early environmental influences; individuals that survive have to cope with the damaging...
Life-long echoes: a critical analysis of the developmental origins of adult disease model (2005)
Gluckman, Peter D., Hanson, Mark A., Morton, Susan M., Pinal, Catherine S.
The hypothesis that there is a developmental component to subsequent adult disease initially arose from epidemiological findings relating birth size to either indices of disease risk or actual...
The developmental origins of adult disease (2005)
Gluckman, Peter D., Hanson, Mark A., Pinal, Catherine
Epidemiological and clinical observations have led to the hypothesis that the risk of developing some chronic diseases in adulthood is influenced not only by genetic and adult lifestyle factors, but...
The fetal, neonatal, and infant environments: the long-term consequences for disease risk (2005)
Gluckman, Peter D., Cutfield, Wayne, Hofman, Paul, Hanson, Mark A.
The developmental origins of health and disease can be understood by reference to the fundamentals of developmental plasticity. It is essential to distinguish between those environmental effects...
Fetal origins of coronary heart disease-implications for cardiothoracic surgery? (2005)
Khan, Omar A., Chau, Ryan, Bertram, Caroline E., Hanson, Mark A., Ohri, Sunil K.
Over the last 15 years, there has been growing evidence that poor nutrition during gestation plays an important role in the development of coronary heart disease. This hypothesis, commonly known as...
Developmental processes and the induction of cardiovascular function: conceptual aspects (2005)
Hanson, Mark A., Gluckman, Peter D.
The epidemiological basis of the developmental origins of disease concept is now widely accepted. The current impetus in research concerns establishing the underlying mechanisms. We discuss the wider...
Khan, Omar A., Torrens, Christopher, Noakes, David E., Poston, Lucilla, Hanson, Mark A., Green, Lucy R., ...
Objective: Previous studies in humans and animals have suggested that undernutrition in utero and in early post-natal life may lead to altered vascular function in a number of peripheral arteries. We...
Developmental origins of disease paradigm: a mechanistic and evolutionary perspective (2004)
Gluckman, Peter D., Hanson, Mark A.
Fetal growth is determined by the interaction between the environment and the fetal genome. The fetal environment, in turn, is determined by the maternal environment and by maternal and placental...
Living with the past: evolution, development, and patterns of disease (2004)
Gluckman, Peter D., Hanson, Mark A.
Epidemiological observations have led to the hypothesis that the risk of developing some chronic noncommunicable diseases in adulthood is influenced not only by genetic and adult life-style factors...
Maternal constraint of fetal growth and its consequences (2004)
Gluckman, Peter D., Hanson, Mark A.
The major non-genetic factor determining the size of the fetus at term is maternal constraint. This term refers to a set of poorly defined processes by which maternal and uteroplacental factors act...
The developmental origins of the metabolic syndrome (2004)
Gluckman, Peter D., Hanson, Mark A.
Both epidemiological and clinical evidence suggest relationships between the antenatal environment and the risk of developing insulin resistance and associated cardiovascular disease (part of the...
Khan, Imran, Dekou, Vasia, Hanson, Mark A., Poston, Lucilla, Taylor, Paul
Background— Population-based studies suggest that fetal adaptive responses to maternal dietary imbalance confer survival benefit when the postnatal diet remains suboptimal but increase...
Smith, Richard P., Miller, Suzanne L., Igosheva, Natalia, Peebles, Donald M., Glover, Vivette, Jenkin, Graham, ...
Objective The purpose of this study was to determine whether physical stimulation is stressful to the ovine fetus, as judged from physiologic changes that are similar to those reported for other...
Kyle D. Zimmer, Mark A. Hanson, Malcolm G. Butler
Submerged macrophytes are important components of wetland ecosystems in the Prairie Pothole Region of North America, but factors influencing species abundance and community structure are poorly...
SELECTIVITY FOR ZOOPLANKTON PREY BY FATHEAD MINNOWS AND BROOK STICKLEBACKS (2003)
Leah M. Laurich, Kyle D. Zimmer, Malcolm G. Butler, Mark A. Hanson
Wetlands in the Prairie Pothole Region of North America are harsh environments for fish, and only two planktivorous species are common in these ecosystems: fathead minnows (Pimephales promelas) and...
The fetal llama versus the fetal sheep: different strategies to withstand hypoxia (2003)
Llanos, Anibal J., Riquelme, Raquel A., Sanhueza, Emilia M., Hanson, Mark A., Blanco, Carlos E., Parer, Julian T., ...
The pregnant llama (Lama glama) has walked for millions of years through the thin oxygen trail of the Andean altiplano. We hypothesize that a pool of genes has been selected in the llama that express...
Nishina, Hidenori, Green, Lucy R., McGarrigle, Hugh H.G., Noakes, David E., Poston, Lucilla, Hanson, Mark A.
Unbalanced maternal nutrition affects fetal endocrine and cardiovascular systems, sometimes accompanied by changes in growth, although this is usually in late gestation. We determined the effect of...
Peebles, Donald M., Miller, Suzanne, Newman, James P., Scott, Rosemary, Hanson, Mark A.
Objective: To investigate the effect of intravenous lipopolysaccharide on systemic and cerebral haemodynamics and oxygenation in the preterm ovine fetus. Design: Prospective observational study....
Gender-linked hypertension in offspring of lard-fed pregnant rats (2003)
Khan, Imran Y., Taylor, Paul D., Dekou, Vasia, Seed, Paul T., Lakasing, Lorin, Graham, Delyth, ...
Epidemiological studies suggest an association between maternal nutrition and offspring cardiovascular disease. We previously demonstrated endothelial dysfunction and abnormal aortic fatty acid...
Torrens, Christopher, Brawley, Lee, Barker, Alison C., Itoh, Shigeru, Poston, Lucilla, Hanson, Mark A.
Dietary protein restriction during gestation has been shown to produce vascular dysfunction in pregnant rats and hypertension in their offspring. However, no studies have to date examined the effects...
Prenatal programming of postnatal endocrine responses by glucocorticoids (2002)
Bertram, Caroline E., Hanson, Mark A.
Epidemiological studies have led to the hypothesis that a major component of the risk of diseases such as hypertension, coronary heart disease and non-insulin-dependent diabetes (the ‘metabolic...
Riquelme, Raquel A., Sánchez, Gina, Liberona, Leonal, Sanhueza, Emilia M., Giussani, Dino A., Blanco, Carlos E., ...
The hypothesis that nitric oxide plays a key role in the regulation of adrenal blood flow and plasma concentrations of cortisol and catecholamines under basal and hypoxaemic conditions in the llama...
Effects of chronic hypoxia and protein malnutrition on growth in the developing chick (2002)
Miller, Suzanne L., Green, Lucy R., Peebles, Donald M., Hanson, Mark A., Blanco, Carlos E.
Objective: the purpose of this study was to determine how chronic hypoxia and/or protein malnutrition in ovo affect growth in developing chicks. Study Design: chicken eggs were incubated under...
Itoh, Shigeru, Brawley, Lee, Wheeler, Timothy, Anthony, Frederick W., Poston, Lucilla, Hanson, Mark A.
Pregnancy is associated with a substantial increase in uterine artery blood flow, which may in part result from dilation in response to vascular endothelial growth factor (VEGF). Uterine blood flow...
A COMPARISON OF HORIZONTALLY AND VERTICALLY DEPLOYED AQUATIC INVERTEBRATE ACTIVITY TRAPS (2001)
Miles J. Muscha, Kyle D. Zimmer, Malcolm G. Butler, Mark A. Hanson
Activity traps are commonly used to develop abundance indices of aquatic invertebrates and may be deployed with either the funnel parallel to the water surface (horizontal position) or facing down...
Thesis(O.D.)--Pacific University, 2001.
Deng, Jing, Birkett, Alex G., Kalache, Karim D., Hanson, Mark A., Peebles, Donald M., Linney, Alfred D., ...
To remove motion artefacts, a device was built to convert "noisy" umbilical arterial Doppler waveforms (UADWs) from an ultrasound (US) system into sharp ECG R-wave-like cardiac cycle triggering...
Deng, Jing, Yates, Robert, Birkett, Alex G., Ruff, Clifford F., Linney, Alfred D., Lees, William R., ...
The aim of this study was to visualise the fetal heart in dynamic three dimensions (4-D) during an ultrasound (US) scan (online), rather than after (offline). With special pairing and sequential...
Kiserud, Torvid, Jauniaux, Eric, West, Daniel, Ozturk, Ozkan, Hanson, Mark A.
Objectives: to determine fetal haemodynamic responses to hyperoxaemia and hypoxaemia in early pregnancy. Design: repeated measurements in acute experiments. Setting: experimental physiology...
Animal models and programming of the metabolic syndrome. Type 2 diabetes (2001)
Bertram, Caroline E., Hanson, Mark A.
The purpose of this review is to consider how current animal models of fetal programming contribute to knowledge of the metabolic syndrome in adult humans. Low birth weight infants have an increased...
Kalache, Karim D., Ojutiku, Dale, Nishina, Hidenori, Green, Lucy R., Hanson, Mark A.
AIMS: We wanted to investigate whether experimental dietary manipulations during early pregnancy influence placental growth and subsequently the cardiovascular system as assessed non-invasively by...
Kalache, Karim D., Nishina, Hidenori, Ojutiku, Dale, Hanson, Mark A.
Objective: There is no information on ultrasonographic visualisation of the upper airways in the sheep fetus, but this species permits to examine the accuracy of ultrasonography in measuring the...
Newman, James P., Peebles, Donald M., Hanson, Mark A.
Rises in fetal adenosine during hypoxia may have a metabolic inhibitory role that helps the fetus adapt to periods of low arterial partial pressure of oxygen (PaO2). We examined the fetal cerebral...
Steyn, Clare, Hawkins, Paul, Saito, Tsukuru, Noakes, David E., Kingdom, John C., Hanson, Mark A.
Objective: To investigate, in sheep, the effects of maternal undernutrition during the first half of pregnancy on placental growth and development and fetal growth. Study design: Six ewes (R) were...
Animal models and programming of the metabolic syndrome: Type 2 diabetes (2001)
Bertram, Caroline E, Hanson, Mark A
The purpose of this review is to consider how current animal models of fetal programming contribute to knowledge of the metabolic syndrome in adult humans. Low birth weight infants have an increased...
Mark A. Hanson, Christiane C. Roy, Ned H. Euliss Jr., Kyle D. Zimmer, Michael R. Riggs, Malcolm G. Butler
We developed a surface-associated activity trap (SAT) for sampling aquatic invertebrates in wetlands. We compared performance of this trap with that of a conventional activity trap (AT) based on...
The movements of carbon dioxide in tissues including chemoreceptors / (1980)
Thesis (D. Phil.)--University of Oxford, 1980.
Developmental processes and the induction of cardiovascular function: conceptual aspects
Hanson, Mark A, Gluckman, Peter D
The epidemiological basis of the developmental origins of disease concept is now widely accepted. The current impetus in research concerns establishing the underlying mechanisms. We discuss the wider...
Developmental processes and the induction of cardiovascular function: conceptual aspects
Hanson, Mark A, Gluckman, Peter D
The epidemiological basis of the developmental origins of disease concept is now widely accepted. The current impetus in research concerns establishing the underlying mechanisms. We discuss the wider...
Gluckman, Peter D, Hanson, Mark A, Spencer, Hamish G, Bateson, Patrick
Early experience has a particularly great effect on most organisms. Normal development may be disrupted by early environmental influences; individuals that survive have to cope with the damaging...
Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, ...
The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
The effect of repeated acute hypoxaemia on fetal cardiovascular development in the sheep
Hypoxaemia during intrauterine life may be important in the development of cardiovascular diseases in later life. Thus it was the aim of this study to investigate the effect of repeated acute hypoxia...
Riquelme, Raquel A, Sánchez, Gina, Liberona, Leonel, Sanhueza, Emilia M, Giussani, Dino A, Blanco, Carlos E, ...
The hypothesis that nitric oxide plays a key role in the regulation of adrenal blood flow and plasma concentrations of cortisol and catecholamines under basal and hypoxaemic conditions in the llama...
Torrens, Christopher, Brawley, Lee, Barker, Alison C, Itoh, Shigeru, Poston, Lucilla, Hanson, Mark A
Dietary protein restriction during gestation has been shown to produce vascular dysfunction in pregnant rats and hypertension in their offspring. However, no studies have to date examined the effects...
Nishina, Hidenori, Green, Lucy R, McGarrigle, Hugh H G, Noakes, David E, Poston, Lucilla, Hanson, Mark A
Unbalanced maternal nutrition affects fetal endocrine and cardiovascular systems, sometimes accompanied by changes in growth, although this is usually in late gestation. We determined the effect of...
Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro
Cleal, Jane K, Brownbill, Paul, Godfrey, Keith M, Jackson, John M, Jackson, Alan A, Sibley, Colin P, ...
Fetal growth is dependent on both the quantity and relative composition of amino acids delivered to the fetal circulation, and impaired placental amino acid supply is associated with restricted fetal...
Johnsen, Synnøve L, Wilsgaard, Tom, Rasmussen, Svein, Hanson, Mark A, Godfrey, Keith M, Kiserud, Torvid
Watkins, Adam J, Wilkins, Adrian, Cunningham, Colm, Perry, V Hugh, Seet, Meei J, Osmond, Clive, ...
Early embryonic development is known to be susceptible to maternal undernutrition, leading to a disease-related postnatal phenotype. To determine whether this sensitivity extended into oocyte...
Bertram, Caroline, Khan, Omar, Ohri, Sunil, Phillips, David I, Matthews, Stephen G, Hanson, Mark A
The perinatal environment is a powerful determinant of risk for developing disease in later life. Here, we have shown that maternal undernutrition causes dramatic changes in heart structure and...
Costello, Paula M, Rowlerson, Anthea, Astaman, Nur Aida, Anthony, Fred Erick W, Sayer, Avan Aihie, Cooper, Cyrus, ...
Poor prenatal nutrition is associated with a greater risk of adult glucose intolerance and insulin insensitivity in the offspring. Skeletal muscle is the primary tissue for glucose utilization, and...
Rodford, Joanne L, Torrens, Christopher, Siow, Richard C M, Mann, Giovanni E, Hanson, Mark A, Clough, Geraldine F
Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant...